PhosphoNET

           
Protein Info 
   
Short Name:  PITX2
Full Name:  Pituitary homeobox 2
Alias:  ALL1-responsive protein ARP1; ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; Paired-like homeodomain 2; PTX2; RGS; RIEG; RIEG bicoid-related homeobox transcription factor; RIEG1; RS; Solurshin
Type:  Motility/polarity/chemotaxis; Transcription factor; Cell cycle regulation
Mass (Da):  35370
Number AA:  317
UniProt ID:  Q99697
International Prot ID:  IPI00220802
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005667     Uniprot OncoNet
Molecular Function:  GO:0043565  GO:0003700  GO:0008134 PhosphoSite+ KinaseNET
Biological Process:  GO:0007368  GO:0009887  GO:0006355 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S27AAVECLFSKDSEIKK
Site 2S30ECLFSKDSEIKKVEF
Site 3T38EIKKVEFTDSPESRK
Site 4S40KKVEFTDSPESRKEA
Site 5S49ESRKEAASSKFFPRQ
Site 6S50SRKEAASSKFFPRQH
Site 7S66GANEKDKSQQGKNED
Site 8T90KRQRRQRTHFTSQQL
Site 9S94RQRTHFTSQQLQELE
Site 10T103QLQELEATFQRNRYP
Site 11Y109ATFQRNRYPDMSTRE
Site 12S113RNRYPDMSTREEIAV
Site 13Y167FNGLMQPYDDMYPGY
Site 14Y171MQPYDDMYPGYSYNN
Site 15Y174YDDMYPGYSYNNWAA
Site 16S186WAAKGLTSASLSTKS
Site 17S188AKGLTSASLSTKSFP
Site 18S193SASLSTKSFPFFNSM
Site 19S199KSFPFFNSMNVNPLS
Site 20S206SMNVNPLSSQSMFSP
Site 21S207MNVNPLSSQSMFSPP
Site 22S209VNPLSSQSMFSPPNS
Site 23S212LSSQSMFSPPNSISS
Site 24S216SMFSPPNSISSMSMS
Site 25S218FSPPNSISSMSMSSS
Site 26S219SPPNSISSMSMSSSM
Site 27S221PNSISSMSMSSSMVP
Site 28S237AVTGVPGSSLNSLNN
Site 29S241VPGSSLNSLNNLNNL
Site 30S249LNNLNNLSSPSLNSA
Site 31S250NNLNNLSSPSLNSAV
Site 32S252LNNLSSPSLNSAVPT
Site 33Y264VPTPACPYAPPTPPY
Site 34T268ACPYAPPTPPYVYRD
Site 35Y271YAPPTPPYVYRDTCN
Site 36T276PPYVYRDTCNSSLAS
Site 37S279VYRDTCNSSLASLRL
Site 38S280YRDTCNSSLASLRLK
Site 39S283TCNSSLASLRLKAKQ
Site 40S293LKAKQHSSFGYASVQ
Site 41Y296KQHSSFGYASVQNPA
Site 42S298HSSFGYASVQNPASN
Site 43S304ASVQNPASNLSACQY
Site 44Y311SNLSACQYAVDRPV_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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