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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP-2 mu2
Full Name:
AP-2 complex subunit mu
Alias:
A2M1; adaptor-related protein complex 2, mu 1 subunit; AP-2 mu 2 chain; AP2M1; AP50; CLAPM1; clathrin adaptor complex AP2, mu subunit; Clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; Clathrin coat assembly protein AP50; Clathrin coat associated protein AP50; clathrin-associated/assembly/adaptor protein, medium 1; HA2 50 kDa subunit; KIAA0109; mu2; Plasma membrane adaptor AP-2 50 kDa protein; plasma membrane adaptor AP-2 50kDA protein
Type:
Adaptor/scaffold; Vesicle protein
Mass (Da):
49650
Number AA:
UniProt ID:
Q96CW1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030131
GO:0030132
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008289
GO:0005515
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0050690
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
H
K
G
E
V
L
I
S
R
V
Y
R
D
D
I
Site 2
Y20
E
V
L
I
S
R
V
Y
R
D
D
I
G
R
N
Site 3
S45
H
A
R
Q
Q
V
R
S
P
V
T
N
I
A
R
Site 4
S54
V
T
N
I
A
R
T
S
F
F
H
V
K
R
S
Site 5
Y120
D
E
I
L
D
F
G
Y
P
Q
N
S
E
T
G
Site 6
S124
D
F
G
Y
P
Q
N
S
E
T
G
A
L
K
T
Site 7
T131
S
E
T
G
A
L
K
T
F
I
T
Q
Q
G
I
Site 8
T134
G
A
L
K
T
F
I
T
Q
Q
G
I
K
S
Q
Site 9
S140
I
T
Q
Q
G
I
K
S
Q
H
Q
T
K
E
E
Site 10
T144
G
I
K
S
Q
H
Q
T
K
E
E
Q
S
Q
I
Site 11
S149
H
Q
T
K
E
E
Q
S
Q
I
T
S
Q
V
T
Site 12
T152
K
E
E
Q
S
Q
I
T
S
Q
V
T
G
Q
I
Site 13
S153
E
E
Q
S
Q
I
T
S
Q
V
T
G
Q
I
G
Site 14
T156
S
Q
I
T
S
Q
V
T
G
Q
I
G
W
R
R
Site 15
Y168
W
R
R
E
G
I
K
Y
R
R
N
E
L
F
L
Site 16
S193
S
P
Q
G
Q
V
L
S
A
H
V
S
G
R
V
Site 17
S204
S
G
R
V
V
M
K
S
Y
L
S
G
M
P
E
Site 18
Y205
G
R
V
V
M
K
S
Y
L
S
G
M
P
E
C
Site 19
T233
G
K
G
T
A
D
E
T
S
K
S
G
K
Q
S
Site 20
S234
K
G
T
A
D
E
T
S
K
S
G
K
Q
S
I
Site 21
S236
T
A
D
E
T
S
K
S
G
K
Q
S
I
A
I
Site 22
S240
T
S
K
S
G
K
Q
S
I
A
I
D
D
C
T
Site 23
S255
F
H
Q
C
V
R
L
S
K
F
D
S
E
R
S
Site 24
S259
V
R
L
S
K
F
D
S
E
R
S
I
S
F
I
Site 25
S262
S
K
F
D
S
E
R
S
I
S
F
I
P
P
D
Site 26
S264
F
D
S
E
R
S
I
S
F
I
P
P
D
G
E
Site 27
Y277
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
I
Site 28
T279
F
E
L
M
R
Y
R
T
T
K
D
I
I
L
P
Site 29
T280
E
L
M
R
Y
R
T
T
K
D
I
I
L
P
F
Site 30
T326
K
I
E
V
R
I
P
T
P
L
N
T
S
G
V
Site 31
Y344
C
M
K
G
K
A
K
Y
K
A
S
E
N
A
I
Site 32
S347
G
K
A
K
Y
K
A
S
E
N
A
I
V
W
K
Site 33
S364
R
M
A
G
M
K
E
S
Q
I
S
A
E
I
E
Site 34
S367
G
M
K
E
S
Q
I
S
A
E
I
E
L
L
P
Site 35
T375
A
E
I
E
L
L
P
T
N
D
K
K
K
W
A
Site 36
Y403
P
S
G
L
K
V
R
Y
L
K
V
F
E
P
K
Site 37
Y424
D
V
I
K
W
V
R
Y
I
G
R
S
G
I
Y
Site 38
Y431
Y
I
G
R
S
G
I
Y
E
T
R
C
_
_
_
Site 39
T433
G
R
S
G
I
Y
E
T
R
C
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation