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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEDD4L
Full Name:
E3 ubiquitin-protein ligase NEDD4-like
Alias:
KIAA0439; NED4L; NEDD4-2; neural precursor cell expressed, developmentally down-regulated 4-like; RSP5; ubiquitin-protein ligase NEDD4-like
Type:
EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Mass (Da):
111930
Number AA:
UniProt ID:
Q96PU5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0017080
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0006883
GO:0007588
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
T
G
L
G
E
P
V
Y
G
L
S
E
D
E
G
Site 2
S13
G
E
P
V
Y
G
L
S
E
D
E
G
E
S
R
Site 3
S41
K
K
D
I
F
G
A
S
D
P
Y
V
K
L
S
Site 4
Y44
I
F
G
A
S
D
P
Y
V
K
L
S
L
Y
V
Site 5
S48
S
D
P
Y
V
K
L
S
L
Y
V
A
D
E
N
Site 6
Y50
P
Y
V
K
L
S
L
Y
V
A
D
E
N
R
E
Site 7
T65
L
A
L
V
Q
T
K
T
I
K
K
T
L
N
P
Site 8
T69
Q
T
K
T
I
K
K
T
L
N
P
K
W
N
E
Site 9
Y79
P
K
W
N
E
E
F
Y
F
R
V
N
P
S
N
Site 10
T100
V
F
D
E
N
R
L
T
R
D
D
F
L
G
Q
Site 11
S113
G
Q
V
D
V
P
L
S
H
L
P
T
E
D
P
Site 12
T117
V
P
L
S
H
L
P
T
E
D
P
T
M
E
R
Site 13
T121
H
L
P
T
E
D
P
T
M
E
R
P
Y
T
F
Site 14
Y126
D
P
T
M
E
R
P
Y
T
F
K
D
F
L
L
Site 15
T127
P
T
M
E
R
P
Y
T
F
K
D
F
L
L
R
Site 16
S137
D
F
L
L
R
P
R
S
H
K
S
R
V
K
G
Site 17
Y152
F
L
R
L
K
M
A
Y
M
P
K
N
G
G
Q
Site 18
S164
G
G
Q
D
E
E
N
S
D
Q
R
D
D
M
E
Site 19
S179
H
G
W
E
V
V
D
S
N
D
S
A
S
Q
H
Site 20
S182
E
V
V
D
S
N
D
S
A
S
Q
H
Q
E
E
Site 21
S184
V
D
S
N
D
S
A
S
Q
H
Q
E
E
L
P
Site 22
Y210
V
D
N
L
G
R
T
Y
Y
V
N
H
N
N
R
Site 23
Y211
D
N
L
G
R
T
Y
Y
V
N
H
N
N
R
T
Site 24
S225
T
T
Q
W
H
R
P
S
L
M
D
V
S
S
E
Site 25
S230
R
P
S
L
M
D
V
S
S
E
S
D
N
N
I
Site 26
S231
P
S
L
M
D
V
S
S
E
S
D
N
N
I
R
Site 27
S233
L
M
D
V
S
S
E
S
D
N
N
I
R
Q
I
Site 28
S251
A
A
H
R
R
F
R
S
R
R
H
I
S
E
D
Site 29
S256
F
R
S
R
R
H
I
S
E
D
L
E
P
E
P
Site 30
S264
E
D
L
E
P
E
P
S
E
G
G
D
V
P
E
Site 31
T275
D
V
P
E
P
W
E
T
I
S
E
E
V
N
I
Site 32
S277
P
E
P
W
E
T
I
S
E
E
V
N
I
A
G
Site 33
S297
A
L
P
P
P
P
A
S
P
G
S
R
T
S
P
Site 34
S300
P
P
P
A
S
P
G
S
R
T
S
P
Q
E
L
Site 35
T302
P
A
S
P
G
S
R
T
S
P
Q
E
L
S
E
Site 36
S303
A
S
P
G
S
R
T
S
P
Q
E
L
S
E
E
Site 37
S308
R
T
S
P
Q
E
L
S
E
E
L
S
R
R
L
Site 38
S312
Q
E
L
S
E
E
L
S
R
R
L
Q
I
T
P
Site 39
T318
L
S
R
R
L
Q
I
T
P
D
S
N
G
E
Q
Site 40
S321
R
L
Q
I
T
P
D
S
N
G
E
Q
F
S
S
Site 41
S328
S
N
G
E
Q
F
S
S
L
I
Q
R
E
P
S
Site 42
S335
S
L
I
Q
R
E
P
S
S
R
L
R
S
C
S
Site 43
S336
L
I
Q
R
E
P
S
S
R
L
R
S
C
S
V
Site 44
S340
E
P
S
S
R
L
R
S
C
S
V
T
D
A
V
Site 45
S342
S
S
R
L
R
S
C
S
V
T
D
A
V
A
E
Site 46
T344
R
L
R
S
C
S
V
T
D
A
V
A
E
Q
G
Site 47
S357
Q
G
H
L
P
P
P
S
A
P
A
G
R
A
R
Site 48
S365
A
P
A
G
R
A
R
S
S
T
V
T
G
G
E
Site 49
S366
P
A
G
R
A
R
S
S
T
V
T
G
G
E
E
Site 50
T367
A
G
R
A
R
S
S
T
V
T
G
G
E
E
P
Site 51
T369
R
A
R
S
S
T
V
T
G
G
E
E
P
T
P
Site 52
T375
V
T
G
G
E
E
P
T
P
S
V
A
Y
V
H
Site 53
S377
G
G
E
E
P
T
P
S
V
A
Y
V
H
T
T
Site 54
Y380
E
P
T
P
S
V
A
Y
V
H
T
T
P
G
L
Site 55
T383
P
S
V
A
Y
V
H
T
T
P
G
L
P
S
G
Site 56
T384
S
V
A
Y
V
H
T
T
P
G
L
P
S
G
W
Site 57
Y402
K
D
A
K
G
R
T
Y
Y
V
N
H
N
N
R
Site 58
Y403
D
A
K
G
R
T
Y
Y
V
N
H
N
N
R
T
Site 59
T414
N
N
R
T
T
T
W
T
R
P
I
M
Q
L
A
Site 60
S426
Q
L
A
E
D
G
A
S
G
S
A
T
N
S
N
Site 61
S428
A
E
D
G
A
S
G
S
A
T
N
S
N
N
H
Site 62
T430
D
G
A
S
G
S
A
T
N
S
N
N
H
L
I
Site 63
S432
A
S
G
S
A
T
N
S
N
N
H
L
I
E
P
Site 64
S446
P
Q
I
R
R
P
R
S
L
S
S
P
T
V
T
Site 65
S448
I
R
R
P
R
S
L
S
S
P
T
V
T
L
S
Site 66
S449
R
R
P
R
S
L
S
S
P
T
V
T
L
S
A
Site 67
T451
P
R
S
L
S
S
P
T
V
T
L
S
A
P
L
Site 68
S455
S
S
P
T
V
T
L
S
A
P
L
E
G
A
K
Site 69
S464
P
L
E
G
A
K
D
S
P
V
R
R
A
V
K
Site 70
T473
V
R
R
A
V
K
D
T
L
S
N
P
Q
S
P
Site 71
S475
R
A
V
K
D
T
L
S
N
P
Q
S
P
Q
P
Site 72
S479
D
T
L
S
N
P
Q
S
P
Q
P
S
P
Y
N
Site 73
S483
N
P
Q
S
P
Q
P
S
P
Y
N
S
P
K
P
Site 74
Y485
Q
S
P
Q
P
S
P
Y
N
S
P
K
P
Q
H
Site 75
S487
P
Q
P
S
P
Y
N
S
P
K
P
Q
H
K
V
Site 76
T495
P
K
P
Q
H
K
V
T
Q
S
F
L
P
P
G
Site 77
S497
P
Q
H
K
V
T
Q
S
F
L
P
P
G
W
E
Site 78
T522
F
I
D
H
N
T
K
T
T
T
W
E
D
P
R
Site 79
S538
K
F
P
V
H
M
R
S
K
T
S
L
N
P
N
Site 80
T540
P
V
H
M
R
S
K
T
S
L
N
P
N
D
L
Site 81
S541
V
H
M
R
S
K
T
S
L
N
P
N
D
L
G
Site 82
T564
R
I
H
L
D
G
R
T
F
Y
I
D
H
N
S
Site 83
Y566
H
L
D
G
R
T
F
Y
I
D
H
N
S
K
I
Site 84
Y593
I
T
G
P
A
V
P
Y
S
R
E
F
K
Q
K
Site 85
S594
T
G
P
A
V
P
Y
S
R
E
F
K
Q
K
Y
Site 86
Y601
S
R
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
Site 87
Y603
E
F
K
Q
K
Y
D
Y
F
R
K
K
L
K
K
Site 88
Y632
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
Site 89
S637
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
L
Site 90
S654
R
L
W
I
E
F
E
S
E
K
G
L
D
Y
G
Site 91
Y660
E
S
E
K
G
L
D
Y
G
G
V
A
R
E
W
Site 92
Y679
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
Site 93
Y680
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
Site 94
Y685
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
Site 95
T688
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
Site 96
Y691
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
Site 97
T692
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
Site 98
Y709
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
Site 99
S751
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
Site 100
S754
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
Site 101
Y756
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
Site 102
Y757
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
Site 103
Y786
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
Site 104
S795
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
Site 105
T800
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
Site 106
Y807
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
Site 107
Y873
H
S
I
Y
K
N
G
Y
C
P
N
H
P
V
I
Site 108
Y917
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
Site 109
S919
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
Site 110
T926
S
N
G
P
Q
L
F
T
I
E
Q
W
G
S
P
Site 111
S932
F
T
I
E
Q
W
G
S
P
E
K
L
P
R
A
Site 112
T941
E
K
L
P
R
A
H
T
C
F
N
R
L
D
L
Site 113
Y951
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
Site 114
T953
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation