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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ILKAP
Full Name:
Integrin-linked kinase-associated serine/threonine phosphatase 2C
Alias:
DKFZP434J2031; EC 3.1.3.16; PP2CX
Type:
Protein-serine phosphatase
Mass (Da):
42907
Number AA:
392
UniProt ID:
Q9H0C8
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0008287
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0030145
GO:0004722
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
GO:0006470
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
L
P
E
P
E
R
S
P
R
P
A
A
G
K
Site 2
S36
F
D
D
L
P
P
A
S
S
T
D
S
G
S
G
Site 3
S37
D
D
L
P
P
A
S
S
T
D
S
G
S
G
G
Site 4
T38
D
L
P
P
A
S
S
T
D
S
G
S
G
G
P
Site 5
S40
P
P
A
S
S
T
D
S
G
S
G
G
P
L
L
Site 6
S42
A
S
S
T
D
S
G
S
G
G
P
L
L
F
D
Site 7
S55
F
D
D
L
P
P
A
S
S
G
D
S
G
S
L
Site 8
S56
D
D
L
P
P
A
S
S
G
D
S
G
S
L
A
Site 9
S59
P
P
A
S
S
G
D
S
G
S
L
A
T
S
I
Site 10
S61
A
S
S
G
D
S
G
S
L
A
T
S
I
S
Q
Site 11
S65
D
S
G
S
L
A
T
S
I
S
Q
M
V
K
T
Site 12
S67
G
S
L
A
T
S
I
S
Q
M
V
K
T
E
G
Site 13
T72
S
I
S
Q
M
V
K
T
E
G
K
G
A
K
R
Site 14
T81
G
K
G
A
K
R
K
T
S
E
E
E
K
N
G
Site 15
S82
K
G
A
K
R
K
T
S
E
E
E
K
N
G
S
Site 16
S89
S
E
E
E
K
N
G
S
E
E
L
V
E
K
K
Site 17
Y110
V
I
F
G
L
K
G
Y
V
A
E
R
K
G
E
Site 18
T132
H
V
I
L
N
D
I
T
E
E
C
R
P
P
S
Site 19
S139
T
E
E
C
R
P
P
S
S
L
I
T
R
V
S
Site 20
S140
E
E
C
R
P
P
S
S
L
I
T
R
V
S
Y
Site 21
S160
G
H
G
G
I
R
A
S
K
F
A
A
Q
N
L
Site 22
S182
F
P
K
G
D
V
I
S
V
E
K
T
V
K
R
Site 23
T194
V
K
R
C
L
L
D
T
F
K
H
T
D
E
E
Site 24
S208
E
F
L
K
Q
A
S
S
Q
K
P
A
W
K
D
Site 25
Y244
S
R
A
I
L
C
R
Y
N
E
E
S
Q
K
H
Site 26
S248
L
C
R
Y
N
E
E
S
Q
K
H
A
A
L
S
Site 27
S255
S
Q
K
H
A
A
L
S
L
S
K
E
H
N
P
Site 28
S257
K
H
A
A
L
S
L
S
K
E
H
N
P
T
Q
Site 29
T263
L
S
K
E
H
N
P
T
Q
Y
E
E
R
M
R
Site 30
Y265
K
E
H
N
P
T
Q
Y
E
E
R
M
R
I
Q
Site 31
S290
V
L
G
V
L
E
V
S
R
S
I
G
D
G
Q
Site 32
S292
G
V
L
E
V
S
R
S
I
G
D
G
Q
Y
K
Site 33
Y298
R
S
I
G
D
G
Q
Y
K
R
C
G
V
T
S
Site 34
S305
Y
K
R
C
G
V
T
S
V
P
D
I
R
R
C
Site 35
T315
D
I
R
R
C
Q
L
T
P
N
D
R
F
I
L
Site 36
T333
D
G
L
F
K
V
F
T
P
E
E
A
V
N
F
Site 37
T352
L
E
D
E
K
I
Q
T
R
E
G
K
S
A
A
Site 38
Y363
K
S
A
A
D
A
R
Y
E
A
A
C
N
R
L
Site 39
S379
N
K
A
V
Q
R
G
S
A
D
N
V
T
V
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation