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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK1
Full Name:
Serine/threonine-protein kinase Nek1
Alias:
EC 2.7.11.1; KIAA1901; NIMA (never in mitosis gene a)-related kinase 1; NimA-related protein kinase 1; NY-REN-55; NY-REN-55 antigen
Type:
Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); EC 2.7.1.37; EC 2.7.11.1; Other group; NEK family
Mass (Da):
142828
Number AA:
1258
UniProt ID:
Q96PY6
International Prot ID:
IPI00044749
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
G
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
Site 2
Y30
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
Site 3
S38
V
I
K
E
I
N
I
S
R
M
S
S
K
E
R
Site 4
S41
E
I
N
I
S
R
M
S
S
K
E
R
E
E
S
Site 5
S42
I
N
I
S
R
M
S
S
K
E
R
E
E
S
R
Site 6
S48
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
Site 7
Y66
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
Site 8
S69
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
L
Site 9
S75
E
S
F
E
E
N
G
S
L
Y
I
V
M
D
Y
Site 10
Y77
F
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
Site 11
S131
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
Site 12
T137
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
Site 13
S155
G
I
A
R
V
L
N
S
T
V
E
L
A
R
T
Site 14
T156
I
A
R
V
L
N
S
T
V
E
L
A
R
T
C
Site 15
T162
S
T
V
E
L
A
R
T
C
I
G
T
P
Y
Y
Site 16
T166
L
A
R
T
C
I
G
T
P
Y
Y
L
S
P
E
Site 17
S171
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
Site 18
Y180
E
I
C
E
N
K
P
Y
N
N
K
S
D
I
W
Site 19
S224
S
G
S
F
P
P
V
S
L
H
Y
S
Y
D
L
Site 20
S228
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
Site 21
Y229
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Site 22
S233
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
Site 23
S236
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
Site 24
S248
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
Site 25
S251
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
Site 26
S267
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
Site 27
T279
A
E
E
F
C
L
K
T
F
S
K
F
G
S
Q
Site 28
S281
E
F
C
L
K
T
F
S
K
F
G
S
Q
P
I
Site 29
S285
K
T
F
S
K
F
G
S
Q
P
I
P
A
K
R
Site 30
S295
I
P
A
K
R
P
A
S
G
Q
N
S
I
S
V
Site 31
S299
R
P
A
S
G
Q
N
S
I
S
V
M
P
A
Q
Site 32
S301
A
S
G
Q
N
S
I
S
V
M
P
A
Q
K
I
Site 33
Y315
I
T
K
P
A
A
K
Y
G
I
P
L
A
Y
K
Site 34
Y321
K
Y
G
I
P
L
A
Y
K
K
Y
G
D
K
K
Site 35
Y324
I
P
L
A
Y
K
K
Y
G
D
K
K
L
H
E
Site 36
T344
K
H
K
Q
A
H
Q
T
P
E
K
R
V
N
T
Site 37
T351
T
P
E
K
R
V
N
T
G
E
E
R
R
K
I
Site 38
S359
G
E
E
R
R
K
I
S
E
E
A
A
R
K
R
Site 39
S383
K
Q
K
D
Q
I
I
S
L
M
K
A
E
Q
M
Site 40
S414
Q
G
W
R
N
V
L
S
A
G
G
S
G
E
V
Site 41
S418
N
V
L
S
A
G
G
S
G
E
V
K
A
P
F
Site 42
S428
V
K
A
P
F
L
G
S
G
G
T
I
A
P
S
Site 43
S435
S
G
G
T
I
A
P
S
S
F
S
S
R
G
Q
Site 44
S436
G
G
T
I
A
P
S
S
F
S
S
R
G
Q
Y
Site 45
S438
T
I
A
P
S
S
F
S
S
R
G
Q
Y
E
H
Site 46
S439
I
A
P
S
S
F
S
S
R
G
Q
Y
E
H
Y
Site 47
Y443
S
F
S
S
R
G
Q
Y
E
H
Y
H
A
I
F
Site 48
Y446
S
R
G
Q
Y
E
H
Y
H
A
I
F
D
Q
M
Site 49
Y470
A
K
W
K
R
E
I
Y
G
R
G
L
P
E
R
Site 50
Y489
G
V
R
P
G
F
P
Y
G
A
A
G
H
H
H
Site 51
T506
D
A
D
D
I
R
K
T
L
K
R
L
K
A
V
Site 52
S514
L
K
R
L
K
A
V
S
K
Q
A
N
A
N
R
Site 53
Y557
R
A
E
G
H
M
V
Y
L
A
R
L
R
Q
I
Site 54
S589
E
K
K
E
A
N
H
S
E
G
Q
E
G
S
E
Site 55
S607
M
R
R
K
K
I
E
S
L
K
A
H
A
N
A
Site 56
Y631
E
R
K
R
K
E
A
Y
E
R
E
K
K
V
W
Site 57
S650
V
A
K
G
V
K
S
S
D
V
S
P
P
L
G
Site 58
S653
G
V
K
S
S
D
V
S
P
P
L
G
Q
H
E
Site 59
T661
P
P
L
G
Q
H
E
T
G
G
S
P
S
K
Q
Site 60
S664
G
Q
H
E
T
G
G
S
P
S
K
Q
Q
M
R
Site 61
S672
P
S
K
Q
Q
M
R
S
V
I
S
V
T
S
A
Site 62
S675
Q
Q
M
R
S
V
I
S
V
T
S
A
L
K
E
Site 63
S688
K
E
V
G
V
D
S
S
L
T
D
T
R
E
T
Site 64
T690
V
G
V
D
S
S
L
T
D
T
R
E
T
S
E
Site 65
T692
V
D
S
S
L
T
D
T
R
E
T
S
E
E
M
Site 66
T695
S
L
T
D
T
R
E
T
S
E
E
M
Q
K
T
Site 67
S696
L
T
D
T
R
E
T
S
E
E
M
Q
K
T
N
Site 68
T702
T
S
E
E
M
Q
K
T
N
N
A
I
S
S
K
Site 69
S707
Q
K
T
N
N
A
I
S
S
K
R
E
I
L
R
Site 70
S708
K
T
N
N
A
I
S
S
K
R
E
I
L
R
R
Site 71
S733
E
K
G
K
Q
N
L
S
D
T
F
E
I
N
V
Site 72
T735
G
K
Q
N
L
S
D
T
F
E
I
N
V
H
E
Site 73
S752
K
E
H
E
K
E
K
S
V
S
S
D
R
K
K
Site 74
S754
H
E
K
E
K
S
V
S
S
D
R
K
K
W
E
Site 75
S755
E
K
E
K
S
V
S
S
D
R
K
K
W
E
A
Site 76
S778
D
E
L
T
L
D
T
S
F
S
T
T
E
R
H
Site 77
S780
L
T
L
D
T
S
F
S
T
T
E
R
H
T
V
Site 78
T782
L
D
T
S
F
S
T
T
E
R
H
T
V
G
E
Site 79
T786
F
S
T
T
E
R
H
T
V
G
E
V
I
K
L
Site 80
S798
I
K
L
G
P
N
G
S
P
R
R
A
W
G
K
Site 81
S806
P
R
R
A
W
G
K
S
P
T
D
S
V
L
K
Site 82
T808
R
A
W
G
K
S
P
T
D
S
V
L
K
I
L
Site 83
S810
W
G
K
S
P
T
D
S
V
L
K
I
L
G
E
Site 84
T830
Q
T
E
L
L
E
N
T
T
I
R
S
E
I
S
Site 85
S834
L
E
N
T
T
I
R
S
E
I
S
P
E
G
E
Site 86
S837
T
T
I
R
S
E
I
S
P
E
G
E
K
Y
K
Site 87
Y843
I
S
P
E
G
E
K
Y
K
P
L
I
T
G
E
Site 88
S857
E
K
K
V
Q
C
I
S
H
E
I
N
P
S
A
Site 89
S868
N
P
S
A
I
V
D
S
P
V
E
T
K
S
P
Site 90
T872
I
V
D
S
P
V
E
T
K
S
P
E
F
S
E
Site 91
S874
D
S
P
V
E
T
K
S
P
E
F
S
E
A
S
Site 92
S878
E
T
K
S
P
E
F
S
E
A
S
P
Q
M
S
Site 93
S881
S
P
E
F
S
E
A
S
P
Q
M
S
L
K
L
Site 94
S885
S
E
A
S
P
Q
M
S
L
K
L
E
G
N
L
Site 95
S914
S
G
T
N
K
D
E
S
L
P
C
T
I
T
D
Site 96
T918
K
D
E
S
L
P
C
T
I
T
D
V
W
I
S
Site 97
T920
E
S
L
P
C
T
I
T
D
V
W
I
S
E
E
Site 98
T930
W
I
S
E
E
K
E
T
K
E
T
Q
S
A
D
Site 99
T933
E
E
K
E
T
K
E
T
Q
S
A
D
R
I
T
Site 100
S935
K
E
T
K
E
T
Q
S
A
D
R
I
T
I
Q
Site 101
T940
T
Q
S
A
D
R
I
T
I
Q
E
N
E
V
S
Site 102
S947
T
I
Q
E
N
E
V
S
E
D
G
V
S
S
T
Site 103
S952
E
V
S
E
D
G
V
S
S
T
V
D
Q
L
S
Site 104
S953
V
S
E
D
G
V
S
S
T
V
D
Q
L
S
D
Site 105
T954
S
E
D
G
V
S
S
T
V
D
Q
L
S
D
I
Site 106
S959
S
S
T
V
D
Q
L
S
D
I
H
I
E
P
G
Site 107
T967
D
I
H
I
E
P
G
T
N
D
S
Q
H
S
K
Site 108
S970
I
E
P
G
T
N
D
S
Q
H
S
K
C
D
V
Site 109
S980
S
K
C
D
V
D
K
S
V
Q
P
E
P
F
F
Site 110
S1004
N
L
V
P
Q
V
Q
S
V
Q
C
S
P
E
E
Site 111
S1008
Q
V
Q
S
V
Q
C
S
P
E
E
S
F
A
F
Site 112
S1012
V
Q
C
S
P
E
E
S
F
A
F
R
S
H
S
Site 113
S1017
E
E
S
F
A
F
R
S
H
S
H
L
P
P
K
Site 114
S1019
S
F
A
F
R
S
H
S
H
L
P
P
K
N
K
Site 115
S1030
P
K
N
K
N
K
N
S
L
L
I
G
L
S
T
Site 116
T1050
N
N
P
K
M
L
R
T
C
S
L
P
D
L
S
Site 117
S1052
P
K
M
L
R
T
C
S
L
P
D
L
S
K
L
Site 118
T1068
R
T
L
M
D
V
P
T
V
G
D
V
R
Q
D
Site 119
S1092
E
N
I
K
E
G
P
S
D
S
E
D
I
V
F
Site 120
S1094
I
K
E
G
P
S
D
S
E
D
I
V
F
E
E
Site 121
T1104
I
V
F
E
E
T
D
T
D
L
Q
E
L
Q
A
Site 122
S1112
D
L
Q
E
L
Q
A
S
M
E
Q
L
L
R
E
Site 123
Y1125
R
E
Q
P
G
E
E
Y
S
E
E
E
E
S
V
Site 124
S1126
E
Q
P
G
E
E
Y
S
E
E
E
E
S
V
L
Site 125
S1131
E
Y
S
E
E
E
E
S
V
L
K
N
S
D
V
Site 126
S1136
E
E
S
V
L
K
N
S
D
V
E
P
T
A
N
Site 127
S1156
D
E
D
D
N
P
S
S
E
S
A
L
N
E
E
Site 128
S1166
A
L
N
E
E
W
H
S
D
N
S
D
G
E
I
Site 129
S1169
E
E
W
H
S
D
N
S
D
G
E
I
A
S
E
Site 130
S1175
N
S
D
G
E
I
A
S
E
C
E
C
D
S
V
Site 131
S1181
A
S
E
C
E
C
D
S
V
F
N
H
L
E
E
Site 132
Y1239
G
N
E
H
Q
H
L
Y
A
K
I
L
H
L
V
Site 133
Y1252
L
V
M
A
D
G
A
Y
Q
E
D
N
D
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation