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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEKK3
Full Name:
Mitogen-activated protein kinase kinase kinase 3
Alias:
EC 2.7.11.25; Kinase MEKK3; M3K3; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3
Type:
EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE11 family
Mass (Da):
70898
Number AA:
626
UniProt ID:
Q99759
International Prot ID:
IPI00181703
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043234
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0043123
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
R
R
H
R
M
P
G
Y
E
T
M
K
N
K
D
Site 2
S39
K
N
K
D
T
G
H
S
N
R
Q
S
D
V
R
Site 3
S43
T
G
H
S
N
R
Q
S
D
V
R
I
K
F
E
Site 4
S61
E
R
R
I
I
A
F
S
R
P
V
K
Y
E
D
Site 5
Y66
A
F
S
R
P
V
K
Y
E
D
V
E
H
K
V
Site 6
T74
E
D
V
E
H
K
V
T
T
V
F
G
Q
P
L
Site 7
T75
D
V
E
H
K
V
T
T
V
F
G
Q
P
L
D
Site 8
Y85
G
Q
P
L
D
L
H
Y
M
N
N
E
L
S
I
Site 9
S110
A
I
D
I
L
D
R
S
S
S
M
K
S
L
R
Site 10
S111
I
D
I
L
D
R
S
S
S
M
K
S
L
R
I
Site 11
S112
D
I
L
D
R
S
S
S
M
K
S
L
R
I
L
Site 12
S115
D
R
S
S
S
M
K
S
L
R
I
L
L
L
S
Site 13
S122
S
L
R
I
L
L
L
S
Q
D
R
N
H
N
S
Site 14
S129
S
Q
D
R
N
H
N
S
S
S
P
H
S
G
V
Site 15
S130
Q
D
R
N
H
N
S
S
S
P
H
S
G
V
S
Site 16
S131
D
R
N
H
N
S
S
S
P
H
S
G
V
S
R
Site 17
S134
H
N
S
S
S
P
H
S
G
V
S
R
Q
V
R
Site 18
S145
R
Q
V
R
I
K
A
S
Q
S
A
G
D
I
N
Site 19
S147
V
R
I
K
A
S
Q
S
A
G
D
I
N
T
I
Site 20
T153
Q
S
A
G
D
I
N
T
I
Y
Q
P
P
E
P
Site 21
Y155
A
G
D
I
N
T
I
Y
Q
P
P
E
P
R
S
Site 22
S162
Y
Q
P
P
E
P
R
S
R
H
L
S
V
S
S
Site 23
S166
E
P
R
S
R
H
L
S
V
S
S
Q
N
P
G
Site 24
S168
R
S
R
H
L
S
V
S
S
Q
N
P
G
R
S
Site 25
S169
S
R
H
L
S
V
S
S
Q
N
P
G
R
S
S
Site 26
S175
S
S
Q
N
P
G
R
S
S
P
P
P
G
Y
V
Site 27
S176
S
Q
N
P
G
R
S
S
P
P
P
G
Y
V
P
Site 28
Y181
R
S
S
P
P
P
G
Y
V
P
E
R
Q
Q
H
Site 29
S194
Q
H
I
A
R
Q
G
S
Y
T
S
I
N
S
E
Site 30
T196
I
A
R
Q
G
S
Y
T
S
I
N
S
E
G
E
Site 31
S197
A
R
Q
G
S
Y
T
S
I
N
S
E
G
E
F
Site 32
T208
E
G
E
F
I
P
E
T
S
E
Q
C
M
L
D
Site 33
S218
Q
C
M
L
D
P
L
S
S
A
E
N
S
L
S
Site 34
S219
C
M
L
D
P
L
S
S
A
E
N
S
L
S
G
Site 35
S223
P
L
S
S
A
E
N
S
L
S
G
S
C
Q
S
Site 36
S225
S
S
A
E
N
S
L
S
G
S
C
Q
S
L
D
Site 37
S227
A
E
N
S
L
S
G
S
C
Q
S
L
D
R
S
Site 38
S230
S
L
S
G
S
C
Q
S
L
D
R
S
A
D
S
Site 39
S234
S
C
Q
S
L
D
R
S
A
D
S
P
S
F
R
Site 40
S237
S
L
D
R
S
A
D
S
P
S
F
R
K
S
R
Site 41
S239
D
R
S
A
D
S
P
S
F
R
K
S
R
M
S
Site 42
S243
D
S
P
S
F
R
K
S
R
M
S
R
A
Q
S
Site 43
S246
S
F
R
K
S
R
M
S
R
A
Q
S
F
P
D
Site 44
S250
S
R
M
S
R
A
Q
S
F
P
D
N
R
Q
E
Site 45
Y258
F
P
D
N
R
Q
E
Y
S
D
R
E
T
Q
L
Site 46
S259
P
D
N
R
Q
E
Y
S
D
R
E
T
Q
L
Y
Site 47
T263
Q
E
Y
S
D
R
E
T
Q
L
Y
D
K
G
V
Site 48
Y266
S
D
R
E
T
Q
L
Y
D
K
G
V
K
G
G
Site 49
T274
D
K
G
V
K
G
G
T
Y
P
R
R
Y
H
V
Site 50
Y275
K
G
V
K
G
G
T
Y
P
R
R
Y
H
V
S
Site 51
Y279
G
G
T
Y
P
R
R
Y
H
V
S
V
H
H
K
Site 52
Y288
V
S
V
H
H
K
D
Y
S
D
G
R
R
T
F
Site 53
S289
S
V
H
H
K
D
Y
S
D
G
R
R
T
F
P
Site 54
T294
D
Y
S
D
G
R
R
T
F
P
R
I
R
R
H
Site 55
T307
R
H
Q
G
N
L
F
T
L
V
P
S
S
R
S
Site 56
S311
N
L
F
T
L
V
P
S
S
R
S
L
S
T
N
Site 57
S314
T
L
V
P
S
S
R
S
L
S
T
N
G
E
N
Site 58
S316
V
P
S
S
R
S
L
S
T
N
G
E
N
M
G
Site 59
T317
P
S
S
R
S
L
S
T
N
G
E
N
M
G
L
Site 60
Y328
N
M
G
L
A
V
Q
Y
L
D
P
R
G
R
L
Site 61
S337
D
P
R
G
R
L
R
S
A
D
S
E
N
A
L
Site 62
S340
G
R
L
R
S
A
D
S
E
N
A
L
S
V
Q
Site 63
S345
A
D
S
E
N
A
L
S
V
Q
E
R
N
V
P
Site 64
T353
V
Q
E
R
N
V
P
T
K
S
P
S
A
P
I
Site 65
S355
E
R
N
V
P
T
K
S
P
S
A
P
I
N
W
Site 66
S357
N
V
P
T
K
S
P
S
A
P
I
N
W
R
R
Site 67
Y377
Q
G
A
F
G
R
V
Y
L
C
Y
D
V
D
T
Site 68
Y380
F
G
R
V
Y
L
C
Y
D
V
D
T
G
R
E
Site 69
T384
Y
L
C
Y
D
V
D
T
G
R
E
L
A
S
K
Site 70
S399
Q
V
Q
F
D
P
D
S
P
E
T
S
K
E
V
Site 71
S403
D
P
D
S
P
E
T
S
K
E
V
S
A
L
E
Site 72
S407
P
E
T
S
K
E
V
S
A
L
E
C
E
I
Q
Site 73
Y427
Q
H
E
R
I
V
Q
Y
Y
G
C
L
R
D
R
Site 74
Y428
H
E
R
I
V
Q
Y
Y
G
C
L
R
D
R
A
Site 75
T438
L
R
D
R
A
E
K
T
L
T
I
F
M
E
Y
Site 76
T440
D
R
A
E
K
T
L
T
I
F
M
E
Y
M
P
Site 77
Y445
T
L
T
I
F
M
E
Y
M
P
G
G
S
V
K
Site 78
T462
L
K
A
Y
G
A
L
T
E
S
V
T
R
K
Y
Site 79
S464
A
Y
G
A
L
T
E
S
V
T
R
K
Y
T
R
Site 80
Y469
T
E
S
V
T
R
K
Y
T
R
Q
I
L
E
G
Site 81
T470
E
S
V
T
R
K
Y
T
R
Q
I
L
E
G
M
Site 82
S499
G
A
N
I
L
R
D
S
A
G
N
V
K
L
G
Site 83
S511
K
L
G
D
F
G
A
S
K
R
L
Q
T
I
C
Site 84
T516
G
A
S
K
R
L
Q
T
I
C
M
S
G
T
G
Site 85
S520
R
L
Q
T
I
C
M
S
G
T
G
M
R
S
V
Site 86
T522
Q
T
I
C
M
S
G
T
G
M
R
S
V
T
G
Site 87
S526
M
S
G
T
G
M
R
S
V
T
G
T
P
Y
W
Site 88
T528
G
T
G
M
R
S
V
T
G
T
P
Y
W
M
S
Site 89
T530
G
M
R
S
V
T
G
T
P
Y
W
M
S
P
E
Site 90
Y532
R
S
V
T
G
T
P
Y
W
M
S
P
E
V
I
Site 91
S535
T
G
T
P
Y
W
M
S
P
E
V
I
S
G
E
Site 92
Y544
E
V
I
S
G
E
G
Y
G
R
K
A
D
V
W
Site 93
T562
C
T
V
V
E
M
L
T
E
K
P
P
W
A
E
Site 94
Y570
E
K
P
P
W
A
E
Y
E
A
M
A
A
I
F
Site 95
S590
P
T
N
P
Q
L
P
S
H
I
S
E
H
G
R
Site 96
S593
P
Q
L
P
S
H
I
S
E
H
G
R
D
F
L
Site 97
S612
V
E
A
R
Q
R
P
S
A
E
E
L
L
T
H
Site 98
T618
P
S
A
E
E
L
L
T
H
H
F
A
Q
L
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation