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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYNGAP1
Full Name:
Ras GTPase-activating protein SynGAP
Alias:
KIAA1938; LYPLA2P1; Neuronal RasGAP; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; Synaptic Ras-GAP 1; Synaptic Ras-GTPase-activating protein 1; SYNGAP; synGAP1
Type:
GTPase-activating protein for G protein
Mass (Da):
148284
Number AA:
1343
UniProt ID:
Q96PV0
International Prot ID:
IPI00177884
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
R
S
R
A
S
I
H
R
G
S
I
P
Site 2
S12
R
A
S
I
H
R
G
S
I
P
A
M
S
Y
A
Site 3
S17
R
G
S
I
P
A
M
S
Y
A
P
F
R
D
V
Site 4
S28
F
R
D
V
R
G
P
S
M
H
R
T
Q
Y
V
Site 5
T32
R
G
P
S
M
H
R
T
Q
Y
V
H
S
P
Y
Site 6
Y34
P
S
M
H
R
T
Q
Y
V
H
S
P
Y
D
R
Site 7
Y39
T
Q
Y
V
H
S
P
Y
D
R
P
G
W
N
P
Site 8
S74
L
L
I
R
D
R
R
S
E
S
S
R
N
K
L
Site 9
S76
I
R
D
R
R
S
E
S
S
R
N
K
L
L
R
Site 10
S77
R
D
R
R
S
E
S
S
R
N
K
L
L
R
R
Site 11
T85
R
N
K
L
L
R
R
T
V
S
V
P
V
E
G
Site 12
S87
K
L
L
R
R
T
V
S
V
P
V
E
G
R
P
Site 13
Y100
R
P
H
G
E
H
E
Y
H
L
G
R
S
R
R
Site 14
S105
H
E
Y
H
L
G
R
S
R
R
K
S
V
P
G
Site 15
S109
L
G
R
S
R
R
K
S
V
P
G
G
K
Q
Y
Site 16
S117
V
P
G
G
K
Q
Y
S
M
E
G
A
P
A
A
Site 17
S129
P
A
A
P
F
R
P
S
Q
G
F
L
S
R
R
Site 18
S134
R
P
S
Q
G
F
L
S
R
R
L
K
S
S
I
Site 19
S139
F
L
S
R
R
L
K
S
S
I
K
R
T
K
S
Site 20
S140
L
S
R
R
L
K
S
S
I
K
R
T
K
S
Q
Site 21
T144
L
K
S
S
I
K
R
T
K
S
Q
P
K
L
D
Site 22
S146
S
S
I
K
R
T
K
S
Q
P
K
L
D
R
T
Site 23
T153
S
Q
P
K
L
D
R
T
S
S
F
R
Q
I
L
Site 24
S154
Q
P
K
L
D
R
T
S
S
F
R
Q
I
L
P
Site 25
S155
P
K
L
D
R
T
S
S
F
R
Q
I
L
P
R
Site 26
S165
Q
I
L
P
R
F
R
S
A
D
H
D
R
A
R
Site 27
S176
D
R
A
R
L
M
Q
S
F
K
E
S
H
S
H
Site 28
S180
L
M
Q
S
F
K
E
S
H
S
H
E
S
L
L
Site 29
S182
Q
S
F
K
E
S
H
S
H
E
S
L
L
S
P
Site 30
S185
K
E
S
H
S
H
E
S
L
L
S
P
S
S
A
Site 31
S188
H
S
H
E
S
L
L
S
P
S
S
A
A
E
A
Site 32
S204
E
L
N
L
D
E
D
S
I
I
K
P
V
H
S
Site 33
S257
V
K
P
N
K
D
N
S
R
R
V
D
N
V
L
Site 34
Y280
E
L
P
P
K
K
R
Y
Y
C
E
L
C
L
D
Site 35
Y281
L
P
P
K
K
R
Y
Y
C
E
L
C
L
D
D
Site 36
Y291
L
C
L
D
D
M
L
Y
A
R
T
T
S
K
P
Site 37
T295
D
M
L
Y
A
R
T
T
S
K
P
R
S
A
S
Site 38
S296
M
L
Y
A
R
T
T
S
K
P
R
S
A
S
G
Site 39
S300
R
T
T
S
K
P
R
S
A
S
G
D
T
V
F
Site 40
S302
T
S
K
P
R
S
A
S
G
D
T
V
F
W
G
Site 41
T305
P
R
S
A
S
G
D
T
V
F
W
G
E
H
F
Site 42
Y328
R
A
L
R
L
H
L
Y
R
D
S
D
K
K
R
Site 43
S331
R
L
H
L
Y
R
D
S
D
K
K
R
K
K
D
Site 44
Y342
R
K
K
D
K
A
G
Y
V
G
L
V
T
V
P
Site 45
T359
T
L
A
G
R
H
F
T
E
Q
W
Y
P
V
T
Site 46
Y363
R
H
F
T
E
Q
W
Y
P
V
T
L
P
T
G
Site 47
T366
T
E
Q
W
Y
P
V
T
L
P
T
G
S
G
G
Site 48
T369
W
Y
P
V
T
L
P
T
G
S
G
G
S
G
G
Site 49
S371
P
V
T
L
P
T
G
S
G
G
S
G
G
M
G
Site 50
S379
G
G
S
G
G
M
G
S
G
G
G
G
G
S
G
Site 51
S385
G
S
G
G
G
G
G
S
G
G
G
S
G
G
K
Site 52
S389
G
G
G
S
G
G
G
S
G
G
K
G
K
G
G
Site 53
Y406
A
V
R
L
K
A
R
Y
Q
T
M
S
I
L
P
Site 54
T408
R
L
K
A
R
Y
Q
T
M
S
I
L
P
M
E
Site 55
S410
K
A
R
Y
Q
T
M
S
I
L
P
M
E
L
Y
Site 56
Y423
L
Y
K
E
F
A
E
Y
V
T
N
H
Y
R
M
Site 57
S449
K
G
K
E
E
V
A
S
A
L
V
H
I
L
Q
Site 58
S466
G
K
A
K
D
F
L
S
D
M
A
M
S
E
V
Site 59
T488
H
L
I
F
R
E
N
T
L
A
T
K
A
I
E
Site 60
Y497
A
T
K
A
I
E
E
Y
M
R
L
I
G
Q
K
Site 61
Y505
M
R
L
I
G
Q
K
Y
L
K
D
A
I
G
E
Site 62
Y518
G
E
F
I
R
A
L
Y
E
S
E
E
N
C
E
Site 63
S520
F
I
R
A
L
Y
E
S
E
E
N
C
E
V
D
Site 64
S571
E
L
K
E
V
F
A
S
W
R
L
R
C
A
E
Site 65
Y614
L
F
G
L
M
Q
E
Y
P
D
E
Q
T
S
R
Site 66
T619
Q
E
Y
P
D
E
Q
T
S
R
T
L
T
L
I
Site 67
T624
E
Q
T
S
R
T
L
T
L
I
A
K
V
I
Q
Site 68
S641
A
N
F
S
K
F
T
S
K
E
D
F
L
G
F
Site 69
Y665
G
S
M
Q
Q
F
L
Y
E
I
S
N
L
D
T
Site 70
T672
Y
E
I
S
N
L
D
T
L
T
N
S
S
S
F
Site 71
T674
I
S
N
L
D
T
L
T
N
S
S
S
F
E
G
Site 72
S676
N
L
D
T
L
T
N
S
S
S
F
E
G
Y
I
Site 73
S678
D
T
L
T
N
S
S
S
F
E
G
Y
I
D
L
Site 74
Y682
N
S
S
S
F
E
G
Y
I
D
L
G
R
E
L
Site 75
S722
P
R
L
L
N
D
I
S
T
A
L
R
N
P
N
Site 76
T723
R
L
L
N
D
I
S
T
A
L
R
N
P
N
I
Site 77
S735
P
N
I
Q
R
Q
P
S
R
Q
S
E
R
P
R
Site 78
S738
Q
R
Q
P
S
R
Q
S
E
R
P
R
P
Q
P
Site 79
S752
P
V
V
L
R
G
P
S
A
E
M
Q
G
Y
M
Site 80
Y758
P
S
A
E
M
Q
G
Y
M
M
R
D
L
N
S
Site 81
S765
M
A
R
G
L
N
S
S
M
D
M
A
R
L
P
Site 82
S766
M
M
R
D
L
N
S
S
I
D
L
Q
S
F
M
Site 83
S771
N
S
S
I
D
L
Q
S
F
M
A
R
G
L
N
Site 84
S780
M
A
R
G
L
N
S
S
M
D
M
A
R
L
P
Site 85
S788
M
D
M
A
R
L
P
S
P
T
K
E
K
P
P
Site 86
T790
M
A
R
L
P
S
P
T
K
E
K
P
P
P
P
Site 87
Y807
G
G
G
K
D
L
F
Y
V
S
R
P
P
L
A
Site 88
S809
G
K
D
L
F
Y
V
S
R
P
P
L
A
R
S
Site 89
S816
S
R
P
P
L
A
R
S
S
P
A
Y
C
T
S
Site 90
S817
R
P
P
L
A
R
S
S
P
A
Y
C
T
S
S
Site 91
Y820
L
A
R
S
S
P
A
Y
C
T
S
S
S
D
I
Site 92
T822
R
S
S
P
A
Y
C
T
S
S
S
D
I
T
E
Site 93
S823
S
S
P
A
Y
C
T
S
S
S
D
I
T
E
P
Site 94
S824
S
P
A
Y
C
T
S
S
S
D
I
T
E
P
E
Site 95
S825
P
A
Y
C
T
S
S
S
D
I
T
E
P
E
Q
Site 96
T828
C
T
S
S
S
D
I
T
E
P
E
Q
K
M
L
Site 97
S836
E
P
E
Q
K
M
L
S
V
N
K
S
V
S
M
Site 98
S840
K
M
L
S
V
N
K
S
V
S
M
L
D
L
Q
Site 99
S842
L
S
V
N
K
S
V
S
M
L
D
L
Q
G
D
Site 100
S857
G
P
G
G
R
L
N
S
S
S
V
S
N
L
A
Site 101
S858
P
G
G
R
L
N
S
S
S
V
S
N
L
A
A
Site 102
S861
R
L
N
S
S
S
V
S
N
L
A
A
V
G
D
Site 103
S892
P
A
P
A
G
R
L
S
Q
G
S
G
S
S
I
Site 104
S895
A
G
R
L
S
Q
G
S
G
S
S
I
T
A
A
Site 105
S907
T
A
A
G
M
R
L
S
Q
M
G
V
T
T
D
Site 106
S926
Q
Q
L
R
I
P
L
S
F
Q
N
P
L
F
H
Site 107
T975
G
G
E
P
P
G
D
T
F
A
P
F
H
G
Y
Site 108
Y982
T
F
A
P
F
H
G
Y
S
K
S
E
D
L
S
Site 109
S983
F
A
P
F
H
G
Y
S
K
S
E
D
L
S
S
Site 110
S985
P
F
H
G
Y
S
K
S
E
D
L
S
S
G
V
Site 111
S989
Y
S
K
S
E
D
L
S
S
G
V
P
K
P
P
Site 112
S990
S
K
S
E
D
L
S
S
G
V
P
K
P
P
A
Site 113
S999
V
P
K
P
P
A
A
S
I
L
H
S
H
S
Y
Site 114
S1003
P
A
A
S
I
L
H
S
H
S
Y
S
D
E
F
Site 115
S1005
A
S
I
L
H
S
H
S
Y
S
D
E
F
G
P
Site 116
Y1006
S
I
L
H
S
H
S
Y
S
D
E
F
G
P
S
Site 117
S1007
I
L
H
S
H
S
Y
S
D
E
F
G
P
S
G
Site 118
S1013
Y
S
D
E
F
G
P
S
G
T
D
F
T
R
R
Site 119
T1018
G
P
S
G
T
D
F
T
R
R
Q
L
S
L
Q
Site 120
S1023
D
F
T
R
R
Q
L
S
L
Q
D
N
L
Q
H
Site 121
S1033
D
N
L
Q
H
M
L
S
P
P
Q
I
T
I
G
Site 122
S1047
G
P
Q
R
P
A
P
S
G
P
G
G
G
S
G
Site 123
S1053
P
S
G
P
G
G
G
S
G
G
G
S
G
G
G
Site 124
S1057
G
G
G
S
G
G
G
S
G
G
G
G
G
G
Q
Site 125
S1073
P
P
L
Q
R
G
K
S
Q
Q
L
T
V
S
A
Site 126
T1077
R
G
K
S
Q
Q
L
T
V
S
A
A
Q
K
P
Site 127
S1079
K
S
Q
Q
L
T
V
S
A
A
Q
K
P
R
P
Site 128
S1087
A
A
Q
K
P
R
P
S
S
G
N
L
L
Q
S
Site 129
S1088
A
Q
K
P
R
P
S
S
G
N
L
L
Q
S
P
Site 130
S1094
S
S
G
N
L
L
Q
S
P
E
P
S
Y
G
P
Site 131
S1098
L
L
Q
S
P
E
P
S
Y
G
P
A
R
P
R
Site 132
Y1099
L
Q
S
P
E
P
S
Y
G
P
A
R
P
R
Q
Site 133
S1108
P
A
R
P
R
Q
Q
S
L
S
K
E
G
S
I
Site 134
S1110
R
P
R
Q
Q
S
L
S
K
E
G
S
I
G
G
Site 135
S1114
Q
S
L
S
K
E
G
S
I
G
G
S
G
G
S
Site 136
S1118
K
E
G
S
I
G
G
S
G
G
S
G
G
G
G
Site 137
S1121
S
I
G
G
S
G
G
S
G
G
G
G
G
G
G
Site 138
S1132
G
G
G
G
L
K
P
S
I
T
K
Q
H
S
Q
Site 139
T1134
G
G
L
K
P
S
I
T
K
Q
H
S
Q
T
P
Site 140
S1138
P
S
I
T
K
Q
H
S
Q
T
P
S
T
L
N
Site 141
T1140
I
T
K
Q
H
S
Q
T
P
S
T
L
N
P
T
Site 142
S1142
K
Q
H
S
Q
T
P
S
T
L
N
P
T
M
P
Site 143
T1143
Q
H
S
Q
T
P
S
T
L
N
P
T
M
P
A
Site 144
S1151
L
N
P
T
M
P
A
S
E
R
T
V
A
W
V
Site 145
T1154
T
M
P
A
S
E
R
T
V
A
W
V
S
N
M
Site 146
S1159
E
R
T
V
A
W
V
S
N
M
P
H
L
S
A
Site 147
S1165
V
S
N
M
P
H
L
S
A
D
I
E
S
A
H
Site 148
Y1178
A
H
I
E
R
E
E
Y
K
L
K
E
Y
S
K
Site 149
Y1183
E
E
Y
K
L
K
E
Y
S
K
S
M
D
E
S
Site 150
S1184
E
Y
K
L
K
E
Y
S
K
S
M
D
E
S
R
Site 151
S1186
K
L
K
E
Y
S
K
S
M
D
E
S
R
L
D
Site 152
S1190
Y
S
K
S
M
D
E
S
R
L
D
R
V
K
E
Site 153
Y1198
R
L
D
R
V
K
E
Y
E
E
E
I
H
S
L
Site 154
S1204
E
Y
E
E
E
I
H
S
L
K
E
R
L
H
M
Site 155
S1212
L
K
E
R
L
H
M
S
N
R
K
L
E
E
Y
Site 156
Y1219
S
N
R
K
L
E
E
Y
E
R
R
L
L
S
Q
Site 157
S1225
E
Y
E
R
R
L
L
S
Q
E
E
Q
T
S
K
Site 158
Y1237
T
S
K
I
L
M
Q
Y
Q
A
R
L
E
Q
S
Site 159
S1244
Y
Q
A
R
L
E
Q
S
E
K
R
L
R
Q
Q
Site 160
S1257
Q
Q
Q
A
E
K
D
S
Q
I
K
S
I
I
G
Site 161
S1261
E
K
D
S
Q
I
K
S
I
I
G
R
L
M
L
Site 162
T1310
G
P
T
N
P
R
V
T
L
A
P
P
W
N
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation