KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
USP7
Full Name:
Ubiquitin carboxyl-terminal hydrolase 7
Alias:
Ubiquitin thioesterase 7
Type:
Mass (Da):
128302
Number AA:
1102
UniProt ID:
Q93009
International Prot ID:
IPI00003965
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0008022
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0016579
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
K
A
G
E
Q
Q
L
S
E
P
E
D
M
E
M
Site 2
T30
M
E
M
E
A
G
D
T
D
D
P
P
R
I
T
Site 3
T37
T
D
D
P
P
R
I
T
Q
N
P
V
I
N
G
Site 4
S49
I
N
G
N
V
A
L
S
D
G
H
N
T
A
E
Site 5
T54
A
L
S
D
G
H
N
T
A
E
E
D
M
E
D
Site 6
T63
E
E
D
M
E
D
D
T
S
W
R
S
E
A
T
Site 7
S64
E
D
M
E
D
D
T
S
W
R
S
E
A
T
F
Site 8
T70
T
S
W
R
S
E
A
T
F
Q
F
T
V
E
R
Site 9
T74
S
E
A
T
F
Q
F
T
V
E
R
F
S
R
L
Site 10
S79
Q
F
T
V
E
R
F
S
R
L
S
E
S
V
L
Site 11
S82
V
E
R
F
S
R
L
S
E
S
V
L
S
P
P
Site 12
S84
R
F
S
R
L
S
E
S
V
L
S
P
P
C
F
Site 13
S87
R
L
S
E
S
V
L
S
P
P
C
F
V
R
N
Site 14
Y106
I
M
V
M
P
R
F
Y
P
D
R
P
H
Q
K
Site 15
S114
P
D
R
P
H
Q
K
S
V
G
F
F
L
Q
C
Site 16
S125
F
L
Q
C
N
A
E
S
D
S
T
S
W
S
C
Site 17
S129
N
A
E
S
D
S
T
S
W
S
C
H
A
Q
A
Site 18
S131
E
S
D
S
T
S
W
S
C
H
A
Q
A
V
L
Site 19
Y143
A
V
L
K
I
I
N
Y
R
D
D
E
K
S
F
Site 20
S149
N
Y
R
D
D
E
K
S
F
S
R
R
I
S
H
Site 21
S151
R
D
D
E
K
S
F
S
R
R
I
S
H
L
F
Site 22
S155
K
S
F
S
R
R
I
S
H
L
F
F
H
K
E
Site 23
T211
A
W
D
S
K
K
H
T
G
Y
V
G
L
K
N
Site 24
Y213
D
S
K
K
H
T
G
Y
V
G
L
K
N
Q
G
Site 25
Y224
K
N
Q
G
A
T
C
Y
M
N
S
L
L
Q
T
Site 26
Y243
N
Q
L
R
K
A
V
Y
M
M
P
T
E
G
D
Site 27
S252
M
P
T
E
G
D
D
S
S
K
S
V
P
L
A
Site 28
S253
P
T
E
G
D
D
S
S
K
S
V
P
L
A
L
Site 29
S255
E
G
D
D
S
S
K
S
V
P
L
A
L
Q
R
Site 30
Y265
L
A
L
Q
R
V
F
Y
E
L
Q
H
S
D
K
Site 31
S270
V
F
Y
E
L
Q
H
S
D
K
P
V
G
T
K
Site 32
T280
P
V
G
T
K
K
L
T
K
S
F
G
W
E
T
Site 33
S282
G
T
K
K
L
T
K
S
F
G
W
E
T
L
D
Site 34
S330
L
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
Site 35
Y331
F
R
G
K
M
V
S
Y
I
Q
C
K
E
V
D
Site 36
Y339
I
Q
C
K
E
V
D
Y
R
S
D
R
R
E
D
Site 37
S341
C
K
E
V
D
Y
R
S
D
R
R
E
D
Y
Y
Site 38
Y347
R
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
Site 39
Y348
S
D
R
R
E
D
Y
Y
D
I
Q
L
S
I
K
Site 40
Y379
Q
L
D
G
D
N
K
Y
D
A
G
E
H
G
L
Site 41
Y411
L
Q
L
M
R
F
M
Y
D
P
Q
T
D
Q
N
Site 42
T440
L
D
E
F
L
Q
K
T
D
P
K
D
P
A
N
Site 43
S457
L
H
A
V
L
V
H
S
G
D
N
H
G
G
H
Site 44
Y465
G
D
N
H
G
G
H
Y
V
V
Y
L
N
P
K
Site 45
Y468
H
G
G
H
Y
V
V
Y
L
N
P
K
G
D
G
Site 46
S486
K
F
D
D
D
V
V
S
R
C
T
K
E
E
A
Site 47
T489
D
D
V
V
S
R
C
T
K
E
E
A
I
E
H
Site 48
S506
G
G
H
D
D
D
L
S
V
R
H
C
T
N
A
Site 49
Y518
T
N
A
Y
M
L
V
Y
I
R
E
S
K
L
S
Site 50
S525
Y
I
R
E
S
K
L
S
E
V
L
Q
A
V
T
Site 51
Y564
E
R
Q
E
A
H
L
Y
M
Q
V
Q
I
V
A
Site 52
Y584
G
H
Q
G
N
D
M
Y
D
E
E
K
V
K
Y
Site 53
Y591
Y
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
Site 54
T592
D
E
E
K
V
K
Y
T
V
F
K
V
L
K
N
Site 55
S601
F
K
V
L
K
N
S
S
L
A
E
F
V
Q
S
Site 56
S610
A
E
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
Site 57
T612
F
V
Q
S
L
S
Q
T
M
G
F
P
Q
D
Q
Site 58
T659
S
D
N
E
N
P
W
T
I
F
L
E
T
V
D
Site 59
T696
L
K
M
Y
D
P
K
T
R
S
L
N
Y
C
G
Site 60
T730
R
A
G
F
I
Q
D
T
S
L
I
L
Y
E
E
Site 61
Y735
Q
D
T
S
L
I
L
Y
E
E
V
K
P
N
L
Site 62
T743
E
E
V
K
P
N
L
T
E
R
I
Q
D
Y
D
Site 63
Y749
L
T
E
R
I
Q
D
Y
D
V
S
L
D
K
A
Site 64
S752
R
I
Q
D
Y
D
V
S
L
D
K
A
L
D
E
Site 65
S778
D
D
P
E
N
D
N
S
E
L
P
T
A
K
E
Site 66
Y786
E
L
P
T
A
K
E
Y
F
R
D
L
Y
H
R
Site 67
Y791
K
E
Y
F
R
D
L
Y
H
R
V
D
V
I
F
Site 68
T812
N
D
P
G
F
V
V
T
L
S
N
R
M
N
Y
Site 69
Y819
T
L
S
N
R
M
N
Y
F
Q
V
A
K
T
V
Site 70
T825
N
Y
F
Q
V
A
K
T
V
A
Q
R
L
N
T
Site 71
S842
M
L
L
Q
F
F
K
S
Q
G
Y
R
D
G
P
Site 72
Y845
Q
F
F
K
S
Q
G
Y
R
D
G
P
G
N
P
Site 73
Y857
G
N
P
L
R
H
N
Y
E
G
T
L
R
D
L
Site 74
T860
L
R
H
N
Y
E
G
T
L
R
D
L
L
Q
F
Site 75
Y877
P
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
Site 76
Y878
R
Q
P
K
K
L
Y
Y
Q
Q
L
K
M
K
I
Site 77
T886
Q
Q
L
K
M
K
I
T
D
F
E
N
R
R
S
Site 78
T909
Q
F
R
E
E
E
I
T
L
Y
P
D
K
H
G
Site 79
Y911
R
E
E
E
I
T
L
Y
P
D
K
H
G
C
V
Site 80
S963
D
E
L
L
E
C
L
S
P
A
T
S
R
T
F
Site 81
S967
E
C
L
S
P
A
T
S
R
T
F
R
I
E
E
Site 82
T969
L
S
P
A
T
S
R
T
F
R
I
E
E
I
P
Site 83
T991
K
E
N
E
M
L
V
T
V
A
H
F
H
K
E
Site 84
S1026
E
V
M
K
R
I
Q
S
L
L
D
I
Q
E
K
Site 85
Y1050
V
M
M
G
R
H
Q
Y
I
N
E
D
E
Y
E
Site 86
Y1056
Q
Y
I
N
E
D
E
Y
E
V
N
L
K
D
F
Site 87
S1071
E
P
Q
P
G
N
M
S
H
P
R
P
W
L
G
Site 88
S1089
F
N
K
A
P
K
R
S
R
Y
T
Y
L
E
K
Site 89
Y1091
K
A
P
K
R
S
R
Y
T
Y
L
E
K
A
I
Site 90
T1092
A
P
K
R
S
R
Y
T
Y
L
E
K
A
I
K
Site 91
Y1093
P
K
R
S
R
Y
T
Y
L
E
K
A
I
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation