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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKT1S1
Full Name:
Proline-rich AKT1 substrate 1
Alias:
40 kDa proline-rich AKT substrate; Akt1 substrate 1 (proline-rich); AKTS1; Lobe; MGC2865; PRAS40; Proline-rich Akt substrate 40 kDa; Proline-rich Akt substrate, 40 kDa
Type:
Inhibitor of mTOR/FRAP
Mass (Da):
27383
Number AA:
256
UniProt ID:
Q96B36
International Prot ID:
IPI00549786
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0044445
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0032007
GO:0045792
GO:0006469
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
A
E
R
F
R
A
R
T
G
T
E
L
V
L
L
Site 2
T32
G
T
E
L
V
L
L
T
A
A
P
P
P
P
P
Site 3
Y46
P
R
P
G
P
C
A
Y
A
A
H
G
R
G
A
Site 4
T73
A
L
A
H
R
A
A
T
A
A
R
P
P
A
P
Site 5
S88
P
P
A
P
Q
P
P
S
P
T
P
S
P
P
R
Site 6
T90
A
P
Q
P
P
S
P
T
P
S
P
P
R
P
T
Site 7
S92
Q
P
P
S
P
T
P
S
P
P
R
P
T
L
A
Site 8
T97
T
P
S
P
P
R
P
T
L
A
R
E
D
N
E
Site 9
T111
E
E
D
E
D
E
P
T
E
T
E
T
S
G
E
Site 10
T113
D
E
D
E
P
T
E
T
E
T
S
G
E
Q
L
Site 11
S116
E
P
T
E
T
E
T
S
G
E
Q
L
G
I
S
Site 12
S123
S
G
E
Q
L
G
I
S
D
N
G
G
L
F
V
Site 13
T136
F
V
M
D
E
D
A
T
L
Q
D
L
P
P
F
Site 14
S146
D
L
P
P
F
C
E
S
D
P
E
S
T
D
D
Site 15
S150
F
C
E
S
D
P
E
S
T
D
D
G
S
L
S
Site 16
T151
C
E
S
D
P
E
S
T
D
D
G
S
L
S
E
Site 17
S155
P
E
S
T
D
D
G
S
L
S
E
E
T
P
A
Site 18
S157
S
T
D
D
G
S
L
S
E
E
T
P
A
G
P
Site 19
T160
D
G
S
L
S
E
E
T
P
A
G
P
P
T
C
Site 20
T166
E
T
P
A
G
P
P
T
C
S
V
P
P
A
S
Site 21
S173
T
C
S
V
P
P
A
S
A
L
P
T
Q
Q
Y
Site 22
T177
P
P
A
S
A
L
P
T
Q
Q
Y
A
K
S
L
Site 23
Y180
S
A
L
P
T
Q
Q
Y
A
K
S
L
P
V
S
Site 24
S183
P
T
Q
Q
Y
A
K
S
L
P
V
S
V
P
V
Site 25
T198
W
G
F
K
E
K
R
T
E
A
R
S
S
D
E
Site 26
S202
E
K
R
T
E
A
R
S
S
D
E
E
N
G
P
Site 27
S203
K
R
T
E
A
R
S
S
D
E
E
N
G
P
P
Site 28
S211
D
E
E
N
G
P
P
S
S
P
D
L
D
R
I
Site 29
S212
E
E
N
G
P
P
S
S
P
D
L
D
R
I
A
Site 30
S221
D
L
D
R
I
A
A
S
M
R
A
L
V
L
R
Site 31
T233
V
L
R
E
A
E
D
T
Q
V
F
G
D
L
P
Site 32
T246
L
P
R
P
R
L
N
T
S
D
F
Q
K
L
K
Site 33
S247
P
R
P
R
L
N
T
S
D
F
Q
K
L
K
R
Site 34
Y256
F
Q
K
L
K
R
K
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation