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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO18A
Full Name:
Myosin-XVIIIa
Alias:
KIAA0216; M18A; Molecule associated with JAK3 N-terminus; MY18A; Myosin 18A; Myosin containing a PDZ domain; Myosin containing PDZ domain; Myosin XVIIIA; MYSPDZ
Type:
Actin binding protein
Mass (Da):
233115
Number AA:
2054
UniProt ID:
Q92614
International Prot ID:
IPI00760846
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005793
GO:0005794
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0008094
PhosphoSite+
KinaseNET
Biological Process:
GO:0006259
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
K
E
K
K
E
R
M
S
A
A
E
L
R
S
L
Site 2
S35
M
S
A
A
E
L
R
S
L
E
E
M
S
L
R
Site 3
S40
L
R
S
L
E
E
M
S
L
R
R
G
F
F
N
Site 4
S51
G
F
F
N
L
N
R
S
S
K
R
E
S
K
T
Site 5
S52
F
F
N
L
N
R
S
S
K
R
E
S
K
T
R
Site 6
S56
N
R
S
S
K
R
E
S
K
T
R
L
E
I
S
Site 7
T58
S
S
K
R
E
S
K
T
R
L
E
I
S
N
P
Site 8
S72
P
I
P
I
K
V
A
S
G
S
D
L
H
L
T
Site 9
S74
P
I
K
V
A
S
G
S
D
L
H
L
T
D
I
Site 10
T79
S
G
S
D
L
H
L
T
D
I
D
S
D
S
N
Site 11
S83
L
H
L
T
D
I
D
S
D
S
N
R
G
S
V
Site 12
S85
L
T
D
I
D
S
D
S
N
R
G
S
V
I
L
Site 13
S89
D
S
D
S
N
R
G
S
V
I
L
D
S
G
H
Site 14
S94
R
G
S
V
I
L
D
S
G
H
L
S
T
A
S
Site 15
S98
I
L
D
S
G
H
L
S
T
A
S
S
S
D
D
Site 16
T99
L
D
S
G
H
L
S
T
A
S
S
S
D
D
L
Site 17
S101
S
G
H
L
S
T
A
S
S
S
D
D
L
K
G
Site 18
S102
G
H
L
S
T
A
S
S
S
D
D
L
K
G
E
Site 19
S103
H
L
S
T
A
S
S
S
D
D
L
K
G
E
E
Site 20
S112
D
L
K
G
E
E
G
S
F
R
G
S
V
L
Q
Site 21
S116
E
E
G
S
F
R
G
S
V
L
Q
R
A
A
K
Site 22
S126
Q
R
A
A
K
F
G
S
L
A
K
Q
N
S
Q
Site 23
S132
G
S
L
A
K
Q
N
S
Q
M
I
V
K
R
F
Site 24
S140
Q
M
I
V
K
R
F
S
F
S
Q
R
S
R
D
Site 25
S142
I
V
K
R
F
S
F
S
Q
R
S
R
D
E
S
Site 26
S145
R
F
S
F
S
Q
R
S
R
D
E
S
A
S
E
Site 27
S149
S
Q
R
S
R
D
E
S
A
S
E
T
S
T
P
Site 28
S151
R
S
R
D
E
S
A
S
E
T
S
T
P
S
E
Site 29
T153
R
D
E
S
A
S
E
T
S
T
P
S
E
H
S
Site 30
T155
E
S
A
S
E
T
S
T
P
S
E
H
S
A
A
Site 31
S157
A
S
E
T
S
T
P
S
E
H
S
A
A
P
S
Site 32
S160
T
S
T
P
S
E
H
S
A
A
P
S
P
Q
V
Site 33
S164
S
E
H
S
A
A
P
S
P
Q
V
E
V
R
T
Site 34
S191
I
P
R
P
G
H
R
S
R
A
P
E
L
V
T
Site 35
T217
V
V
P
L
P
P
P
T
L
R
E
L
E
L
Q
Site 36
T228
L
E
L
Q
R
R
P
T
G
D
F
G
F
S
L
Site 37
S234
P
T
G
D
F
G
F
S
L
R
R
T
T
M
L
Site 38
T238
F
G
F
S
L
R
R
T
T
M
L
D
R
G
P
Site 39
T239
G
F
S
L
R
R
T
T
M
L
D
R
G
P
E
Site 40
S288
G
H
N
V
E
S
K
S
R
D
E
I
V
E
M
Site 41
S299
I
V
E
M
I
R
Q
S
G
D
S
V
R
L
K
Site 42
S302
M
I
R
Q
S
G
D
S
V
R
L
K
V
Q
P
Site 43
S314
V
Q
P
I
P
E
L
S
E
L
S
R
S
W
L
Site 44
S317
I
P
E
L
S
E
L
S
R
S
W
L
R
S
G
Site 45
S319
E
L
S
E
L
S
R
S
W
L
R
S
G
E
G
Site 46
S323
L
S
R
S
W
L
R
S
G
E
G
P
R
R
E
Site 47
S332
E
G
P
R
R
E
P
S
D
A
K
T
E
E
Q
Site 48
T336
R
E
P
S
D
A
K
T
E
E
Q
I
A
A
E
Site 49
S361
L
V
H
R
D
G
F
S
L
A
S
Q
L
K
S
Site 50
S364
R
D
G
F
S
L
A
S
Q
L
K
S
E
E
L
Site 51
S368
S
L
A
S
Q
L
K
S
E
E
L
N
L
P
E
Site 52
S412
D
R
L
E
D
L
A
S
L
V
Y
L
N
E
S
Site 53
Y415
E
D
L
A
S
L
V
Y
L
N
E
S
S
V
L
Site 54
S420
L
V
Y
L
N
E
S
S
V
L
H
T
L
R
Q
Site 55
T424
N
E
S
S
V
L
H
T
L
R
Q
R
Y
G
A
Site 56
Y429
L
H
T
L
R
Q
R
Y
G
A
S
L
L
H
T
Site 57
S432
L
R
Q
R
Y
G
A
S
L
L
H
T
Y
A
G
Site 58
Y454
P
R
G
A
P
A
V
Y
S
E
K
V
M
H
M
Site 59
Y475
E
D
M
A
P
H
I
Y
A
V
A
Q
T
A
Y
Site 60
S488
A
Y
R
A
M
L
M
S
R
Q
D
Q
S
I
I
Site 61
S493
L
M
S
R
Q
D
Q
S
I
I
L
L
G
S
S
Site 62
S502
I
L
L
G
S
S
G
S
G
K
T
T
S
C
Q
Site 63
T506
S
S
G
S
G
K
T
T
S
C
Q
H
L
V
Q
Site 64
S507
S
G
S
G
K
T
T
S
C
Q
H
L
V
Q
Y
Site 65
S528
I
S
G
N
K
V
F
S
V
E
K
W
Q
A
L
Site 66
S557
N
G
N
A
T
R
F
S
Q
I
L
S
L
D
F
Site 67
S561
T
R
F
S
Q
I
L
S
L
D
F
D
Q
A
G
Site 68
S591
R
V
A
R
R
P
A
S
E
A
T
F
N
V
F
Site 69
T594
R
R
P
A
S
E
A
T
F
N
V
F
Y
Y
L
Site 70
T611
C
G
D
G
T
L
R
T
E
L
H
L
N
H
L
Site 71
S655
A
M
K
V
L
G
I
S
P
D
E
Q
K
A
C
Site 72
S710
G
C
S
L
E
E
L
S
S
A
I
F
K
H
Q
Site 73
S711
C
S
L
E
E
L
S
S
A
I
F
K
H
Q
H
Site 74
T722
K
H
Q
H
K
G
G
T
L
Q
R
S
T
S
F
Site 75
S726
K
G
G
T
L
Q
R
S
T
S
F
R
Q
G
P
Site 76
T727
G
G
T
L
Q
R
S
T
S
F
R
Q
G
P
E
Site 77
S728
G
T
L
Q
R
S
T
S
F
R
Q
G
P
E
E
Site 78
S736
F
R
Q
G
P
E
E
S
G
L
G
D
G
T
G
Site 79
T742
E
S
G
L
G
D
G
T
G
P
K
L
S
A
L
Site 80
S747
D
G
T
G
P
K
L
S
A
L
E
C
L
E
G
Site 81
S777
L
V
N
R
A
L
K
S
S
Q
H
S
L
C
S
Site 82
S778
V
N
R
A
L
K
S
S
Q
H
S
L
C
S
M
Site 83
S784
S
S
Q
H
S
L
C
S
M
M
I
V
D
T
P
Site 84
T790
C
S
M
M
I
V
D
T
P
G
F
Q
N
P
E
Site 85
S801
Q
N
P
E
Q
G
G
S
A
R
G
A
S
F
E
Site 86
S806
G
G
S
A
R
G
A
S
F
E
E
L
C
H
N
Site 87
T815
E
E
L
C
H
N
Y
T
Q
D
R
L
Q
R
L
Site 88
T827
Q
R
L
F
H
E
R
T
F
V
Q
E
L
E
R
Site 89
Y835
F
V
Q
E
L
E
R
Y
K
E
E
N
I
E
L
Site 90
S854
L
E
P
P
T
D
D
S
V
A
A
V
D
Q
A
Site 91
S862
V
A
A
V
D
Q
A
S
H
Q
S
L
V
R
S
Site 92
S865
V
D
Q
A
S
H
Q
S
L
V
R
S
L
A
R
Site 93
S869
S
H
Q
S
L
V
R
S
L
A
R
T
D
E
A
Site 94
T873
L
V
R
S
L
A
R
T
D
E
A
R
G
L
L
Site 95
S893
E
A
L
V
P
G
A
S
E
D
T
L
L
E
R
Site 96
T896
V
P
G
A
S
E
D
T
L
L
E
R
L
F
S
Site 97
S903
T
L
L
E
R
L
F
S
Y
Y
G
P
Q
E
G
Site 98
Y904
L
L
E
R
L
F
S
Y
Y
G
P
Q
E
G
D
Site 99
Y905
L
E
R
L
F
S
Y
Y
G
P
Q
E
G
D
K
Site 100
S916
E
G
D
K
K
G
Q
S
P
L
L
H
S
S
K
Site 101
S921
G
Q
S
P
L
L
H
S
S
K
P
H
H
F
L
Site 102
S922
Q
S
P
L
L
H
S
S
K
P
H
H
F
L
L
Site 103
S965
A
P
R
L
L
Q
D
S
Q
K
K
I
I
S
N
Site 104
S985
A
G
S
A
T
V
L
S
G
S
I
A
G
L
E
Site 105
S987
S
A
T
V
L
S
G
S
I
A
G
L
E
G
G
Site 106
S995
I
A
G
L
E
G
G
S
Q
L
A
L
R
R
A
Site 107
T1003
Q
L
A
L
R
R
A
T
S
M
R
K
T
F
T
Site 108
S1004
L
A
L
R
R
A
T
S
M
R
K
T
F
T
T
Site 109
T1008
R
A
T
S
M
R
K
T
F
T
T
G
M
A
A
Site 110
T1011
S
M
R
K
T
F
T
T
G
M
A
A
V
K
K
Site 111
T1035
Q
V
D
A
L
I
D
T
I
K
K
S
K
L
H
Site 112
S1039
L
I
D
T
I
K
K
S
K
L
H
F
V
H
C
Site 113
S1060
G
W
A
G
E
P
R
S
A
S
S
R
R
V
S
Site 114
S1062
A
G
E
P
R
S
A
S
S
R
R
V
S
S
S
Site 115
S1063
G
E
P
R
S
A
S
S
R
R
V
S
S
S
S
Site 116
S1067
S
A
S
S
R
R
V
S
S
S
S
E
L
D
L
Site 117
S1068
A
S
S
R
R
V
S
S
S
S
E
L
D
L
P
Site 118
S1069
S
S
R
R
V
S
S
S
S
E
L
D
L
P
S
Site 119
S1070
S
R
R
V
S
S
S
S
E
L
D
L
P
S
G
Site 120
S1076
S
S
E
L
D
L
P
S
G
D
H
C
E
A
G
Site 121
T1094
L
D
V
P
L
L
R
T
Q
L
R
G
S
R
L
Site 122
S1099
L
R
T
Q
L
R
G
S
R
L
L
D
A
M
R
Site 123
Y1108
L
L
D
A
M
R
M
Y
R
Q
G
Y
P
D
H
Site 124
Y1140
T
K
K
H
G
R
N
Y
I
V
V
D
E
R
R
Site 125
S1162
C
L
D
L
E
K
S
S
C
C
M
G
L
S
R
Site 126
T1176
R
V
F
F
R
A
G
T
L
A
R
L
E
E
Q
Site 127
T1188
E
E
Q
R
D
E
Q
T
S
R
N
L
T
L
F
Site 128
S1189
E
Q
R
D
E
Q
T
S
R
N
L
T
L
F
Q
Site 129
T1193
E
Q
T
S
R
N
L
T
L
F
Q
A
A
C
R
Site 130
Y1202
F
Q
A
A
C
R
G
Y
L
A
R
Q
H
F
K
Site 131
S1252
P
L
I
E
V
Q
L
S
E
E
Q
I
R
N
K
Site 132
S1284
R
N
E
L
R
L
N
S
D
R
L
E
S
R
I
Site 133
S1289
L
N
S
D
R
L
E
S
R
I
S
E
L
T
S
Site 134
S1292
D
R
L
E
S
R
I
S
E
L
T
S
E
L
T
Site 135
T1295
E
S
R
I
S
E
L
T
S
E
L
T
D
E
R
Site 136
S1296
S
R
I
S
E
L
T
S
E
L
T
D
E
R
N
Site 137
T1299
S
E
L
T
S
E
L
T
D
E
R
N
T
G
E
Site 138
T1304
E
L
T
D
E
R
N
T
G
E
S
A
S
Q
L
Site 139
S1307
D
E
R
N
T
G
E
S
A
S
Q
L
L
D
A
Site 140
T1316
S
Q
L
L
D
A
E
T
A
E
R
L
R
A
E
Site 141
Y1375
G
G
E
W
R
L
K
Y
E
R
A
V
R
E
V
Site 142
T1385
A
V
R
E
V
D
F
T
K
K
R
L
Q
Q
E
Site 143
S1418
L
G
D
L
Q
A
D
S
E
E
S
Q
R
A
L
Site 144
S1421
L
Q
A
D
S
E
E
S
Q
R
A
L
Q
Q
L
Site 145
T1436
K
K
K
C
Q
R
L
T
A
E
L
Q
D
T
K
Site 146
T1442
L
T
A
E
L
Q
D
T
K
L
H
L
E
G
Q
Site 147
S1465
K
K
Q
R
R
F
D
S
E
L
S
Q
A
H
E
Site 148
S1468
R
R
F
D
S
E
L
S
Q
A
H
E
E
A
Q
Site 149
S1497
M
L
L
A
E
A
F
S
L
K
Q
Q
L
E
E
Site 150
S1518
G
F
T
Q
K
V
V
S
L
E
A
E
L
Q
D
Site 151
S1527
E
A
E
L
Q
D
I
S
S
Q
E
S
K
D
E
Site 152
S1528
A
E
L
Q
D
I
S
S
Q
E
S
K
D
E
A
Site 153
S1531
Q
D
I
S
S
Q
E
S
K
D
E
A
S
L
A
Site 154
S1536
Q
E
S
K
D
E
A
S
L
A
K
V
K
K
Q
Site 155
T1564
E
L
D
E
Q
A
G
T
I
Q
M
L
E
Q
A
Site 156
T1585
E
M
E
R
M
R
Q
T
H
S
K
E
M
E
S
Site 157
S1587
E
R
M
R
Q
T
H
S
K
E
M
E
S
R
D
Site 158
S1603
E
V
E
E
A
R
Q
S
C
Q
K
K
L
K
Q
Site 159
S1640
E
G
K
L
A
T
L
S
D
Q
V
N
R
R
D
Site 160
S1650
V
N
R
R
D
F
E
S
E
K
R
L
R
K
D
Site 161
S1678
M
L
D
H
L
K
N
S
A
P
S
K
R
E
I
Site 162
S1681
H
L
K
N
S
A
P
S
K
R
E
I
A
Q
L
Site 163
S1735
T
A
L
E
E
Q
L
S
R
L
Q
R
E
K
N
Site 164
S1802
E
K
L
Q
A
L
Q
S
Q
V
E
F
L
E
Q
Site 165
S1810
Q
V
E
F
L
E
Q
S
M
V
D
K
S
L
V
Site 166
S1815
E
Q
S
M
V
D
K
S
L
V
S
R
Q
E
A
Site 167
T1836
T
R
L
E
F
E
R
T
Q
V
K
R
L
E
S
Site 168
S1843
T
Q
V
K
R
L
E
S
L
A
S
R
L
K
E
Site 169
S1846
K
R
L
E
S
L
A
S
R
L
K
E
N
M
E
Site 170
T1883
L
Q
R
Q
L
R
D
T
K
E
E
M
G
E
L
Site 171
S1898
A
R
K
E
A
E
A
S
R
K
K
H
E
L
E
Site 172
S1910
E
L
E
M
D
L
E
S
L
E
A
A
N
Q
S
Site 173
S1942
A
I
E
D
E
M
E
S
D
E
N
E
D
L
I
Site 174
S1951
E
N
E
D
L
I
N
S
L
Q
D
M
V
T
K
Site 175
T1957
N
S
L
Q
D
M
V
T
K
Y
Q
K
R
K
N
Site 176
Y1959
L
Q
D
M
V
T
K
Y
Q
K
R
K
N
K
L
Site 177
S1970
K
N
K
L
E
G
D
S
D
V
D
S
E
L
E
Site 178
S1974
E
G
D
S
D
V
D
S
E
L
E
D
R
V
D
Site 179
S1985
D
R
V
D
G
V
K
S
W
L
S
K
N
K
G
Site 180
S1988
D
G
V
K
S
W
L
S
K
N
K
G
P
S
K
Site 181
S1994
L
S
K
N
K
G
P
S
K
A
A
S
D
D
G
Site 182
S1998
K
G
P
S
K
A
A
S
D
D
G
S
L
K
S
Site 183
S2002
K
A
A
S
D
D
G
S
L
K
S
S
S
P
T
Site 184
S2005
S
D
D
G
S
L
K
S
S
S
P
T
S
Y
W
Site 185
S2006
D
D
G
S
L
K
S
S
S
P
T
S
Y
W
K
Site 186
S2007
D
G
S
L
K
S
S
S
P
T
S
Y
W
K
S
Site 187
T2009
S
L
K
S
S
S
P
T
S
Y
W
K
S
L
A
Site 188
S2010
L
K
S
S
S
P
T
S
Y
W
K
S
L
A
P
Site 189
Y2011
K
S
S
S
P
T
S
Y
W
K
S
L
A
P
D
Site 190
S2014
S
P
T
S
Y
W
K
S
L
A
P
D
R
S
D
Site 191
S2020
K
S
L
A
P
D
R
S
D
D
E
H
D
P
L
Site 192
T2030
E
H
D
P
L
D
N
T
S
R
P
R
Y
S
H
Site 193
S2031
H
D
P
L
D
N
T
S
R
P
R
Y
S
H
S
Site 194
Y2035
D
N
T
S
R
P
R
Y
S
H
S
Y
L
S
D
Site 195
S2036
N
T
S
R
P
R
Y
S
H
S
Y
L
S
D
S
Site 196
S2038
S
R
P
R
Y
S
H
S
Y
L
S
D
S
D
T
Site 197
Y2039
R
P
R
Y
S
H
S
Y
L
S
D
S
D
T
E
Site 198
S2041
R
Y
S
H
S
Y
L
S
D
S
D
T
E
A
K
Site 199
S2043
S
H
S
Y
L
S
D
S
D
T
E
A
K
L
T
Site 200
T2045
S
Y
L
S
D
S
D
T
E
A
K
L
T
E
T
Site 201
T2050
S
D
T
E
A
K
L
T
E
T
N
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation