KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZFYVE20
Full Name:
Rabenosyn-5
Alias:
FYVE finger-containing Rab5 effector protein rabenosyn-5; Rabenosyn-5: FYVE finger-containing Rab5 effector protein rabenosyn-5: Zinc finger FYVE domain-containing protein 20: 110 kDa protein
Type:
Adapter/scaffold protein
Mass (Da):
88870
Number AA:
784
UniProt ID:
Q9H1K0
International Prot ID:
IPI00007057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0005768
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008270
GO:0008270
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
GO:0016197
GO:0015031
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
L
C
L
K
D
L
Q
S
F
Y
Q
L
H
S
H
Site 2
Y27
L
K
D
L
Q
S
F
Y
Q
L
H
S
H
Y
E
Site 3
S31
Q
S
F
Y
Q
L
H
S
H
Y
E
E
E
H
S
Site 4
Y33
F
Y
Q
L
H
S
H
Y
E
E
E
H
S
G
E
Site 5
S38
S
H
Y
E
E
E
H
S
G
E
D
R
D
V
K
Site 6
S50
D
V
K
G
Q
I
K
S
L
V
Q
K
A
K
K
Site 7
S73
E
G
D
D
R
A
E
S
G
T
Q
G
Y
E
S
Site 8
T75
D
D
R
A
E
S
G
T
Q
G
Y
E
S
F
S
Site 9
Y78
A
E
S
G
T
Q
G
Y
E
S
F
S
Y
G
G
Site 10
S80
S
G
T
Q
G
Y
E
S
F
S
Y
G
G
V
D
Site 11
S82
T
Q
G
Y
E
S
F
S
Y
G
G
V
D
P
Y
Site 12
Y83
Q
G
Y
E
S
F
S
Y
G
G
V
D
P
Y
M
Site 13
Y89
S
Y
G
G
V
D
P
Y
M
W
E
P
Q
E
L
Site 14
S101
Q
E
L
G
A
V
R
S
H
L
S
D
F
K
K
Site 15
S104
G
A
V
R
S
H
L
S
D
F
K
K
H
R
A
Site 16
Y117
R
A
A
R
I
D
H
Y
V
V
E
V
N
K
L
Site 17
T132
I
I
R
L
E
K
L
T
A
F
D
R
T
N
T
Site 18
T137
K
L
T
A
F
D
R
T
N
T
E
S
A
K
I
Site 19
T139
T
A
F
D
R
T
N
T
E
S
A
K
I
R
A
Site 20
S141
F
D
R
T
N
T
E
S
A
K
I
R
A
I
E
Site 21
S150
K
I
R
A
I
E
K
S
V
V
P
W
V
N
D
Site 22
S195
K
K
C
M
E
L
I
S
L
P
L
A
N
K
L
Site 23
T203
L
P
L
A
N
K
L
T
S
A
S
K
E
S
L
Site 24
S204
P
L
A
N
K
L
T
S
A
S
K
E
S
L
S
Site 25
S206
A
N
K
L
T
S
A
S
K
E
S
L
S
T
H
Site 26
S209
L
T
S
A
S
K
E
S
L
S
T
H
T
S
P
Site 27
S211
S
A
S
K
E
S
L
S
T
H
T
S
P
S
Q
Site 28
T212
A
S
K
E
S
L
S
T
H
T
S
P
S
Q
S
Site 29
T214
K
E
S
L
S
T
H
T
S
P
S
Q
S
P
N
Site 30
S215
E
S
L
S
T
H
T
S
P
S
Q
S
P
N
S
Site 31
S217
L
S
T
H
T
S
P
S
Q
S
P
N
S
V
H
Site 32
S219
T
H
T
S
P
S
Q
S
P
N
S
V
H
G
S
Site 33
S222
S
P
S
Q
S
P
N
S
V
H
G
S
R
R
G
Site 34
S226
S
P
N
S
V
H
G
S
R
R
G
S
I
S
S
Site 35
S230
V
H
G
S
R
R
G
S
I
S
S
M
S
S
V
Site 36
S232
G
S
R
R
G
S
I
S
S
M
S
S
V
S
S
Site 37
S233
S
R
R
G
S
I
S
S
M
S
S
V
S
S
V
Site 38
S235
R
G
S
I
S
S
M
S
S
V
S
S
V
L
D
Site 39
S236
G
S
I
S
S
M
S
S
V
S
S
V
L
D
E
Site 40
S239
S
S
M
S
S
V
S
S
V
L
D
E
K
D
D
Site 41
T272
Q
I
D
E
K
E
H
T
P
D
I
V
K
L
Y
Site 42
Y296
V
D
Q
K
A
P
E
Y
I
R
M
A
A
S
L
Site 43
S311
N
A
G
E
T
T
Y
S
L
E
H
A
S
D
L
Site 44
S316
T
Y
S
L
E
H
A
S
D
L
R
V
E
V
Q
Site 45
S350
Q
D
P
P
P
H
P
S
N
L
R
L
Q
R
M
Site 46
S361
L
Q
R
M
I
R
Y
S
A
T
L
F
V
Q
E
Site 47
T363
R
M
I
R
Y
S
A
T
L
F
V
Q
E
K
L
Site 48
S375
E
K
L
L
G
L
M
S
L
P
T
K
E
Q
F
Site 49
T378
L
G
L
M
S
L
P
T
K
E
Q
F
E
E
L
Site 50
S407
E
R
Q
A
A
L
E
S
Q
R
R
L
E
E
R
Site 51
S416
R
R
L
E
E
R
Q
S
G
L
A
S
R
A
A
Site 52
S420
E
R
Q
S
G
L
A
S
R
A
A
N
G
E
V
Site 53
S429
A
A
N
G
E
V
A
S
L
R
R
G
P
A
P
Site 54
S447
A
E
G
W
L
P
L
S
G
G
Q
G
Q
S
E
Site 55
S453
L
S
G
G
Q
G
Q
S
E
D
S
D
P
L
L
Site 56
S456
G
Q
G
Q
S
E
D
S
D
P
L
L
Q
Q
I
Site 57
Y496
L
R
Q
L
Q
D
E
Y
D
Q
Q
Q
T
E
K
Site 58
T501
D
E
Y
D
Q
Q
Q
T
E
K
A
I
E
L
S
Site 59
S508
T
E
K
A
I
E
L
S
R
R
Q
A
E
E
E
Site 60
S541
R
E
Q
F
R
V
A
S
L
H
T
R
T
R
S
Site 61
S548
S
L
H
T
R
T
R
S
L
D
F
R
E
I
G
Site 62
S562
G
P
F
Q
L
E
P
S
R
E
P
R
T
H
L
Site 63
Y571
E
P
R
T
H
L
A
Y
A
L
D
L
G
S
S
Site 64
S577
A
Y
A
L
D
L
G
S
S
P
V
P
S
S
T
Site 65
S578
Y
A
L
D
L
G
S
S
P
V
P
S
S
T
A
Site 66
S582
L
G
S
S
P
V
P
S
S
T
A
P
K
T
P
Site 67
S583
G
S
S
P
V
P
S
S
T
A
P
K
T
P
S
Site 68
T584
S
S
P
V
P
S
S
T
A
P
K
T
P
S
L
Site 69
T588
P
S
S
T
A
P
K
T
P
S
L
S
S
T
Q
Site 70
S590
S
T
A
P
K
T
P
S
L
S
S
T
Q
P
T
Site 71
S592
A
P
K
T
P
S
L
S
S
T
Q
P
T
R
V
Site 72
S593
P
K
T
P
S
L
S
S
T
Q
P
T
R
V
W
Site 73
T594
K
T
P
S
L
S
S
T
Q
P
T
R
V
W
S
Site 74
T597
S
L
S
S
T
Q
P
T
R
V
W
S
G
P
P
Site 75
S601
T
Q
P
T
R
V
W
S
G
P
P
A
V
G
Q
Site 76
S614
G
Q
E
R
L
P
Q
S
S
M
P
Q
Q
H
E
Site 77
S615
Q
E
R
L
P
Q
S
S
M
P
Q
Q
H
E
G
Site 78
S624
P
Q
Q
H
E
G
P
S
L
N
P
F
D
E
E
Site 79
S634
P
F
D
E
E
D
L
S
S
P
M
E
E
A
T
Site 80
S635
F
D
E
E
D
L
S
S
P
M
E
E
A
T
T
Site 81
T641
S
S
P
M
E
E
A
T
T
G
P
P
A
A
G
Site 82
T642
S
P
M
E
E
A
T
T
G
P
P
A
A
G
V
Site 83
S654
A
G
V
S
L
D
P
S
A
R
I
L
K
E
Y
Site 84
Y661
S
A
R
I
L
K
E
Y
N
P
F
E
E
E
D
Site 85
S684
N
P
F
I
Q
P
D
S
P
A
P
N
P
F
S
Site 86
S691
S
P
A
P
N
P
F
S
E
E
D
E
H
P
Q
Site 87
S702
E
H
P
Q
Q
R
L
S
S
P
L
V
P
G
N
Site 88
S703
H
P
Q
Q
R
L
S
S
P
L
V
P
G
N
P
Site 89
S724
I
N
P
F
E
M
D
S
D
S
G
P
E
A
E
Site 90
S726
P
F
E
M
D
S
D
S
G
P
E
A
E
E
P
Site 91
T775
N
L
R
E
L
K
H
T
L
A
K
Q
K
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation