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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2A
Full Name:
Eukaryotic translation initiation factor 2A
Alias:
65 kDa eukaryotic translation initiation factor 2A; EIF-2A; Eukaryotic translation initiation factor 2A, 65kDa
Type:
Translation
Mass (Da):
64990
Number AA:
585
UniProt ID:
Q9BY44
International Prot ID:
IPI00012462
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005850
GO:0005850
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0043022
GO:0000049
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006417
GO:0042255
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
P
S
T
P
L
L
T
V
R
Site 2
T9
A
P
S
T
P
L
L
T
V
R
G
S
E
G
L
Site 3
Y17
V
R
G
S
E
G
L
Y
M
V
N
G
P
P
H
Site 4
S28
G
P
P
H
F
T
E
S
T
V
F
P
R
E
S
Site 5
T29
P
P
H
F
T
E
S
T
V
F
P
R
E
S
G
Site 6
S35
S
T
V
F
P
R
E
S
G
K
N
C
K
V
C
Site 7
T88
L
E
F
S
P
K
N
T
V
L
A
T
W
Q
P
Site 8
T97
L
A
T
W
Q
P
Y
T
T
S
K
D
G
T
A
Site 9
S99
T
W
Q
P
Y
T
T
S
K
D
G
T
A
G
I
Site 10
Y112
G
I
P
N
L
Q
L
Y
D
V
K
T
G
T
C
Site 11
S122
K
T
G
T
C
L
K
S
F
I
Q
K
K
M
Q
Site 12
T140
P
S
W
S
E
D
E
T
L
C
A
R
N
V
N
Site 13
S176
K
I
N
D
F
V
L
S
P
G
P
Q
P
Y
K
Site 14
Y187
Q
P
Y
K
V
A
V
Y
V
P
G
S
K
G
A
Site 15
S196
P
G
S
K
G
A
P
S
F
V
R
L
Y
Q
Y
Site 16
Y201
A
P
S
F
V
R
L
Y
Q
Y
P
N
F
A
G
Site 17
Y203
S
F
V
R
L
Y
Q
Y
P
N
F
A
G
P
H
Site 18
S217
H
A
A
L
A
N
K
S
F
F
K
A
D
K
V
Site 19
T241
A
V
L
V
I
A
S
T
D
V
D
K
T
G
A
Site 20
T246
A
S
T
D
V
D
K
T
G
A
S
Y
Y
G
E
Site 21
S249
D
V
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
Site 22
Y250
V
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Site 23
Y251
D
K
T
G
A
S
Y
Y
G
E
Q
T
L
H
Y
Site 24
Y258
Y
G
E
Q
T
L
H
Y
I
A
T
N
G
E
S
Site 25
Y277
L
P
K
N
G
P
I
Y
D
V
V
W
N
S
S
Site 26
T314
D
P
V
F
D
F
G
T
G
P
R
N
A
A
Y
Site 27
Y321
T
G
P
R
N
A
A
Y
Y
S
P
H
G
H
I
Site 28
Y322
G
P
R
N
A
A
Y
Y
S
P
H
G
H
I
L
Site 29
S323
P
R
N
A
A
Y
Y
S
P
H
G
H
I
L
V
Site 30
S353
V
K
N
Y
K
L
I
S
K
P
V
A
S
D
S
Site 31
S360
S
K
P
V
A
S
D
S
T
Y
F
A
W
C
P
Site 32
Y362
P
V
A
S
D
S
T
Y
F
A
W
C
P
D
G
Site 33
T374
P
D
G
E
H
I
L
T
A
T
C
A
P
R
L
Site 34
Y387
R
L
R
V
N
N
G
Y
K
I
W
H
Y
T
G
Site 35
Y392
N
G
Y
K
I
W
H
Y
T
G
S
I
L
H
K
Site 36
Y400
T
G
S
I
L
H
K
Y
D
V
P
S
N
A
E
Site 37
Y428
F
P
A
K
T
I
T
Y
Q
A
V
P
S
E
V
Site 38
S433
I
T
Y
Q
A
V
P
S
E
V
P
N
E
E
P
Site 39
Y446
E
P
K
V
A
T
A
Y
R
P
P
A
L
R
N
Site 40
T457
A
L
R
N
K
P
I
T
N
S
K
L
H
E
E
Site 41
S459
R
N
K
P
I
T
N
S
K
L
H
E
E
E
P
Site 42
S474
P
Q
N
M
K
P
Q
S
G
N
D
K
P
L
S
Site 43
S481
S
G
N
D
K
P
L
S
K
T
A
L
K
N
Q
Site 44
S503
A
A
K
Q
E
A
R
S
D
K
S
P
D
L
A
Site 45
S506
Q
E
A
R
S
D
K
S
P
D
L
A
P
T
P
Site 46
T512
K
S
P
D
L
A
P
T
P
A
P
Q
S
T
P
Site 47
S517
A
P
T
P
A
P
Q
S
T
P
R
N
T
V
S
Site 48
T518
P
T
P
A
P
Q
S
T
P
R
N
T
V
S
Q
Site 49
T522
P
Q
S
T
P
R
N
T
V
S
Q
S
I
S
G
Site 50
S524
S
T
P
R
N
T
V
S
Q
S
I
S
G
D
P
Site 51
S526
P
R
N
T
V
S
Q
S
I
S
G
D
P
E
I
Site 52
S528
N
T
V
S
Q
S
I
S
G
D
P
E
I
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation