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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDHD1
Full Name:
Phospholipase DDHD1
Alias:
DDHD domain containing 1; DDHD domain-containing protein 1;Phosphatidic acid-preferring phospholipase A1 homolog;PA-PLA1; KIAA1705; PA-PLA1; Phosphatidic acid-preferring phospholipase A1
Type:
EC 3.1.1.-; Phospholipase
Mass (Da):
100435
Number AA:
900
UniProt ID:
Q8NEL9
International Prot ID:
IPI00376941
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016787
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
N
Y
P
G
R
G
S
P
R
S
P
E
H
N
Site 2
S11
P
G
R
G
S
P
R
S
P
E
H
N
G
R
G
Site 3
S28
G
G
A
W
E
L
G
S
D
A
R
P
A
F
G
Site 4
T71
G
L
H
L
A
P
G
T
D
D
H
N
H
H
L
Site 5
S85
L
A
L
D
P
C
L
S
D
E
N
Y
D
F
S
Site 6
Y89
P
C
L
S
D
E
N
Y
D
F
S
S
A
E
S
Site 7
S92
S
D
E
N
Y
D
F
S
S
A
E
S
G
S
S
Site 8
S93
D
E
N
Y
D
F
S
S
A
E
S
G
S
S
L
Site 9
S96
Y
D
F
S
S
A
E
S
G
S
S
L
R
Y
Y
Site 10
S99
S
S
A
E
S
G
S
S
L
R
Y
Y
S
E
G
Site 11
Y102
E
S
G
S
S
L
R
Y
Y
S
E
G
E
S
G
Site 12
Y103
S
G
S
S
L
R
Y
Y
S
E
G
E
S
G
G
Site 13
S104
G
S
S
L
R
Y
Y
S
E
G
E
S
G
G
G
Site 14
S108
R
Y
Y
S
E
G
E
S
G
G
G
G
S
S
L
Site 15
S114
E
S
G
G
G
G
S
S
L
S
L
H
P
P
Q
Site 16
S116
G
G
G
G
S
S
L
S
L
H
P
P
Q
Q
P
Site 17
S130
P
P
L
V
P
T
N
S
G
G
G
G
A
T
G
Site 18
S139
G
G
G
A
T
G
G
S
P
G
E
R
K
R
T
Site 19
T146
S
P
G
E
R
K
R
T
R
L
G
G
P
A
A
Site 20
Y157
G
P
A
A
R
H
R
Y
E
V
V
T
E
L
G
Site 21
Y172
P
E
E
V
R
W
F
Y
K
E
D
K
K
T
W
Site 22
T200
A
F
R
T
L
L
Q
T
T
G
A
R
P
Q
G
Site 23
S217
R
D
G
D
H
V
C
S
P
T
G
P
A
S
S
Site 24
T219
G
D
H
V
C
S
P
T
G
P
A
S
S
S
G
Site 25
S223
C
S
P
T
G
P
A
S
S
S
G
E
D
D
D
Site 26
S225
P
T
G
P
A
S
S
S
G
E
D
D
D
E
D
Site 27
S240
R
A
C
G
F
C
Q
S
T
T
G
H
E
P
E
Site 28
Y264
V
C
V
R
G
G
L
Y
E
V
D
V
T
Q
G
Site 29
T269
G
L
Y
E
V
D
V
T
Q
G
E
C
Y
P
V
Site 30
Y277
Q
G
E
C
Y
P
V
Y
W
N
Q
A
D
K
I
Site 31
S305
Q
P
L
E
E
E
E
S
N
L
I
E
Q
E
H
Site 32
S332
F
D
I
E
V
S
K
S
I
D
G
K
D
A
V
Site 33
S341
D
G
K
D
A
V
H
S
F
K
L
S
R
N
H
Site 34
Y358
W
H
S
V
D
E
V
Y
L
Y
S
D
A
T
T
Site 35
Y360
S
V
D
E
V
Y
L
Y
S
D
A
T
T
S
K
Site 36
T371
T
T
S
K
I
A
R
T
V
T
Q
K
L
G
F
Site 37
T373
S
K
I
A
R
T
V
T
Q
K
L
G
F
S
K
Site 38
S379
V
T
Q
K
L
G
F
S
K
A
S
S
S
G
T
Site 39
S382
K
L
G
F
S
K
A
S
S
S
G
T
R
L
H
Site 40
S383
L
G
F
S
K
A
S
S
S
G
T
R
L
H
R
Site 41
S384
G
F
S
K
A
S
S
S
G
T
R
L
H
R
G
Site 42
T386
S
K
A
S
S
S
G
T
R
L
H
R
G
Y
V
Site 43
Y392
G
T
R
L
H
R
G
Y
V
E
E
A
T
L
E
Site 44
T397
R
G
Y
V
E
E
A
T
L
E
D
K
P
S
Q
Site 45
S403
A
T
L
E
D
K
P
S
Q
T
T
H
I
V
F
Site 46
T428
Q
G
R
I
I
K
N
T
A
M
M
R
E
A
A
Site 47
S444
K
I
E
E
R
H
F
S
N
H
A
T
H
V
E
Site 48
T448
R
H
F
S
N
H
A
T
H
V
E
F
L
P
V
Site 49
T467
K
L
T
L
D
G
D
T
V
D
S
I
T
P
D
Site 50
S470
L
D
G
D
T
V
D
S
I
T
P
D
K
V
R
Site 51
T472
G
D
T
V
D
S
I
T
P
D
K
V
R
G
L
Site 52
S485
G
L
R
D
M
L
N
S
S
A
M
D
I
M
Y
Site 53
Y492
S
S
A
M
D
I
M
Y
Y
T
S
P
L
Y
R
Site 54
Y493
S
A
M
D
I
M
Y
Y
T
S
P
L
Y
R
D
Site 55
Y498
M
Y
Y
T
S
P
L
Y
R
D
E
L
V
K
G
Site 56
Y514
Q
Q
E
L
N
R
L
Y
S
L
F
C
S
R
N
Site 57
S515
Q
E
L
N
R
L
Y
S
L
F
C
S
R
N
P
Site 58
S519
R
L
Y
S
L
F
C
S
R
N
P
D
F
E
E
Site 59
S532
E
E
K
G
G
K
V
S
I
V
S
H
S
L
G
Site 60
Y556
G
W
N
P
V
R
L
Y
E
Q
L
L
Q
K
E
Site 61
S573
L
P
D
E
R
W
M
S
Y
E
E
R
H
L
L
Site 62
Y574
P
D
E
R
W
M
S
Y
E
E
R
H
L
L
D
Site 63
Y584
R
H
L
L
D
E
L
Y
I
T
K
R
R
L
K
Site 64
T586
L
L
D
E
L
Y
I
T
K
R
R
L
K
E
I
Site 65
S603
R
L
H
G
L
K
A
S
S
M
T
Q
T
P
A
Site 66
S604
L
H
G
L
K
A
S
S
M
T
Q
T
P
A
L
Site 67
T608
K
A
S
S
M
T
Q
T
P
A
L
K
F
K
V
Site 68
S641
I
R
P
G
N
T
G
S
Q
D
H
I
L
P
R
Site 69
Y676
E
P
L
I
L
K
H
Y
S
N
I
S
P
V
Q
Site 70
Y687
S
P
V
Q
I
H
W
Y
N
T
S
N
P
L
P
Site 71
Y695
N
T
S
N
P
L
P
Y
E
H
M
K
P
S
F
Site 72
S701
P
Y
E
H
M
K
P
S
F
L
N
P
A
K
E
Site 73
S711
N
P
A
K
E
P
T
S
V
S
E
N
E
G
I
Site 74
S713
A
K
E
P
T
S
V
S
E
N
E
G
I
S
T
Site 75
S719
V
S
E
N
E
G
I
S
T
I
P
S
P
V
T
Site 76
T720
S
E
N
E
G
I
S
T
I
P
S
P
V
T
S
Site 77
S723
E
G
I
S
T
I
P
S
P
V
T
S
P
V
L
Site 78
T726
S
T
I
P
S
P
V
T
S
P
V
L
S
R
R
Site 79
S727
T
I
P
S
P
V
T
S
P
V
L
S
R
R
H
Site 80
S731
P
V
T
S
P
V
L
S
R
R
H
Y
G
E
S
Site 81
Y735
P
V
L
S
R
R
H
Y
G
E
S
I
T
N
I
Site 82
S738
S
R
R
H
Y
G
E
S
I
T
N
I
G
K
A
Site 83
S763
G
L
G
G
M
L
F
S
R
F
G
R
S
S
T
Site 84
S768
L
F
S
R
F
G
R
S
S
T
T
Q
S
S
E
Site 85
S769
F
S
R
F
G
R
S
S
T
T
Q
S
S
E
T
Site 86
T770
S
R
F
G
R
S
S
T
T
Q
S
S
E
T
S
Site 87
T771
R
F
G
R
S
S
T
T
Q
S
S
E
T
S
K
Site 88
S773
G
R
S
S
T
T
Q
S
S
E
T
S
K
D
S
Site 89
S774
R
S
S
T
T
Q
S
S
E
T
S
K
D
S
M
Site 90
S777
T
T
Q
S
S
E
T
S
K
D
S
M
E
D
E
Site 91
S780
S
S
E
T
S
K
D
S
M
E
D
E
K
K
P
Site 92
S790
D
E
K
K
P
V
A
S
P
S
A
T
T
V
G
Site 93
S792
K
K
P
V
A
S
P
S
A
T
T
V
G
T
Q
Site 94
T800
A
T
T
V
G
T
Q
T
L
P
H
S
S
S
G
Site 95
S804
G
T
Q
T
L
P
H
S
S
S
G
F
L
D
S
Site 96
S806
Q
T
L
P
H
S
S
S
G
F
L
D
S
A
Y
Site 97
S811
S
S
S
G
F
L
D
S
A
Y
F
R
L
Q
E
Site 98
Y813
S
G
F
L
D
S
A
Y
F
R
L
Q
E
S
F
Site 99
S819
A
Y
F
R
L
Q
E
S
F
F
N
L
P
Q
L
Site 100
Y860
E
G
L
V
E
S
R
Y
W
S
A
V
T
S
H
Site 101
S862
L
V
E
S
R
Y
W
S
A
V
T
S
H
T
A
Site 102
T868
W
S
A
V
T
S
H
T
A
Y
W
S
S
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation