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Updated November 2019
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Protein Info
Short Name:
Nuclear envelope pore membrane protein POM 121
Full Name:
Nuclear envelope pore membrane protein POM 121
Alias:
Type:
Mass (Da):
Number AA:
UniProt ID:
Q96HA1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
P
A
A
A
A
A
G
Site 2
S19
E
R
R
R
P
I
A
S
V
R
D
G
R
G
R
Site 3
S70
T
A
A
W
W
G
L
S
R
E
P
R
G
S
R
Site 4
S76
L
S
R
E
P
R
G
S
R
P
L
S
S
F
V
Site 5
S80
P
R
G
S
R
P
L
S
S
F
V
R
K
A
R
Site 6
S81
R
G
S
R
P
L
S
S
F
V
R
K
A
R
H
Site 7
S93
A
R
H
R
R
P
L
S
S
F
V
R
K
A
R
Site 8
S94
R
H
R
R
P
L
S
S
F
V
R
K
A
R
H
Site 9
T104
R
K
A
R
H
R
R
T
L
F
A
S
P
L
A
Site 10
S108
H
R
R
T
L
F
A
S
P
L
A
K
S
T
A
Site 11
T124
G
N
L
L
E
P
R
T
L
L
E
G
P
D
P
Site 12
S174
P
A
R
P
A
P
R
S
P
P
P
R
S
P
P
Site 13
S179
P
R
S
P
P
P
R
S
P
P
P
R
S
P
P
Site 14
S184
P
R
S
P
P
P
R
S
P
P
P
S
P
P
T
Site 15
S188
P
P
R
S
P
P
P
S
P
P
T
H
R
A
H
Site 16
T191
S
P
P
P
S
P
P
T
H
R
A
H
H
V
Y
Site 17
Y198
T
H
R
A
H
H
V
Y
P
S
L
P
T
P
L
Site 18
S200
R
A
H
H
V
Y
P
S
L
P
T
P
L
L
R
Site 19
T203
H
V
Y
P
S
L
P
T
P
L
L
R
P
S
R
Site 20
S209
P
T
P
L
L
R
P
S
R
R
P
S
P
R
D
Site 21
S213
L
R
P
S
R
R
P
S
P
R
D
C
G
T
L
Site 22
T219
P
S
P
R
D
C
G
T
L
P
N
R
F
V
I
Site 23
T227
L
P
N
R
F
V
I
T
P
R
R
R
Y
P
I
Site 24
Y232
V
I
T
P
R
R
R
Y
P
I
H
Q
A
Q
Y
Site 25
Y253
P
T
V
C
W
N
G
Y
H
K
K
A
V
L
S
Site 26
S260
Y
H
K
K
A
V
L
S
P
R
N
S
R
M
V
Site 27
S269
R
N
S
R
M
V
C
S
P
V
T
V
R
I
A
Site 28
T272
R
M
V
C
S
P
V
T
V
R
I
A
P
P
D
Site 29
S283
A
P
P
D
R
R
F
S
R
S
A
I
P
E
Q
Site 30
S285
P
D
R
R
F
S
R
S
A
I
P
E
Q
I
I
Site 31
S293
A
I
P
E
Q
I
I
S
S
T
L
S
S
P
S
Site 32
S294
I
P
E
Q
I
I
S
S
T
L
S
S
P
S
S
Site 33
T295
P
E
Q
I
I
S
S
T
L
S
S
P
S
S
N
Site 34
S297
Q
I
I
S
S
T
L
S
S
P
S
S
N
A
P
Site 35
S298
I
I
S
S
T
L
S
S
P
S
S
N
A
P
D
Site 36
S300
S
S
T
L
S
S
P
S
S
N
A
P
D
P
C
Site 37
S301
S
T
L
S
S
P
S
S
N
A
P
D
P
C
A
Site 38
S314
C
A
K
E
T
V
L
S
A
L
K
E
K
E
K
Site 39
T324
K
E
K
E
K
K
R
T
V
E
E
E
D
Q
I
Site 40
S345
N
K
R
R
R
H
D
S
S
G
S
G
H
S
A
Site 41
S346
K
R
R
R
H
D
S
S
G
S
G
H
S
A
F
Site 42
S348
R
R
H
D
S
S
G
S
G
H
S
A
F
E
P
Site 43
S351
D
S
S
G
S
G
H
S
A
F
E
P
L
V
A
Site 44
S371
S
F
V
P
K
P
G
S
L
K
R
G
L
N
S
Site 45
S378
S
L
K
R
G
L
N
S
Q
S
S
D
D
H
L
Site 46
S380
K
R
G
L
N
S
Q
S
S
D
D
H
L
N
K
Site 47
S381
R
G
L
N
S
Q
S
S
D
D
H
L
N
K
R
Site 48
S389
D
D
H
L
N
K
R
S
R
S
S
S
M
S
S
Site 49
S391
H
L
N
K
R
S
R
S
S
S
M
S
S
L
T
Site 50
S392
L
N
K
R
S
R
S
S
S
M
S
S
L
T
G
Site 51
S393
N
K
R
S
R
S
S
S
M
S
S
L
T
G
A
Site 52
S395
R
S
R
S
S
S
M
S
S
L
T
G
A
Y
A
Site 53
S396
S
R
S
S
S
M
S
S
L
T
G
A
Y
A
S
Site 54
T398
S
S
S
M
S
S
L
T
G
A
Y
A
S
G
I
Site 55
Y401
M
S
S
L
T
G
A
Y
A
S
G
I
P
S
S
Site 56
S403
S
L
T
G
A
Y
A
S
G
I
P
S
S
S
R
Site 57
S407
A
Y
A
S
G
I
P
S
S
S
R
N
A
I
T
Site 58
S408
Y
A
S
G
I
P
S
S
S
R
N
A
I
T
S
Site 59
S409
A
S
G
I
P
S
S
S
R
N
A
I
T
S
S
Site 60
T414
S
S
S
R
N
A
I
T
S
S
Y
S
S
T
R
Site 61
S415
S
S
R
N
A
I
T
S
S
Y
S
S
T
R
G
Site 62
S416
S
R
N
A
I
T
S
S
Y
S
S
T
R
G
I
Site 63
Y417
R
N
A
I
T
S
S
Y
S
S
T
R
G
I
S
Site 64
S418
N
A
I
T
S
S
Y
S
S
T
R
G
I
S
Q
Site 65
S419
A
I
T
S
S
Y
S
S
T
R
G
I
S
Q
L
Site 66
T420
I
T
S
S
Y
S
S
T
R
G
I
S
Q
L
W
Site 67
S424
Y
S
S
T
R
G
I
S
Q
L
W
K
R
N
G
Site 68
S433
L
W
K
R
N
G
P
S
S
S
P
F
S
S
P
Site 69
S434
W
K
R
N
G
P
S
S
S
P
F
S
S
P
A
Site 70
S435
K
R
N
G
P
S
S
S
P
F
S
S
P
A
S
Site 71
S438
G
P
S
S
S
P
F
S
S
P
A
S
S
R
S
Site 72
S439
P
S
S
S
P
F
S
S
P
A
S
S
R
S
Q
Site 73
S442
S
P
F
S
S
P
A
S
S
R
S
Q
T
P
E
Site 74
S443
P
F
S
S
P
A
S
S
R
S
Q
T
P
E
R
Site 75
S445
S
S
P
A
S
S
R
S
Q
T
P
E
R
P
A
Site 76
T447
P
A
S
S
R
S
Q
T
P
E
R
P
A
K
K
Site 77
S464
E
E
E
L
C
H
H
S
S
S
S
T
P
L
A
Site 78
S465
E
E
L
C
H
H
S
S
S
S
T
P
L
A
A
Site 79
S466
E
L
C
H
H
S
S
S
S
T
P
L
A
A
D
Site 80
T468
C
H
H
S
S
S
S
T
P
L
A
A
D
R
E
Site 81
S476
P
L
A
A
D
R
E
S
Q
G
E
K
A
A
D
Site 82
T485
G
E
K
A
A
D
T
T
P
R
K
K
Q
N
S
Site 83
S492
T
P
R
K
K
Q
N
S
N
S
Q
S
T
P
G
Site 84
S494
R
K
K
Q
N
S
N
S
Q
S
T
P
G
S
S
Site 85
S496
K
Q
N
S
N
S
Q
S
T
P
G
S
S
G
Q
Site 86
T497
Q
N
S
N
S
Q
S
T
P
G
S
S
G
Q
R
Site 87
S500
N
S
Q
S
T
P
G
S
S
G
Q
R
K
R
K
Site 88
S501
S
Q
S
T
P
G
S
S
G
Q
R
K
R
K
V
Site 89
S513
R
K
V
Q
L
L
P
S
R
R
G
E
Q
L
T
Site 90
T520
S
R
R
G
E
Q
L
T
L
P
P
P
P
Q
L
Site 91
S543
L
D
L
E
K
K
A
S
L
Q
W
F
N
Q
A
Site 92
S555
N
Q
A
L
E
D
K
S
D
A
A
S
N
S
V
Site 93
S559
E
D
K
S
D
A
A
S
N
S
V
T
E
T
P
Site 94
S561
K
S
D
A
A
S
N
S
V
T
E
T
P
P
I
Site 95
T563
D
A
A
S
N
S
V
T
E
T
P
P
I
T
Q
Site 96
T565
A
S
N
S
V
T
E
T
P
P
I
T
Q
P
S
Site 97
T569
V
T
E
T
P
P
I
T
Q
P
S
F
T
F
T
Site 98
S588
A
P
A
S
P
P
T
S
L
L
A
P
S
T
N
Site 99
S593
P
T
S
L
L
A
P
S
T
N
P
L
L
E
S
Site 100
S600
S
T
N
P
L
L
E
S
L
K
K
M
Q
T
P
Site 101
T606
E
S
L
K
K
M
Q
T
P
P
S
L
P
P
C
Site 102
S609
K
K
M
Q
T
P
P
S
L
P
P
C
P
E
S
Site 103
S616
S
L
P
P
C
P
E
S
A
G
A
A
T
T
E
Site 104
T622
E
S
A
G
A
A
T
T
E
A
L
S
P
P
K
Site 105
S626
A
A
T
T
E
A
L
S
P
P
K
T
P
S
L
Site 106
T630
E
A
L
S
P
P
K
T
P
S
L
L
P
P
L
Site 107
S642
P
P
L
G
L
S
Q
S
G
P
P
G
L
L
P
Site 108
S650
G
P
P
G
L
L
P
S
P
S
F
D
S
K
P
Site 109
S652
P
G
L
L
P
S
P
S
F
D
S
K
P
P
T
Site 110
S655
L
P
S
P
S
F
D
S
K
P
P
T
T
L
L
Site 111
T674
A
P
S
M
V
P
A
T
D
T
K
A
P
P
T
Site 112
T676
S
M
V
P
A
T
D
T
K
A
P
P
T
L
Q
Site 113
T693
T
A
T
K
P
Q
A
T
S
A
P
S
P
A
P
Site 114
S697
P
Q
A
T
S
A
P
S
P
A
P
K
Q
S
F
Site 115
S703
P
S
P
A
P
K
Q
S
F
L
F
G
T
Q
N
Site 116
T708
K
Q
S
F
L
F
G
T
Q
N
T
S
P
S
S
Site 117
T711
F
L
F
G
T
Q
N
T
S
P
S
S
P
A
A
Site 118
S712
L
F
G
T
Q
N
T
S
P
S
S
P
A
A
P
Site 119
S714
G
T
Q
N
T
S
P
S
S
P
A
A
P
A
A
Site 120
S715
T
Q
N
T
S
P
S
S
P
A
A
P
A
A
S
Site 121
S722
S
P
A
A
P
A
A
S
S
A
P
P
M
F
K
Site 122
S723
P
A
A
P
A
A
S
S
A
P
P
M
F
K
P
Site 123
T733
P
M
F
K
P
I
F
T
A
P
P
K
S
E
K
Site 124
S738
I
F
T
A
P
P
K
S
E
K
E
G
P
T
P
Site 125
T744
K
S
E
K
E
G
P
T
P
P
G
P
S
V
T
Site 126
S749
G
P
T
P
P
G
P
S
V
T
A
T
A
P
S
Site 127
T753
P
G
P
S
V
T
A
T
A
P
S
S
S
S
L
Site 128
S756
S
V
T
A
T
A
P
S
S
S
S
L
P
T
T
Site 129
S757
V
T
A
T
A
P
S
S
S
S
L
P
T
T
T
Site 130
S758
T
A
T
A
P
S
S
S
S
L
P
T
T
T
S
Site 131
S759
A
T
A
P
S
S
S
S
L
P
T
T
T
S
T
Site 132
T762
P
S
S
S
S
L
P
T
T
T
S
T
T
A
P
Site 133
T763
S
S
S
S
L
P
T
T
T
S
T
T
A
P
T
Site 134
S765
S
S
L
P
T
T
T
S
T
T
A
P
T
F
Q
Site 135
T766
S
L
P
T
T
T
S
T
T
A
P
T
F
Q
P
Site 136
T770
T
T
S
T
T
A
P
T
F
Q
P
V
F
S
S
Site 137
S776
P
T
F
Q
P
V
F
S
S
M
G
P
P
A
S
Site 138
T794
P
A
P
F
F
K
Q
T
T
T
P
A
T
A
P
Site 139
T796
P
F
F
K
Q
T
T
T
P
A
T
A
P
T
T
Site 140
T822
T
S
A
V
A
P
I
T
S
A
S
P
S
T
D
Site 141
S823
S
A
V
A
P
I
T
S
A
S
P
S
T
D
S
Site 142
S825
V
A
P
I
T
S
A
S
P
S
T
D
S
A
S
Site 143
S827
P
I
T
S
A
S
P
S
T
D
S
A
S
K
P
Site 144
T828
I
T
S
A
S
P
S
T
D
S
A
S
K
P
A
Site 145
S830
S
A
S
P
S
T
D
S
A
S
K
P
A
F
G
Site 146
S832
S
P
S
T
D
S
A
S
K
P
A
F
G
F
G
Site 147
S844
G
F
G
I
N
S
V
S
S
S
S
V
S
T
T
Site 148
S845
F
G
I
N
S
V
S
S
S
S
V
S
T
T
T
Site 149
S846
G
I
N
S
V
S
S
S
S
V
S
T
T
T
S
Site 150
S847
I
N
S
V
S
S
S
S
V
S
T
T
T
S
T
Site 151
S849
S
V
S
S
S
S
V
S
T
T
T
S
T
A
T
Site 152
T850
V
S
S
S
S
V
S
T
T
T
S
T
A
T
A
Site 153
T851
S
S
S
S
V
S
T
T
T
S
T
A
T
A
A
Site 154
S853
S
S
V
S
T
T
T
S
T
A
T
A
A
S
Q
Site 155
T893
K
P
P
A
L
P
T
T
T
T
V
T
T
F
S
Site 156
T895
P
A
L
P
T
T
T
T
V
T
T
F
S
Q
S
Site 157
T898
P
T
T
T
T
V
T
T
F
S
Q
S
L
H
T
Site 158
S928
F
G
S
T
L
A
T
S
A
P
A
T
S
S
Q
Site 159
T932
L
A
T
S
A
P
A
T
S
S
Q
P
T
L
T
Site 160
S934
T
S
A
P
A
T
S
S
Q
P
T
L
T
F
S
Site 161
T937
P
A
T
S
S
Q
P
T
L
T
F
S
N
T
S
Site 162
T939
T
S
S
Q
P
T
L
T
F
S
N
T
S
T
P
Site 163
S941
S
Q
P
T
L
T
F
S
N
T
S
T
P
T
F
Site 164
T943
P
T
L
T
F
S
N
T
S
T
P
T
F
N
I
Site 165
T945
L
T
F
S
N
T
S
T
P
T
F
N
I
P
F
Site 166
T947
F
S
N
T
S
T
P
T
F
N
I
P
F
G
S
Site 167
S954
T
F
N
I
P
F
G
S
S
A
K
S
P
L
P
Site 168
S955
F
N
I
P
F
G
S
S
A
K
S
P
L
P
S
Site 169
S958
P
F
G
S
S
A
K
S
P
L
P
S
Y
P
G
Site 170
S962
S
A
K
S
P
L
P
S
Y
P
G
A
N
P
Q
Site 171
Y963
A
K
S
P
L
P
S
Y
P
G
A
N
P
Q
P
Site 172
T996
P
S
F
G
S
S
F
T
F
G
N
S
A
A
P
Site 173
T1024
V
V
P
A
Y
V
P
T
P
I
H
P
I
F
G
Site 174
S1052
S
A
F
G
A
P
A
S
S
Q
P
A
F
G
G
Site 175
S1053
A
F
G
A
P
A
S
S
Q
P
A
F
G
G
S
Site 176
T1077
S
S
G
F
G
A
T
T
Q
T
A
S
S
G
S
Site 177
T1079
G
F
G
A
T
T
Q
T
A
S
S
G
S
S
S
Site 178
S1081
G
A
T
T
Q
T
A
S
S
G
S
S
S
S
V
Site 179
S1082
A
T
T
Q
T
A
S
S
G
S
S
S
S
V
F
Site 180
S1085
Q
T
A
S
S
G
S
S
S
S
V
F
G
S
T
Site 181
S1086
T
A
S
S
G
S
S
S
S
V
F
G
S
T
T
Site 182
S1087
A
S
S
G
S
S
S
S
V
F
G
S
T
T
P
Site 183
S1091
S
S
S
S
V
F
G
S
T
T
P
S
P
F
T
Site 184
T1093
S
S
V
F
G
S
T
T
P
S
P
F
T
F
G
Site 185
T1098
S
T
T
P
S
P
F
T
F
G
G
S
A
A
P
Site 186
T1117
S
F
G
I
N
V
A
T
P
G
S
S
T
T
T
Site 187
T1124
T
P
G
S
S
T
T
T
G
A
F
S
F
G
A
Site 188
S1128
S
T
T
T
G
A
F
S
F
G
A
G
Q
S
G
Site 189
S1134
F
S
F
G
A
G
Q
S
G
S
T
A
T
S
T
Site 190
S1136
F
G
A
G
Q
S
G
S
T
A
T
S
T
P
F
Site 191
S1140
Q
S
G
S
T
A
T
S
T
P
F
A
G
G
L
Site 192
T1141
S
G
S
T
A
T
S
T
P
F
A
G
G
L
G
Site 193
T1154
L
G
Q
N
A
L
G
T
T
G
Q
S
T
P
F
Site 194
S1166
T
P
F
A
F
N
V
S
S
T
T
E
S
K
P
Site 195
S1167
P
F
A
F
N
V
S
S
T
T
E
S
K
P
V
Site 196
S1171
N
V
S
S
T
T
E
S
K
P
V
F
G
G
T
Site 197
T1187
T
P
T
F
G
L
N
T
P
A
P
G
V
G
T
Site 198
T1194
T
P
A
P
G
V
G
T
S
G
S
S
L
S
F
Site 199
S1200
G
T
S
G
S
S
L
S
F
G
A
S
S
A
P
Site 200
T1232
S
I
G
A
G
S
K
T
P
G
A
R
Q
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation