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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STK31
Full Name:
Serine/threonine-protein kinase 31
Alias:
EC 2.7.11.1; NYD-SPK; Serine/threonine kinase 31; Serine/threonine-protein kinase NYD-SPK; SgK396; ST31; Sugen kinase 396; TDRD8
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; Other-Unique family
Mass (Da):
115694
Number AA:
1019
UniProt ID:
Q9BXU1
International Prot ID:
IPI00419204
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003676
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
W
V
Q
G
H
S
S
R
A
S
A
T
E
Site 2
S11
Q
G
H
S
S
R
A
S
A
T
E
S
V
S
F
Site 3
T13
H
S
S
R
A
S
A
T
E
S
V
S
F
S
G
Site 4
S19
A
T
E
S
V
S
F
S
G
I
V
Q
M
D
E
Site 5
T28
I
V
Q
M
D
E
D
T
H
Y
D
K
V
E
D
Site 6
Y30
Q
M
D
E
D
T
H
Y
D
K
V
E
D
V
V
Site 7
Y85
N
L
D
P
N
K
I
Y
G
G
L
F
S
E
D
Site 8
Y96
F
S
E
D
Q
C
W
Y
R
C
K
V
L
K
I
Site 9
Y113
V
E
K
C
L
V
R
Y
I
D
Y
G
N
T
E
Site 10
T119
R
Y
I
D
Y
G
N
T
E
I
L
N
R
S
D
Site 11
S125
N
T
E
I
L
N
R
S
D
I
V
E
I
P
L
Site 12
S137
I
P
L
E
L
Q
F
S
S
V
A
K
K
Y
K
Site 13
S138
P
L
E
L
Q
F
S
S
V
A
K
K
Y
K
L
Site 14
Y143
F
S
S
V
A
K
K
Y
K
L
W
G
L
H
I
Site 15
S152
L
W
G
L
H
I
P
S
D
Q
E
V
T
Q
F
Site 16
T163
V
T
Q
F
D
Q
G
T
T
F
L
G
S
L
I
Site 17
T182
I
K
M
R
I
K
A
T
S
E
D
G
T
V
I
Site 18
S183
K
M
R
I
K
A
T
S
E
D
G
T
V
I
A
Site 19
T187
K
A
T
S
E
D
G
T
V
I
A
Q
A
E
Y
Site 20
S196
I
A
Q
A
E
Y
G
S
V
D
I
G
E
E
V
Site 21
S216
A
E
K
C
R
L
A
S
R
T
D
I
C
E
E
Site 22
T218
K
C
R
L
A
S
R
T
D
I
C
E
E
K
K
Site 23
S247
I
P
L
W
G
H
R
S
N
Q
S
T
F
S
R
Site 24
S250
W
G
H
R
S
N
Q
S
T
F
S
R
P
K
G
Site 25
T251
G
H
R
S
N
Q
S
T
F
S
R
P
K
G
H
Site 26
S253
R
S
N
Q
S
T
F
S
R
P
K
G
H
L
S
Site 27
S260
S
R
P
K
G
H
L
S
E
K
M
T
L
D
L
Site 28
T264
G
H
L
S
E
K
M
T
L
D
L
K
D
E
N
Site 29
T278
N
D
A
G
N
L
I
T
F
P
K
E
S
L
A
Site 30
S296
F
N
L
G
S
N
V
S
L
E
K
I
K
Q
D
Site 31
T315
E
E
N
E
K
L
K
T
E
K
D
A
L
L
E
Site 32
S383
E
M
R
H
V
D
I
S
V
R
F
G
K
D
L
Site 33
T427
L
A
Q
E
N
I
K
T
C
E
Y
V
S
E
G
Site 34
Y430
E
N
I
K
T
C
E
Y
V
S
E
G
N
I
L
Site 35
Y449
N
E
M
Q
Q
K
L
Y
M
S
V
E
D
F
I
Site 36
S451
M
Q
Q
K
L
Y
M
S
V
E
D
F
I
L
E
Site 37
S462
F
I
L
E
V
D
E
S
S
L
N
K
R
L
K
Site 38
S463
I
L
E
V
D
E
S
S
L
N
K
R
L
K
T
Site 39
T470
S
L
N
K
R
L
K
T
L
Q
D
L
S
V
S
Site 40
Y482
S
V
S
L
E
A
V
Y
G
Q
A
K
E
G
A
Site 41
S491
Q
A
K
E
G
A
N
S
D
E
I
L
K
K
F
Site 42
S511
D
K
R
E
E
F
T
S
V
R
S
E
T
D
A
Site 43
T516
F
T
S
V
R
S
E
T
D
A
S
L
H
R
L
Site 44
S519
V
R
S
E
T
D
A
S
L
H
R
L
V
A
W
Site 45
S560
E
I
L
E
K
T
E
S
S
V
C
K
E
L
E
Site 46
S561
I
L
E
K
T
E
S
S
V
C
K
E
L
E
I
Site 47
S582
D
A
D
K
E
I
I
S
N
T
Y
S
Q
V
L
Site 48
S586
E
I
I
S
N
T
Y
S
Q
V
L
Q
K
I
H
Site 49
S594
Q
V
L
Q
K
I
H
S
E
E
R
L
I
A
T
Site 50
T601
S
E
E
R
L
I
A
T
V
Q
A
K
Y
K
D
Site 51
Y619
F
K
K
Q
L
I
E
Y
L
N
K
S
P
S
V
Site 52
S623
L
I
E
Y
L
N
K
S
P
S
V
D
H
L
L
Site 53
S625
E
Y
L
N
K
S
P
S
V
D
H
L
L
S
I
Site 54
S631
P
S
V
D
H
L
L
S
I
K
K
T
L
K
S
Site 55
S638
S
I
K
K
T
L
K
S
L
K
A
L
L
R
W
Site 56
S651
R
W
K
L
V
E
K
S
N
L
E
E
S
D
D
Site 57
S656
E
K
S
N
L
E
E
S
D
D
P
D
G
S
Q
Site 58
S662
E
S
D
D
P
D
G
S
Q
I
E
K
I
K
E
Site 59
Y683
N
N
V
F
Q
E
I
Y
H
E
R
E
E
Y
E
Site 60
Y689
I
Y
H
E
R
E
E
Y
E
M
L
T
S
L
A
Site 61
S694
E
E
Y
E
M
L
T
S
L
A
Q
K
W
F
P
Site 62
Y715
P
E
I
G
L
L
K
Y
M
N
S
G
G
L
L
Site 63
S740
A
E
P
M
K
E
L
S
S
K
R
P
L
V
R
Site 64
S741
E
P
M
K
E
L
S
S
K
R
P
L
V
R
S
Site 65
S748
S
K
R
P
L
V
R
S
E
V
N
G
Q
I
I
Site 66
T766
G
Y
S
V
D
V
D
T
E
A
K
V
I
E
R
Site 67
T776
K
V
I
E
R
A
A
T
Y
H
R
A
W
R
E
Site 68
Y777
V
I
E
R
A
A
T
Y
H
R
A
W
R
E
A
Site 69
Y806
C
K
S
D
P
M
A
Y
L
M
V
P
Y
Y
P
Site 70
Y812
A
Y
L
M
V
P
Y
Y
P
R
A
N
L
N
A
Site 71
T876
I
V
G
D
F
D
F
T
K
S
V
S
Q
R
A
Site 72
S878
G
D
F
D
F
T
K
S
V
S
Q
R
A
S
V
Site 73
S880
F
D
F
T
K
S
V
S
Q
R
A
S
V
N
M
Site 74
S884
K
S
V
S
Q
R
A
S
V
N
M
M
V
G
D
Site 75
S896
V
G
D
L
S
L
M
S
P
E
L
K
M
G
K
Site 76
S906
L
K
M
G
K
P
A
S
P
G
S
D
L
Y
A
Site 77
S909
G
K
P
A
S
P
G
S
D
L
Y
A
Y
G
C
Site 78
Y989
N
P
E
K
D
T
E
Y
T
L
Y
K
K
E
E
Site 79
Y992
K
D
T
E
Y
T
L
Y
K
K
E
E
E
I
K
Site 80
T1000
K
K
E
E
E
I
K
T
E
N
L
D
K
C
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation