KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ITCH
Full Name:
E3 ubiquitin-protein ligase Itchy homolog
Alias:
AIF4; AIP4; Atrophin-1-interacting protein 4; Itch; Itchy E3 ubiquitin protein ligase; Itchy homolog E3 ubiquitin protein ligase; NAPP1; NFE2-associated polypeptide 1; Ubiquitin protein ligase ITCH
Type:
Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Ubiquitin ligase
Mass (Da):
102803
Number AA:
903
UniProt ID:
Q96J02
International Prot ID:
IPI00061780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004842
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0001558
GO:0006464
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
D
S
G
S
Q
L
G
Site 2
S6
_
_
M
S
D
S
G
S
Q
L
G
S
M
G
S
Site 3
S10
D
S
G
S
Q
L
G
S
M
G
S
L
T
M
K
Site 4
S13
S
Q
L
G
S
M
G
S
L
T
M
K
S
Q
L
Site 5
T15
L
G
S
M
G
S
L
T
M
K
S
Q
L
Q
I
Site 6
S40
K
K
N
W
F
G
P
S
P
Y
V
E
V
T
V
Site 7
Y42
N
W
F
G
P
S
P
Y
V
E
V
T
V
D
G
Site 8
T46
P
S
P
Y
V
E
V
T
V
D
G
Q
S
K
K
Site 9
S62
E
K
C
N
N
T
N
S
P
K
W
K
Q
P
L
Site 10
S85
K
L
H
F
R
V
W
S
H
Q
T
L
K
S
D
Site 11
S91
W
S
H
Q
T
L
K
S
D
V
L
L
G
T
A
Site 12
Y103
G
T
A
A
L
D
I
Y
E
T
L
K
S
N
N
Site 13
S108
D
I
Y
E
T
L
K
S
N
N
M
K
L
E
E
Site 14
T131
G
D
K
E
P
T
E
T
I
G
D
L
S
I
C
Site 15
T150
Q
L
E
S
E
V
V
T
N
G
E
T
T
C
S
Site 16
S157
T
N
G
E
T
T
C
S
E
N
G
V
S
L
C
Site 17
S162
T
C
S
E
N
G
V
S
L
C
L
P
R
L
E
Site 18
S172
L
P
R
L
E
C
N
S
A
I
S
A
H
C
N
Site 19
S193
S
D
S
P
I
S
A
S
R
V
A
G
F
T
G
Site 20
T199
A
S
R
V
A
G
F
T
G
A
S
Q
N
D
D
Site 21
S202
V
A
G
F
T
G
A
S
Q
N
D
D
G
S
R
Site 22
S208
A
S
Q
N
D
D
G
S
R
S
K
D
E
T
R
Site 23
S210
Q
N
D
D
G
S
R
S
K
D
E
T
R
V
S
Site 24
T214
G
S
R
S
K
D
E
T
R
V
S
T
N
G
S
Site 25
S217
S
K
D
E
T
R
V
S
T
N
G
S
D
D
P
Site 26
T218
K
D
E
T
R
V
S
T
N
G
S
D
D
P
E
Site 27
S221
T
R
V
S
T
N
G
S
D
D
P
E
D
A
G
Site 28
S236
A
G
E
N
R
R
V
S
G
N
N
S
P
S
L
Site 29
S240
R
R
V
S
G
N
N
S
P
S
L
S
N
G
G
Site 30
S242
V
S
G
N
N
S
P
S
L
S
N
G
G
F
K
Site 31
S244
G
N
N
S
P
S
L
S
N
G
G
F
K
P
S
Site 32
S251
S
N
G
G
F
K
P
S
R
P
P
R
P
S
R
Site 33
S257
P
S
R
P
P
R
P
S
R
P
P
P
P
T
P
Site 34
T263
P
S
R
P
P
P
P
T
P
R
R
P
A
S
V
Site 35
S269
P
T
P
R
R
P
A
S
V
N
G
S
P
S
A
Site 36
S273
R
P
A
S
V
N
G
S
P
S
A
T
S
E
S
Site 37
S275
A
S
V
N
G
S
P
S
A
T
S
E
S
D
G
Site 38
T277
V
N
G
S
P
S
A
T
S
E
S
D
G
S
S
Site 39
S278
N
G
S
P
S
A
T
S
E
S
D
G
S
S
T
Site 40
S280
S
P
S
A
T
S
E
S
D
G
S
S
T
G
S
Site 41
S283
A
T
S
E
S
D
G
S
S
T
G
S
L
P
P
Site 42
S284
T
S
E
S
D
G
S
S
T
G
S
L
P
P
T
Site 43
S287
S
D
G
S
S
T
G
S
L
P
P
T
N
T
N
Site 44
T291
S
T
G
S
L
P
P
T
N
T
N
T
N
T
S
Site 45
T293
G
S
L
P
P
T
N
T
N
T
N
T
S
E
G
Site 46
S298
T
N
T
N
T
N
T
S
E
G
A
T
S
G
L
Site 47
T324
P
R
P
L
N
P
V
T
Q
A
P
L
P
P
G
Site 48
Y343
V
D
Q
H
G
R
V
Y
Y
V
D
H
V
E
K
Site 49
Y344
D
Q
H
G
R
V
Y
Y
V
D
H
V
E
K
R
Site 50
T353
D
H
V
E
K
R
T
T
W
D
R
P
E
P
L
Site 51
Y375
V
D
N
M
G
R
I
Y
Y
V
D
H
F
T
R
Site 52
Y376
D
N
M
G
R
I
Y
Y
V
D
H
F
T
R
T
Site 53
T384
V
D
H
F
T
R
T
T
T
W
Q
R
P
T
L
Site 54
T385
D
H
F
T
R
T
T
T
W
Q
R
P
T
L
E
Site 55
T390
T
T
T
W
Q
R
P
T
L
E
S
V
R
N
Y
Site 56
S393
W
Q
R
P
T
L
E
S
V
R
N
Y
E
Q
W
Site 57
Y397
T
L
E
S
V
R
N
Y
E
Q
W
Q
L
Q
R
Site 58
S405
E
Q
W
Q
L
Q
R
S
Q
L
Q
G
A
M
Q
Site 59
Y420
Q
F
N
Q
R
F
I
Y
G
N
Q
D
L
F
A
Site 60
S429
N
Q
D
L
F
A
T
S
Q
S
K
E
F
D
P
Site 61
S450
G
W
E
K
R
T
D
S
N
G
R
V
Y
F
V
Site 62
Y455
T
D
S
N
G
R
V
Y
F
V
N
H
N
T
R
Site 63
T464
V
N
H
N
T
R
I
T
Q
W
E
D
P
R
S
Site 64
S471
T
Q
W
E
D
P
R
S
Q
G
Q
L
N
E
K
Site 65
Y495
F
T
V
D
G
I
P
Y
F
V
D
H
N
R
R
Site 66
T503
F
V
D
H
N
R
R
T
T
T
Y
I
D
P
R
Site 67
T504
V
D
H
N
R
R
T
T
T
Y
I
D
P
R
T
Site 68
T505
D
H
N
R
R
T
T
T
Y
I
D
P
R
T
G
Site 69
Y506
H
N
R
R
T
T
T
Y
I
D
P
R
T
G
K
Site 70
T511
T
T
Y
I
D
P
R
T
G
K
S
A
L
D
N
Site 71
Y524
D
N
G
P
Q
I
A
Y
V
R
D
F
K
A
K
Site 72
T551
M
P
Q
H
I
K
I
T
V
T
R
K
T
L
F
Site 73
T556
K
I
T
V
T
R
K
T
L
F
E
D
S
F
Q
Site 74
S561
R
K
T
L
F
E
D
S
F
Q
Q
I
M
S
F
Site 75
S567
D
S
F
Q
Q
I
M
S
F
S
P
Q
D
L
R
Site 76
S569
F
Q
Q
I
M
S
F
S
P
Q
D
L
R
R
R
Site 77
Y589
P
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
Site 78
Y620
E
Y
A
G
K
D
N
Y
C
L
Q
I
N
P
A
Site 79
Y629
L
Q
I
N
P
A
S
Y
I
N
P
D
H
L
K
Site 80
Y637
I
N
P
D
H
L
K
Y
F
R
F
I
G
R
F
Site 81
Y664
T
G
F
S
L
P
F
Y
K
R
I
L
N
K
P
Site 82
S679
V
G
L
K
D
L
E
S
I
D
P
E
F
Y
N
Site 83
Y685
E
S
I
D
P
E
F
Y
N
S
L
I
W
V
K
Site 84
Y704
E
E
C
D
L
E
M
Y
F
S
V
D
K
E
I
Site 85
S717
E
I
L
G
E
I
K
S
H
D
L
K
P
N
G
Site 86
T730
N
G
G
N
I
L
V
T
E
E
N
K
E
E
Y
Site 87
Y737
T
E
E
N
K
E
E
Y
I
R
M
V
A
E
W
Site 88
S747
M
V
A
E
W
R
L
S
R
G
V
E
E
Q
T
Site 89
T754
S
R
G
V
E
E
Q
T
Q
A
F
F
E
G
F
Site 90
Y769
N
E
I
L
P
Q
Q
Y
L
Q
Y
F
D
A
K
Site 91
Y772
L
P
Q
Q
Y
L
Q
Y
F
D
A
K
E
L
E
Site 92
Y802
R
H
A
I
Y
R
H
Y
A
R
T
S
K
Q
I
Site 93
S848
G
F
A
D
L
M
G
S
N
G
P
Q
K
F
C
Site 94
T870
N
W
L
P
R
S
H
T
C
F
N
R
L
D
L
Site 95
Y880
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
Site 96
S882
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation