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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PBK
Full Name:
Lymphokine-activated killer T-cell-originated protein kinase
Alias:
CT84; EC 2.7.12.2; NORI3; SPK; T-LAK cell-originated protein kinase; TOPK
Type:
Protein-serine kinase, Other group, TOPK family
Mass (Da):
36085
Number AA:
322
UniProt ID:
Q96KB5
International Prot ID:
IPI00306708
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007067
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Lymphokine-activated killer T-cell-originated protein kinase Y74 phosphosite-specific antibody AB-PK754#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK754#Lymphokine-activated killer T-cell-originated protein kinase (G3-C22, human) peptide - Powder PE-01BEI70#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEI70#Lymphokine-activated killer T-cell-originated protein kinase (N71-V77, human) pY74 phosphopeptide - Powder PE-04AOM95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOM95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
E
G
I
S
N
F
K
T
P
S
K
L
S
E
K
Site 2
S14
F
K
T
P
S
K
L
S
E
K
K
K
S
V
L
Site 3
S19
K
L
S
E
K
K
K
S
V
L
C
S
T
P
T
Site 4
S23
K
K
K
S
V
L
C
S
T
P
T
I
N
I
P
Site 5
T24
K
K
S
V
L
C
S
T
P
T
I
N
I
P
A
Site 6
T26
S
V
L
C
S
T
P
T
I
N
I
P
A
S
P
Site 7
S32
P
T
I
N
I
P
A
S
P
F
M
Q
K
L
G
Site 8
T42
M
Q
K
L
G
F
G
T
G
V
N
V
Y
L
M
Site 9
Y47
F
G
T
G
V
N
V
Y
L
M
K
R
S
P
R
Site 10
S52
N
V
Y
L
M
K
R
S
P
R
G
L
S
H
S
Site 11
S57
K
R
S
P
R
G
L
S
H
S
P
W
A
V
K
Site 12
S59
S
P
R
G
L
S
H
S
P
W
A
V
K
K
I
Site 13
Y74
N
P
I
C
N
D
H
Y
R
S
V
Y
Q
K
R
Lymphokine-activated killer T-cell-originated protein kinase Y74 phosphosite-specific antibody AB-PK754#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK754#Lymphokine-activated killer T-cell-originated protein kinase (N71-V77, human) pY74 phosphopeptide - Powder PE-04AOM95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOM95
Site 14
S76
I
C
N
D
H
Y
R
S
V
Y
Q
K
R
L
M
Site 15
Y78
N
D
H
Y
R
S
V
Y
Q
K
R
L
M
D
E
Site 16
S91
D
E
A
K
I
L
K
S
L
H
H
P
N
I
V
Site 17
T104
I
V
G
Y
R
A
F
T
E
A
N
D
G
S
L
Site 18
S110
F
T
E
A
N
D
G
S
L
C
L
A
M
E
Y
Site 19
S122
M
E
Y
G
G
E
K
S
L
N
D
L
I
E
E
Site 20
S134
I
E
E
R
Y
K
A
S
Q
D
P
F
P
A
A
Site 21
Y156
N
M
A
R
G
L
K
Y
L
H
Q
E
K
K
L
Site 22
T198
L
P
L
D
E
N
M
T
V
T
D
P
E
A
C
Site 23
Y206
V
T
D
P
E
A
C
Y
I
G
T
E
P
W
K
Site 24
S251
S
I
P
H
I
N
L
S
N
D
D
D
D
E
D
Site 25
T260
D
D
D
D
E
D
K
T
F
D
E
S
D
F
D
Site 26
S264
E
D
K
T
F
D
E
S
D
F
D
D
E
A
Y
Site 27
Y271
S
D
F
D
D
E
A
Y
Y
A
A
L
G
T
R
Site 28
Y272
D
F
D
D
E
A
Y
Y
A
A
L
G
T
R
P
Site 29
S289
N
M
E
E
L
D
E
S
Y
Q
K
V
I
E
L
Site 30
Y290
M
E
E
L
D
E
S
Y
Q
K
V
I
E
L
F
Site 31
S310
E
D
P
K
D
R
P
S
A
A
H
I
V
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation