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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ephexin1
Full Name:
Ephexin-1
Alias:
Ephexin; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; NGEF
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
82478
Number AA:
710
UniProt ID:
Q8N5V2
International Prot ID:
IPI00166928
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0030426
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0030154
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
T
R
E
S
E
D
L
E
K
T
R
Site 2
T12
E
S
E
D
L
E
K
T
R
R
K
S
A
S
D
Site 3
S16
L
E
K
T
R
R
K
S
A
S
D
Q
W
N
T
Site 4
S18
K
T
R
R
K
S
A
S
D
Q
W
N
T
D
N
Site 5
S63
H
I
P
I
K
R
N
S
I
F
N
R
S
I
R
Site 6
S68
R
N
S
I
F
N
R
S
I
R
R
K
S
K
A
Site 7
S73
N
R
S
I
R
R
K
S
K
A
K
A
R
D
N
Site 8
S86
D
N
P
E
R
N
A
S
C
L
A
D
S
Q
D
Site 9
S91
N
A
S
C
L
A
D
S
Q
D
N
G
K
S
V
Site 10
S97
D
S
Q
D
N
G
K
S
V
N
E
P
L
T
L
Site 11
T103
K
S
V
N
E
P
L
T
L
N
I
P
W
S
R
Site 12
T120
P
C
R
T
A
M
Q
T
D
P
G
A
Q
E
M
Site 13
S128
D
P
G
A
Q
E
M
S
E
S
S
S
T
P
G
Site 14
S130
G
A
Q
E
M
S
E
S
S
S
T
P
G
N
G
Site 15
S131
A
Q
E
M
S
E
S
S
S
T
P
G
N
G
A
Site 16
S132
Q
E
M
S
E
S
S
S
T
P
G
N
G
A
T
Site 17
T133
E
M
S
E
S
S
S
T
P
G
N
G
A
T
P
Site 18
T139
S
T
P
G
N
G
A
T
P
E
E
W
P
A
L
Site 19
S149
E
W
P
A
L
A
D
S
P
T
T
L
T
E
A
Site 20
T151
P
A
L
A
D
S
P
T
T
L
T
E
A
L
R
Site 21
Y179
I
E
Q
I
G
L
L
Y
Q
E
Y
R
D
K
S
Site 22
Y182
I
G
L
L
Y
Q
E
Y
R
D
K
S
T
L
Q
Site 23
S186
Y
Q
E
Y
R
D
K
S
T
L
Q
E
I
E
T
Site 24
T193
S
T
L
Q
E
I
E
T
R
R
Q
Q
D
A
E
Site 25
S208
I
E
D
N
T
N
G
S
P
A
S
E
D
T
P
Site 26
T214
G
S
P
A
S
E
D
T
P
E
E
E
E
E
E
Site 27
S229
E
E
E
E
E
P
A
S
P
P
E
R
K
T
L
Site 28
T235
A
S
P
P
E
R
K
T
L
P
Q
I
C
L
L
Site 29
S243
L
P
Q
I
C
L
L
S
N
P
H
S
R
F
N
Site 30
S284
A
M
F
E
L
V
T
S
E
A
S
Y
Y
K
S
Site 31
S287
E
L
V
T
S
E
A
S
Y
Y
K
S
L
N
L
Site 32
Y288
L
V
T
S
E
A
S
Y
Y
K
S
L
N
L
L
Site 33
Y289
V
T
S
E
A
S
Y
Y
K
S
L
N
L
L
V
Site 34
S291
S
E
A
S
Y
Y
K
S
L
N
L
L
V
S
H
Site 35
S297
K
S
L
N
L
L
V
S
H
F
M
E
N
E
R
Site 36
Y353
S
D
V
C
D
I
V
Y
R
Y
A
A
D
H
F
Site 37
Y363
A
A
D
H
F
S
V
Y
I
T
Y
V
S
N
Q
Site 38
Y366
H
F
S
V
Y
I
T
Y
V
S
N
Q
T
Y
Q
Site 39
Y372
T
Y
V
S
N
Q
T
Y
Q
E
R
T
Y
K
Q
Site 40
Y377
Q
T
Y
Q
E
R
T
Y
K
Q
L
L
Q
E
K
Site 41
S434
L
K
R
V
E
E
R
S
E
R
E
C
T
A
L
Site 42
T439
E
R
S
E
R
E
C
T
A
L
D
A
H
K
E
Site 43
S462
N
E
G
V
R
K
M
S
R
T
E
Q
M
I
S
Site 44
T464
G
V
R
K
M
S
R
T
E
Q
M
I
S
I
Q
Site 45
S469
S
R
T
E
Q
M
I
S
I
Q
K
K
M
E
F
Site 46
S480
K
M
E
F
K
I
K
S
V
P
I
I
S
H
S
Site 47
S500
Q
G
E
L
Q
Q
M
S
G
P
K
T
S
R
T
Site 48
T504
Q
Q
M
S
G
P
K
T
S
R
T
L
R
T
K
Site 49
T507
S
G
P
K
T
S
R
T
L
R
T
K
K
L
F
Site 50
Y518
K
K
L
F
H
E
I
Y
L
F
L
F
N
D
L
Site 51
Y537
R
Q
I
P
G
D
K
Y
Q
V
F
D
S
A
P
Site 52
S542
D
K
Y
Q
V
F
D
S
A
P
R
G
L
L
R
Site 53
T578
N
A
D
D
R
E
A
T
Y
M
L
K
A
S
S
Site 54
Y579
A
D
D
R
E
A
T
Y
M
L
K
A
S
S
Q
Site 55
S585
T
Y
M
L
K
A
S
S
Q
S
E
M
K
R
W
Site 56
T594
S
E
M
K
R
W
M
T
S
L
A
P
N
R
R
Site 57
S595
E
M
K
R
W
M
T
S
L
A
P
N
R
R
T
Site 58
T602
S
L
A
P
N
R
R
T
K
F
V
S
F
T
S
Site 59
S606
N
R
R
T
K
F
V
S
F
T
S
R
L
L
D
Site 60
Y623
Q
V
Q
C
V
H
P
Y
V
A
Q
Q
P
D
E
Site 61
T632
A
Q
Q
P
D
E
L
T
L
E
L
A
D
I
L
Site 62
S665
Q
E
R
G
W
F
P
S
S
M
T
E
E
I
L
Site 63
S666
E
R
G
W
F
P
S
S
M
T
E
E
I
L
N
Site 64
S678
I
L
N
P
K
I
R
S
Q
N
L
K
E
C
F
Site 65
S696
K
M
D
D
P
Q
R
S
Q
N
K
D
R
R
K
Site 66
S706
K
D
R
R
K
L
G
S
R
N
R
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation