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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADNP
Full Name:
Activity-dependent neuroprotector homeobox protein
Alias:
Activity-dependent neuroprotective protein; Activity-dependent neuroprotector; Activity-dependent neuroprotector homeobox; ADNP homeobox 1; ADNP1; KIAA0784
Type:
Apoptosis
Mass (Da):
123563
Number AA:
1102
UniProt ID:
Q9H2P0
International Prot ID:
IPI00022215
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
P
V
N
N
L
G
S
L
R
K
A
R
K
T
Site 2
T18
S
L
R
K
A
R
K
T
V
K
K
I
L
S
D
Site 3
Y47
Q
F
E
P
N
D
F
Y
L
K
N
T
T
W
E
Site 4
S62
D
V
G
L
W
D
P
S
L
T
K
N
Q
D
Y
Site 5
Y69
S
L
T
K
N
Q
D
Y
R
T
K
P
F
C
C
Site 6
S77
R
T
K
P
F
C
C
S
A
C
P
F
S
S
K
Site 7
S87
P
F
S
S
K
F
F
S
A
Y
K
S
H
F
R
Site 8
Y89
S
S
K
F
F
S
A
Y
K
S
H
F
R
N
V
Site 9
S98
S
H
F
R
N
V
H
S
E
D
F
E
N
R
I
Site 10
Y111
R
I
L
L
N
C
P
Y
C
T
F
N
A
D
K
Site 11
T120
T
F
N
A
D
K
K
T
L
E
T
H
I
K
I
Site 12
S134
I
F
H
A
P
N
A
S
A
P
S
S
S
L
S
Site 13
S137
A
P
N
A
S
A
P
S
S
S
L
S
T
F
K
Site 14
S138
P
N
A
S
A
P
S
S
S
L
S
T
F
K
D
Site 15
S139
N
A
S
A
P
S
S
S
L
S
T
F
K
D
K
Site 16
S141
S
A
P
S
S
S
L
S
T
F
K
D
K
N
K
Site 17
T142
A
P
S
S
S
L
S
T
F
K
D
K
N
K
N
Site 18
S159
L
K
P
K
Q
A
D
S
V
E
Q
A
V
Y
Y
Site 19
Y165
D
S
V
E
Q
A
V
Y
Y
C
K
K
C
T
Y
Site 20
Y166
S
V
E
Q
A
V
Y
Y
C
K
K
C
T
Y
R
Site 21
Y172
Y
Y
C
K
K
C
T
Y
R
D
P
L
Y
E
I
Site 22
Y177
C
T
Y
R
D
P
L
Y
E
I
V
R
K
H
I
Site 23
Y185
E
I
V
R
K
H
I
Y
R
E
H
F
Q
H
V
Site 24
Y196
F
Q
H
V
A
A
P
Y
I
A
K
A
G
E
K
Site 25
S213
N
G
A
V
P
L
G
S
N
A
R
E
E
S
S
Site 26
S219
G
S
N
A
R
E
E
S
S
I
H
C
K
R
C
Site 27
Y249
E
D
H
E
R
I
G
Y
Q
V
T
A
M
I
G
Site 28
S280
P
K
P
Q
D
K
K
S
M
G
L
P
P
R
I
Site 29
S289
G
L
P
P
R
I
G
S
L
A
S
G
N
V
R
Site 30
S292
P
R
I
G
S
L
A
S
G
N
V
R
S
L
P
Site 31
S297
L
A
S
G
N
V
R
S
L
P
S
Q
Q
M
V
Site 32
S300
G
N
V
R
S
L
P
S
Q
Q
M
V
N
R
L
Site 33
S308
Q
Q
M
V
N
R
L
S
I
P
K
P
N
L
N
Site 34
T317
P
K
P
N
L
N
S
T
G
V
N
M
M
S
S
Site 35
Y332
V
H
L
Q
Q
N
N
Y
G
V
K
S
V
G
Q
Site 36
S336
Q
N
N
Y
G
V
K
S
V
G
Q
G
Y
S
V
Site 37
S342
K
S
V
G
Q
G
Y
S
V
G
Q
S
M
R
L
Site 38
S346
Q
G
Y
S
V
G
Q
S
M
R
L
G
L
G
G
Site 39
S358
L
G
G
N
A
P
V
S
I
P
Q
Q
S
Q
S
Site 40
S363
P
V
S
I
P
Q
Q
S
Q
S
V
K
Q
L
L
Site 41
S365
S
I
P
Q
Q
S
Q
S
V
K
Q
L
L
P
S
Site 42
S372
S
V
K
Q
L
L
P
S
G
N
G
R
S
Y
G
Site 43
S377
L
P
S
G
N
G
R
S
Y
G
L
G
S
E
Q
Site 44
Y378
P
S
G
N
G
R
S
Y
G
L
G
S
E
Q
R
Site 45
S382
G
R
S
Y
G
L
G
S
E
Q
R
S
Q
A
P
Site 46
S386
G
L
G
S
E
Q
R
S
Q
A
P
A
R
Y
S
Site 47
S393
S
Q
A
P
A
R
Y
S
L
Q
S
A
N
A
S
Site 48
S396
P
A
R
Y
S
L
Q
S
A
N
A
S
S
L
S
Site 49
S400
S
L
Q
S
A
N
A
S
S
L
S
S
G
Q
L
Site 50
S401
L
Q
S
A
N
A
S
S
L
S
S
G
Q
L
K
Site 51
S403
S
A
N
A
S
S
L
S
S
G
Q
L
K
S
P
Site 52
S404
A
N
A
S
S
L
S
S
G
Q
L
K
S
P
S
Site 53
S409
L
S
S
G
Q
L
K
S
P
S
L
S
Q
S
Q
Site 54
S411
S
G
Q
L
K
S
P
S
L
S
Q
S
Q
A
S
Site 55
S413
Q
L
K
S
P
S
L
S
Q
S
Q
A
S
R
V
Site 56
S415
K
S
P
S
L
S
Q
S
Q
A
S
R
V
L
G
Site 57
S418
S
L
S
Q
S
Q
A
S
R
V
L
G
Q
S
S
Site 58
S424
A
S
R
V
L
G
Q
S
S
S
K
P
A
A
A
Site 59
S425
S
R
V
L
G
Q
S
S
S
K
P
A
A
A
A
Site 60
S426
R
V
L
G
Q
S
S
S
K
P
A
A
A
A
T
Site 61
T433
S
K
P
A
A
A
A
T
G
P
P
P
G
N
T
Site 62
S442
P
P
P
G
N
T
S
S
T
Q
K
W
K
I
C
Site 63
Y493
N
F
T
S
K
C
L
Y
C
N
R
Y
L
P
T
Site 64
Y497
K
C
L
Y
C
N
R
Y
L
P
T
D
T
L
L
Site 65
T502
N
R
Y
L
P
T
D
T
L
L
N
H
M
L
I
Site 66
Y516
I
H
G
L
S
C
P
Y
C
R
S
T
F
N
D
Site 67
T544
D
E
E
M
G
P
K
T
D
S
T
L
S
F
D
Site 68
S546
E
M
G
P
K
T
D
S
T
L
S
F
D
L
T
Site 69
T547
M
G
P
K
T
D
S
T
L
S
F
D
L
T
L
Site 70
S549
P
K
T
D
S
T
L
S
F
D
L
T
L
Q
Q
Site 71
T553
S
T
L
S
F
D
L
T
L
Q
Q
G
S
H
T
Site 72
Y581
A
P
A
E
S
V
A
Y
H
A
Q
N
N
P
P
Site 73
S607
K
A
D
I
P
V
K
S
S
P
Q
A
A
V
P
Site 74
S608
A
D
I
P
V
K
S
S
P
Q
A
A
V
P
Y
Site 75
T622
Y
K
K
D
V
G
K
T
L
C
P
L
C
F
S
Site 76
S629
T
L
C
P
L
C
F
S
I
L
K
G
P
I
S
Site 77
T652
E
R
H
Q
V
I
Q
T
V
H
P
V
E
K
K
Site 78
Y662
P
V
E
K
K
L
T
Y
K
C
I
H
C
L
G
Site 79
S678
Y
T
S
N
M
T
A
S
T
I
T
L
H
L
V
Site 80
T693
H
C
R
G
V
G
K
T
Q
N
G
Q
D
K
T
Site 81
T700
T
Q
N
G
Q
D
K
T
N
A
P
S
R
L
N
Site 82
S709
A
P
S
R
L
N
Q
S
P
S
L
A
P
V
K
Site 83
S711
S
R
L
N
Q
S
P
S
L
A
P
V
K
R
T
Site 84
Y719
L
A
P
V
K
R
T
Y
E
Q
M
E
F
P
L
Site 85
S736
K
R
K
L
D
D
D
S
D
S
P
S
F
F
E
Site 86
S738
K
L
D
D
D
S
D
S
P
S
F
F
E
E
K
Site 87
S740
D
D
D
S
D
S
P
S
F
F
E
E
K
P
E
Site 88
S763
P
K
G
H
E
D
D
S
Y
E
A
R
K
S
F
Site 89
Y764
K
G
H
E
D
D
S
Y
E
A
R
K
S
F
L
Site 90
S769
D
S
Y
E
A
R
K
S
F
L
T
K
Y
F
N
Site 91
T772
E
A
R
K
S
F
L
T
K
Y
F
N
K
Q
P
Site 92
Y774
R
K
S
F
L
T
K
Y
F
N
K
Q
P
Y
P
Site 93
Y780
K
Y
F
N
K
Q
P
Y
P
T
R
R
E
I
E
Site 94
S792
E
I
E
K
L
A
A
S
L
W
L
W
K
S
D
Site 95
S798
A
S
L
W
L
W
K
S
D
I
A
S
H
F
S
Site 96
S802
L
W
K
S
D
I
A
S
H
F
S
N
K
R
K
Site 97
S805
S
D
I
A
S
H
F
S
N
K
R
K
K
C
V
Site 98
Y818
C
V
R
D
C
E
K
Y
K
P
G
V
L
L
G
Site 99
T861
S
R
V
N
A
S
K
T
A
D
K
K
L
N
L
Site 100
S874
N
L
G
K
E
D
D
S
S
S
D
S
F
E
N
Site 101
S875
L
G
K
E
D
D
S
S
S
D
S
F
E
N
L
Site 102
S876
G
K
E
D
D
S
S
S
D
S
F
E
N
L
E
Site 103
S878
E
D
D
S
S
S
D
S
F
E
N
L
E
E
E
Site 104
S886
F
E
N
L
E
E
E
S
N
E
S
G
S
P
F
Site 105
S889
L
E
E
E
S
N
E
S
G
S
P
F
D
P
V
Site 106
S891
E
E
S
N
E
S
G
S
P
F
D
P
V
F
E
Site 107
S904
F
E
V
E
P
K
I
S
N
D
N
P
E
E
H
Site 108
S921
K
V
I
P
E
D
A
S
E
S
E
E
K
L
D
Site 109
S934
L
D
Q
K
E
D
G
S
K
Y
E
T
I
H
L
Site 110
Y936
Q
K
E
D
G
S
K
Y
E
T
I
H
L
T
E
Site 111
T938
E
D
G
S
K
Y
E
T
I
H
L
T
E
E
P
Site 112
T942
K
Y
E
T
I
H
L
T
E
E
P
T
K
L
M
Site 113
S953
T
K
L
M
H
N
A
S
D
S
E
V
D
Q
D
Site 114
S955
L
M
H
N
A
S
D
S
E
V
D
Q
D
D
V
Site 115
S970
V
E
W
K
D
G
A
S
P
S
E
S
G
P
G
Site 116
S972
W
K
D
G
A
S
P
S
E
S
G
P
G
S
Q
Site 117
S974
D
G
A
S
P
S
E
S
G
P
G
S
Q
Q
V
Site 118
S978
P
S
E
S
G
P
G
S
Q
Q
V
S
D
F
E
Site 119
S982
G
P
G
S
Q
Q
V
S
D
F
E
D
N
T
C
Site 120
T988
V
S
D
F
E
D
N
T
C
E
M
K
P
G
T
Site 121
T995
T
C
E
M
K
P
G
T
W
S
D
E
S
S
Q
Site 122
S997
E
M
K
P
G
T
W
S
D
E
S
S
Q
S
E
Site 123
S1000
P
G
T
W
S
D
E
S
S
Q
S
E
D
A
R
Site 124
S1001
G
T
W
S
D
E
S
S
Q
S
E
D
A
R
S
Site 125
S1003
W
S
D
E
S
S
Q
S
E
D
A
R
S
S
K
Site 126
S1008
S
Q
S
E
D
A
R
S
S
K
P
A
A
K
K
Site 127
S1009
Q
S
E
D
A
R
S
S
K
P
A
A
K
K
K
Site 128
S1031
E
Q
L
K
W
K
N
S
S
Y
G
K
V
E
G
Site 129
Y1033
L
K
W
K
N
S
S
Y
G
K
V
E
G
F
W
Site 130
S1058
S
E
N
D
E
R
L
S
N
P
Q
I
E
W
Q
Site 131
S1067
P
Q
I
E
W
Q
N
S
T
I
D
S
E
D
G
Site 132
S1071
W
Q
N
S
T
I
D
S
E
D
G
E
Q
F
D
Site 133
T1081
G
E
Q
F
D
N
M
T
D
G
V
A
E
P
M
Site 134
S1098
S
L
A
G
V
K
L
S
S
Q
Q
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation