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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Abi-1
Full Name:
Abl interactor 1
Alias:
Abelson interactor 1; ABI1; ABI-1; Abl-binding protein 4; Abl-interactor 1; Ablphilin-1; E3B1; Eps8 binding protein; Eps8 SH3 domain-binding protein; Interactor protein AblBP4; Nap1-binding protein; Spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; SSH3BP1
Type:
Adapter/scaffold protein
Mass (Da):
55081
Number AA:
508
UniProt ID:
Q8IZP0
International Prot ID:
IPI00431025
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005856
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
GO:0018108
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
L
E
E
E
I
P
S
G
K
R
A
L
I
E
Site 2
S22
G
K
R
A
L
I
E
S
Y
Q
N
L
T
R
V
Site 3
Y23
K
R
A
L
I
E
S
Y
Q
N
L
T
R
V
A
Site 4
Y32
N
L
T
R
V
A
D
Y
C
E
N
N
Y
I
Q
Site 5
Y53
A
L
E
E
T
K
A
Y
T
T
Q
S
L
A
S
Site 6
S57
T
K
A
Y
T
T
Q
S
L
A
S
V
A
Y
Q
Site 7
S81
Q
L
L
D
I
Q
A
S
Q
L
R
R
M
E
S
Site 8
S88
S
Q
L
R
R
M
E
S
S
I
N
H
I
S
Q
Site 9
S89
Q
L
R
R
M
E
S
S
I
N
H
I
S
Q
T
Site 10
S94
E
S
S
I
N
H
I
S
Q
T
V
D
I
H
K
Site 11
T113
R
R
E
I
G
I
L
T
T
N
K
N
T
S
R
Site 12
Y136
N
M
E
R
P
V
R
Y
I
R
K
P
I
D
Y
Site 13
Y143
Y
I
R
K
P
I
D
Y
T
V
L
D
D
V
G
Site 14
T144
I
R
K
P
I
D
Y
T
V
L
D
D
V
G
H
Site 15
T170
N
Q
P
A
R
T
G
T
L
S
R
T
N
P
P
Site 16
S172
P
A
R
T
G
T
L
S
R
T
N
P
P
T
Q
Site 17
T174
R
T
G
T
L
S
R
T
N
P
P
T
Q
K
P
Site 18
T178
L
S
R
T
N
P
P
T
Q
K
P
P
S
P
P
Site 19
S183
P
P
T
Q
K
P
P
S
P
P
M
S
G
R
G
Site 20
S187
K
P
P
S
P
P
M
S
G
R
G
T
L
G
R
Site 21
T191
P
P
M
S
G
R
G
T
L
G
R
N
T
P
Y
Site 22
T196
R
G
T
L
G
R
N
T
P
Y
K
T
L
E
P
Site 23
Y198
T
L
G
R
N
T
P
Y
K
T
L
E
P
V
K
Site 24
T200
G
R
N
T
P
Y
K
T
L
E
P
V
K
P
P
Site 25
T208
L
E
P
V
K
P
P
T
V
P
N
D
Y
M
T
Site 26
Y213
P
P
T
V
P
N
D
Y
M
T
S
P
A
R
L
Site 27
T215
T
V
P
N
D
Y
M
T
S
P
A
R
L
G
S
Site 28
S216
V
P
N
D
Y
M
T
S
P
A
R
L
G
S
Q
Site 29
S222
T
S
P
A
R
L
G
S
Q
H
S
P
G
R
T
Site 30
S225
A
R
L
G
S
Q
H
S
P
G
R
T
A
S
L
Site 31
T229
S
Q
H
S
P
G
R
T
A
S
L
N
Q
R
P
Site 32
S231
H
S
P
G
R
T
A
S
L
N
Q
R
P
R
T
Site 33
T238
S
L
N
Q
R
P
R
T
H
S
G
S
S
G
G
Site 34
S240
N
Q
R
P
R
T
H
S
G
S
S
G
G
S
G
Site 35
S242
R
P
R
T
H
S
G
S
S
G
G
S
G
S
R
Site 36
S243
P
R
T
H
S
G
S
S
G
G
S
G
S
R
E
Site 37
S246
H
S
G
S
S
G
G
S
G
S
R
E
N
S
G
Site 38
S248
G
S
S
G
G
S
G
S
R
E
N
S
G
S
S
Site 39
S252
G
S
G
S
R
E
N
S
G
S
S
S
I
G
I
Site 40
S254
G
S
R
E
N
S
G
S
S
S
I
G
I
P
I
Site 41
S256
R
E
N
S
G
S
S
S
I
G
I
P
I
A
V
Site 42
T265
G
I
P
I
A
V
P
T
P
S
P
P
T
I
G
Site 43
S267
P
I
A
V
P
T
P
S
P
P
T
I
G
P
E
Site 44
T270
V
P
T
P
S
P
P
T
I
G
P
E
N
I
S
Site 45
S277
T
I
G
P
E
N
I
S
V
P
P
P
S
G
A
Site 46
S282
N
I
S
V
P
P
P
S
G
A
P
P
A
P
P
Site 47
S309
A
P
G
S
A
P
G
S
Q
Y
G
T
M
T
R
Site 48
T313
A
P
G
S
Q
Y
G
T
M
T
R
Q
I
S
R
Site 49
T315
G
S
Q
Y
G
T
M
T
R
Q
I
S
R
H
N
Site 50
S319
G
T
M
T
R
Q
I
S
R
H
N
S
T
T
S
Site 51
S323
R
Q
I
S
R
H
N
S
T
T
S
S
T
S
S
Site 52
T324
Q
I
S
R
H
N
S
T
T
S
S
T
S
S
G
Site 53
T325
I
S
R
H
N
S
T
T
S
S
T
S
S
G
G
Site 54
S326
S
R
H
N
S
T
T
S
S
T
S
S
G
G
Y
Site 55
S327
R
H
N
S
T
T
S
S
T
S
S
G
G
Y
R
Site 56
T328
H
N
S
T
T
S
S
T
S
S
G
G
Y
R
R
Site 57
S329
N
S
T
T
S
S
T
S
S
G
G
Y
R
R
T
Site 58
S330
S
T
T
S
S
T
S
S
G
G
Y
R
R
T
P
Site 59
Y333
S
S
T
S
S
G
G
Y
R
R
T
P
S
V
T
Site 60
T336
S
S
G
G
Y
R
R
T
P
S
V
T
A
Q
F
Site 61
S338
G
G
Y
R
R
T
P
S
V
T
A
Q
F
S
A
Site 62
T340
Y
R
R
T
P
S
V
T
A
Q
F
S
A
Q
P
Site 63
Y355
H
V
N
G
G
P
L
Y
S
Q
N
S
I
S
I
Site 64
S356
V
N
G
G
P
L
Y
S
Q
N
S
I
S
I
A
Site 65
S359
G
P
L
Y
S
Q
N
S
I
S
I
A
P
P
P
Site 66
S361
L
Y
S
Q
N
S
I
S
I
A
P
P
P
P
P
Site 67
T373
P
P
P
M
P
Q
L
T
P
Q
I
P
L
T
G
Site 68
S392
V
Q
E
N
I
A
D
S
P
T
P
P
P
P
P
Site 69
T394
E
N
I
A
D
S
P
T
P
P
P
P
P
P
P
Site 70
S410
D
I
P
M
F
D
D
S
P
P
P
P
P
P
P
Site 71
Y421
P
P
P
P
P
V
D
Y
E
D
E
E
A
A
V
Site 72
Y431
E
E
A
A
V
V
Q
Y
N
D
P
Y
A
D
G
Site 73
Y435
V
V
Q
Y
N
D
P
Y
A
D
G
D
P
A
W
Site 74
Y455
I
E
K
V
V
A
I
Y
D
Y
T
K
D
K
D
Site 75
Y457
K
V
V
A
I
Y
D
Y
T
K
D
K
D
D
E
Site 76
T458
V
V
A
I
Y
D
Y
T
K
D
K
D
D
E
L
Site 77
S466
K
D
K
D
D
E
L
S
F
M
E
G
A
I
I
Site 78
Y484
K
K
N
D
D
G
W
Y
E
G
V
C
N
R
V
Site 79
T492
E
G
V
C
N
R
V
T
G
L
F
P
G
N
Y
Site 80
Y499
T
G
L
F
P
G
N
Y
V
E
S
I
M
H
Y
Site 81
S502
F
P
G
N
Y
V
E
S
I
M
H
Y
T
D
_
Site 82
Y506
Y
V
E
S
I
M
H
Y
T
D
_
_
_
_
_
Site 83
T507
V
E
S
I
M
H
Y
T
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation