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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COBRA1
Full Name:
Negative elongation factor B
Alias:
Cofactor of BRCA1; KIAA1182; NELFB; NELF-B
Type:
Transcription, coactivator/corepressor
Mass (Da):
65697
Number AA:
580
UniProt ID:
Q8WX92
International Prot ID:
IPI00103483
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016481
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
E
D
L
K
E
T
L
T
N
C
T
E
P
L
K
Site 2
T35
K
A
I
E
Q
F
Q
T
E
N
G
V
L
L
P
Site 3
T56
P
F
L
D
L
H
G
T
P
R
L
E
F
H
Q
Site 4
S64
P
R
L
E
F
H
Q
S
V
F
D
E
L
R
D
Site 5
S78
D
K
L
L
E
R
V
S
A
I
A
S
E
G
K
Site 6
S82
E
R
V
S
A
I
A
S
E
G
K
A
E
E
R
Site 7
Y90
E
G
K
A
E
E
R
Y
K
K
L
E
D
L
L
Site 8
S178
E
K
E
S
A
L
F
S
T
E
L
S
V
L
H
Site 9
S189
S
V
L
H
N
F
F
S
P
S
P
K
T
R
R
Site 10
S191
L
H
N
F
F
S
P
S
P
K
T
R
R
Q
G
Site 11
T194
F
F
S
P
S
P
K
T
R
R
Q
G
E
V
V
Site 12
T205
G
E
V
V
Q
R
L
T
R
M
V
G
K
N
V
Site 13
T236
T
R
N
V
H
Y
C
T
L
R
A
E
L
L
M
Site 14
T263
V
D
P
C
H
K
F
T
W
C
L
D
A
C
I
Site 15
S277
I
R
E
R
F
V
D
S
K
R
A
R
E
L
Q
Site 16
T330
Q
E
L
V
G
Q
E
T
L
P
R
D
S
P
D
Site 17
S335
Q
E
T
L
P
R
D
S
P
D
L
L
L
L
L
Site 18
S357
G
A
W
D
M
I
D
S
Q
V
F
K
E
P
K
Site 19
Y385
M
S
F
L
V
D
D
Y
T
F
N
V
D
Q
K
Site 20
T386
S
F
L
V
D
D
Y
T
F
N
V
D
Q
K
L
Site 21
S402
A
E
E
K
A
P
V
S
Y
P
N
T
L
P
E
Site 22
Y403
E
E
K
A
P
V
S
Y
P
N
T
L
P
E
S
Site 23
T406
A
P
V
S
Y
P
N
T
L
P
E
S
F
T
K
Site 24
S410
Y
P
N
T
L
P
E
S
F
T
K
F
L
Q
E
Site 25
T492
L
F
D
G
F
F
L
T
A
S
P
R
K
E
N
Site 26
S494
D
G
F
F
L
T
A
S
P
R
K
E
N
V
H
Site 27
Y541
G
E
A
V
K
E
L
Y
S
Q
L
G
E
K
L
Site 28
S542
E
A
V
K
E
L
Y
S
Q
L
G
E
K
L
E
Site 29
S557
Q
L
D
H
R
K
P
S
P
A
Q
A
A
E
T
Site 30
T564
S
P
A
Q
A
A
E
T
P
A
L
E
L
P
L
Site 31
S573
A
L
E
L
P
L
P
S
V
P
A
P
A
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation