PhosphoNET

           
Protein Info 
   
Short Name:  WNK1
Full Name:  Serine/threonine-protein kinase WNK1
Alias:  EC 2.7.11.1; PRKWNK1; Protein kinase with no lysine 1; Protein kinase, lysine-deficient 1
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family
Mass (Da):  250756
Number AA:  2382
UniProt ID:  Q9H4A3
International Prot ID:  IPI00004472
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005624  GO:0005625 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004860 PhosphoSite+ KinaseNET
Biological Process:  GO:0006811  GO:0006468  GO:0007243 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S10GGAAEKQSSTPGSLF
Site 2S11GAAEKQSSTPGSLFL
Site 3T12AAEKQSSTPGSLFLS
Site 4S15KQSSTPGSLFLSPPA
Site 5S19TPGSLFLSPPAPAPK
Site 6S29APAPKNGSSSDSSVG
Site 7S30PAPKNGSSSDSSVGE
Site 8S31APKNGSSSDSSVGEK
Site 9S33KNGSSSDSSVGEKLG
Site 10S34NGSSSDSSVGEKLGA
Site 11Y54VTGRTEEYRRRRHTM
Site 12T60 EYRRRRHTMDKDSRG
Site 13S65RHTMDKDSRGAAATT
Site 14T71DSRGAAATTTTTEHR
Site 15T72SRGAAATTTTTEHRF
Site 16T74GAAATTTTTEHRFFR
Site 17T75AAATTTTTEHRFFRR
Site 18S83EHRFFRRSVICDSNA
Site 19S88RRSVICDSNATALEL
Site 20S114IPAAVPQSAPPEPHR
Site 21T124PEPHREETVTATATS
Site 22T126PHREETVTATATSQV
Site 23T155VAGPAPSTVPSSTSK
Site 24S158PAPSTVPSSTSKDRP
Site 25S159APSTVPSSTSKDRPV
Site 26S161STVPSSTSKDRPVSQ
Site 27S167TSKDRPVSQPSLVGS
Site 28S170DRPVSQPSLVGSKEE
Site 29S174SQPSLVGSKEEPPPA
Site 30S183EEPPPARSGSGGGSA
Site 31S185PPPARSGSGGGSAKE
Site 32S189RSGSGGGSAKEPQEE
Site 33T209DDIEELETKAVGMSN
Site 34S231DIEIGRGSFKTVYKG
Site 35Y236RGSFKTVYKGLDTET
Site 36T244KGLDTETTVEVAWCE
Site 37T258ELQDRKLTKSERQRF
Site 38Y284HPNIVRFYDSWESTV
Site 39S286NIVRFYDSWESTVKG
Site 40T308TELMTSGTLKTYLKR
Site 41Y312TSGTLKTYLKRFKVM
Site 42T340KGLQFLHTRTPPIIH
Site 43T342LQFLHTRTPPIIHRD
Site 44T373IGDLGLATLKRASFA
Site 45S378LATLKRASFAKSVIG
Site 46S382KRASFAKSVIGTPEF
Site 47Y399PEMYEEKYDESVDVY
Site 48S402YEEKYDESVDVYAFG
Site 49Y420LEMATSEYPYSECQN
Site 50S423ATSEYPYSECQNAAQ
Site 51Y432CQNAAQIYRRVTSGV
Site 52T436AQIYRRVTSGVKPAS
Site 53S437QIYRRVTSGVKPASF
Site 54S443TSGVKPASFDKVAIP
Site 55Y468RQNKDERYSIKDLLN
Site 56S469QNKDERYSIKDLLNH
Site 57Y516IKKLKGKYKDNEAIE
Site 58S525DNEAIEFSFDLERDV
Site 59S543VAQEMVESGYVCEGD
Site 60Y545QEMVESGYVCEGDHK
Site 61T553VCEGDHKTMAKAIKD
Site 62S563KAIKDRVSLIKRKRE
Site 63S599QVEQSSASQTGIKQL
Site 64T601EQSSASQTGIKQLPS
Site 65S608TGIKQLPSASTGIPT
Site 66T615SASTGIPTASTTSAS
Site 67S617STGIPTASTTSASVS
Site 68T618TGIPTASTTSASVST
Site 69S624STTSASVSTQVEPEE
Site 70Y642DQHQQLQYQQPSISV
Site 71S646QLQYQQPSISVLSDG
Site 72S648QYQQPSISVLSDGTV
Site 73S651QPSISVLSDGTVDSG
Site 74T654ISVLSDGTVDSGQGS
Site 75S657LSDGTVDSGQGSSVF
Site 76S661TVDSGQGSSVFTESR
Site 77S662VDSGQGSSVFTESRV
Site 78T665GQGSSVFTESRVSSQ
Site 79S667GSSVFTESRVSSQQT
Site 80S670VFTESRVSSQQTVSY
Site 81S671FTESRVSSQQTVSYG
Site 82T674SRVSSQQTVSYGSQH
Site 83S676VSSQQTVSYGSQHEQ
Site 84Y677SSQQTVSYGSQHEQA
Site 85S686SQHEQAHSTGTVPGH
Site 86T689EQAHSTGTVPGHIPS
Site 87S696TVPGHIPSTVQAQSQ
Site 88T697VPGHIPSTVQAQSQP
Site 89S702PSTVQAQSQPHGVYP
Site 90Y708QSQPHGVYPPSSVAQ
Site 91S711PHGVYPPSSVAQGQS
Site 92S712HGVYPPSSVAQGQSQ
Site 93S718SSVAQGQSQGQPSSS
Site 94S723GQSQGQPSSSSLTGV
Site 95S724QSQGQPSSSSLTGVS
Site 96S725SQGQPSSSSLTGVSS
Site 97S726QGQPSSSSLTGVSSS
Site 98T728QPSSSSLTGVSSSQP
Site 99S731SSSLTGVSSSQPIQH
Site 100S732SSLTGVSSSQPIQHP
Site 101S733SLTGVSSSQPIQHPQ
Site 102T754QTAPPQQTVQYSLSQ
Site 103S758PQQTVQYSLSQTSTS
Site 104S760QTVQYSLSQTSTSSE
Site 105T762VQYSLSQTSTSSEAT
Site 106T764YSLSQTSTSSEATTA
Site 107T770STSSEATTAQPVSQP
Site 108S775ATTAQPVSQPQAPQV
Site 109S795AGKQLPVSQPVPTIQ
Site 110T833PVGQPLPTPLLPQYP
Site 111T848VSQIPISTPHVSTAQ
Site 112T904PTLLQPVTQLPSQVH
Site 113S908QPVTQLPSQVHPQLL
Site 114S937QAAEVPLSSGDVLYQ
Site 115Y943LSSGDVLYQGFPPRL
Site 116Y954PPRLPPQYPGDSNIA
Site 117S958PPQYPGDSNIAPSSN
Site 118T1028GSLAQAPTTSSQQAV
Site 119S1031AQAPTTSSQQAVLES
Site 120T1063PQATQPTTLASSVDS
Site 121S1066TQPTTLASSVDSAHS
Site 122S1067QPTTLASSVDSAHSD
Site 123S1070TLASSVDSAHSDVAS
Site 124S1073SSVDSAHSDVASGMS
Site 125S1077SAHSDVASGMSDGNE
Site 126S1088DGNENVPSSSGRHEG
Site 127S1089GNENVPSSSGRHEGR
Site 128S1090NENVPSSSGRHEGRT
Site 129T1097SGRHEGRTTKRHYRK
Site 130T1098GRHEGRTTKRHYRKS
Site 131Y1102GRTTKRHYRKSVRSR
Site 132S1105TKRHYRKSVRSRSRH
Site 133S1108HYRKSVRSRSRHEKT
Site 134S1110RKSVRSRSRHEKTSR
Site 135T1115SRSRHEKTSRPKLRI
Site 136S1116RSRHEKTSRPKLRIL
Site 137S1126KLRILNVSNKGDRVV
Site 138T1146THNRKMVTFKFDLDG
Site 139T1161DNPEEIATIMVNNDF
Site 140S1176ILAIERESFVDQVRE
Site 141S1193EKADEMLSEDVSVEP
Site 142S1197EMLSEDVSVEPEGDQ
Site 143S1208EGDQGLESLQGKDDY
Site 144Y1215SLQGKDDYGFSGSQK
Site 145S1218GKDDYGFSGSQKLEG
Site 146S1220DDYGFSGSQKLEGEF
Site 147S1234FKQPIPASSMPQQIG
Site 148S1235KQPIPASSMPQQIGI
Site 149S1253SLTQVVHSAGRRFIV
Site 150S1261AGRRFIVSPVPESRL
Site 151S1266IVSPVPESRLRESKV
Site 152S1271PESRLRESKVFPSEI
Site 153T1281FPSEITDTVAASTAQ
Site 154S1285ITDTVAASTAQSPGM
Site 155S1289VAASTAQSPGMNLSH
Site 156S1295QSPGMNLSHSASSLS
Site 157S1297PGMNLSHSASSLSLQ
Site 158S1299MNLSHSASSLSLQQA
Site 159S1300NLSHSASSLSLQQAF
Site 160S1302SHSASSLSLQQAFSE
Site 161S1308LSLQQAFSELRRAQM
Site 162T1316ELRRAQMTEGPNTAP
Site 163T1321QMTEGPNTAPPNFSH
Site 164S1327NTAPPNFSHTGPTFP
Site 165T1329APPNFSHTGPTFPVV
Site 166T1332NFSHTGPTFPVVPPF
Site 167T1359ATAPVPATSSPPNDI
Site 168S1360TAPVPATSSPPNDIS
Site 169S1361APVPATSSPPNDIST
Site 170S1367SSPPNDISTSVIQSE
Site 171T1368SPPNDISTSVIQSEV
Site 172S1369PPNDISTSVIQSEVT
Site 173S1430SISTTSPSLQVPTST
Site 174S1463TSASAGGSTATPGPK
Site 175T1464SASAGGSTATPGPKP
Site 176T1466SAGGSTATPGPKPPA
Site 177S1476PKPPAVVSQQAAGST
Site 178T1494ATLTSVSTTTSFPST
Site 179T1495TLTSVSTTTSFPSTA
Site 180T1496LTSVSTTTSFPSTAS
Site 181S1497TSVSTTTSFPSTASQ
Site 182S1500STTTSFPSTASQLSI
Site 183T1501TTTSFPSTASQLSIQ
Site 184S1503TSFPSTASQLSIQLS
Site 185S1506PSTASQLSIQLSSST
Site 186S1510SQLSIQLSSSTSTPT
Site 187S1514IQLSSSTSTPTLAET
Site 188T1515QLSSSTSTPTLAETV
Site 189S1528TVVVSAHSLDKTSHS
Site 190T1532SAHSLDKTSHSSTTG
Site 191S1533AHSLDKTSHSSTTGL
Site 192S1535SLDKTSHSSTTGLAF
Site 193T1537DKTSHSSTTGLAFSL
Site 194S1545TGLAFSLSAPSSSSS
Site 195S1548AFSLSAPSSSSSPGA
Site 196S1549FSLSAPSSSSSPGAG
Site 197S1550SLSAPSSSSSPGAGV
Site 198S1551LSAPSSSSSPGAGVS
Site 199S1552SAPSSSSSPGAGVSS
Site 200S1558SSPGAGVSSYISQPG
Site 201S1559SPGAGVSSYISQPGG
Site 202Y1560PGAGVSSYISQPGGL
Site 203S1562AGVSSYISQPGGLHP
Site 204S1590PQAAGPTSTPLLPQV
Site 205T1591QAAGPTSTPLLPQVP
Site 206T1616NVPAVQQTLIHSQPQ
Site 207S1620VQQTLIHSQPQPALL
Site 208T1633LLPNQPHTHCPEVDS
Site 209S1640THCPEVDSDTQPKAP
Site 210T1642CPEVDSDTQPKAPGI
Site 211T1654PGIDDIKTLEEKLRS
Site 212S1661TLEEKLRSLFSEHSS
Site 213S1664EKLRSLFSEHSSSGA
Site 214S1667RSLFSEHSSSGAQHA
Site 215S1668SLFSEHSSSGAQHAS
Site 216S1669LFSEHSSSGAQHASV
Site 217S1675SSGAQHASVSLETSL
Site 218T1706PSKLLTSTTSTCLPP
Site 219T1707SKLLTSTTSTCLPPT
Site 220S1708KLLTSTTSTCLPPTN
Site 221T1736VTPGQVSTPVSTTTS
Site 222S1739GQVSTPVSTTTSGVK
Site 223S1743TPVSTTTSGVKPGTA
Site 224T1749TSGVKPGTAPSKPPL
Site 225S1752VKPGTAPSKPPLTKA
Site 226S1775LPAGTLPSEQLPPFP
Site 227S1785LPPFPGPSLTQSQQP
Site 228T1787PFPGPSLTQSQQPLE
Site 229S1789PGPSLTQSQQPLEDL
Site 230T1803LDAQLRRTLSPEIIT
Site 231T1810TLSPEIITVTSAVGP
Site 232S1838TQPQKGVSQVKEGPV
Site 233T1848KEGPVLATSSGAGVF
Site 234S1863KMGRFQVSVAADGAQ
Site 235S1877QKEGKNKSEDAKSVH
Site 236S1882NKSEDAKSVHFESST
Site 237S1887AKSVHFESSTSESSV
Site 238S1888KSVHFESSTSESSVL
Site 239T1889SVHFESSTSESSVLS
Site 240S1890VHFESSTSESSVLSS
Site 241S1892FESSTSESSVLSSSS
Site 242S1893ESSTSESSVLSSSSP
Site 243S1896TSESSVLSSSSPEST
Site 244S1897SESSVLSSSSPESTL
Site 245S1898ESSVLSSSSPESTLV
Site 246S1899SSVLSSSSPESTLVK
Site 247S1902LSSSSPESTLVKPEP
Site 248T1903SSSSPESTLVKPEPN
Site 249S1919ITIPGISSDVPESAH
Site 250S1924ISSDVPESAHKTTAS
Site 251T1928VPESAHKTTASEAKS
Site 252S1931SAHKTTASEAKSDTG
Site 253S1935TTASEAKSDTGQPTK
Site 254T1937ASEAKSDTGQPTKVG
Site 255T1950VGRFQVTTTANKVGR
Site 256S1959ANKVGRFSVSKTEDK
Site 257T1963GRFSVSKTEDKITDT
Site 258T1968SKTEDKITDTKKEGP
Site 259T1970TEDKITDTKKEGPVA
Site 260S1978KKEGPVASPPFMDLE
Site 261S2002KKEKPELSEPSHLNG
Site 262S2005KPELSEPSHLNGPSS
Site 263S2011PSHLNGPSSDPEAAF
Site 264S2012SHLNGPSSDPEAAFL
Site 265S2020DPEAAFLSRDVDDGS
Site 266S2027SRDVDDGSGSPHSPH
Site 267S2029DVDDGSGSPHSPHQL
Site 268S2032DGSGSPHSPHQLSSK
Site 269S2037PHSPHQLSSKSLPSQ
Site 270S2038HSPHQLSSKSLPSQN
Site 271S2040PHQLSSKSLPSQNLS
Site 272S2043LSSKSLPSQNLSQSL
Site 273S2047SLPSQNLSQSLSNSF
Site 274S2049PSQNLSQSLSNSFNS
Site 275S2051QNLSQSLSNSFNSSY
Site 276S2053LSQSLSNSFNSSYMS
Site 277S2056SLSNSFNSSYMSSDN
Site 278S2057LSNSFNSSYMSSDNE
Site 279Y2058SNSFNSSYMSSDNES
Site 280S2060SFNSSYMSSDNESDI
Site 281S2061FNSSYMSSDNESDIE
Site 282S2065YMSSDNESDIEDEDL
Site 283S2092KEIQDLQSRQKHEIE
Site 284S2100RQKHEIESLYTKLGK
Site 285Y2102KHEIESLYTKLGKVP
Site 286S2121IPPAAPLSGRRRRPT
Site 287T2128SGRRRRPTKSKGSKS
Site 288S2130RRRRPTKSKGSKSSR
Site 289S2133RPTKSKGSKSSRSSS
Site 290S2135TKSKGSKSSRSSSLG
Site 291S2136KSKGSKSSRSSSLGN
Site 292S2138KGSKSSRSSSLGNKS
Site 293S2139GSKSSRSSSLGNKSP
Site 294S2140SKSSRSSSLGNKSPQ
Site 295S2145SSSLGNKSPQLSGNL
Site 296S2149GNKSPQLSGNLSGQS
Site 297S2153PQLSGNLSGQSAASV
Site 298S2156SGNLSGQSAASVLHP
Site 299T2166SVLHPQQTLHPPGNI
Site 300S2176PPGNIPESGQNQLLQ
Site 301S2188LLQPLKPSPSSDNLY
Site 302S2190QPLKPSPSSDNLYSA
Site 303S2191PLKPSPSSDNLYSAF
Site 304Y2195SPSSDNLYSAFTSDG
Site 305S2196PSSDNLYSAFTSDGA
Site 306S2208DGAISVPSLSAPGQG
Site 307S2218APGQGTSSTNTVGAT
Site 308T2219PGQGTSSTNTVGATV
Site 309T2221QGTSSTNTVGATVNS
Site 310S2240AQPPAMTSSRKGTFT
Site 311S2241QPPAMTSSRKGTFTD
Site 312T2245MTSSRKGTFTDDLHK
Site 313T2247SSRKGTFTDDLHKLV
Site 314S2265ARDAMNLSGRRGSKG
Site 315S2270NLSGRRGSKGHMNYE
Site 316Y2276GSKGHMNYEGPGMAR
Site 317S2286PGMARKFSAPGQLCI
Site 318Y2326SMCPPQQYGFPATPF
Site 319T2331QQYGFPATPFGAQWS
Site 320S2338TPFGAQWSGTGGPAP
Site 321T2340FGAQWSGTGGPAPQP
Site 322S2358FQPVGTASLQNFNIS
Site 323S2365SLQNFNISNLQKSIS
Site 324S2370NISNLQKSISNPPGS
Site 325S2372SNLQKSISNPPGSNL
Site 326S2377SISNPPGSNLRTT__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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