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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAPK15
Full Name:
Mitogen-activated protein kinase 15
Alias:
EC 2.7.11.24; ERK7; ERK8; Extracellular signal regulated kinase 8; Extracellular signal-regulated kinase 8; Mitogen-activated protein kinase 15; MK15
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24;
CMGC
group; MAPK family; Erk7 subfamily
Mass (Da):
59832
Number AA:
544
UniProt ID:
Q8TD08
International Prot ID:
IPI00165955
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004707
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Mitogen-activated protein kinase 15 (A173-A179, human) pT175+pY177 phosphopeptide - Powder PE-04ATV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATV99#Mitogen-activated protein kinase 15 (Q172-A179, human) pT175+pY177 phosphopeptide - Powder PE-04ATW80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATW80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
D
P
R
I
V
R
R
Y
L
L
R
R
Q
L
G
Site 2
T35
W
K
A
V
D
R
R
T
G
E
V
V
A
I
K
Site 3
T52
F
D
A
F
R
D
K
T
D
A
Q
R
T
F
R
Site 4
T57
D
K
T
D
A
Q
R
T
F
R
E
I
T
L
L
Site 5
T62
Q
R
T
F
R
E
I
T
L
L
Q
E
F
G
D
Site 6
Y89
A
E
N
D
R
D
I
Y
L
V
F
E
F
M
D
Site 7
T125
F
Y
Q
L
L
R
A
T
R
F
L
H
S
G
H
Site 8
S141
V
H
R
D
Q
K
P
S
N
V
L
L
D
A
N
Site 9
S161
C
D
F
G
L
A
R
S
L
G
D
L
P
E
G
Site 10
T175
G
P
E
D
Q
A
V
T
E
Y
V
A
T
R
W
Mitogen-activated protein kinase 15 (A173-A179, human) pT175+pY177 phosphopeptide - Powder PE-04ATV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATV99#Mitogen-activated protein kinase 15 (Q172-A179, human) pT175+pY177 phosphopeptide - Powder PE-04ATW80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATW80
Site 11
Y177
E
D
Q
A
V
T
E
Y
V
A
T
R
W
Y
R
Mitogen-activated protein kinase 15 (A173-A179, human) pT175+pY177 phosphopeptide - Powder PE-04ATV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATV99#Mitogen-activated protein kinase 15 (Q172-A179, human) pT175+pY177 phosphopeptide - Powder PE-04ATW80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATW80
Site 12
Y183
E
Y
V
A
T
R
W
Y
R
A
P
E
V
L
L
Site 13
S191
R
A
P
E
V
L
L
S
S
H
R
Y
T
L
G
Site 14
S192
A
P
E
V
L
L
S
S
H
R
Y
T
L
G
V
Site 15
T196
L
L
S
S
H
R
Y
T
L
G
V
D
M
W
S
Site 16
S222
R
P
L
F
P
G
T
S
T
L
H
Q
L
E
L
Site 17
S238
L
E
T
I
P
P
P
S
E
E
D
L
L
A
L
Site 18
S259
S
V
L
H
Q
L
G
S
R
P
R
Q
T
L
D
Site 19
T264
L
G
S
R
P
R
Q
T
L
D
A
L
L
P
P
Site 20
T273
D
A
L
L
P
P
D
T
S
P
E
A
L
D
L
Site 21
S294
F
A
P
D
K
R
L
S
A
T
Q
A
L
Q
H
Site 22
Y303
T
Q
A
L
Q
H
P
Y
V
Q
R
F
H
C
P
Site 23
S311
V
Q
R
F
H
C
P
S
D
E
W
A
R
E
A
Site 24
S331
A
H
E
G
V
Q
L
S
V
P
E
Y
R
S
R
Site 25
Y335
V
Q
L
S
V
P
E
Y
R
S
R
V
Y
Q
M
Site 26
Y340
P
E
Y
R
S
R
V
Y
Q
M
I
L
E
C
G
Site 27
S349
M
I
L
E
C
G
G
S
S
G
T
S
R
E
K
Site 28
T352
E
C
G
G
S
S
G
T
S
R
E
K
G
P
E
Site 29
S353
C
G
G
S
S
G
T
S
R
E
K
G
P
E
G
Site 30
S362
E
K
G
P
E
G
V
S
P
S
Q
A
H
L
H
Site 31
S364
G
P
E
G
V
S
P
S
Q
A
H
L
H
K
P
Site 32
S379
R
A
D
P
Q
L
P
S
R
T
P
V
Q
G
P
Site 33
T381
D
P
Q
L
P
S
R
T
P
V
Q
G
P
R
P
Site 34
S392
G
P
R
P
R
P
Q
S
S
P
G
H
D
P
A
Site 35
S393
P
R
P
R
P
Q
S
S
P
G
H
D
P
A
E
Site 36
S403
H
D
P
A
E
H
E
S
P
R
A
A
K
N
V
Site 37
S415
K
N
V
P
R
Q
N
S
A
P
L
L
Q
T
A
Site 38
T440
A
K
E
A
P
P
L
T
L
S
L
V
K
P
S
Site 39
S442
E
A
P
P
L
T
L
S
L
V
K
P
S
G
R
Site 40
S454
S
G
R
G
A
A
P
S
L
T
S
Q
A
A
A
Site 41
S483
G
G
G
V
R
V
A
S
V
Q
Q
V
P
P
R
Site 42
S503
R
P
G
R
R
M
F
S
T
S
A
L
Q
G
A
Site 43
T504
P
G
R
R
M
F
S
T
S
A
L
Q
G
A
Q
Site 44
S505
G
R
R
M
F
S
T
S
A
L
Q
G
A
Q
G
Site 45
Y525
L
G
G
Y
S
Q
A
Y
G
T
V
C
H
S
A
Site 46
T527
G
Y
S
Q
A
Y
G
T
V
C
H
S
A
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation