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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DYRK2
Full Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Alias:
EC 2.7.12.1
Type:
Protein kinase, dual-specificity, CMGC group, DYRK family, Dyrk2 subfamily
Mass (Da):
66652
Number AA:
601
UniProt ID:
Q92630
International Prot ID:
IPI00022521
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0042771
GO:0006915
GO:0045725
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity tyrosine-phosphorylation-regulated kinase 2 pan-specific antibody AB-NK266-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK266-1#Dual specificity tyrosine-phosphorylation-regulated kinase 2 Y382 phosphosite-specific antibody AB-PK598#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK598#Dual specificity tyrosine-phosphorylation-regulated kinase 2 (G69-Q87, human) peptide - Powder PE-01BCT85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BCT85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
T
R
K
P
S
A
A
A
P
A
A
Y
Site 2
Y14
S
A
A
A
P
A
A
Y
P
T
G
R
G
G
D
Site 3
T16
A
A
P
A
A
Y
P
T
G
R
G
G
D
S
A
Site 4
S22
P
T
G
R
G
G
D
S
A
V
R
Q
L
Q
A
Site 5
S30
A
V
R
Q
L
Q
A
S
P
G
L
G
A
G
A
Site 6
T38
P
G
L
G
A
G
A
T
R
S
G
V
G
T
G
Site 7
S40
L
G
A
G
A
T
R
S
G
V
G
T
G
P
P
Site 8
T44
A
T
R
S
G
V
G
T
G
P
P
S
P
I
A
Site 9
S48
G
V
G
T
G
P
P
S
P
I
A
L
P
P
L
Site 10
S98
Q
Q
L
F
E
D
N
S
N
K
R
T
V
L
T
Site 11
T102
E
D
N
S
N
K
R
T
V
L
T
T
Q
P
N
Site 12
T105
S
N
K
R
T
V
L
T
T
Q
P
N
G
L
T
Site 13
T106
N
K
R
T
V
L
T
T
Q
P
N
G
L
T
T
Site 14
T113
T
Q
P
N
G
L
T
T
V
G
K
T
G
L
P
Site 15
S129
V
P
E
R
Q
L
D
S
I
H
R
R
Q
G
S
Site 16
S136
S
I
H
R
R
Q
G
S
S
T
S
L
K
S
M
Site 17
S137
I
H
R
R
Q
G
S
S
T
S
L
K
S
M
E
Site 18
T138
H
R
R
Q
G
S
S
T
S
L
K
S
M
E
G
Site 19
S139
R
R
Q
G
S
S
T
S
L
K
S
M
E
G
M
Site 20
S142
G
S
S
T
S
L
K
S
M
E
G
M
G
K
V
Site 21
T152
G
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
Site 22
T155
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Site 23
Y178
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
Site 24
Y203
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
Site 25
S209
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
Site 26
Y210
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
Site 27
Y222
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
Site 28
Y240
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
Site 29
Y309
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
Site 30
S331
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
Site 31
Y380
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Site 32
T381
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
Site 33
Y382
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
Dual specificity tyrosine-phosphorylation-regulated kinase 2 Y382 phosphosite-specific antibody AB-PK598#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK598
Site 34
S385
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
Site 35
Y388
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
Site 36
S442
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
Site 37
S449
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
Site 38
S457
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
Site 39
Y461
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
Site 40
Y464
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
Site 41
T466
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
Site 42
T468
Y
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
Site 43
S482
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
Site 44
S493
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
Site 45
T525
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
Site 46
T544
R
R
L
P
K
P
P
T
G
E
K
T
S
V
K
Site 47
S549
P
P
T
G
E
K
T
S
V
K
R
I
T
E
S
Site 48
T554
K
T
S
V
K
R
I
T
E
S
T
G
A
I
T
Site 49
S556
S
V
K
R
I
T
E
S
T
G
A
I
T
S
I
Site 50
T557
V
K
R
I
T
E
S
T
G
A
I
T
S
I
S
Site 51
S562
E
S
T
G
A
I
T
S
I
S
K
L
P
P
P
Site 52
S564
T
G
A
I
T
S
I
S
K
L
P
P
P
S
S
Site 53
S570
I
S
K
L
P
P
P
S
S
S
A
S
K
L
R
Site 54
S571
S
K
L
P
P
P
S
S
S
A
S
K
L
R
T
Site 55
S572
K
L
P
P
P
S
S
S
A
S
K
L
R
T
N
Site 56
S574
P
P
P
S
S
S
A
S
K
L
R
T
N
L
A
Site 57
T578
S
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
Site 58
T594
N
G
N
I
Q
Q
R
T
V
L
P
K
L
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation