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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC12A5
Full Name:
Solute carrier family 12 member 5
Alias:
Electroneutral potassium-chloride cotransporter 2; Erythroid K-Cl cotransporter 2; KCC2; KIAA1176; Neuronal K-Cl cotransporter; S12A5; Solute carrier family 12 (potassium-chloride transporter) member 5; Solute carrier family 12, 5
Type:
Transporter; Membrane protein, integral
Mass (Da):
126184
Number AA:
1139
UniProt ID:
Q9H2X9
International Prot ID:
IPI00301180
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0015379
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Solute carrier family 12 member 5 pan-specific antibody AB-NN322-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN322-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
R
R
F
T
V
T
S
L
P
P
A
Site 2
T8
M
S
R
R
F
T
V
T
S
L
P
P
A
G
P
Site 3
S9
S
R
R
F
T
V
T
S
L
P
P
A
G
P
A
Site 4
S18
P
P
A
G
P
A
R
S
P
D
P
E
S
R
R
Site 5
S23
A
R
S
P
D
P
E
S
R
R
H
S
V
A
D
Site 6
S27
D
P
E
S
R
R
H
S
V
A
D
P
R
H
L
Site 7
S48
G
D
G
N
P
K
E
S
S
P
F
I
N
S
T
Site 8
S49
D
G
N
P
K
E
S
S
P
F
I
N
S
T
D
Site 9
S54
E
S
S
P
F
I
N
S
T
D
T
E
K
G
K
Site 10
T55
S
S
P
F
I
N
S
T
D
T
E
K
G
K
E
Site 11
T57
P
F
I
N
S
T
D
T
E
K
G
K
E
Y
D
Site 12
Y63
D
T
E
K
G
K
E
Y
D
G
K
N
M
A
L
Site 13
T77
L
F
E
E
E
M
D
T
S
P
M
V
S
S
L
Site 14
S78
F
E
E
E
M
D
T
S
P
M
V
S
S
L
L
Site 15
T92
L
S
G
L
A
N
Y
T
N
L
P
Q
G
S
R
Site 16
S192
G
G
S
Y
Y
M
I
S
R
S
L
G
P
E
F
Site 17
S194
S
Y
Y
M
I
S
R
S
L
G
P
E
F
G
G
Site 18
T316
I
C
L
L
G
N
R
T
L
S
R
H
G
F
D
Site 19
S318
L
L
G
N
R
T
L
S
R
H
G
F
D
V
C
Site 20
T335
L
A
W
E
G
N
E
T
V
T
T
R
L
W
G
Site 21
T338
E
G
N
E
T
V
T
T
R
L
W
G
L
F
C
Site 22
T353
S
S
R
F
L
N
A
T
C
D
E
Y
F
T
R
Site 23
Y357
L
N
A
T
C
D
E
Y
F
T
R
N
N
V
T
Site 24
S383
L
I
K
E
N
L
W
S
S
Y
L
T
K
G
V
Site 25
S384
I
K
E
N
L
W
S
S
Y
L
T
K
G
V
I
Site 26
Y385
K
E
N
L
W
S
S
Y
L
T
K
G
V
I
V
Site 27
T387
N
L
W
S
S
Y
L
T
K
G
V
I
V
E
R
Site 28
S399
V
E
R
S
G
M
T
S
V
G
L
A
D
G
T
Site 29
T406
S
V
G
L
A
D
G
T
P
I
D
M
D
H
P
Site 30
Y414
P
I
D
M
D
H
P
Y
V
F
S
D
M
T
S
Site 31
S441
V
T
G
I
M
A
G
S
N
R
S
G
D
L
R
Site 32
S453
D
L
R
D
A
Q
K
S
I
P
T
G
T
I
L
Site 33
T501
N
G
N
L
V
V
G
T
L
A
W
P
S
P
W
Site 34
T607
A
V
Q
T
L
L
R
T
P
N
W
R
P
R
F
Site 35
Y617
W
R
P
R
F
R
Y
Y
H
W
T
L
S
F
L
Site 36
S622
R
Y
Y
H
W
T
L
S
F
L
G
M
S
L
C
Site 37
S672
G
D
G
I
R
G
L
S
L
S
A
A
R
Y
A
Site 38
T690
L
E
E
G
P
P
H
T
K
N
W
R
P
Q
L
Site 39
S719
P
Q
L
L
S
L
T
S
Q
L
K
A
G
K
G
Site 40
T737
V
G
S
V
L
E
G
T
F
L
E
N
H
P
Q
Site 41
S751
Q
A
Q
R
A
E
E
S
I
R
R
L
M
E
A
Site 42
S778
S
N
L
R
D
G
V
S
H
L
I
Q
S
G
G
Site 43
T821
F
I
E
L
V
R
E
T
T
A
G
H
L
A
L
Site 44
T831
G
H
L
A
L
L
V
T
K
N
V
S
M
F
P
Site 45
S845
P
G
N
P
E
R
F
S
E
G
S
I
D
V
W
Site 46
T899
I
Q
M
K
K
D
L
T
T
F
L
Y
H
L
R
Site 47
T900
Q
M
K
K
D
L
T
T
F
L
Y
H
L
R
I
Site 48
Y903
K
D
L
T
T
F
L
Y
H
L
R
I
T
A
E
Site 49
S919
E
V
V
E
M
H
E
S
D
I
S
A
Y
T
Y
Site 50
S922
E
M
H
E
S
D
I
S
A
Y
T
Y
E
K
T
Site 51
Y926
S
D
I
S
A
Y
T
Y
E
K
T
L
V
M
E
Site 52
T929
S
A
Y
T
Y
E
K
T
L
V
M
E
Q
R
S
Site 53
S936
T
L
V
M
E
Q
R
S
Q
I
L
K
Q
M
H
Site 54
S955
E
R
E
R
E
I
Q
S
I
T
D
E
S
R
G
Site 55
T957
E
R
E
I
Q
S
I
T
D
E
S
R
G
S
I
Site 56
S960
I
Q
S
I
T
D
E
S
R
G
S
I
R
R
K
Site 57
S963
I
T
D
E
S
R
G
S
I
R
R
K
N
P
A
Site 58
S986
P
E
E
T
A
G
D
S
E
E
K
P
E
E
E
Site 59
S1001
V
Q
L
I
H
D
Q
S
A
P
S
C
P
S
S
Site 60
S1004
I
H
D
Q
S
A
P
S
C
P
S
S
S
P
S
Site 61
S1007
Q
S
A
P
S
C
P
S
S
S
P
S
P
G
E
Site 62
S1008
S
A
P
S
C
P
S
S
S
P
S
P
G
E
E
Site 63
S1009
A
P
S
C
P
S
S
S
P
S
P
G
E
E
P
Site 64
S1011
S
C
P
S
S
S
P
S
P
G
E
E
P
E
G
Site 65
T1030
D
P
E
K
V
H
L
T
W
T
K
D
K
S
V
Site 66
T1032
E
K
V
H
L
T
W
T
K
D
K
S
V
A
E
Site 67
S1036
L
T
W
T
K
D
K
S
V
A
E
K
N
K
G
Site 68
S1045
A
E
K
N
K
G
P
S
P
V
S
S
E
G
I
Site 69
S1048
N
K
G
P
S
P
V
S
S
E
G
I
K
D
F
Site 70
S1049
K
G
P
S
P
V
S
S
E
G
I
K
D
F
F
Site 71
T1075
S
N
V
R
R
M
H
T
A
V
R
L
N
E
V
Site 72
Y1110
N
R
N
G
D
E
N
Y
M
E
F
L
E
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation