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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ER-beta
Full Name:
Estrogen receptor beta
Alias:
ER beta; Erb; ESR2; ESTRB; Estrogen receptor 2; NR3A2; Nuclear receptor subfamily 3 group A member 2
Type:
Transcription protein (receptor)
Mass (Da):
59216
Number AA:
530
UniProt ID:
Q92731
International Prot ID:
IPI00023212
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0030284
GO:0048019
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0030520
GO:0030308
Phosida
TranscriptoNet
STRING
Kinexus Products
Estrogen receptor-beta (M1-S12, human) peptide - Powder PE-01ANN90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ANN90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
I
K
N
S
P
S
S
L
N
S
P
Site 2
S8
M
D
I
K
N
S
P
S
S
L
N
S
P
S
S
Site 3
S9
D
I
K
N
S
P
S
S
L
N
S
P
S
S
Y
Site 4
S12
N
S
P
S
S
L
N
S
P
S
S
Y
N
C
S
Site 5
S14
P
S
S
L
N
S
P
S
S
Y
N
C
S
Q
S
Site 6
S15
S
S
L
N
S
P
S
S
Y
N
C
S
Q
S
I
Site 7
Y16
S
L
N
S
P
S
S
Y
N
C
S
Q
S
I
L
Site 8
S19
S
P
S
S
Y
N
C
S
Q
S
I
L
P
L
E
Site 9
S21
S
S
Y
N
C
S
Q
S
I
L
P
L
E
H
G
Site 10
Y31
P
L
E
H
G
S
I
Y
I
P
S
S
Y
V
D
Site 11
S34
H
G
S
I
Y
I
P
S
S
Y
V
D
S
H
H
Site 12
S35
G
S
I
Y
I
P
S
S
Y
V
D
S
H
H
E
Site 13
Y36
S
I
Y
I
P
S
S
Y
V
D
S
H
H
E
Y
Site 14
S39
I
P
S
S
Y
V
D
S
H
H
E
Y
P
A
M
Site 15
Y43
Y
V
D
S
H
H
E
Y
P
A
M
T
F
Y
S
Site 16
Y49
E
Y
P
A
M
T
F
Y
S
P
A
V
M
N
Y
Site 17
Y56
Y
S
P
A
V
M
N
Y
S
I
P
S
N
V
T
Site 18
S57
S
P
A
V
M
N
Y
S
I
P
S
N
V
T
N
Site 19
S60
V
M
N
Y
S
I
P
S
N
V
T
N
L
E
G
Site 20
T73
E
G
G
P
G
R
Q
T
T
S
P
N
V
L
W
Site 21
T74
G
G
P
G
R
Q
T
T
S
P
N
V
L
W
P
Site 22
S75
G
P
G
R
Q
T
T
S
P
N
V
L
W
P
T
Site 23
T82
S
P
N
V
L
W
P
T
P
G
H
L
S
P
L
Site 24
S87
W
P
T
P
G
H
L
S
P
L
V
V
H
R
Q
Site 25
S96
L
V
V
H
R
Q
L
S
H
L
Y
A
E
P
Q
Site 26
Y99
H
R
Q
L
S
H
L
Y
A
E
P
Q
K
S
P
Site 27
S105
L
Y
A
E
P
Q
K
S
P
W
C
E
A
R
S
Site 28
S112
S
P
W
C
E
A
R
S
L
E
H
T
L
P
V
Site 29
T116
E
A
R
S
L
E
H
T
L
P
V
N
R
E
T
Site 30
T123
T
L
P
V
N
R
E
T
L
K
R
K
V
S
G
Site 31
S129
E
T
L
K
R
K
V
S
G
N
R
C
A
S
P
Site 32
S135
V
S
G
N
R
C
A
S
P
V
T
G
P
G
S
Site 33
T138
N
R
C
A
S
P
V
T
G
P
G
S
K
R
D
Site 34
S142
S
P
V
T
G
P
G
S
K
R
D
A
H
F
C
Site 35
Y161
D
Y
A
S
G
Y
H
Y
G
V
W
S
C
E
G
Site 36
S165
G
Y
H
Y
G
V
W
S
C
E
G
C
K
A
F
Site 37
S176
C
K
A
F
F
K
R
S
I
Q
G
H
N
D
Y
Site 38
Y183
S
I
Q
G
H
N
D
Y
I
C
P
A
T
N
Q
Site 39
S200
I
D
K
N
R
R
K
S
C
Q
A
C
R
L
R
Site 40
Y226
S
R
R
E
R
C
G
Y
R
L
V
R
R
Q
R
Site 41
S234
R
L
V
R
R
Q
R
S
A
D
E
Q
L
H
C
Site 42
T271
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
Site 43
S283
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
Site 44
S286
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
Site 45
T290
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
Site 46
S297
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
Site 47
S311
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
Site 48
S385
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Site 49
S422
T
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
Site 50
S448
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
Site 51
S452
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
Site 52
S463
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
Site 53
S469
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
Site 54
S505
H
V
L
R
G
C
K
S
S
I
T
G
S
E
C
Site 55
S506
V
L
R
G
C
K
S
S
I
T
G
S
E
C
S
Site 56
T508
R
G
C
K
S
S
I
T
G
S
E
C
S
P
A
Site 57
S510
C
K
S
S
I
T
G
S
E
C
S
P
A
E
D
Site 58
S513
S
I
T
G
S
E
C
S
P
A
E
D
S
K
S
Site 59
S518
E
C
S
P
A
E
D
S
K
S
K
E
G
S
Q
Site 60
S520
S
P
A
E
D
S
K
S
K
E
G
S
Q
N
P
Site 61
S524
D
S
K
S
K
E
G
S
Q
N
P
Q
S
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation