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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKAP1
Full Name:
A-kinase anchor protein 1, mitochondrial
Alias:
A kinase (PRKA) anchor protein 1; AKAP 149; AKAP121; AKAP149; AKAP84; A-kinase anchor protein 149 kDa; AKP1; D-AKAP-1; Dual specificity A-kinase anchoring protein 1; PRKA1; Protein kinase A anchoring protein 1; Protein kinase A1; Protein kinase A-anchoring protein 1; SAKAP84; S-AKAP84; Spermatid A-kinase anchor protein 84
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
97342
Number AA:
903
UniProt ID:
Q92667
International Prot ID:
IPI00022585
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005741
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
S
R
K
K
G
H
V
S
S
H
D
E
Q
Q
V
Site 2
S35
R
K
K
G
H
V
S
S
H
D
E
Q
Q
V
E
Site 3
S69
D
V
C
P
K
V
V
S
T
P
P
S
V
T
E
Site 4
T70
V
C
P
K
V
V
S
T
P
P
S
V
T
E
P
Site 5
S73
K
V
V
S
T
P
P
S
V
T
E
P
P
E
K
Site 6
T75
V
S
T
P
P
S
V
T
E
P
P
E
K
E
L
Site 7
S83
E
P
P
E
K
E
L
S
T
V
S
K
L
P
A
Site 8
T84
P
P
E
K
E
L
S
T
V
S
K
L
P
A
E
Site 9
T98
E
P
P
A
L
L
Q
T
H
P
P
C
R
R
S
Site 10
S105
T
H
P
P
C
R
R
S
E
S
S
G
I
L
P
Site 11
S107
P
P
C
R
R
S
E
S
S
G
I
L
P
N
T
Site 12
S108
P
C
R
R
S
E
S
S
G
I
L
P
N
T
T
Site 13
T114
S
S
G
I
L
P
N
T
T
D
M
R
L
R
P
Site 14
T115
S
G
I
L
P
N
T
T
D
M
R
L
R
P
G
Site 15
T123
D
M
R
L
R
P
G
T
R
R
D
D
S
T
K
Site 16
S128
P
G
T
R
R
D
D
S
T
K
L
E
L
A
L
Site 17
T129
G
T
R
R
D
D
S
T
K
L
E
L
A
L
T
Site 18
S151
P
L
E
C
P
L
S
S
P
K
G
V
L
F
S
Site 19
S158
S
P
K
G
V
L
F
S
S
K
S
A
E
V
C
Site 20
S159
P
K
G
V
L
F
S
S
K
S
A
E
V
C
K
Site 21
S161
G
V
L
F
S
S
K
S
A
E
V
C
K
Q
D
Site 22
S169
A
E
V
C
K
Q
D
S
P
F
S
R
V
P
R
Site 23
S172
C
K
Q
D
S
P
F
S
R
V
P
R
K
V
Q
Site 24
Y182
P
R
K
V
Q
P
G
Y
P
V
V
P
A
E
K
Site 25
S192
V
P
A
E
K
R
S
S
G
E
R
A
R
E
T
Site 26
T199
S
G
E
R
A
R
E
T
G
G
A
E
G
T
G
Site 27
S231
H
V
L
E
L
E
N
S
K
G
P
S
L
A
S
Site 28
S235
L
E
N
S
K
G
P
S
L
A
S
L
E
G
E
Site 29
S238
S
K
G
P
S
L
A
S
L
E
G
E
E
D
K
Site 30
S248
G
E
E
D
K
G
K
S
S
S
S
Q
V
V
G
Site 31
S250
E
D
K
G
K
S
S
S
S
Q
V
V
G
P
V
Site 32
S251
D
K
G
K
S
S
S
S
Q
V
V
G
P
V
Q
Site 33
Y262
G
P
V
Q
E
E
E
Y
V
A
E
K
L
P
S
Site 34
S269
Y
V
A
E
K
L
P
S
R
F
I
E
S
A
H
Site 35
T277
R
F
I
E
S
A
H
T
E
L
A
K
D
D
A
Site 36
S309
G
E
L
G
N
E
E
S
L
D
R
N
E
E
G
Site 37
S330
G
L
D
R
N
E
E
S
L
D
R
N
E
E
G
Site 38
S353
R
A
A
F
Q
I
I
S
Q
V
I
S
E
A
T
Site 39
S357
Q
I
I
S
Q
V
I
S
E
A
T
E
Q
V
L
Site 40
T360
S
Q
V
I
S
E
A
T
E
Q
V
L
A
T
T
Site 41
T366
A
T
E
Q
V
L
A
T
T
V
G
K
V
A
G
Site 42
S379
A
G
R
V
C
Q
A
S
Q
L
Q
G
Q
K
E
Site 43
T402
K
T
V
L
G
P
D
T
A
E
P
A
T
A
E
Site 44
S429
P
G
L
P
A
E
G
S
P
P
P
K
T
Y
V
Site 45
T434
E
G
S
P
P
P
K
T
Y
V
S
C
L
K
S
Site 46
Y435
G
S
P
P
P
K
T
Y
V
S
C
L
K
S
L
Site 47
S437
P
P
P
K
T
Y
V
S
C
L
K
S
L
L
S
Site 48
S441
T
Y
V
S
C
L
K
S
L
L
S
S
P
T
K
Site 49
S444
S
C
L
K
S
L
L
S
S
P
T
K
D
S
K
Site 50
S445
C
L
K
S
L
L
S
S
P
T
K
D
S
K
P
Site 51
T447
K
S
L
L
S
S
P
T
K
D
S
K
P
N
I
Site 52
S450
L
S
S
P
T
K
D
S
K
P
N
I
S
A
H
Site 53
T469
A
S
C
L
A
L
T
T
P
S
E
E
L
P
D
Site 54
S497
C
M
S
D
S
S
Q
S
V
P
L
V
A
S
P
Site 55
S503
Q
S
V
P
L
V
A
S
P
G
H
C
S
D
S
Site 56
S508
V
A
S
P
G
H
C
S
D
S
F
S
T
S
G
Site 57
S510
S
P
G
H
C
S
D
S
F
S
T
S
G
L
E
Site 58
S512
G
H
C
S
D
S
F
S
T
S
G
L
E
D
S
Site 59
S514
C
S
D
S
F
S
T
S
G
L
E
D
S
C
T
Site 60
S519
S
T
S
G
L
E
D
S
C
T
E
T
S
S
S
Site 61
T521
S
G
L
E
D
S
C
T
E
T
S
S
S
P
R
Site 62
T523
L
E
D
S
C
T
E
T
S
S
S
P
R
D
K
Site 63
S524
E
D
S
C
T
E
T
S
S
S
P
R
D
K
A
Site 64
S526
S
C
T
E
T
S
S
S
P
R
D
K
A
I
T
Site 65
T533
S
P
R
D
K
A
I
T
P
P
L
P
E
S
T
Site 66
S539
I
T
P
P
L
P
E
S
T
V
P
F
S
N
G
Site 67
T540
T
P
P
L
P
E
S
T
V
P
F
S
N
G
V
Site 68
S544
P
E
S
T
V
P
F
S
N
G
V
L
K
G
E
Site 69
S553
G
V
L
K
G
E
L
S
D
L
G
A
E
D
G
Site 70
T562
L
G
A
E
D
G
W
T
M
D
A
E
A
D
H
Site 71
S570
M
D
A
E
A
D
H
S
G
G
S
D
R
N
S
Site 72
S573
E
A
D
H
S
G
G
S
D
R
N
S
M
D
S
Site 73
S577
S
G
G
S
D
R
N
S
M
D
S
V
D
S
C
Site 74
S580
S
D
R
N
S
M
D
S
V
D
S
C
C
S
L
Site 75
S583
N
S
M
D
S
V
D
S
C
C
S
L
K
K
T
Site 76
S586
D
S
V
D
S
C
C
S
L
K
K
T
E
S
F
Site 77
T590
S
C
C
S
L
K
K
T
E
S
F
Q
N
A
Q
Site 78
S592
C
S
L
K
K
T
E
S
F
Q
N
A
Q
A
G
Site 79
S600
F
Q
N
A
Q
A
G
S
N
P
K
K
V
D
L
Site 80
Y629
L
I
G
K
Q
G
R
Y
V
S
F
L
K
Q
T
Site 81
S631
G
K
Q
G
R
Y
V
S
F
L
K
Q
T
S
G
Site 82
Y642
Q
T
S
G
A
K
I
Y
I
S
T
L
P
Y
T
Site 83
S644
S
G
A
K
I
Y
I
S
T
L
P
Y
T
Q
S
Site 84
T681
K
F
K
E
L
N
L
T
N
I
Y
A
P
P
L
Site 85
T732
V
Q
Q
H
T
H
P
T
F
H
A
L
R
S
L
Site 86
S738
P
T
F
H
A
L
R
S
L
D
Q
Q
M
Y
L
Site 87
Y744
R
S
L
D
Q
Q
M
Y
L
C
Y
S
Q
P
G
Site 88
Y747
D
Q
Q
M
Y
L
C
Y
S
Q
P
G
I
P
T
Site 89
T786
V
V
A
S
Y
E
E
T
N
E
V
E
I
R
Y
Site 90
Y793
T
N
E
V
E
I
R
Y
V
D
Y
G
G
Y
K
Site 91
Y796
V
E
I
R
Y
V
D
Y
G
G
Y
K
R
V
K
Site 92
Y799
R
Y
V
D
Y
G
G
Y
K
R
V
K
V
D
V
Site 93
T816
Q
I
R
S
D
F
V
T
L
P
F
Q
G
A
E
Site 94
S833
L
D
S
V
M
P
L
S
D
D
D
Q
F
S
P
Site 95
S839
L
S
D
D
D
Q
F
S
P
E
A
D
A
A
M
Site 96
Y900
A
Q
W
V
D
S
Y
Y
T
S
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation