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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDLIM5
Full Name:
PDZ and LIM domain protein 5
Alias:
Enh; Enigma; Enigma-like PDZ and LIM domains protein; LIM; PDLI5; PDZ and LIM domain 5; PDZ and LIM domain protein 5: Enigma homolog: Enigma-like PDZ and LIM domains protein
Type:
Adapter/scaffold protein
Mass (Da):
64002
Number AA:
596
UniProt ID:
Q96HC4
International Prot ID:
IPI00007935
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005829
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0042805
GO:0005080
PhosphoSite+
KinaseNET
Biological Process:
GO:0007507
Phosida
TranscriptoNet
STRING
Kinexus Products
PDZ and LIM domain protein 5 Y251 phosphosite-specific antibody AB-PN522#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN522
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
K
D
F
N
M
P
L
T
I
S
S
L
K
D
G
Site 2
S31
F
N
M
P
L
T
I
S
S
L
K
D
G
G
K
Site 3
S32
N
M
P
L
T
I
S
S
L
K
D
G
G
K
A
Site 4
S76
K
I
K
G
C
T
G
S
L
N
M
T
L
Q
R
Site 5
S85
N
M
T
L
Q
R
A
S
A
A
P
K
P
E
P
Site 6
T110
V
V
K
P
V
P
I
T
S
P
A
V
S
K
V
Site 7
S111
V
K
P
V
P
I
T
S
P
A
V
S
K
V
T
Site 8
S115
P
I
T
S
P
A
V
S
K
V
T
S
T
N
N
Site 9
S119
P
A
V
S
K
V
T
S
T
N
N
M
A
Y
N
Site 10
Y125
T
S
T
N
N
M
A
Y
N
K
A
P
R
P
F
Site 11
S134
K
A
P
R
P
F
G
S
V
S
S
P
K
V
T
Site 12
S136
P
R
P
F
G
S
V
S
S
P
K
V
T
S
I
Site 13
S137
R
P
F
G
S
V
S
S
P
K
V
T
S
I
P
Site 14
T141
S
V
S
S
P
K
V
T
S
I
P
S
P
S
S
Site 15
S142
V
S
S
P
K
V
T
S
I
P
S
P
S
S
A
Site 16
S145
P
K
V
T
S
I
P
S
P
S
S
A
F
T
P
Site 17
S147
V
T
S
I
P
S
P
S
S
A
F
T
P
A
H
Site 18
S148
T
S
I
P
S
P
S
S
A
F
T
P
A
H
A
Site 19
T151
P
S
P
S
S
A
F
T
P
A
H
A
T
T
S
Site 20
S158
T
P
A
H
A
T
T
S
S
H
A
S
P
S
P
Site 21
S159
P
A
H
A
T
T
S
S
H
A
S
P
S
P
V
Site 22
S164
T
S
S
H
A
S
P
S
P
V
A
A
V
T
P
Site 23
S186
L
H
A
N
A
N
L
S
A
D
Q
S
P
S
A
Site 24
S190
A
N
L
S
A
D
Q
S
P
S
A
L
S
A
G
Site 25
S192
L
S
A
D
Q
S
P
S
A
L
S
A
G
K
T
Site 26
T199
S
A
L
S
A
G
K
T
A
V
N
V
P
R
Q
Site 27
T208
V
N
V
P
R
Q
P
T
V
T
S
V
C
S
E
Site 28
T210
V
P
R
Q
P
T
V
T
S
V
C
S
E
T
S
Site 29
S211
P
R
Q
P
T
V
T
S
V
C
S
E
T
S
Q
Site 30
T216
V
T
S
V
C
S
E
T
S
Q
E
L
A
E
G
Site 31
S228
A
E
G
Q
R
R
G
S
Q
G
D
S
K
Q
Q
Site 32
S232
R
R
G
S
Q
G
D
S
K
Q
Q
N
G
P
P
Site 33
Y247
R
K
H
I
V
E
R
Y
T
E
F
Y
H
V
P
Site 34
T248
K
H
I
V
E
R
Y
T
E
F
Y
H
V
P
T
Site 35
Y251
V
E
R
Y
T
E
F
Y
H
V
P
T
H
S
D
PDZ and LIM domain protein 5 Y251 phosphosite-specific antibody AB-PN522#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN522
Site 36
T255
T
E
F
Y
H
V
P
T
H
S
D
A
S
K
K
Site 37
S257
F
Y
H
V
P
T
H
S
D
A
S
K
K
R
L
Site 38
T268
K
K
R
L
I
E
D
T
E
D
W
R
P
R
T
Site 39
T275
T
E
D
W
R
P
R
T
G
T
T
Q
S
R
S
Site 40
T277
D
W
R
P
R
T
G
T
T
Q
S
R
S
F
R
Site 41
T278
W
R
P
R
T
G
T
T
Q
S
R
S
F
R
I
Site 42
S280
P
R
T
G
T
T
Q
S
R
S
F
R
I
L
A
Site 43
S282
T
G
T
T
Q
S
R
S
F
R
I
L
A
Q
I
Site 44
S298
G
T
E
H
L
K
E
S
E
A
D
N
T
K
K
Site 45
T303
K
E
S
E
A
D
N
T
K
K
A
N
N
S
Q
Site 46
S309
N
T
K
K
A
N
N
S
Q
E
P
S
P
Q
L
Site 47
S313
A
N
N
S
Q
E
P
S
P
Q
L
A
S
S
V
Site 48
S318
E
P
S
P
Q
L
A
S
S
V
A
S
T
R
S
Site 49
S319
P
S
P
Q
L
A
S
S
V
A
S
T
R
S
M
Site 50
S322
Q
L
A
S
S
V
A
S
T
R
S
M
P
E
S
Site 51
T323
L
A
S
S
V
A
S
T
R
S
M
P
E
S
L
Site 52
S325
S
S
V
A
S
T
R
S
M
P
E
S
L
D
S
Site 53
S329
S
T
R
S
M
P
E
S
L
D
S
P
T
S
G
Site 54
S332
S
M
P
E
S
L
D
S
P
T
S
G
R
P
G
Site 55
S335
E
S
L
D
S
P
T
S
G
R
P
G
V
T
S
Site 56
S360
G
S
T
G
V
I
K
S
P
S
W
Q
R
P
N
Site 57
S362
T
G
V
I
K
S
P
S
W
Q
R
P
N
Q
G
Site 58
S372
R
P
N
Q
G
V
P
S
T
G
R
I
S
N
S
Site 59
T373
P
N
Q
G
V
P
S
T
G
R
I
S
N
S
A
Site 60
S377
V
P
S
T
G
R
I
S
N
S
A
T
Y
S
G
Site 61
S379
S
T
G
R
I
S
N
S
A
T
Y
S
G
S
V
Site 62
T381
G
R
I
S
N
S
A
T
Y
S
G
S
V
A
P
Site 63
Y382
R
I
S
N
S
A
T
Y
S
G
S
V
A
P
A
Site 64
S383
I
S
N
S
A
T
Y
S
G
S
V
A
P
A
N
Site 65
S385
N
S
A
T
Y
S
G
S
V
A
P
A
N
S
A
Site 66
T403
T
Q
P
S
D
Q
D
T
L
V
Q
R
A
E
H
Site 67
S438
F
L
V
A
L
G
K
S
W
H
P
E
E
F
N
Site 68
T452
N
C
A
H
C
K
N
T
M
A
Y
I
G
F
V
Site 69
Y455
H
C
K
N
T
M
A
Y
I
G
F
V
E
E
K
Site 70
Y466
V
E
E
K
G
A
L
Y
C
E
L
C
Y
E
K
Site 71
Y530
E
P
Y
C
E
T
D
Y
Y
A
L
F
G
T
I
Site 72
Y531
P
Y
C
E
T
D
Y
Y
A
L
F
G
T
I
C
Site 73
S580
L
E
G
Q
T
F
F
S
K
K
D
K
P
L
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation