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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRK7
Full Name:
G protein-coupled receptor kinase 7
Alias:
EC 2.7.1.-; EC 2.7.11.16
Type:
Protein-serine kinase, AGC group, GRK family, GRK subfamily
Mass (Da):
62212
Number AA:
553
UniProt ID:
Q8WTQ7
International Prot ID:
IPI00102804
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004703
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0050896
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
GRKtide KinSub - GRK protein kinase substrate peptide - Powder PE-01ACS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACS95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
Y
L
Q
A
R
K
P
S
D
C
D
S
K
E
L
Site 2
S27
R
K
P
S
D
C
D
S
K
E
L
Q
R
R
R
Site 3
S36
E
L
Q
R
R
R
R
S
L
A
L
P
G
L
Q
Site 4
S53
A
E
L
R
Q
K
L
S
L
N
F
H
S
L
C
Site 5
S58
K
L
S
L
N
F
H
S
L
C
E
Q
Q
P
I
Site 6
T101
E
L
A
E
E
G
P
T
K
D
S
A
L
Q
G
Site 7
S127
G
N
P
Q
P
F
L
S
Q
A
V
A
T
K
C
Site 8
Y190
M
Q
P
V
S
D
K
Y
F
T
E
F
R
V
L
Site 9
Y217
V
K
N
T
G
K
M
Y
A
C
K
K
L
D
K
Site 10
Y281
G
D
L
K
F
H
I
Y
N
V
G
T
R
G
L
Site 11
S291
G
T
R
G
L
D
M
S
R
V
I
F
Y
S
A
Site 12
T348
M
K
G
G
K
P
I
T
Q
R
A
G
T
N
G
Site 13
T353
P
I
T
Q
R
A
G
T
N
G
Y
M
A
P
E
Site 14
Y356
Q
R
A
G
T
N
G
Y
M
A
P
E
I
L
M
Site 15
Y370
M
E
K
V
S
Y
S
Y
P
V
D
W
F
A
M
Site 16
T389
Y
E
M
V
A
G
R
T
P
F
K
D
Y
K
E
Site 17
Y394
G
R
T
P
F
K
D
Y
K
E
K
V
S
K
E
Site 18
T420
K
F
Q
H
D
N
F
T
E
E
A
K
D
I
C
Site 19
S441
K
P
E
Q
R
L
G
S
R
E
K
S
D
D
P
Site 20
S445
R
L
G
S
R
E
K
S
D
D
P
R
K
H
H
Site 21
T456
R
K
H
H
F
F
K
T
I
N
F
P
R
L
E
Site 22
T524
W
Q
E
E
I
I
E
T
G
L
F
E
E
L
N
Site 23
T537
L
N
D
P
N
R
P
T
G
C
E
E
G
N
S
Site 24
S544
T
G
C
E
E
G
N
S
S
K
S
G
V
C
L
Site 25
S545
G
C
E
E
G
N
S
S
K
S
G
V
C
L
L
Site 26
S547
E
E
G
N
S
S
K
S
G
V
C
L
L
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation