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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VRK1
Full Name:
Serine/threonine-protein kinase VRK1
Alias:
EC 2.7.11.1; Serine/threonine protein kinase VRK1; vaccinia related kinase 1; Vaccinia-related kinase 1
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CK1
group; TTBK family
Mass (Da):
45476
Number AA:
396
UniProt ID:
Q99986
International Prot ID:
IPI00019640
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0006468
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
A
Q
A
G
R
Q
S
S
A
K
R
H
L
A
Site 2
S14
A
Q
A
G
R
Q
S
S
A
K
R
H
L
A
E
Site 3
S58
I
Y
L
A
D
M
N
S
S
E
S
V
G
S
D
Site 4
S59
Y
L
A
D
M
N
S
S
E
S
V
G
S
D
A
Site 5
S61
A
D
M
N
S
S
E
S
V
G
S
D
A
P
C
Site 6
S64
N
S
S
E
S
V
G
S
D
A
P
C
V
V
K
Site 7
Y87
L
F
T
E
L
K
F
Y
Q
R
A
A
K
P
E
Site 8
Y107
I
R
T
R
K
L
K
Y
L
G
V
P
K
Y
W
Site 9
Y113
K
Y
L
G
V
P
K
Y
W
G
S
G
L
H
D
Site 10
S116
G
V
P
K
Y
W
G
S
G
L
H
D
K
N
G
Site 11
S136
M
I
M
D
R
F
G
S
D
L
Q
K
I
Y
E
Site 12
Y142
G
S
D
L
Q
K
I
Y
E
A
N
A
K
R
F
Site 13
S150
E
A
N
A
K
R
F
S
R
K
T
V
L
Q
L
Site 14
T153
A
K
R
F
S
R
K
T
V
L
Q
L
S
L
R
Site 15
S158
R
K
T
V
L
Q
L
S
L
R
I
L
D
I
L
Site 16
Y167
R
I
L
D
I
L
E
Y
I
H
E
H
E
Y
V
Site 17
Y173
E
Y
I
H
E
H
E
Y
V
H
G
D
I
K
A
Site 18
Y187
A
S
N
L
L
L
N
Y
K
N
P
D
Q
V
Y
Site 19
Y194
Y
K
N
P
D
Q
V
Y
L
V
D
Y
G
L
A
Site 20
Y198
D
Q
V
Y
L
V
D
Y
G
L
A
Y
R
Y
C
Site 21
Y204
D
Y
G
L
A
Y
R
Y
C
P
E
G
V
H
K
Site 22
T224
P
K
R
C
H
D
G
T
I
E
F
T
S
I
D
Site 23
S229
D
G
T
I
E
F
T
S
I
D
A
H
N
G
V
Site 24
S239
A
H
N
G
V
A
P
S
R
R
G
D
L
E
I
Site 25
Y270
D
N
L
K
D
P
K
Y
V
R
D
S
K
I
R
Site 26
S274
D
P
K
Y
V
R
D
S
K
I
R
Y
R
E
N
Site 27
Y278
V
R
D
S
K
I
R
Y
R
E
N
I
A
S
L
Site 28
S284
R
Y
R
E
N
I
A
S
L
M
D
K
C
F
P
Site 29
Y302
K
P
G
E
I
A
K
Y
M
E
T
V
K
L
L
Site 30
T305
E
I
A
K
Y
M
E
T
V
K
L
L
D
Y
T
Site 31
Y311
E
T
V
K
L
L
D
Y
T
E
K
P
L
Y
E
Site 32
T312
T
V
K
L
L
D
Y
T
E
K
P
L
Y
E
N
Site 33
Y317
D
Y
T
E
K
P
L
Y
E
N
L
R
D
I
L
Site 34
S333
Q
G
L
K
A
I
G
S
K
D
D
G
K
L
D
Site 35
S342
D
D
G
K
L
D
L
S
V
V
E
N
G
G
L
Site 36
T353
N
G
G
L
K
A
K
T
I
T
K
K
R
K
K
Site 37
T355
G
L
K
A
K
T
I
T
K
K
R
K
K
E
I
Site 38
S365
R
K
K
E
I
E
E
S
K
E
P
G
V
E
D
Site 39
S376
G
V
E
D
T
E
W
S
N
T
Q
T
E
E
A
Site 40
T378
E
D
T
E
W
S
N
T
Q
T
E
E
A
I
Q
Site 41
T380
T
E
W
S
N
T
Q
T
E
E
A
I
Q
T
R
Site 42
T386
Q
T
E
E
A
I
Q
T
R
S
R
T
R
K
R
Site 43
S388
E
E
A
I
Q
T
R
S
R
T
R
K
R
V
Q
Site 44
T390
A
I
Q
T
R
S
R
T
R
K
R
V
Q
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation