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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SgK288
Full Name:
Ankyrin repeat and protein kinase domain-containing protein 1
Alias:
ANKK1; ANKRD4; Ankyrin repeat and kinase domain containing 1; Ankyrin repeat domain protein 4; EC 2.7.11.1; X-kinase
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
TKL
group; RIPK family
Mass (Da):
84632
Number AA:
765
UniProt ID:
Q8NFD2
International Prot ID:
IPI00168819
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein kinase Sgk288; Protein kinase PKK2 pan-specific antibody AB-NK295-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK295-1#Protein kinase Sgk288 / Protein kinase PKK2 (G11-A29, human) peptide - Powder PE-01BFH99T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFH99T
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
T
E
L
R
L
G
S
L
P
V
F
T
R
D
Site 2
T46
A
R
H
R
R
W
R
T
E
Y
A
I
K
C
A
Site 3
Y48
H
R
R
W
R
T
E
Y
A
I
K
C
A
P
C
Site 4
S63
L
P
P
D
A
A
S
S
D
V
N
Y
L
I
E
Site 5
Y67
A
A
S
S
D
V
N
Y
L
I
E
E
A
A
K
Site 6
S111
G
S
L
E
K
V
L
S
T
H
S
L
C
W
K
Site 7
S114
E
K
V
L
S
T
H
S
L
C
W
K
L
R
F
Site 8
S155
P
G
N
I
L
L
D
S
N
M
H
V
K
I
S
Site 9
S167
K
I
S
D
F
G
L
S
K
W
M
E
Q
S
T
Site 10
Y178
E
Q
S
T
R
M
Q
Y
I
E
R
S
A
L
R
Site 11
S182
R
M
Q
Y
I
E
R
S
A
L
R
G
M
L
S
Site 12
Y190
A
L
R
G
M
L
S
Y
I
P
P
E
M
F
L
Site 13
Y207
N
K
A
P
G
P
K
Y
D
V
Y
S
F
A
I
Site 14
S245
V
A
A
G
M
R
P
S
L
Q
P
V
S
D
Q
Site 15
S250
R
P
S
L
Q
P
V
S
D
Q
W
P
S
E
A
Site 16
S301
S
R
V
A
V
P
E
S
K
A
L
A
R
K
V
Site 17
S309
K
A
L
A
R
K
V
S
C
K
L
S
L
R
Q
Site 18
S313
R
K
V
S
C
K
L
S
L
R
Q
P
G
E
V
Site 19
S325
G
E
V
N
E
D
I
S
Q
E
L
M
D
S
D
Site 20
S331
I
S
Q
E
L
M
D
S
D
S
G
N
Y
L
K
Site 21
S333
Q
E
L
M
D
S
D
S
G
N
Y
L
K
R
A
Site 22
S344
L
K
R
A
L
Q
L
S
D
R
K
N
L
V
P
Site 23
Y359
R
D
E
E
L
C
I
Y
E
N
K
V
T
P
L
Site 24
T392
E
V
D
V
D
C
Q
T
A
S
G
Y
T
P
L
Site 25
T443
A
Q
N
G
D
D
G
T
A
R
L
L
L
D
H
Site 26
T463
A
Q
E
R
E
G
W
T
P
L
H
L
A
A
Q
Site 27
T496
L
H
E
A
E
G
K
T
P
L
H
V
A
A
Y
Site 28
T529
A
Q
Q
R
N
L
R
T
P
L
H
L
A
V
E
Site 29
S559
V
P
D
A
L
D
Q
S
G
Y
G
P
L
H
T
Site 30
T566
S
G
Y
G
P
L
H
T
A
A
A
R
G
K
Y
Site 31
S585
M
L
L
R
Y
G
A
S
L
E
L
P
T
H
Q
Site 32
T595
L
P
T
H
Q
G
W
T
P
L
H
L
A
A
Y
Site 33
T661
A
A
E
Q
S
G
W
T
P
L
H
L
A
V
Q
Site 34
T694
A
R
N
K
V
G
W
T
P
A
H
L
A
A
L
Site 35
S742
S
R
K
Q
G
I
M
S
F
L
E
G
K
E
P
Site 36
S750
F
L
E
G
K
E
P
S
V
A
T
L
G
G
S
Site 37
T753
G
K
E
P
S
V
A
T
L
G
G
S
K
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation