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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKL1
Full Name:
MKL/myocardin-like protein 1
Alias:
Basic, SAP and coiled-coil domain; BSAC; KIAA1438; MAL; Megakaryoblastic leukemia (translocation) 1; Megakaryocytic acute leukemia; Megakaryocytic acute leukemia protein; MKL/myocardin-like 1; MKL/myocardin-like protein 1: Myocardin-related transcription factor A: Megakaryoblastic leukemia 1 protein: Megakaryocytic acute leukemia protein: MKL1 protein; MRTF-A; Myocardin-related transcription factor A
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
98919
Number AA:
931
UniProt ID:
Q969V6
International Prot ID:
IPI00163729
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003785
GO:0003676
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
P
L
K
S
P
A
A
F
H
E
Q
Site 2
S16
A
F
H
E
Q
R
R
S
L
E
R
A
R
T
E
Site 3
T22
R
S
L
E
R
A
R
T
E
D
Y
L
K
R
K
Site 4
Y25
E
R
A
R
T
E
D
Y
L
K
R
K
I
R
S
Site 5
S49
M
H
I
L
E
E
T
S
A
E
P
S
L
Q
A
Site 6
S53
E
E
T
S
A
E
P
S
L
Q
A
K
Q
L
K
Site 7
S112
N
Y
P
K
V
A
D
S
S
S
F
D
E
D
S
Site 8
S114
P
K
V
A
D
S
S
S
F
D
E
D
S
S
D
Site 9
S119
S
S
S
F
D
E
D
S
S
D
A
L
S
P
E
Site 10
S120
S
S
F
D
E
D
S
S
D
A
L
S
P
E
Q
Site 11
S124
E
D
S
S
D
A
L
S
P
E
Q
P
A
S
H
Site 12
S130
L
S
P
E
Q
P
A
S
H
E
S
Q
G
S
V
Site 13
S133
E
Q
P
A
S
H
E
S
Q
G
S
V
P
S
P
Site 14
S136
A
S
H
E
S
Q
G
S
V
P
S
P
L
E
A
Site 15
S139
E
S
Q
G
S
V
P
S
P
L
E
A
R
V
S
Site 16
S146
S
P
L
E
A
R
V
S
E
P
L
L
S
A
T
Site 17
S151
R
V
S
E
P
L
L
S
A
T
S
A
S
P
T
Site 18
T158
S
A
T
S
A
S
P
T
Q
V
V
S
Q
L
P
Site 19
S162
A
S
P
T
Q
V
V
S
Q
L
P
M
G
R
D
Site 20
S170
Q
L
P
M
G
R
D
S
R
E
M
L
F
L
A
Site 21
S191
P
P
P
L
L
P
P
S
L
T
N
G
T
T
I
Site 22
T204
T
I
P
T
A
K
S
T
P
T
L
I
K
Q
S
Site 23
T206
P
T
A
K
S
T
P
T
L
I
K
Q
S
Q
P
Site 24
S211
T
P
T
L
I
K
Q
S
Q
P
K
S
A
S
E
Site 25
S215
I
K
Q
S
Q
P
K
S
A
S
E
K
S
Q
R
Site 26
S217
Q
S
Q
P
K
S
A
S
E
K
S
Q
R
S
K
Site 27
S220
P
K
S
A
S
E
K
S
Q
R
S
K
K
A
K
Site 28
Y238
P
K
V
K
K
L
K
Y
H
Q
Y
I
P
P
D
Site 29
Y241
K
K
L
K
Y
H
Q
Y
I
P
P
D
Q
K
Q
Site 30
S257
R
G
A
P
P
M
D
S
S
Y
A
K
I
L
Q
Site 31
S258
G
A
P
P
M
D
S
S
Y
A
K
I
L
Q
Q
Site 32
Y259
A
P
P
M
D
S
S
Y
A
K
I
L
Q
Q
Q
Site 33
Y285
Q
Q
Q
Q
H
H
N
Y
Q
A
I
L
P
A
P
Site 34
S295
I
L
P
A
P
P
K
S
A
G
E
A
L
G
S
Site 35
S302
S
A
G
E
A
L
G
S
S
G
T
P
P
V
R
Site 36
S303
A
G
E
A
L
G
S
S
G
T
P
P
V
R
S
Site 37
T305
E
A
L
G
S
S
G
T
P
P
V
R
S
L
S
Site 38
S310
S
G
T
P
P
V
R
S
L
S
T
T
N
S
S
Site 39
S312
T
P
P
V
R
S
L
S
T
T
N
S
S
S
S
Site 40
T313
P
P
V
R
S
L
S
T
T
N
S
S
S
S
S
Site 41
T314
P
V
R
S
L
S
T
T
N
S
S
S
S
S
G
Site 42
S316
R
S
L
S
T
T
N
S
S
S
S
S
G
A
P
Site 43
S317
S
L
S
T
T
N
S
S
S
S
S
G
A
P
G
Site 44
S318
L
S
T
T
N
S
S
S
S
S
G
A
P
G
P
Site 45
S319
S
T
T
N
S
S
S
S
S
G
A
P
G
P
C
Site 46
S320
T
T
N
S
S
S
S
S
G
A
P
G
P
C
G
Site 47
S333
C
G
L
A
R
Q
N
S
T
S
L
T
G
K
P
Site 48
T334
G
L
A
R
Q
N
S
T
S
L
T
G
K
P
G
Site 49
S335
L
A
R
Q
N
S
T
S
L
T
G
K
P
G
A
Site 50
T337
R
Q
N
S
T
S
L
T
G
K
P
G
A
L
P
Site 51
S363
K
Q
E
L
K
L
R
S
L
P
V
S
G
T
K
Site 52
S367
K
L
R
S
L
P
V
S
G
T
K
T
E
L
I
Site 53
T369
R
S
L
P
V
S
G
T
K
T
E
L
I
E
R
Site 54
T371
L
P
V
S
G
T
K
T
E
L
I
E
R
L
R
Site 55
Y380
L
I
E
R
L
R
A
Y
Q
D
Q
I
S
P
V
Site 56
S385
R
A
Y
Q
D
Q
I
S
P
V
P
G
A
P
K
Site 57
S416
A
F
P
A
A
R
L
S
T
G
P
A
L
V
A
Site 58
T447
G
V
V
K
F
G
S
T
G
S
T
P
P
V
S
Site 59
S449
V
K
F
G
S
T
G
S
T
P
P
V
S
P
T
Site 60
T450
K
F
G
S
T
G
S
T
P
P
V
S
P
T
P
Site 61
S454
T
G
S
T
P
P
V
S
P
T
P
S
E
R
S
Site 62
T456
S
T
P
P
V
S
P
T
P
S
E
R
S
L
L
Site 63
S458
P
P
V
S
P
T
P
S
E
R
S
L
L
S
T
Site 64
S461
S
P
T
P
S
E
R
S
L
L
S
T
G
D
E
Site 65
S464
P
S
E
R
S
L
L
S
T
G
D
E
N
S
T
Site 66
T465
S
E
R
S
L
L
S
T
G
D
E
N
S
T
P
Site 67
S470
L
S
T
G
D
E
N
S
T
P
G
D
T
F
G
Site 68
T471
S
T
G
D
E
N
S
T
P
G
D
T
F
G
E
Site 69
T475
E
N
S
T
P
G
D
T
F
G
E
M
V
T
S
Site 70
T488
T
S
P
L
T
Q
L
T
L
Q
A
S
P
L
Q
Site 71
S507
E
E
G
P
R
A
G
S
C
C
L
S
P
G
G
Site 72
S511
R
A
G
S
C
C
L
S
P
G
G
R
A
E
L
Site 73
T573
P
A
P
A
P
L
G
T
P
V
K
Q
E
N
S
Site 74
S580
T
P
V
K
Q
E
N
S
F
S
S
C
Q
L
S
Site 75
S582
V
K
Q
E
N
S
F
S
S
C
Q
L
S
Q
Q
Site 76
S583
K
Q
E
N
S
F
S
S
C
Q
L
S
Q
Q
P
Site 77
S587
S
F
S
S
C
Q
L
S
Q
Q
P
L
G
P
A
Site 78
T670
T
G
T
H
L
V
L
T
V
T
N
K
N
A
D
Site 79
S678
V
T
N
K
N
A
D
S
P
G
L
S
S
G
S
Site 80
S682
N
A
D
S
P
G
L
S
S
G
S
P
Q
Q
P
Site 81
S683
A
D
S
P
G
L
S
S
G
S
P
Q
Q
P
S
Site 82
S685
S
P
G
L
S
S
G
S
P
Q
Q
P
S
S
Q
Site 83
S690
S
G
S
P
Q
Q
P
S
S
Q
P
G
S
P
A
Site 84
S691
G
S
P
Q
Q
P
S
S
Q
P
G
S
P
A
P
Site 85
S695
Q
P
S
S
Q
P
G
S
P
A
P
A
P
S
A
Site 86
S701
G
S
P
A
P
A
P
S
A
Q
M
D
L
E
H
Site 87
T716
P
L
Q
P
L
F
G
T
P
T
S
L
L
K
K
Site 88
S719
P
L
F
G
T
P
T
S
L
L
K
K
E
P
P
Site 89
Y728
L
K
K
E
P
P
G
Y
E
E
A
M
S
Q
Q
Site 90
S733
P
G
Y
E
E
A
M
S
Q
Q
P
K
Q
Q
E
Site 91
S743
P
K
Q
Q
E
N
G
S
S
S
Q
Q
M
D
D
Site 92
S744
K
Q
Q
E
N
G
S
S
S
Q
Q
M
D
D
L
Site 93
S745
Q
Q
E
N
G
S
S
S
Q
Q
M
D
D
L
F
Site 94
S762
L
I
Q
S
G
E
I
S
A
D
F
K
E
P
P
Site 95
S770
A
D
F
K
E
P
P
S
L
P
G
K
E
K
P
Site 96
S778
L
P
G
K
E
K
P
S
P
K
T
V
C
G
S
Site 97
T781
K
E
K
P
S
P
K
T
V
C
G
S
P
L
A
Site 98
S785
S
P
K
T
V
C
G
S
P
L
A
A
Q
P
S
Site 99
S792
S
P
L
A
A
Q
P
S
P
S
A
E
L
P
Q
Site 100
S807
A
A
P
P
P
P
G
S
P
S
L
P
G
R
L
Site 101
S809
P
P
P
P
G
S
P
S
L
P
G
R
L
E
D
Site 102
S829
T
G
L
P
L
L
T
S
G
H
D
G
P
E
P
Site 103
S838
H
D
G
P
E
P
L
S
L
I
D
D
L
H
S
Site 104
S845
S
L
I
D
D
L
H
S
Q
M
L
S
S
T
A
Site 105
S849
D
L
H
S
Q
M
L
S
S
T
A
I
L
D
H
Site 106
S850
L
H
S
Q
M
L
S
S
T
A
I
L
D
H
P
Site 107
S859
A
I
L
D
H
P
P
S
P
M
D
T
S
E
L
Site 108
T863
H
P
P
S
P
M
D
T
S
E
L
H
F
V
P
Site 109
S864
P
P
S
P
M
D
T
S
E
L
H
F
V
P
E
Site 110
T875
F
V
P
E
P
S
S
T
M
G
L
D
L
A
D
Site 111
S887
L
A
D
G
H
L
D
S
M
D
W
L
E
L
S
Site 112
T908
S
L
A
P
L
S
T
T
A
P
S
L
F
S
T
Site 113
T915
T
A
P
S
L
F
S
T
D
F
L
D
G
H
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation