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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CIC
Full Name:
Protein capicua homolog
Alias:
Capicua; Capicua homolog (Drosophila); KIAA0306
Type:
DNA binding protein
Mass (Da):
163820
Number AA:
1608
UniProt ID:
Q96RK0
International Prot ID:
IPI00045360
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
H
R
P
L
M
P
A
S
S
A
A
S
R
G
L
Site 2
S13
R
P
L
M
P
A
S
S
A
A
S
R
G
L
G
Site 3
T25
G
L
G
M
F
V
W
T
N
V
E
P
R
S
V
Site 4
S47
L
V
P
F
L
A
P
S
Q
P
D
P
S
V
Q
Site 5
S52
A
P
S
Q
P
D
P
S
V
Q
P
S
E
A
Q
Site 6
S56
P
D
P
S
V
Q
P
S
E
A
Q
Q
P
A
S
Site 7
S63
S
E
A
Q
Q
P
A
S
H
P
V
A
S
N
Q
Site 8
S68
P
A
S
H
P
V
A
S
N
Q
S
K
E
P
A
Site 9
S71
H
P
V
A
S
N
Q
S
K
E
P
A
E
S
A
Site 10
S77
Q
S
K
E
P
A
E
S
A
A
V
A
H
E
R
Site 11
S91
R
P
P
G
G
T
G
S
A
D
P
E
R
P
P
Site 12
T101
P
E
R
P
P
G
A
T
C
P
E
S
P
G
P
Site 13
S105
P
G
A
T
C
P
E
S
P
G
P
G
P
P
H
Site 14
S119
H
P
L
G
V
V
E
S
G
K
G
P
P
P
T
Site 15
T126
S
G
K
G
P
P
P
T
T
E
E
E
A
S
G
Site 16
T127
G
K
G
P
P
P
T
T
E
E
E
A
S
G
P
Site 17
S132
P
T
T
E
E
E
A
S
G
P
P
G
E
P
R
Site 18
S142
P
G
E
P
R
L
D
S
E
T
E
S
D
H
D
Site 19
T144
E
P
R
L
D
S
E
T
E
S
D
H
D
D
A
Site 20
S146
R
L
D
S
E
T
E
S
D
H
D
D
A
F
L
Site 21
S154
D
H
D
D
A
F
L
S
I
M
S
P
E
I
Q
Site 22
T171
L
P
P
G
K
R
R
T
Q
S
L
S
A
L
P
Site 23
S173
P
G
K
R
R
T
Q
S
L
S
A
L
P
K
E
Site 24
S175
K
R
R
T
Q
S
L
S
A
L
P
K
E
R
D
Site 25
S183
A
L
P
K
E
R
D
S
S
S
E
K
D
G
R
Site 26
S184
L
P
K
E
R
D
S
S
S
E
K
D
G
R
S
Site 27
S185
P
K
E
R
D
S
S
S
E
K
D
G
R
S
P
Site 28
S191
S
S
E
K
D
G
R
S
P
N
K
R
E
K
D
Site 29
S211
M
N
A
F
M
I
F
S
K
R
H
R
A
L
V
Site 30
T229
H
P
N
Q
D
N
R
T
V
S
K
I
L
G
E
Site 31
S231
N
Q
D
N
R
T
V
S
K
I
L
G
E
W
W
Site 32
Y239
K
I
L
G
E
W
W
Y
A
L
G
P
K
E
K
Site 33
Y249
G
P
K
E
K
Q
K
Y
H
D
L
A
F
Q
V
Site 34
S277
C
N
K
D
R
K
K
S
S
S
E
A
K
P
T
Site 35
S278
N
K
D
R
K
K
S
S
S
E
A
K
P
T
S
Site 36
S279
K
D
R
K
K
S
S
S
E
A
K
P
T
S
L
Site 37
T284
S
S
S
E
A
K
P
T
S
L
G
L
A
G
G
Site 38
S285
S
S
E
A
K
P
T
S
L
G
L
A
G
G
H
Site 39
T295
L
A
G
G
H
K
E
T
R
E
R
S
M
S
E
Site 40
S299
H
K
E
T
R
E
R
S
M
S
E
T
G
T
A
Site 41
S301
E
T
R
E
R
S
M
S
E
T
G
T
A
A
A
Site 42
T303
R
E
R
S
M
S
E
T
G
T
A
A
A
P
G
Site 43
T305
R
S
M
S
E
T
G
T
A
A
A
P
G
V
S
Site 44
S325
V
A
A
Q
T
L
L
S
S
D
T
K
A
P
G
Site 45
S326
A
A
Q
T
L
L
S
S
D
T
K
A
P
G
S
Site 46
T328
Q
T
L
L
S
S
D
T
K
A
P
G
S
S
S
Site 47
S333
S
D
T
K
A
P
G
S
S
S
C
G
A
E
R
Site 48
S335
T
K
A
P
G
S
S
S
C
G
A
E
R
L
H
Site 49
T343
C
G
A
E
R
L
H
T
V
G
G
P
G
S
A
Site 50
S349
H
T
V
G
G
P
G
S
A
R
P
R
A
F
S
Site 51
S356
S
A
R
P
R
A
F
S
H
S
G
V
H
S
L
Site 52
S358
R
P
R
A
F
S
H
S
G
V
H
S
L
D
G
Site 53
S362
F
S
H
S
G
V
H
S
L
D
G
G
E
V
D
Site 54
S370
L
D
G
G
E
V
D
S
Q
A
L
Q
E
L
T
Site 55
T377
S
Q
A
L
Q
E
L
T
Q
M
V
S
G
P
A
Site 56
S381
Q
E
L
T
Q
M
V
S
G
P
A
S
Y
S
G
Site 57
S385
Q
M
V
S
G
P
A
S
Y
S
G
P
K
P
S
Site 58
Y386
M
V
S
G
P
A
S
Y
S
G
P
K
P
S
T
Site 59
S387
V
S
G
P
A
S
Y
S
G
P
K
P
S
T
Q
Site 60
S392
S
Y
S
G
P
K
P
S
T
Q
Y
G
A
P
G
Site 61
T393
Y
S
G
P
K
P
S
T
Q
Y
G
A
P
G
P
Site 62
Y395
G
P
K
P
S
T
Q
Y
G
A
P
G
P
F
A
Site 63
T421
G
R
P
P
L
L
P
T
R
A
S
R
S
Q
R
Site 64
S424
P
L
L
P
T
R
A
S
R
S
Q
R
A
A
S
Site 65
S426
L
P
T
R
A
S
R
S
Q
R
A
A
S
E
D
Site 66
S431
S
R
S
Q
R
A
A
S
E
D
M
T
S
D
E
Site 67
T435
R
A
A
S
E
D
M
T
S
D
E
E
R
M
V
Site 68
S436
A
A
S
E
D
M
T
S
D
E
E
R
M
V
I
Site 69
T472
L
K
C
K
E
R
V
T
D
S
E
S
G
D
S
Site 70
S474
C
K
E
R
V
T
D
S
E
S
G
D
S
S
G
Site 71
S476
E
R
V
T
D
S
E
S
G
D
S
S
G
E
D
Site 72
S479
T
D
S
E
S
G
D
S
S
G
E
D
P
E
G
Site 73
S480
D
S
E
S
G
D
S
S
G
E
D
P
E
G
N
Site 74
S496
G
F
G
R
K
V
F
S
P
V
I
R
S
S
F
Site 75
S502
F
S
P
V
I
R
S
S
F
T
H
C
R
P
P
Site 76
T504
P
V
I
R
S
S
F
T
H
C
R
P
P
L
D
Site 77
Y528
P
V
A
F
G
K
G
Y
G
S
A
P
S
S
S
Site 78
S530
A
F
G
K
G
Y
G
S
A
P
S
S
S
A
S
Site 79
S533
K
G
Y
G
S
A
P
S
S
S
A
S
S
P
A
Site 80
S534
G
Y
G
S
A
P
S
S
S
A
S
S
P
A
S
Site 81
S535
Y
G
S
A
P
S
S
S
A
S
S
P
A
S
S
Site 82
S537
S
A
P
S
S
S
A
S
S
P
A
S
S
S
A
Site 83
S538
A
P
S
S
S
A
S
S
P
A
S
S
S
A
S
Site 84
S541
S
S
A
S
S
P
A
S
S
S
A
S
A
A
T
Site 85
S542
S
A
S
S
P
A
S
S
S
A
S
A
A
T
S
Site 86
S543
A
S
S
P
A
S
S
S
A
S
A
A
T
S
F
Site 87
S545
S
P
A
S
S
S
A
S
A
A
T
S
F
S
L
Site 88
S549
S
S
A
S
A
A
T
S
F
S
L
G
S
G
T
Site 89
T556
S
F
S
L
G
S
G
T
F
K
A
Q
E
S
G
Site 90
S562
G
T
F
K
A
Q
E
S
G
Q
G
S
T
A
G
Site 91
S566
A
Q
E
S
G
Q
G
S
T
A
G
P
L
R
P
Site 92
T583
P
G
A
G
G
P
A
T
P
S
K
A
T
R
F
Site 93
S585
A
G
G
P
A
T
P
S
K
A
T
R
F
L
P
Site 94
T597
F
L
P
M
D
P
A
T
F
R
R
K
R
P
E
Site 95
S605
F
R
R
K
R
P
E
S
V
G
G
L
E
P
P
Site 96
S688
S
T
P
V
P
I
A
S
K
P
F
P
T
S
G
Site 97
S694
A
S
K
P
F
P
T
S
G
R
A
E
A
S
P
Site 98
S700
T
S
G
R
A
E
A
S
P
N
D
T
A
G
A
Site 99
T704
A
E
A
S
P
N
D
T
A
G
A
R
T
E
M
Site 100
T713
G
A
R
T
E
M
G
T
G
S
R
V
P
G
G
Site 101
S715
R
T
E
M
G
T
G
S
R
V
P
G
G
S
P
Site 102
S721
G
S
R
V
P
G
G
S
P
L
G
V
S
L
V
Site 103
S726
G
G
S
P
L
G
V
S
L
V
Y
S
D
K
K
Site 104
S734
L
V
Y
S
D
K
K
S
A
A
A
T
S
P
A
Site 105
S739
K
K
S
A
A
A
T
S
P
A
P
H
L
V
A
Site 106
T790
Q
G
A
P
G
G
G
T
T
A
G
S
G
A
G
Site 107
S794
G
G
G
T
T
A
G
S
G
A
G
A
G
S
G
Site 108
S800
G
S
G
A
G
A
G
S
G
P
N
G
P
V
P
Site 109
T848
A
P
A
P
A
P
G
T
K
A
A
A
P
S
G
Site 110
S854
G
T
K
A
A
A
P
S
G
P
A
P
T
T
S
Site 111
T860
P
S
G
P
A
P
T
T
S
I
R
F
T
L
P
Site 112
S861
S
G
P
A
P
T
T
S
I
R
F
T
L
P
P
Site 113
T865
P
T
T
S
I
R
F
T
L
P
P
G
T
S
T
Site 114
S894
P
I
L
Q
S
V
P
S
A
P
P
P
K
A
Q
Site 115
S902
A
P
P
P
K
A
Q
S
V
S
P
V
Q
A
P
Site 116
S904
P
P
K
A
Q
S
V
S
P
V
Q
A
P
P
P
Site 117
S914
Q
A
P
P
P
G
G
S
A
Q
L
L
P
G
K
Site 118
S961
Q
N
G
A
Q
P
P
S
K
I
I
Q
L
T
P
Site 119
T985
V
P
P
L
S
P
A
T
L
P
G
P
T
S
Q
Site 120
S991
A
T
L
P
G
P
T
S
Q
P
Q
K
V
L
L
Site 121
S1001
Q
K
V
L
L
P
S
S
T
R
I
T
Y
V
Q
Site 122
T1005
L
P
S
S
T
R
I
T
Y
V
Q
S
A
G
G
Site 123
Y1006
P
S
S
T
R
I
T
Y
V
Q
S
A
G
G
H
Site 124
T1019
G
H
A
L
P
L
G
T
S
P
A
S
S
Q
A
Site 125
S1020
H
A
L
P
L
G
T
S
P
A
S
S
Q
A
G
Site 126
S1023
P
L
G
T
S
P
A
S
S
Q
A
G
T
V
T
Site 127
S1024
L
G
T
S
P
A
S
S
Q
A
G
T
V
T
S
Site 128
T1028
P
A
S
S
Q
A
G
T
V
T
S
Y
G
P
T
Site 129
S1031
S
Q
A
G
T
V
T
S
Y
G
P
T
S
S
V
Site 130
Y1032
Q
A
G
T
V
T
S
Y
G
P
T
S
S
V
A
Site 131
S1037
T
S
Y
G
P
T
S
S
V
A
L
G
F
T
S
Site 132
S1099
I
T
A
F
Y
S
G
S
P
A
P
T
S
S
A
Site 133
T1103
Y
S
G
S
P
A
P
T
S
S
A
P
L
A
Q
Site 134
S1104
S
G
S
P
A
P
T
S
S
A
P
L
A
Q
P
Site 135
S1105
G
S
P
A
P
T
S
S
A
P
L
A
Q
P
S
Site 136
S1112
S
A
P
L
A
Q
P
S
Q
A
P
P
S
L
V
Site 137
S1117
Q
P
S
Q
A
P
P
S
L
V
Y
T
V
A
T
Site 138
T1132
S
T
T
P
P
A
A
T
I
L
P
K
G
P
P
Site 139
T1143
K
G
P
P
A
P
A
T
A
T
P
A
P
T
S
Site 140
T1145
P
P
A
P
A
T
A
T
P
A
P
T
S
P
F
Site 141
S1150
T
A
T
P
A
P
T
S
P
F
P
S
A
T
A
Site 142
S1154
A
P
T
S
P
F
P
S
A
T
A
G
S
M
T
Site 143
T1156
T
S
P
F
P
S
A
T
A
G
S
M
T
Y
S
Site 144
S1163
T
A
G
S
M
T
Y
S
L
V
A
P
K
A
Q
Site 145
S1173
A
P
K
A
Q
R
P
S
P
K
A
P
Q
K
V
Site 146
S1197
G
S
F
E
A
G
A
S
G
R
P
G
P
A
P
Site 147
T1217
P
G
P
V
R
E
P
T
A
P
E
S
E
L
E
Site 148
S1221
R
E
P
T
A
P
E
S
E
L
E
G
Q
P
T
Site 149
T1228
S
E
L
E
G
Q
P
T
P
P
A
P
P
P
L
Site 150
T1238
A
P
P
P
L
P
E
T
W
T
P
T
A
R
S
Site 151
T1240
P
P
L
P
E
T
W
T
P
T
A
R
S
S
P
Site 152
T1242
L
P
E
T
W
T
P
T
A
R
S
S
P
P
L
Site 153
S1245
T
W
T
P
T
A
R
S
S
P
P
L
P
P
P
Site 154
S1246
W
T
P
T
A
R
S
S
P
P
L
P
P
P
A
Site 155
S1258
P
P
A
E
E
R
T
S
A
K
G
P
E
T
M
Site 156
T1264
T
S
A
K
G
P
E
T
M
A
S
K
F
P
S
Site 157
S1267
K
G
P
E
T
M
A
S
K
F
P
S
S
S
S
Site 158
S1271
T
M
A
S
K
F
P
S
S
S
S
D
W
R
V
Site 159
S1272
M
A
S
K
F
P
S
S
S
S
D
W
R
V
P
Site 160
S1273
A
S
K
F
P
S
S
S
S
D
W
R
V
P
G
Site 161
S1274
S
K
F
P
S
S
S
S
D
W
R
V
P
G
Q
Site 162
T1291
E
N
R
G
E
P
P
T
P
P
S
P
A
P
A
Site 163
S1294
G
E
P
P
T
P
P
S
P
A
P
A
P
A
V
Site 164
S1306
P
A
V
A
P
G
G
S
S
E
S
S
S
G
R
Site 165
S1307
A
V
A
P
G
G
S
S
E
S
S
S
G
R
A
Site 166
S1309
A
P
G
G
S
S
E
S
S
S
G
R
A
A
G
Site 167
S1310
P
G
G
S
S
E
S
S
S
G
R
A
A
G
D
Site 168
S1311
G
G
S
S
E
S
S
S
G
R
A
A
G
D
T
Site 169
T1318
S
G
R
A
A
G
D
T
P
E
R
K
E
A
A
Site 170
T1341
R
P
P
P
L
K
K
T
F
D
S
V
D
N
R
Site 171
S1344
P
L
K
K
T
F
D
S
V
D
N
R
V
L
S
Site 172
S1351
S
V
D
N
R
V
L
S
E
V
D
F
E
E
R
Site 173
S1373
R
P
E
E
V
L
P
S
P
T
L
Q
S
L
A
Site 174
T1375
E
E
V
L
P
S
P
T
L
Q
S
L
A
T
S
Site 175
S1378
L
P
S
P
T
L
Q
S
L
A
T
S
P
R
A
Site 176
T1381
P
T
L
Q
S
L
A
T
S
P
R
A
I
L
G
Site 177
S1382
T
L
Q
S
L
A
T
S
P
R
A
I
L
G
S
Site 178
S1389
S
P
R
A
I
L
G
S
Y
R
K
K
R
K
N
Site 179
S1397
Y
R
K
K
R
K
N
S
T
D
L
D
S
A
P
Site 180
T1398
R
K
K
R
K
N
S
T
D
L
D
S
A
P
E
Site 181
S1402
K
N
S
T
D
L
D
S
A
P
E
D
P
T
S
Site 182
T1408
D
S
A
P
E
D
P
T
S
P
K
R
K
M
R
Site 183
S1409
S
A
P
E
D
P
T
S
P
K
R
K
M
R
R
Site 184
S1418
K
R
K
M
R
R
R
S
S
C
S
S
E
P
N
Site 185
S1419
R
K
M
R
R
R
S
S
C
S
S
E
P
N
T
Site 186
S1421
M
R
R
R
S
S
C
S
S
E
P
N
T
P
K
Site 187
S1422
R
R
R
S
S
C
S
S
E
P
N
T
P
K
S
Site 188
T1426
S
C
S
S
E
P
N
T
P
K
S
A
K
C
E
Site 189
S1429
S
E
P
N
T
P
K
S
A
K
C
E
G
D
I
Site 190
T1438
K
C
E
G
D
I
F
T
F
D
R
T
G
T
E
Site 191
T1444
F
T
F
D
R
T
G
T
E
A
E
D
V
L
G
Site 192
Y1455
D
V
L
G
E
L
E
Y
D
K
V
P
Y
S
S
Site 193
S1461
E
Y
D
K
V
P
Y
S
S
L
R
R
T
L
D
Site 194
S1462
Y
D
K
V
P
Y
S
S
L
R
R
T
L
D
Q
Site 195
T1466
P
Y
S
S
L
R
R
T
L
D
Q
R
R
A
L
Site 196
S1486
Q
D
H
G
F
F
P
S
A
Q
A
T
A
A
F
Site 197
Y1497
T
A
A
F
Q
A
R
Y
A
D
I
F
P
S
K
Site 198
T1523
Q
K
I
M
Q
A
A
T
P
T
E
Q
P
P
G
Site 199
T1550
T
A
A
A
P
A
P
T
P
S
P
A
G
G
P
Site 200
S1552
A
A
P
A
P
T
P
S
P
A
G
G
P
D
P
Site 201
T1560
P
A
G
G
P
D
P
T
S
P
S
S
D
S
G
Site 202
S1561
A
G
G
P
D
P
T
S
P
S
S
D
S
G
T
Site 203
S1563
G
P
D
P
T
S
P
S
S
D
S
G
T
A
Q
Site 204
S1564
P
D
P
T
S
P
S
S
D
S
G
T
A
Q
A
Site 205
S1566
P
T
S
P
S
S
D
S
G
T
A
Q
A
A
P
Site 206
T1568
S
P
S
S
D
S
G
T
A
Q
A
A
P
P
L
Site 207
S1581
P
L
P
P
P
P
E
S
G
P
G
Q
P
G
W
Site 208
S1595
W
E
G
A
P
Q
P
S
P
P
P
P
G
P
S
Site 209
S1602
S
P
P
P
P
G
P
S
T
A
A
T
G
R
_
Site 210
T1603
P
P
P
P
G
P
S
T
A
A
T
G
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation