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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC42EP4
Full Name:
Cdc42 effector protein 4
Alias:
Binder of Rho GTPases 4; BORG4; CDC42 effector protein (Rho GTPase binding) 4; CEP4; KAIA1777; MGC17125; MGC3740
Type:
Cytoskeletal protein
Mass (Da):
37980
Number AA:
356
UniProt ID:
Q9H3Q1
International Prot ID:
IPI00015894
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0017049
PhosphoSite+
KinaseNET
Biological Process:
GO:0031274
GO:0008360
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
I
L
K
Q
L
V
S
S
S
V
H
S
K
R
Site 2
S11
L
K
Q
L
V
S
S
S
V
H
S
K
R
R
S
Site 3
S14
L
V
S
S
S
V
H
S
K
R
R
S
R
A
D
Site 4
S18
S
V
H
S
K
R
R
S
R
A
D
L
T
A
E
Site 5
T23
R
R
S
R
A
D
L
T
A
E
M
I
S
A
P
Site 6
T37
P
L
G
D
F
R
H
T
M
H
V
G
R
A
G
Site 7
T50
A
G
D
A
F
G
D
T
S
F
L
N
S
K
A
Site 8
S51
G
D
A
F
G
D
T
S
F
L
N
S
K
A
G
Site 9
S55
G
D
T
S
F
L
N
S
K
A
G
E
P
D
G
Site 10
S64
A
G
E
P
D
G
E
S
L
D
E
Q
P
S
S
Site 11
S70
E
S
L
D
E
Q
P
S
S
S
S
S
K
R
S
Site 12
S71
S
L
D
E
Q
P
S
S
S
S
S
K
R
S
L
Site 13
S72
L
D
E
Q
P
S
S
S
S
S
K
R
S
L
L
Site 14
S73
D
E
Q
P
S
S
S
S
S
K
R
S
L
L
S
Site 15
S74
E
Q
P
S
S
S
S
S
K
R
S
L
L
S
R
Site 16
S77
S
S
S
S
S
K
R
S
L
L
S
R
K
F
R
Site 17
S80
S
S
K
R
S
L
L
S
R
K
F
R
G
S
K
Site 18
S86
L
S
R
K
F
R
G
S
K
R
S
Q
S
V
T
Site 19
S89
K
F
R
G
S
K
R
S
Q
S
V
T
R
G
E
Site 20
S91
R
G
S
K
R
S
Q
S
V
T
R
G
E
R
E
Site 21
T93
S
K
R
S
Q
S
V
T
R
G
E
R
E
Q
R
Site 22
S105
E
Q
R
D
M
L
G
S
L
R
D
S
A
L
F
Site 23
S109
M
L
G
S
L
R
D
S
A
L
F
V
K
N
A
Site 24
S118
L
F
V
K
N
A
M
S
L
P
Q
L
N
E
K
Site 25
S133
E
A
A
E
K
G
T
S
K
L
P
K
S
L
S
Site 26
S138
G
T
S
K
L
P
K
S
L
S
S
S
P
V
K
Site 27
S140
K
L
P
K
S
L
S
S
S
P
V
K
K
A
N
Site 28
S141
K
L
P
K
S
L
S
S
S
P
V
K
K
A
N
Site 29
S142
L
P
K
S
L
S
S
S
P
V
K
K
A
N
D
Site 30
T159
G
G
D
E
E
A
G
T
E
E
A
V
P
R
R
Site 31
S174
N
G
A
A
G
P
H
S
P
D
P
L
L
D
E
Site 32
T188
E
Q
A
F
G
D
L
T
D
L
P
V
V
P
K
Site 33
S208
K
H
A
E
S
I
M
S
F
H
I
D
L
G
P
Site 34
S223
S
M
L
G
D
V
L
S
I
M
D
K
E
E
W
Site 35
Y239
P
E
E
G
E
G
G
Y
H
G
D
E
G
A
A
Site 36
Y255
T
I
T
Q
A
P
P
Y
A
V
A
A
P
P
L
Site 37
S275
K
A
G
P
D
L
P
S
L
P
S
H
A
L
E
Site 38
S278
P
D
L
P
S
L
P
S
H
A
L
E
D
E
G
Site 39
S292
G
W
A
A
A
A
P
S
P
G
S
A
R
S
M
Site 40
S295
A
A
A
P
S
P
G
S
A
R
S
M
G
S
H
Site 41
S298
P
S
P
G
S
A
R
S
M
G
S
H
T
T
R
Site 42
S301
G
S
A
R
S
M
G
S
H
T
T
R
D
S
S
Site 43
T303
A
R
S
M
G
S
H
T
T
R
D
S
S
S
L
Site 44
T304
R
S
M
G
S
H
T
T
R
D
S
S
S
L
S
Site 45
S307
G
S
H
T
T
R
D
S
S
S
L
S
S
C
T
Site 46
S308
S
H
T
T
R
D
S
S
S
L
S
S
C
T
S
Site 47
S309
H
T
T
R
D
S
S
S
L
S
S
C
T
S
G
Site 48
S311
T
R
D
S
S
S
L
S
S
C
T
S
G
I
L
Site 49
S312
R
D
S
S
S
L
S
S
C
T
S
G
I
L
E
Site 50
T314
S
S
S
L
S
S
C
T
S
G
I
L
E
E
R
Site 51
S315
S
S
L
S
S
C
T
S
G
I
L
E
E
R
S
Site 52
S322
S
G
I
L
E
E
R
S
P
A
F
R
G
P
D
Site 53
S344
R
Q
P
D
K
E
F
S
F
M
D
E
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation