KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
THOC2
Full Name:
THO complex subunit 2
Alias:
CXorf3; DJ506G2.1; HTREX120; THO complex 2; Tho2; THO2
Type:
RNA binding protein
Mass (Da):
182775
Number AA:
1593
UniProt ID:
Q8NI27
International Prot ID:
IPI00158615
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000445
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0046784
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
H
L
C
R
I
L
S
E
N
K
S
H
D
S
Site 2
S36
R
I
L
S
E
N
K
S
H
D
S
S
T
Y
R
Site 3
S39
S
E
N
K
S
H
D
S
S
T
Y
R
D
F
Q
Site 4
S40
E
N
K
S
H
D
S
S
T
Y
R
D
F
Q
Q
Site 5
T41
N
K
S
H
D
S
S
T
Y
R
D
F
Q
Q
A
Site 6
Y50
R
D
F
Q
Q
A
L
Y
E
L
S
Y
H
V
I
Site 7
Y54
Q
A
L
Y
E
L
S
Y
H
V
I
K
G
N
L
Site 8
S67
N
L
K
H
E
Q
A
S
N
V
L
S
D
I
S
Site 9
S71
E
Q
A
S
N
V
L
S
D
I
S
E
F
R
E
Site 10
S74
S
N
V
L
S
D
I
S
E
F
R
E
D
M
P
Site 11
Y106
E
E
K
S
K
R
D
Y
F
T
Q
L
V
L
A
Site 12
T108
K
S
K
R
D
Y
F
T
Q
L
V
L
A
C
L
Site 13
T131
K
E
R
L
D
P
E
T
L
E
S
L
G
L
I
Site 14
S134
L
D
P
E
T
L
E
S
L
G
L
I
K
Q
S
Site 15
S141
S
L
G
L
I
K
Q
S
Q
Q
F
N
Q
K
S
Site 16
S148
S
Q
Q
F
N
Q
K
S
V
K
I
K
T
K
L
Site 17
Y172
L
R
E
E
N
E
G
Y
A
K
L
I
A
E
L
Site 18
S184
A
E
L
G
Q
D
L
S
G
S
I
T
S
D
L
Site 19
T188
Q
D
L
S
G
S
I
T
S
D
L
I
L
E
N
Site 20
S230
E
H
D
D
F
F
I
S
L
L
E
S
Y
M
S
Site 21
S237
S
L
L
E
S
Y
M
S
M
C
E
P
Q
T
L
Site 22
Y255
L
G
F
K
F
K
F
Y
Q
E
P
N
G
E
T
Site 23
T262
Y
Q
E
P
N
G
E
T
P
S
S
L
Y
R
V
Site 24
S265
P
N
G
E
T
P
S
S
L
Y
R
V
A
A
V
Site 25
T314
K
Q
I
V
R
K
L
T
M
V
V
L
S
S
E
Site 26
Y371
I
M
D
Q
M
P
P
Y
Y
A
A
S
H
K
L
Site 27
Y372
M
D
Q
M
P
P
Y
Y
A
A
S
H
K
L
I
Site 28
Y395
H
I
T
I
E
P
L
Y
R
R
V
G
V
P
K
Site 29
S407
V
P
K
G
A
K
G
S
P
V
N
A
L
Q
N
Site 30
S423
R
A
P
K
Q
A
E
S
F
E
D
L
R
R
D
Site 31
S458
K
V
V
R
I
G
K
S
F
M
K
E
F
Q
S
Site 32
S465
S
F
M
K
E
F
Q
S
D
G
S
K
Q
E
D
Site 33
T476
K
Q
E
D
K
E
K
T
E
V
I
L
S
C
L
Site 34
Y517
G
M
F
K
T
F
P
Y
Q
H
R
Y
R
L
Y
Site 35
Y521
T
F
P
Y
Q
H
R
Y
R
L
Y
G
Q
W
K
Site 36
Y524
Y
Q
H
R
Y
R
L
Y
G
Q
W
K
N
E
T
Site 37
Y532
G
Q
W
K
N
E
T
Y
N
S
H
P
L
L
V
Site 38
Y551
Q
T
I
D
R
A
K
Y
I
M
K
R
L
T
K
Site 39
T557
K
Y
I
M
K
R
L
T
K
E
N
V
K
P
S
Site 40
S564
T
K
E
N
V
K
P
S
G
R
Q
I
G
K
L
Site 41
S572
G
R
Q
I
G
K
L
S
H
S
N
P
T
I
L
Site 42
S574
Q
I
G
K
L
S
H
S
N
P
T
I
L
F
D
Site 43
T595
Q
K
Y
D
N
L
I
T
P
V
V
D
S
L
K
Site 44
S600
L
I
T
P
V
V
D
S
L
K
Y
L
T
S
L
Site 45
Y603
P
V
V
D
S
L
K
Y
L
T
S
L
N
Y
D
Site 46
S606
D
S
L
K
Y
L
T
S
L
N
Y
D
V
L
A
Site 47
T633
E
R
M
K
H
D
D
T
T
I
S
S
W
L
Q
Site 48
T634
R
M
K
H
D
D
T
T
I
S
S
W
L
Q
S
Site 49
S637
H
D
D
T
T
I
S
S
W
L
Q
S
L
A
S
Site 50
S673
N
Q
L
K
A
G
K
S
F
D
L
L
I
L
K
Site 51
T722
Y
F
G
Q
I
R
N
T
K
K
S
S
Q
R
L
Site 52
S725
Q
I
R
N
T
K
K
S
S
Q
R
L
K
D
A
Site 53
S726
I
R
N
T
K
K
S
S
Q
R
L
K
D
A
L
Site 54
Y770
L
K
L
V
G
K
L
Y
D
Q
C
H
D
T
L
Site 55
S786
Q
F
G
G
F
L
A
S
N
L
S
T
E
D
Y
Site 56
S789
G
F
L
A
S
N
L
S
T
E
D
Y
I
K
R
Site 57
T790
F
L
A
S
N
L
S
T
E
D
Y
I
K
R
V
Site 58
Y793
S
N
L
S
T
E
D
Y
I
K
R
V
P
S
I
Site 59
S799
D
Y
I
K
R
V
P
S
I
D
V
L
C
N
E
Site 60
Y822
F
F
L
S
R
P
M
Y
A
H
H
I
S
S
K
Site 61
Y830
A
H
H
I
S
S
K
Y
D
E
L
K
K
S
E
Site 62
S836
K
Y
D
E
L
K
K
S
E
K
G
S
K
Q
Q
Site 63
S840
L
K
K
S
E
K
G
S
K
Q
Q
H
K
V
H
Site 64
Y849
Q
Q
H
K
V
H
K
Y
I
T
S
C
E
M
V
Site 65
Y881
D
D
I
S
P
Q
F
Y
A
T
F
W
S
L
T
Site 66
S898
D
L
A
V
P
H
T
S
Y
E
R
E
V
N
K
Site 67
Y899
L
A
V
P
H
T
S
Y
E
R
E
V
N
K
L
Site 68
T932
K
K
E
K
E
R
C
T
A
L
Q
D
K
L
L
Site 69
S968
D
N
W
L
L
A
K
S
T
K
N
E
T
I
T
Site 70
T1008
E
L
V
H
Q
Q
K
T
P
N
F
S
T
L
L
Site 71
S1030
D
I
I
Y
T
V
A
S
C
T
E
N
E
A
S
Site 72
S1037
S
C
T
E
N
E
A
S
R
Y
G
R
F
L
C
Site 73
Y1039
T
E
N
E
A
S
R
Y
G
R
F
L
C
C
M
Site 74
S1055
E
T
V
T
R
W
H
S
D
R
A
T
Y
E
K
Site 75
T1059
R
W
H
S
D
R
A
T
Y
E
K
E
C
G
N
Site 76
Y1060
W
H
S
D
R
A
T
Y
E
K
E
C
G
N
Y
Site 77
Y1067
Y
E
K
E
C
G
N
Y
P
G
F
L
T
I
L
Site 78
Y1090
N
K
A
D
Q
L
D
Y
E
N
F
R
H
V
V
Site 79
Y1117
H
C
L
E
T
G
E
Y
T
H
I
R
N
I
L
Site 80
Y1163
K
E
K
R
P
D
L
Y
A
L
A
M
G
Y
S
Site 81
S1170
Y
A
L
A
M
G
Y
S
G
Q
L
K
S
R
K
Site 82
S1175
G
Y
S
G
Q
L
K
S
R
K
S
Y
M
I
P
Site 83
S1178
G
Q
L
K
S
R
K
S
Y
M
I
P
E
N
E
Site 84
Y1179
Q
L
K
S
R
K
S
Y
M
I
P
E
N
E
F
Site 85
S1199
P
P
R
N
A
V
A
S
V
Q
N
G
P
G
G
Site 86
S1209
N
G
P
G
G
G
P
S
S
S
S
I
G
S
A
Site 87
S1210
G
P
G
G
G
P
S
S
S
S
I
G
S
A
S
Site 88
S1211
P
G
G
G
P
S
S
S
S
I
G
S
A
S
K
Site 89
S1212
G
G
G
P
S
S
S
S
I
G
S
A
S
K
S
Site 90
S1215
P
S
S
S
S
I
G
S
A
S
K
S
D
E
S
Site 91
S1217
S
S
S
I
G
S
A
S
K
S
D
E
S
S
T
Site 92
S1219
S
I
G
S
A
S
K
S
D
E
S
S
T
E
E
Site 93
S1222
S
A
S
K
S
D
E
S
S
T
E
E
T
D
K
Site 94
S1223
A
S
K
S
D
E
S
S
T
E
E
T
D
K
S
Site 95
T1224
S
K
S
D
E
S
S
T
E
E
T
D
K
S
R
Site 96
T1227
D
E
S
S
T
E
E
T
D
K
S
R
E
R
S
Site 97
S1230
S
T
E
E
T
D
K
S
R
E
R
S
Q
C
G
Site 98
S1234
T
D
K
S
R
E
R
S
Q
C
G
V
K
A
V
Site 99
T1248
V
N
K
A
S
S
T
T
P
K
G
N
S
S
N
Site 100
S1253
S
T
T
P
K
G
N
S
S
N
G
N
S
G
S
Site 101
S1254
T
T
P
K
G
N
S
S
N
G
N
S
G
S
N
Site 102
S1258
G
N
S
S
N
G
N
S
G
S
N
S
N
K
A
Site 103
S1260
S
S
N
G
N
S
G
S
N
S
N
K
A
V
K
Site 104
S1262
N
G
N
S
G
S
N
S
N
K
A
V
K
E
N
Site 105
T1285
E
K
E
K
K
E
K
T
P
A
T
T
P
E
A
Site 106
T1288
K
K
E
K
T
P
A
T
T
P
E
A
R
V
L
Site 107
T1289
K
E
K
T
P
A
T
T
P
E
A
R
V
L
G
Site 108
T1317
K
D
E
K
A
R
E
T
K
E
R
T
P
K
S
Site 109
T1321
A
R
E
T
K
E
R
T
P
K
S
D
K
E
K
Site 110
S1324
T
K
E
R
T
P
K
S
D
K
E
K
E
K
F
Site 111
T1344
A
K
D
E
K
F
K
T
T
V
P
N
A
E
S
Site 112
T1345
K
D
E
K
F
K
T
T
V
P
N
A
E
S
K
Site 113
S1353
V
P
N
A
E
S
K
S
T
Q
E
R
E
R
E
Site 114
T1354
P
N
A
E
S
K
S
T
Q
E
R
E
R
E
K
Site 115
S1364
R
E
R
E
K
E
P
S
R
E
R
D
I
A
K
Site 116
S1375
D
I
A
K
E
M
K
S
K
E
N
V
K
G
G
Site 117
T1385
N
V
K
G
G
E
K
T
P
V
S
G
S
L
K
Site 118
S1388
G
G
E
K
T
P
V
S
G
S
L
K
S
P
V
Site 119
S1390
E
K
T
P
V
S
G
S
L
K
S
P
V
P
R
Site 120
S1393
P
V
S
G
S
L
K
S
P
V
P
R
S
D
I
Site 121
S1398
L
K
S
P
V
P
R
S
D
I
P
E
P
E
R
Site 122
T1414
Q
K
R
R
K
I
D
T
H
P
S
P
S
H
S
Site 123
S1417
R
K
I
D
T
H
P
S
P
S
H
S
S
T
V
Site 124
S1419
I
D
T
H
P
S
P
S
H
S
S
T
V
K
D
Site 125
S1421
T
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Site 126
S1422
H
P
S
P
S
H
S
S
T
V
K
D
S
L
I
Site 127
T1423
P
S
P
S
H
S
S
T
V
K
D
S
L
I
E
Site 128
S1427
H
S
S
T
V
K
D
S
L
I
E
L
K
E
S
Site 129
S1434
S
L
I
E
L
K
E
S
S
A
K
L
Y
I
N
Site 130
Y1439
K
E
S
S
A
K
L
Y
I
N
H
T
P
P
P
Site 131
T1443
A
K
L
Y
I
N
H
T
P
P
P
L
S
K
S
Site 132
S1448
N
H
T
P
P
P
L
S
K
S
K
E
R
E
M
Site 133
S1450
T
P
P
P
L
S
K
S
K
E
R
E
M
D
K
Site 134
S1463
D
K
K
D
L
D
K
S
R
E
R
S
R
E
R
Site 135
S1467
L
D
K
S
R
E
R
S
R
E
R
E
K
K
D
Site 136
S1486
K
E
R
K
R
D
H
S
N
N
D
R
E
V
P
Site 137
T1497
R
E
V
P
P
D
L
T
K
R
R
K
E
E
N
Site 138
T1506
R
R
K
E
E
N
G
T
M
G
V
S
K
H
K
Site 139
S1510
E
N
G
T
M
G
V
S
K
H
K
S
E
S
P
Site 140
S1514
M
G
V
S
K
H
K
S
E
S
P
C
E
S
P
Site 141
S1516
V
S
K
H
K
S
E
S
P
C
E
S
P
Y
P
Site 142
S1520
K
S
E
S
P
C
E
S
P
Y
P
N
E
K
D
Site 143
Y1522
E
S
P
C
E
S
P
Y
P
N
E
K
D
K
E
Site 144
S1533
K
D
K
E
K
N
K
S
K
S
S
G
K
E
K
Site 145
S1535
K
E
K
N
K
S
K
S
S
G
K
E
K
G
S
Site 146
S1542
S
S
G
K
E
K
G
S
D
S
F
K
S
E
K
Site 147
S1544
G
K
E
K
G
S
D
S
F
K
S
E
K
M
D
Site 148
S1547
K
G
S
D
S
F
K
S
E
K
M
D
K
I
S
Site 149
S1554
S
E
K
M
D
K
I
S
S
G
G
K
K
E
S
Site 150
S1555
E
K
M
D
K
I
S
S
G
G
K
K
E
S
R
Site 151
S1561
S
S
G
G
K
K
E
S
R
H
D
K
E
K
I
Site 152
S1576
E
K
K
E
K
R
D
S
S
G
G
K
E
E
K
Site 153
S1577
K
K
E
K
R
D
S
S
G
G
K
E
E
K
K
Site 154
S1588
E
E
K
K
H
H
K
S
S
D
K
H
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation