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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKD2
Full Name:
Serine/threonine-protein kinase D2
Alias:
DKFZP586E0820; EC 2.7.11.13; HSPC187; Kinase PKD2; KPCD2; KPCO; NPKC-D2; PKD2; Protein kinase C, D2 type; Protein kinase D2; Protein kinase D2 homolog
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13;
CAMK
group; PKD family
Mass (Da):
96722
Number AA:
878
UniProt ID:
Q9BZL6
International Prot ID:
IPI00009334
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004697
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase D2 S197+S198 phosphosite-specific antibody AB-PK784#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK784#CREB1 (123-135) KinSub - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95#Serine/threonine-protein kinase D2 (R194-L201, human) pS197+pS198 phosphopeptide - Powder PE-04APB99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APB99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
A
T
A
P
S
Y
P
A
G
L
P
G
S
Site 2
S14
Y
P
A
G
L
P
G
S
P
G
P
G
S
P
P
Site 3
S19
P
G
S
P
G
P
G
S
P
P
P
P
G
G
L
Site 4
S30
P
G
G
L
E
L
Q
S
P
P
P
L
L
P
Q
Site 5
S43
P
Q
I
P
A
P
G
S
G
V
S
F
H
I
Q
Site 6
S75
H
V
K
Q
L
A
C
S
I
V
D
Q
K
F
P
Site 7
Y87
K
F
P
E
C
G
F
Y
G
L
Y
D
K
I
L
Site 8
S111
N
L
L
Q
L
V
R
S
S
G
D
I
Q
E
G
Site 9
S112
L
L
Q
L
V
R
S
S
G
D
I
Q
E
G
D
Site 10
T142
Q
I
R
P
H
A
L
T
V
H
S
Y
R
A
P
Site 11
Y146
H
A
L
T
V
H
S
Y
R
A
P
A
F
C
D
Site 12
Y176
C
D
G
C
G
L
N
Y
H
K
R
C
A
F
S
Site 13
S189
F
S
I
P
N
N
C
S
G
A
R
K
R
R
L
Site 14
S197
G
A
R
K
R
R
L
S
S
T
S
L
A
S
G
Serine/threonine-protein kinase D2 S197+S198 phosphosite-specific antibody AB-PK784#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK784#Serine/threonine-protein kinase D2 (R194-L201, human) pS197+pS198 phosphopeptide - Powder PE-04APB99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APB99
Site 15
S198
A
R
K
R
R
L
S
S
T
S
L
A
S
G
H
Serine/threonine-protein kinase D2 S197+S198 phosphosite-specific antibody AB-PK784#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK784#Serine/threonine-protein kinase D2 (R194-L201, human) pS197+pS198 phosphopeptide - Powder PE-04APB99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APB99
Site 16
T199
R
K
R
R
L
S
S
T
S
L
A
S
G
H
S
Site 17
S200
K
R
R
L
S
S
T
S
L
A
S
G
H
S
V
Site 18
S203
L
S
S
T
S
L
A
S
G
H
S
V
R
L
G
Site 19
S206
T
S
L
A
S
G
H
S
V
R
L
G
T
S
E
Site 20
T211
G
H
S
V
R
L
G
T
S
E
S
L
P
C
T
Site 21
S212
H
S
V
R
L
G
T
S
E
S
L
P
C
T
A
Site 22
S214
V
R
L
G
T
S
E
S
L
P
C
T
A
E
E
Site 23
T218
T
S
E
S
L
P
C
T
A
E
E
L
S
R
S
Site 24
S223
P
C
T
A
E
E
L
S
R
S
T
T
E
L
L
Site 25
S225
T
A
E
E
L
S
R
S
T
T
E
L
L
P
R
Site 26
T226
A
E
E
L
S
R
S
T
T
E
L
L
P
R
R
Site 27
T227
E
E
L
S
R
S
T
T
E
L
L
P
R
R
P
Site 28
S236
L
L
P
R
R
P
P
S
S
S
S
S
S
S
A
Site 29
S237
L
P
R
R
P
P
S
S
S
S
S
S
S
A
S
Site 30
S238
P
R
R
P
P
S
S
S
S
S
S
S
A
S
S
Site 31
S239
R
R
P
P
S
S
S
S
S
S
S
A
S
S
Y
Site 32
S240
R
P
P
S
S
S
S
S
S
S
A
S
S
Y
T
Site 33
S241
P
P
S
S
S
S
S
S
S
A
S
S
Y
T
G
Site 34
S242
P
S
S
S
S
S
S
S
A
S
S
Y
T
G
R
Site 35
S244
S
S
S
S
S
S
A
S
S
Y
T
G
R
P
I
Site 36
S245
S
S
S
S
S
A
S
S
Y
T
G
R
P
I
E
Site 37
Y246
S
S
S
S
A
S
S
Y
T
G
R
P
I
E
L
Site 38
T247
S
S
S
A
S
S
Y
T
G
R
P
I
E
L
D
Site 39
S259
E
L
D
K
M
L
L
S
K
V
K
V
P
H
T
Site 40
T266
S
K
V
K
V
P
H
T
F
L
I
H
S
Y
T
Site 41
Y272
H
T
F
L
I
H
S
Y
T
R
P
T
V
C
Q
Site 42
S333
M
E
E
A
T
D
F
S
E
A
D
K
S
A
L
Site 43
S338
D
F
S
E
A
D
K
S
A
L
M
D
E
S
E
Site 44
S344
K
S
A
L
M
D
E
S
E
D
S
G
V
I
P
Site 45
S347
L
M
D
E
S
E
D
S
G
V
I
P
G
S
H
Site 46
S353
D
S
G
V
I
P
G
S
H
S
E
N
A
L
H
Site 47
S355
G
V
I
P
G
S
H
S
E
N
A
L
H
A
S
Site 48
S362
S
E
N
A
L
H
A
S
E
E
E
E
G
E
G
Site 49
S374
G
E
G
G
K
A
Q
S
S
L
G
Y
I
P
L
Site 50
S375
E
G
G
K
A
Q
S
S
L
G
Y
I
P
L
M
Site 51
Y378
K
A
Q
S
S
L
G
Y
I
P
L
M
R
V
V
Site 52
S387
P
L
M
R
V
V
Q
S
V
R
H
T
T
R
K
Site 53
T391
V
V
Q
S
V
R
H
T
T
R
K
S
S
T
T
Site 54
T392
V
Q
S
V
R
H
T
T
R
K
S
S
T
T
L
Site 55
S395
V
R
H
T
T
R
K
S
S
T
T
L
R
E
G
Site 56
S396
R
H
T
T
R
K
S
S
T
T
L
R
E
G
W
Site 57
T398
T
T
R
K
S
S
T
T
L
R
E
G
W
V
V
Site 58
Y407
R
E
G
W
V
V
H
Y
S
N
K
D
T
L
R
Site 59
Y418
D
T
L
R
K
R
H
Y
W
R
L
D
C
K
C
Site 60
Y438
N
N
T
T
N
R
Y
Y
K
E
I
P
L
S
E
Site 61
S444
Y
Y
K
E
I
P
L
S
E
I
L
T
V
E
S
Site 62
S456
V
E
S
A
Q
N
F
S
L
V
P
P
G
T
N
Site 63
T485
V
G
E
M
P
G
G
T
P
G
G
P
S
G
Q
Site 64
S490
G
G
T
P
G
G
P
S
G
Q
G
A
E
A
A
Site 65
S518
V
I
L
Q
D
A
P
S
A
P
G
H
A
P
H
Site 66
S529
H
A
P
H
R
Q
A
S
L
S
I
S
V
S
N
Site 67
S531
P
H
R
Q
A
S
L
S
I
S
V
S
N
S
Q
Site 68
S533
R
Q
A
S
L
S
I
S
V
S
N
S
Q
I
Q
Site 69
S535
A
S
L
S
I
S
V
S
N
S
Q
I
Q
E
N
Site 70
S537
L
S
I
S
V
S
N
S
Q
I
Q
E
N
V
D
Site 71
T547
Q
E
N
V
D
I
A
T
V
Y
Q
I
F
P
D
Site 72
Y566
S
G
Q
F
G
V
V
Y
G
G
K
H
R
K
T
Site 73
T573
Y
G
G
K
H
R
K
T
G
R
D
V
A
V
K
Site 74
T589
I
D
K
L
R
F
P
T
K
Q
E
S
Q
L
R
Site 75
S593
R
F
P
T
K
Q
E
S
Q
L
R
N
E
V
A
Site 76
T619
N
L
E
C
M
F
E
T
P
E
K
V
F
V
V
Site 77
S640
D
M
L
E
M
I
L
S
S
E
K
G
R
L
P
Site 78
T651
G
R
L
P
E
R
L
T
K
F
L
I
T
Q
I
Site 79
S706
A
R
I
I
G
E
K
S
F
R
R
S
V
V
G
Site 80
S710
G
E
K
S
F
R
R
S
V
V
G
T
P
A
Y
Site 81
T714
F
R
R
S
V
V
G
T
P
A
Y
L
A
P
E
Site 82
Y717
S
V
V
G
T
P
A
Y
L
A
P
E
V
L
L
Site 83
Y728
E
V
L
L
N
Q
G
Y
N
R
S
L
D
M
W
Site 84
S731
L
N
Q
G
Y
N
R
S
L
D
M
W
S
V
G
Site 85
T748
M
Y
V
S
L
S
G
T
F
P
F
N
E
D
E
Site 86
Y796
Q
V
K
M
R
K
R
Y
S
V
D
K
S
L
S
Site 87
S797
V
K
M
R
K
R
Y
S
V
D
K
S
L
S
H
Site 88
S801
K
R
Y
S
V
D
K
S
L
S
H
P
W
L
Q
Site 89
S803
Y
S
V
D
K
S
L
S
H
P
W
L
Q
E
Y
Site 90
Y810
S
H
P
W
L
Q
E
Y
Q
T
W
L
D
L
R
Site 91
Y827
E
G
K
M
G
E
R
Y
I
T
H
E
S
D
D
Site 92
T829
K
M
G
E
R
Y
I
T
H
E
S
D
D
A
R
Site 93
S832
E
R
Y
I
T
H
E
S
D
D
A
R
W
E
Q
Site 94
S849
A
E
H
P
L
P
G
S
G
L
P
T
D
R
D
Site 95
T853
L
P
G
S
G
L
P
T
D
R
D
L
G
G
A
Site 96
S876
Q
G
L
A
E
R
I
S
V
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation