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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TUBA1C
Full Name:
Tubulin alpha-1C chain
Alias:
Alpha-tubulin 6; Bcm948; MGC10851; MGC14580; TBA1C; TBA6; TUBA6; Tubulin alpha-6 chain; Tubulin, alpha 1c; Tubulin, alpha-6
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
49895
Number AA:
449
UniProt ID:
Q9BQE3
International Prot ID:
IPI00218343
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
GO:0051258
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
G
N
A
C
W
E
L
Y
C
L
E
H
G
I
Q
Site 2
S38
Q
P
D
G
Q
M
P
S
D
K
T
I
G
G
G
Site 3
T41
G
Q
M
P
S
D
K
T
I
G
G
G
D
D
S
Site 4
S48
T
I
G
G
G
D
D
S
F
N
T
F
F
S
E
Site 5
T51
G
G
D
D
S
F
N
T
F
F
S
E
T
G
A
Site 6
S54
D
S
F
N
T
F
F
S
E
T
G
A
G
K
H
Site 7
T56
F
N
T
F
F
S
E
T
G
A
G
K
H
V
P
Site 8
T73
V
F
V
D
L
E
P
T
V
I
D
E
V
R
T
Site 9
T80
T
V
I
D
E
V
R
T
G
T
Y
R
Q
L
F
Site 10
T82
I
D
E
V
R
T
G
T
Y
R
Q
L
F
H
P
Site 11
Y83
D
E
V
R
T
G
T
Y
R
Q
L
F
H
P
E
Site 12
T94
F
H
P
E
Q
L
I
T
G
K
E
D
A
A
N
Site 13
Y103
K
E
D
A
A
N
N
Y
A
R
G
H
Y
T
I
Site 14
Y108
N
N
Y
A
R
G
H
Y
T
I
G
K
E
I
I
Site 15
T109
N
Y
A
R
G
H
Y
T
I
G
K
E
I
I
D
Site 16
S158
S
L
L
M
E
R
L
S
V
D
Y
G
k
K
S
Site 17
Y161
M
E
R
L
S
V
D
Y
G
K
K
S
K
L
E
Site 18
S165
S
V
D
Y
G
K
K
S
K
L
E
F
S
I
Y
Site 19
Y172
S
K
L
E
F
S
I
Y
P
A
P
Q
V
S
T
Site 20
Y185
S
T
A
V
V
E
P
Y
N
S
I
L
T
T
H
Site 21
S187
A
V
V
E
P
Y
N
S
I
L
T
T
H
T
T
Site 22
T190
E
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
Site 23
T191
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
S
Site 24
T193
N
S
I
L
T
T
H
T
T
L
E
H
S
D
C
Site 25
T194
S
I
L
T
T
H
T
T
L
E
H
S
D
C
A
Site 26
S198
T
H
T
T
L
E
H
S
D
C
A
F
M
V
D
Site 27
Y210
M
V
D
N
E
A
I
Y
D
I
C
R
R
N
L
Site 28
T223
N
L
D
I
E
R
P
T
Y
T
N
L
N
R
L
Site 29
Y224
L
D
I
E
R
P
T
Y
T
N
L
N
R
L
I
Site 30
T225
D
I
E
R
P
T
Y
T
N
L
N
R
L
I
S
Site 31
S232
T
N
L
N
R
L
I
S
Q
I
V
S
S
I
T
Site 32
S236
R
L
I
S
Q
I
V
S
S
I
T
A
S
L
R
Site 33
S237
L
I
S
Q
I
V
S
S
I
T
A
S
L
R
F
Site 34
T239
S
Q
I
V
S
S
I
T
A
S
L
R
F
D
G
Site 35
S241
I
V
S
S
I
T
A
S
L
R
F
D
G
A
L
Site 36
Y262
F
Q
T
N
L
V
P
Y
P
R
I
H
F
P
L
Site 37
T271
R
I
H
F
P
L
A
T
Y
A
P
V
I
S
A
Site 38
Y272
I
H
F
P
L
A
T
Y
A
P
V
I
S
A
E
Site 39
S277
A
T
Y
A
P
V
I
S
A
E
K
A
Y
H
E
Site 40
Y282
V
I
S
A
E
K
A
Y
H
E
Q
L
T
V
A
Site 41
T287
K
A
Y
H
E
Q
L
T
V
A
E
I
T
N
A
Site 42
Y312
C
D
P
R
H
G
K
Y
M
A
C
C
L
L
Y
Site 43
Y319
Y
M
A
C
C
L
L
Y
R
G
D
V
V
P
K
Site 44
T334
D
V
N
A
A
I
A
T
I
K
T
K
R
T
I
Site 45
T337
A
A
I
A
T
I
K
T
K
R
T
I
Q
F
V
Site 46
T340
A
T
I
K
T
K
R
T
I
Q
F
V
D
W
C
Site 47
T349
Q
F
V
D
W
C
P
T
G
F
K
V
G
I
N
Site 48
Y357
G
F
K
V
G
I
N
Y
Q
P
P
T
V
V
P
Site 49
T361
G
I
N
Y
Q
P
P
T
V
V
P
G
G
D
L
Site 50
S379
Q
R
A
V
C
M
L
S
N
T
T
A
V
A
E
Site 51
Y399
D
H
K
F
D
L
M
Y
A
K
R
A
F
V
H
Site 52
Y408
K
R
A
F
V
H
W
Y
V
G
E
G
M
E
E
Site 53
S419
G
M
E
E
G
E
F
S
E
A
R
E
D
M
A
Site 54
Y432
M
A
A
L
E
K
D
Y
E
E
V
G
A
D
S
Site 55
S439
Y
E
E
V
G
A
D
S
A
D
G
E
D
E
G
Site 56
Y449
G
E
D
E
G
E
E
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation