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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CdkL2
Full Name:
Cyclin-dependent kinase-like 2
Alias:
EC 2.7.11.22; Kinase CdkL2; KKIAMRE; P56; Protein kinase p56 KKIAMRE; Serine/threonine-protein kinase KKIAMRE
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22;
CMGC
group; CDKL family
Mass (Da):
56019
Number AA:
493
UniProt ID:
Q92772
International Prot ID:
IPI00940400
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004693
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007548
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Cyclin-dependent kinase-like 2; Serine/threonine protein kinase KKIAMRE pan-specific antibody AB-NK261-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK261-1#Cyclin-dependent kinase-like 2 / Serine/threonine protein kinase KKIAMRE (L478-H493, human) peptide - Powder PE-01BCN85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BCN85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
Site 2
T26
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
Site 3
S38
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
Site 4
Y77
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
Site 5
Y100
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
Site 6
Y106
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
Site 7
Y161
P
G
E
V
Y
T
D
Y
V
A
T
R
W
Y
R
Site 8
Y167
D
Y
V
A
T
R
W
Y
R
A
P
E
L
L
V
Site 9
S206
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
Site 10
Y253
R
E
P
L
E
R
R
Y
P
K
L
S
E
V
V
Site 11
S257
E
R
R
Y
P
K
L
S
E
V
V
I
D
L
A
Site 12
S297
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Site 13
S312
Q
K
D
A
R
N
V
S
L
S
K
K
S
Q
N
Site 14
S314
D
A
R
N
V
S
L
S
K
K
S
Q
N
R
K
Site 15
S317
N
V
S
L
S
K
K
S
Q
N
R
K
K
E
K
Site 16
S329
K
E
K
E
K
D
D
S
L
V
E
E
R
K
T
Site 17
T336
S
L
V
E
E
R
K
T
L
V
V
Q
D
T
N
Site 18
T342
K
T
L
V
V
Q
D
T
N
A
D
P
K
I
K
Site 19
Y351
A
D
P
K
I
K
D
Y
K
L
F
K
I
K
G
Site 20
S359
K
L
F
K
I
K
G
S
K
I
D
G
E
K
A
Site 21
S373
A
E
K
G
N
R
A
S
N
A
S
C
L
H
D
Site 22
S376
G
N
R
A
S
N
A
S
C
L
H
D
S
R
T
Site 23
T383
S
C
L
H
D
S
R
T
S
H
N
K
I
V
P
Site 24
S384
C
L
H
D
S
R
T
S
H
N
K
I
V
P
S
Site 25
S391
S
H
N
K
I
V
P
S
T
S
L
K
D
C
S
Site 26
S393
N
K
I
V
P
S
T
S
L
K
D
C
S
N
V
Site 27
S398
S
T
S
L
K
D
C
S
N
V
S
V
D
H
T
Site 28
S401
L
K
D
C
S
N
V
S
V
D
H
T
R
N
P
Site 29
T405
S
N
V
S
V
D
H
T
R
N
P
S
V
A
I
Site 30
S409
V
D
H
T
R
N
P
S
V
A
I
P
P
L
T
Site 31
T432
S
I
N
S
G
M
G
T
E
T
I
P
I
Q
G
Site 32
T434
N
S
G
M
G
T
E
T
I
P
I
Q
G
Y
R
Site 33
T446
G
Y
R
V
D
E
K
T
K
K
C
S
I
P
F
Site 34
S460
F
V
K
P
N
R
H
S
P
S
G
I
Y
N
I
Site 35
S479
L
V
S
G
P
P
L
S
D
D
S
G
A
D
L
Site 36
S482
G
P
P
L
S
D
D
S
G
A
D
L
P
Q
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation