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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPHLN1
Full Name:
Periphilin-1
Alias:
gastric cancer antigen Ga50; periphilin 1; PPHLN
Type:
Cytoskeletal protein
Mass (Da):
52737
Number AA:
458
UniProt ID:
Q8NEY8
International Prot ID:
IPI00410039
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0031424
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
W
S
E
G
R
Y
E
Y
E
R
I
P
R
Site 2
Y9
W
S
E
G
R
Y
E
Y
E
R
I
P
R
E
R
Site 3
S21
R
E
R
A
P
P
R
S
H
P
S
D
G
Y
N
Site 4
Y27
R
S
H
P
S
D
G
Y
N
R
L
V
N
I
V
Site 5
S48
L
D
R
P
G
E
G
S
Y
N
R
Y
Y
S
H
Site 6
Y49
D
R
P
G
E
G
S
Y
N
R
Y
Y
S
H
V
Site 7
Y52
G
E
G
S
Y
N
R
Y
Y
S
H
V
D
Y
R
Site 8
Y53
E
G
S
Y
N
R
Y
Y
S
H
V
D
Y
R
D
Site 9
S54
G
S
Y
N
R
Y
Y
S
H
V
D
Y
R
D
Y
Site 10
Y58
R
Y
Y
S
H
V
D
Y
R
D
Y
D
E
G
R
Site 11
Y61
S
H
V
D
Y
R
D
Y
D
E
G
R
S
F
S
Site 12
S66
R
D
Y
D
E
G
R
S
F
S
H
D
R
R
S
Site 13
S68
Y
D
E
G
R
S
F
S
H
D
R
R
S
G
P
Site 14
S73
S
F
S
H
D
R
R
S
G
P
P
H
R
G
D
Site 15
S82
P
P
H
R
G
D
E
S
G
Y
R
W
T
R
D
Site 16
T87
D
E
S
G
Y
R
W
T
R
D
D
H
S
A
S
Site 17
S92
R
W
T
R
D
D
H
S
A
S
R
Q
P
E
Y
Site 18
S94
T
R
D
D
H
S
A
S
R
Q
P
E
Y
R
D
Site 19
Y99
S
A
S
R
Q
P
E
Y
R
D
M
R
D
G
F
Site 20
S110
R
D
G
F
R
R
K
S
F
Y
S
S
H
Y
A
Site 21
Y112
G
F
R
R
K
S
F
Y
S
S
H
Y
A
R
E
Site 22
S113
F
R
R
K
S
F
Y
S
S
H
Y
A
R
E
R
Site 23
S114
R
R
K
S
F
Y
S
S
H
Y
A
R
E
R
S
Site 24
Y116
K
S
F
Y
S
S
H
Y
A
R
E
R
S
P
Y
Site 25
S121
S
H
Y
A
R
E
R
S
P
Y
K
R
D
N
T
Site 26
Y123
Y
A
R
E
R
S
P
Y
K
R
D
N
T
F
F
Site 27
T128
S
P
Y
K
R
D
N
T
F
F
R
E
S
P
V
Site 28
S133
D
N
T
F
F
R
E
S
P
V
G
R
K
D
S
Site 29
S140
S
P
V
G
R
K
D
S
P
H
S
R
S
G
S
Site 30
S143
G
R
K
D
S
P
H
S
R
S
G
S
S
V
S
Site 31
S145
K
D
S
P
H
S
R
S
G
S
S
V
S
S
R
Site 32
S147
S
P
H
S
R
S
G
S
S
V
S
S
R
S
Y
Site 33
S148
P
H
S
R
S
G
S
S
V
S
S
R
S
Y
S
Site 34
S150
S
R
S
G
S
S
V
S
S
R
S
Y
S
P
E
Site 35
S151
R
S
G
S
S
V
S
S
R
S
Y
S
P
E
R
Site 36
S153
G
S
S
V
S
S
R
S
Y
S
P
E
R
S
K
Site 37
Y154
S
S
V
S
S
R
S
Y
S
P
E
R
S
K
S
Site 38
S155
S
V
S
S
R
S
Y
S
P
E
R
S
K
S
Y
Site 39
S159
R
S
Y
S
P
E
R
S
K
S
Y
S
F
H
Q
Site 40
S161
Y
S
P
E
R
S
K
S
Y
S
F
H
Q
S
Q
Site 41
Y162
S
P
E
R
S
K
S
Y
S
F
H
Q
S
Q
H
Site 42
S163
P
E
R
S
K
S
Y
S
F
H
Q
S
Q
H
R
Site 43
S167
K
S
Y
S
F
H
Q
S
Q
H
R
K
S
V
R
Site 44
S172
H
Q
S
Q
H
R
K
S
V
R
P
G
A
S
Y
Site 45
S178
K
S
V
R
P
G
A
S
Y
K
R
Q
N
E
G
Site 46
Y179
S
V
R
P
G
A
S
Y
K
R
Q
N
E
G
N
Site 47
S197
D
K
E
R
P
V
Q
S
L
K
T
S
R
D
T
Site 48
T200
R
P
V
Q
S
L
K
T
S
R
D
T
S
P
S
Site 49
S201
P
V
Q
S
L
K
T
S
R
D
T
S
P
S
S
Site 50
T204
S
L
K
T
S
R
D
T
S
P
S
S
G
S
A
Site 51
S205
L
K
T
S
R
D
T
S
P
S
S
G
S
A
V
Site 52
S207
T
S
R
D
T
S
P
S
S
G
S
A
V
S
S
Site 53
S208
S
R
D
T
S
P
S
S
G
S
A
V
S
S
S
Site 54
S210
D
T
S
P
S
S
G
S
A
V
S
S
S
K
V
Site 55
S213
P
S
S
G
S
A
V
S
S
S
K
V
L
D
K
Site 56
S214
S
S
G
S
A
V
S
S
S
K
V
L
D
K
P
Site 57
S215
S
G
S
A
V
S
S
S
K
V
L
D
K
P
S
Site 58
S222
S
K
V
L
D
K
P
S
R
L
T
E
K
E
L
Site 59
T225
L
D
K
P
S
R
L
T
E
K
E
L
A
E
A
Site 60
S244
A
A
E
K
L
E
K
S
D
E
S
N
L
P
E
Site 61
S247
K
L
E
K
S
D
E
S
N
L
P
E
I
S
E
Site 62
S253
E
S
N
L
P
E
I
S
E
Y
E
A
G
S
T
Site 63
Y255
N
L
P
E
I
S
E
Y
E
A
G
S
T
A
P
Site 64
S259
I
S
E
Y
E
A
G
S
T
A
P
L
F
T
D
Site 65
T260
S
E
Y
E
A
G
S
T
A
P
L
F
T
D
Q
Site 66
S273
D
Q
P
E
E
P
E
S
N
T
T
H
G
I
E
Site 67
T276
E
E
P
E
S
N
T
T
H
G
I
E
L
F
E
Site 68
S285
G
I
E
L
F
E
D
S
Q
L
T
T
R
S
K
Site 69
T288
L
F
E
D
S
Q
L
T
T
R
S
K
A
I
A
Site 70
T289
F
E
D
S
Q
L
T
T
R
S
K
A
I
A
S
Site 71
T298
S
K
A
I
A
S
K
T
K
E
I
E
Q
V
Y
Site 72
Y305
T
K
E
I
E
Q
V
Y
R
Q
D
C
E
T
F
Site 73
S325
M
L
I
E
K
D
P
S
L
E
K
S
I
Q
F
Site 74
S329
K
D
P
S
L
E
K
S
I
Q
F
A
L
R
Q
Site 75
T347
E
I
E
S
A
G
Q
T
W
Q
Q
V
P
P
V
Site 76
T357
Q
V
P
P
V
R
N
T
E
M
D
H
D
G
T
Site 77
T364
T
E
M
D
H
D
G
T
P
E
N
E
G
E
E
Site 78
T372
P
E
N
E
G
E
E
T
A
Q
S
A
P
Q
P
Site 79
S375
E
G
E
E
T
A
Q
S
A
P
Q
P
P
Q
A
Site 80
T396
R
K
K
R
V
R
R
T
T
Q
L
R
R
T
T
Site 81
T397
K
K
R
V
R
R
T
T
Q
L
R
R
T
T
G
Site 82
T402
R
T
T
Q
L
R
R
T
T
G
A
P
D
I
T
Site 83
T403
T
T
Q
L
R
R
T
T
G
A
P
D
I
T
W
Site 84
T427
A
E
R
I
L
L
R
T
Q
T
P
F
T
P
E
Site 85
T429
R
I
L
L
R
T
Q
T
P
F
T
P
E
N
L
Site 86
T432
L
R
T
Q
T
P
F
T
P
E
N
L
F
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation