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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WAC
Full Name:
WW domain-containing adapter protein with coiled-coil
Alias:
BM-016; FLJ31290; MGC10753; PRO1741; WW domain containing adaptor with coiled-coil; WW domain-containing adapter with a coiled-coil region; WW domain-containing adaptor with coiled coil; Wwp4
Type:
Adaptor/scaffold
Mass (Da):
70724
Number AA:
647
UniProt ID:
Q9BTA9
International Prot ID:
IPI00256605
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0016604
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
R
K
Q
Q
R
L
S
D
G
C
H
D
R
R
Site 2
S22
C
H
D
R
R
G
D
S
Q
P
Y
Q
A
L
K
Site 3
Y25
R
R
G
D
S
Q
P
Y
Q
A
L
K
Y
S
S
Site 4
Y30
Q
P
Y
Q
A
L
K
Y
S
S
K
S
H
P
S
Site 5
S31
P
Y
Q
A
L
K
Y
S
S
K
S
H
P
S
S
Site 6
S32
Y
Q
A
L
K
Y
S
S
K
S
H
P
S
S
G
Site 7
S34
A
L
K
Y
S
S
K
S
H
P
S
S
G
D
H
Site 8
S38
S
S
K
S
H
P
S
S
G
D
H
R
H
E
K
Site 9
S53
M
R
D
A
G
D
P
S
P
P
N
K
M
L
R
Site 10
S62
P
N
K
M
L
R
R
S
D
S
P
E
N
K
Y
Site 11
S64
K
M
L
R
R
S
D
S
P
E
N
K
Y
S
D
Site 12
Y69
S
D
S
P
E
N
K
Y
S
D
S
T
G
H
S
Site 13
S70
D
S
P
E
N
K
Y
S
D
S
T
G
H
S
K
Site 14
S72
P
E
N
K
Y
S
D
S
T
G
H
S
K
A
K
Site 15
S76
Y
S
D
S
T
G
H
S
K
A
K
N
V
H
T
Site 16
T83
S
K
A
K
N
V
H
T
H
R
V
R
E
R
D
Site 17
S94
R
E
R
D
G
G
T
S
Y
S
P
Q
E
N
S
Site 18
Y95
E
R
D
G
G
T
S
Y
S
P
Q
E
N
S
H
Site 19
S96
R
D
G
G
T
S
Y
S
P
Q
E
N
S
H
N
Site 20
S101
S
Y
S
P
Q
E
N
S
H
N
H
S
A
L
H
Site 21
S105
Q
E
N
S
H
N
H
S
A
L
H
S
S
N
S
Site 22
S109
H
N
H
S
A
L
H
S
S
N
S
H
S
S
N
Site 23
S110
N
H
S
A
L
H
S
S
N
S
H
S
S
N
P
Site 24
S112
S
A
L
H
S
S
N
S
H
S
S
N
P
S
N
Site 25
S114
L
H
S
S
N
S
H
S
S
N
P
S
N
N
P
Site 26
S115
H
S
S
N
S
H
S
S
N
P
S
N
N
P
S
Site 27
S118
N
S
H
S
S
N
P
S
N
N
P
S
K
T
S
Site 28
S122
S
N
P
S
N
N
P
S
K
T
S
D
A
P
Y
Site 29
S125
S
N
N
P
S
K
T
S
D
A
P
Y
D
S
A
Site 30
Y129
S
K
T
S
D
A
P
Y
D
S
A
D
D
W
S
Site 31
S131
T
S
D
A
P
Y
D
S
A
D
D
W
S
E
H
Site 32
S136
Y
D
S
A
D
D
W
S
E
H
I
S
S
S
G
Site 33
S140
D
D
W
S
E
H
I
S
S
S
G
K
K
Y
Y
Site 34
Y146
I
S
S
S
G
K
K
Y
Y
Y
N
C
R
T
E
Site 35
Y147
S
S
S
G
K
K
Y
Y
Y
N
C
R
T
E
V
Site 36
Y148
S
S
G
K
K
Y
Y
Y
N
C
R
T
E
V
S
Site 37
S180
A
N
K
M
A
V
N
S
F
P
K
D
R
D
Y
Site 38
Y187
S
F
P
K
D
R
D
Y
R
R
E
V
M
Q
A
Site 39
T195
R
R
E
V
M
Q
A
T
A
T
S
G
F
A
S
Site 40
T197
E
V
M
Q
A
T
A
T
S
G
F
A
S
G
M
Site 41
S198
V
M
Q
A
T
A
T
S
G
F
A
S
G
M
E
Site 42
S202
T
A
T
S
G
F
A
S
G
M
E
D
K
H
S
Site 43
S209
S
G
M
E
D
K
H
S
S
D
A
S
S
L
L
Site 44
S210
G
M
E
D
K
H
S
S
D
A
S
S
L
L
P
Site 45
S213
D
K
H
S
S
D
A
S
S
L
L
P
Q
N
I
Site 46
S214
K
H
S
S
D
A
S
S
L
L
P
Q
N
I
L
Site 47
S222
L
L
P
Q
N
I
L
S
Q
T
S
R
H
N
D
Site 48
T224
P
Q
N
I
L
S
Q
T
S
R
H
N
D
R
D
Site 49
Y232
S
R
H
N
D
R
D
Y
R
L
P
R
A
E
T
Site 50
T239
Y
R
L
P
R
A
E
T
H
S
S
S
T
P
V
Site 51
S241
L
P
R
A
E
T
H
S
S
S
T
P
V
Q
H
Site 52
S242
P
R
A
E
T
H
S
S
S
T
P
V
Q
H
P
Site 53
S243
R
A
E
T
H
S
S
S
T
P
V
Q
H
P
I
Site 54
T244
A
E
T
H
S
S
S
T
P
V
Q
H
P
I
K
Site 55
T259
P
V
V
H
P
T
A
T
P
S
T
V
P
S
S
Site 56
S261
V
H
P
T
A
T
P
S
T
V
P
S
S
P
F
Site 57
T262
H
P
T
A
T
P
S
T
V
P
S
S
P
F
T
Site 58
S265
A
T
P
S
T
V
P
S
S
P
F
T
L
Q
S
Site 59
S266
T
P
S
T
V
P
S
S
P
F
T
L
Q
S
D
Site 60
T269
T
V
P
S
S
P
F
T
L
Q
S
D
H
Q
P
Site 61
S272
S
S
P
F
T
L
Q
S
D
H
Q
P
K
K
S
Site 62
S279
S
D
H
Q
P
K
K
S
F
D
A
N
G
A
S
Site 63
S286
S
F
D
A
N
G
A
S
T
L
S
K
L
P
T
Site 64
T287
F
D
A
N
G
A
S
T
L
S
K
L
P
T
P
Site 65
S289
A
N
G
A
S
T
L
S
K
L
P
T
P
T
S
Site 66
T293
S
T
L
S
K
L
P
T
P
T
S
S
V
P
A
Site 67
S296
S
K
L
P
T
P
T
S
S
V
P
A
Q
K
T
Site 68
S297
K
L
P
T
P
T
S
S
V
P
A
Q
K
T
E
Site 69
T303
S
S
V
P
A
Q
K
T
E
R
K
E
S
T
S
Site 70
S308
Q
K
T
E
R
K
E
S
T
S
G
D
K
P
V
Site 71
T309
K
T
E
R
K
E
S
T
S
G
D
K
P
V
S
Site 72
S310
T
E
R
K
E
S
T
S
G
D
K
P
V
S
H
Site 73
S316
T
S
G
D
K
P
V
S
H
S
C
T
T
P
S
Site 74
S318
G
D
K
P
V
S
H
S
C
T
T
P
S
T
S
Site 75
T320
K
P
V
S
H
S
C
T
T
P
S
T
S
S
A
Site 76
T321
P
V
S
H
S
C
T
T
P
S
T
S
S
A
S
Site 77
S323
S
H
S
C
T
T
P
S
T
S
S
A
S
G
L
Site 78
T324
H
S
C
T
T
P
S
T
S
S
A
S
G
L
N
Site 79
S325
S
C
T
T
P
S
T
S
S
A
S
G
L
N
P
Site 80
T333
S
A
S
G
L
N
P
T
S
A
P
P
T
S
A
Site 81
S334
A
S
G
L
N
P
T
S
A
P
P
T
S
A
S
Site 82
T338
N
P
T
S
A
P
P
T
S
A
S
A
V
P
V
Site 83
S339
P
T
S
A
P
P
T
S
A
S
A
V
P
V
S
Site 84
T373
L
L
P
A
L
Q
A
T
L
Q
L
N
N
S
N
Site 85
S379
A
T
L
Q
L
N
N
S
N
V
D
I
S
K
I
Site 86
S418
P
S
A
F
N
I
T
S
L
I
S
Q
A
A
Q
Site 87
S427
I
S
Q
A
A
Q
L
S
T
Q
A
Q
P
S
N
Site 88
S433
L
S
T
Q
A
Q
P
S
N
Q
S
P
M
S
L
Site 89
S436
Q
A
Q
P
S
N
Q
S
P
M
S
L
T
S
D
Site 90
S439
P
S
N
Q
S
P
M
S
L
T
S
D
A
S
S
Site 91
T441
N
Q
S
P
M
S
L
T
S
D
A
S
S
P
R
Site 92
S442
Q
S
P
M
S
L
T
S
D
A
S
S
P
R
S
Site 93
S445
M
S
L
T
S
D
A
S
S
P
R
S
Y
V
S
Site 94
S446
S
L
T
S
D
A
S
S
P
R
S
Y
V
S
P
Site 95
S449
S
D
A
S
S
P
R
S
Y
V
S
P
R
I
S
Site 96
Y450
D
A
S
S
P
R
S
Y
V
S
P
R
I
S
T
Site 97
S452
S
S
P
R
S
Y
V
S
P
R
I
S
T
P
Q
Site 98
S456
S
Y
V
S
P
R
I
S
T
P
Q
T
N
T
V
Site 99
T457
Y
V
S
P
R
I
S
T
P
Q
T
N
T
V
P
Site 100
T460
P
R
I
S
T
P
Q
T
N
T
V
P
I
K
P
Site 101
T462
I
S
T
P
Q
T
N
T
V
P
I
K
P
L
I
Site 102
S470
V
P
I
K
P
L
I
S
T
P
P
V
S
S
Q
Site 103
T471
P
I
K
P
L
I
S
T
P
P
V
S
S
Q
P
Site 104
S475
L
I
S
T
P
P
V
S
S
Q
P
K
V
S
T
Site 105
S476
I
S
T
P
P
V
S
S
Q
P
K
V
S
T
P
Site 106
S481
V
S
S
Q
P
K
V
S
T
P
V
V
K
Q
G
Site 107
T482
S
S
Q
P
K
V
S
T
P
V
V
K
Q
G
P
Site 108
S491
V
V
K
Q
G
P
V
S
Q
S
A
T
Q
Q
P
Site 109
T495
G
P
V
S
Q
S
A
T
Q
Q
P
V
T
A
D
Site 110
T500
S
A
T
Q
Q
P
V
T
A
D
K
Q
Q
G
H
Site 111
S511
Q
Q
G
H
E
P
V
S
P
R
S
L
Q
R
S
Site 112
S514
H
E
P
V
S
P
R
S
L
Q
R
S
S
S
Q
Site 113
S518
S
P
R
S
L
Q
R
S
S
S
Q
R
S
P
S
Site 114
S519
P
R
S
L
Q
R
S
S
S
Q
R
S
P
S
P
Site 115
S520
R
S
L
Q
R
S
S
S
Q
R
S
P
S
P
G
Site 116
S523
Q
R
S
S
S
Q
R
S
P
S
P
G
P
N
H
Site 117
S525
S
S
S
Q
R
S
P
S
P
G
P
N
H
T
S
Site 118
T531
P
S
P
G
P
N
H
T
S
N
S
S
N
A
S
Site 119
S532
S
P
G
P
N
H
T
S
N
S
S
N
A
S
N
Site 120
S534
G
P
N
H
T
S
N
S
S
N
A
S
N
A
T
Site 121
S535
P
N
H
T
S
N
S
S
N
A
S
N
A
T
V
Site 122
S538
T
S
N
S
S
N
A
S
N
A
T
V
V
P
Q
Site 123
T541
S
S
N
A
S
N
A
T
V
V
P
Q
N
S
S
Site 124
S547
A
T
V
V
P
Q
N
S
S
A
R
S
T
C
S
Site 125
S548
T
V
V
P
Q
N
S
S
A
R
S
T
C
S
L
Site 126
S551
P
Q
N
S
S
A
R
S
T
C
S
L
T
P
A
Site 127
T552
Q
N
S
S
A
R
S
T
C
S
L
T
P
A
L
Site 128
S584
D
H
A
E
K
Q
A
S
R
L
R
E
E
A
H
Site 129
T603
I
H
M
S
E
I
C
T
E
L
K
N
L
R
S
Site 130
T620
R
V
C
E
I
Q
A
T
L
R
E
Q
R
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation