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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF2
Full Name:
Rho guanine nucleotide exchange factor 2
Alias:
GEFH1; GEF-H1; Guanine nucleotide exchange factor GEF-H1; Proliferating cell nucleolar antigen p40; Rho/rac guanine nucleotide exchange factor 2
Type:
Intracellular, Spindle, Cytoplasm, Cell junction, Tight junction, Golgi apparatus protein
Mass (Da):
111543
Number AA:
986
UniProt ID:
Q92974
International Prot ID:
IPI00412782
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0048365
GO:0030676
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0007015
GO:0006915
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
R
I
E
S
L
T
R
A
R
I
D
Site 2
T8
M
S
R
I
E
S
L
T
R
A
R
I
D
R
S
Site 3
S15
T
R
A
R
I
D
R
S
R
E
L
A
S
K
T
Site 4
S20
D
R
S
R
E
L
A
S
K
T
R
E
K
E
K
Site 5
T22
S
R
E
L
A
S
K
T
R
E
K
E
K
M
K
Site 6
Y36
K
E
A
K
D
A
R
Y
T
N
G
H
L
F
T
Site 7
T37
E
A
K
D
A
R
Y
T
N
G
H
L
F
T
T
Site 8
S107
K
N
N
T
A
L
Q
S
V
S
L
R
S
K
T
Site 9
S109
N
T
A
L
Q
S
V
S
L
R
S
K
T
T
I
Site 10
T114
S
V
S
L
R
S
K
T
T
I
R
E
R
P
S
Site 11
T115
V
S
L
R
S
K
T
T
I
R
E
R
P
S
S
Site 12
S121
T
T
I
R
E
R
P
S
S
A
I
Y
P
S
D
Site 13
S122
T
I
R
E
R
P
S
S
A
I
Y
P
S
D
S
Site 14
Y125
E
R
P
S
S
A
I
Y
P
S
D
S
F
R
Q
Site 15
S127
P
S
S
A
I
Y
P
S
D
S
F
R
Q
S
L
Site 16
S129
S
A
I
Y
P
S
D
S
F
R
Q
S
L
L
G
Site 17
S133
P
S
D
S
F
R
Q
S
L
L
G
S
R
R
G
Site 18
S137
F
R
Q
S
L
L
G
S
R
R
G
R
S
S
L
Site 19
S142
L
G
S
R
R
G
R
S
S
L
S
L
A
K
S
Site 20
S143
G
S
R
R
G
R
S
S
L
S
L
A
K
S
V
Site 21
S145
R
R
G
R
S
S
L
S
L
A
K
S
V
S
T
Site 22
S149
S
S
L
S
L
A
K
S
V
S
T
T
N
I
A
Site 23
S151
L
S
L
A
K
S
V
S
T
T
N
I
A
G
H
Site 24
T152
S
L
A
K
S
V
S
T
T
N
I
A
G
H
F
Site 25
T153
L
A
K
S
V
S
T
T
N
I
A
G
H
F
N
Site 26
S163
A
G
H
F
N
D
E
S
P
L
G
L
R
R
I
Site 27
S172
L
G
L
R
R
I
L
S
Q
S
T
D
S
L
N
Site 28
S174
L
R
R
I
L
S
Q
S
T
D
S
L
N
M
R
Site 29
T175
R
R
I
L
S
Q
S
T
D
S
L
N
M
R
N
Site 30
S177
I
L
S
Q
S
T
D
S
L
N
M
R
N
R
T
Site 31
T184
S
L
N
M
R
N
R
T
L
S
V
E
S
L
I
Site 32
S186
N
M
R
N
R
T
L
S
V
E
S
L
I
D
E
Site 33
S189
N
R
T
L
S
V
E
S
L
I
D
E
A
E
V
Site 34
S199
D
E
A
E
V
I
Y
S
E
L
M
S
D
F
E
Site 35
S203
V
I
Y
S
E
L
M
S
D
F
E
M
D
E
K
Site 36
S216
E
K
D
F
A
A
D
S
W
S
L
A
V
D
S
Site 37
S224
W
S
L
A
V
D
S
S
F
L
Q
Q
H
K
K
Site 38
Y241
M
K
Q
Q
D
V
I
Y
E
L
I
Q
T
E
L
Site 39
T291
D
E
L
S
D
I
H
T
R
F
L
S
Q
L
L
Site 40
S295
D
I
H
T
R
F
L
S
Q
L
L
E
R
R
R
Site 41
S309
R
Q
A
L
C
P
G
S
T
R
N
F
V
I
H
Site 42
T310
Q
A
L
C
P
G
S
T
R
N
F
V
I
H
R
Site 43
S327
D
L
L
I
S
Q
F
S
G
P
S
A
E
Q
M
Site 44
T337
S
A
E
Q
M
C
K
T
Y
S
E
F
C
S
R
Site 45
S343
K
T
Y
S
E
F
C
S
R
H
S
K
A
L
K
Site 46
S346
S
E
F
C
S
R
H
S
K
A
L
K
L
Y
K
Site 47
Y356
L
K
L
Y
K
E
L
Y
A
R
D
K
R
F
Q
Site 48
T370
Q
Q
F
I
R
K
V
T
R
P
A
V
L
K
R
Site 49
T388
Q
E
C
I
L
L
V
T
Q
R
I
T
K
Y
P
Site 50
S405
I
S
R
I
L
Q
H
S
H
G
I
E
E
E
R
Site 51
T416
E
E
E
R
Q
D
L
T
T
A
L
G
L
V
K
Site 52
T417
E
E
R
Q
D
L
T
T
A
L
G
L
V
K
E
Site 53
S427
G
L
V
K
E
L
L
S
N
V
D
E
G
I
Y
Site 54
Y434
S
N
V
D
E
G
I
Y
Q
L
E
K
G
A
R
Site 55
Y446
G
A
R
L
Q
E
I
Y
N
R
M
D
P
R
A
Site 56
T455
R
M
D
P
R
A
Q
T
P
V
P
G
K
G
P
Site 57
T483
D
G
C
L
L
W
K
T
A
T
G
R
F
K
D
Site 58
Y510
L
Q
E
K
D
Q
K
Y
I
F
P
T
L
D
K
Site 59
S522
L
D
K
P
S
V
V
S
L
Q
N
L
I
V
R
Site 60
Y549
S
A
A
P
P
E
M
Y
E
V
H
T
A
S
R
Site 61
S560
T
A
S
R
D
D
R
S
T
W
I
R
V
I
Q
Site 62
T561
A
S
R
D
D
R
S
T
W
I
R
V
I
Q
Q
Site 63
S575
Q
S
V
R
T
C
P
S
R
E
D
F
P
L
I
Site 64
Y589
I
E
T
E
D
E
A
Y
L
R
R
I
K
M
E
Site 65
T619
V
G
L
F
A
E
M
T
H
F
Q
A
E
E
D
Site 66
S629
Q
A
E
E
D
G
G
S
G
M
A
L
P
T
L
Site 67
S643
L
P
R
G
L
F
R
S
E
S
L
E
S
P
R
Site 68
S645
R
G
L
F
R
S
E
S
L
E
S
P
R
G
E
Site 69
S648
F
R
S
E
S
L
E
S
P
R
G
E
R
L
L
Site 70
T679
P
G
V
E
L
L
L
T
P
R
E
P
A
L
P
Site 71
S691
A
L
P
L
E
P
D
S
G
G
N
T
S
P
G
Site 72
T695
E
P
D
S
G
G
N
T
S
P
G
V
T
A
N
Site 73
S696
P
D
S
G
G
N
T
S
P
G
V
T
A
N
G
Site 74
T700
G
N
T
S
P
G
V
T
A
N
G
E
A
R
T
Site 75
T707
T
A
N
G
E
A
R
T
F
N
G
S
I
E
L
Site 76
S711
E
A
R
T
F
N
G
S
I
E
L
C
R
A
D
Site 77
S719
I
E
L
C
R
A
D
S
D
S
S
Q
R
D
R
Site 78
S721
L
C
R
A
D
S
D
S
S
Q
R
D
R
N
G
Site 79
S722
C
R
A
D
S
D
S
S
Q
R
D
R
N
G
N
Site 80
S733
R
N
G
N
Q
L
R
S
P
Q
E
E
A
L
Q
Site 81
S782
E
K
L
C
R
A
N
S
R
D
G
E
A
G
R
Site 82
T802
V
A
P
E
K
Q
A
T
E
L
A
L
L
Q
R
Site 83
T830
R
L
G
E
E
R
A
T
E
A
G
S
L
E
A
Site 84
S842
L
E
A
R
L
R
E
S
E
Q
A
R
A
L
L
Site 85
S886
P
V
D
P
R
R
R
S
L
P
A
G
D
A
L
Site 86
Y894
L
P
A
G
D
A
L
Y
L
S
F
N
P
P
Q
Site 87
S896
A
G
D
A
L
Y
L
S
F
N
P
P
Q
P
S
Site 88
S903
S
F
N
P
P
Q
P
S
R
G
T
D
R
L
D
Site 89
T906
P
P
Q
P
S
R
G
T
D
R
L
D
L
P
V
Site 90
T914
D
R
L
D
L
P
V
T
T
R
S
V
H
R
N
Site 91
S917
D
L
P
V
T
T
R
S
V
H
R
N
F
E
D
Site 92
S932
R
E
R
Q
E
L
G
S
P
E
E
R
L
Q
D
Site 93
S940
P
E
E
R
L
Q
D
S
S
D
P
D
T
G
S
Site 94
S941
E
E
R
L
Q
D
S
S
D
P
D
T
G
S
E
Site 95
T945
Q
D
S
S
D
P
D
T
G
S
E
E
E
G
S
Site 96
S947
S
S
D
P
D
T
G
S
E
E
E
G
S
S
R
Site 97
S952
T
G
S
E
E
E
G
S
S
R
L
S
P
P
H
Site 98
S953
G
S
E
E
E
G
S
S
R
L
S
P
P
H
S
Site 99
S956
E
E
G
S
S
R
L
S
P
P
H
S
P
R
D
Site 100
S960
S
R
L
S
P
P
H
S
P
R
D
F
T
R
M
Site 101
T965
P
H
S
P
R
D
F
T
R
M
Q
D
I
P
E
Site 102
S976
D
I
P
E
E
T
E
S
R
D
G
E
A
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation