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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHACTR4
Full Name:
Phosphatase and actin regulator 4
Alias:
FLJ13171; PHAR4; PRO2963
Type:
Phosphatase, actin binding protein
Mass (Da):
78211
Number AA:
702
UniProt ID:
Q8IZ21
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004864
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
F
E
E
A
D
Q
P
T
T
E
P
G
M
V
L
Site 2
S21
E
P
G
M
V
L
D
S
V
E
A
G
D
T
T
Site 3
T27
D
S
V
E
A
G
D
T
T
P
P
T
K
R
K
Site 4
T28
S
V
E
A
G
D
T
T
P
P
T
K
R
K
S
Site 5
T31
A
G
D
T
T
P
P
T
K
R
K
S
K
F
S
Site 6
S35
T
P
P
T
K
R
K
S
K
F
S
G
F
G
K
Site 7
S38
T
K
R
K
S
K
F
S
G
F
G
K
I
F
K
Site 8
S54
W
K
W
R
K
K
K
S
S
D
K
F
K
E
T
Site 9
S55
K
W
R
K
K
K
S
S
D
K
F
K
E
T
S
Site 10
S70
E
V
L
E
R
K
I
S
M
R
K
P
R
E
E
Site 11
S99
G
E
D
P
G
K
P
S
D
A
M
L
K
N
G
Site 12
T109
M
L
K
N
G
H
T
T
P
I
G
N
A
R
S
Site 13
S116
T
P
I
G
N
A
R
S
S
S
P
V
Q
V
E
Site 14
S117
P
I
G
N
A
R
S
S
S
P
V
Q
V
E
E
Site 15
S118
I
G
N
A
R
S
S
S
P
V
Q
V
E
E
E
Site 16
S131
E
E
P
V
R
L
A
S
L
R
K
A
I
P
E
Site 17
S147
D
L
K
K
R
L
G
S
T
G
S
Q
P
N
S
Site 18
T148
L
K
K
R
L
G
S
T
G
S
Q
P
N
S
E
Site 19
S150
K
R
L
G
S
T
G
S
Q
P
N
S
E
A
E
Site 20
S154
S
T
G
S
Q
P
N
S
E
A
E
S
V
P
E
Site 21
S158
Q
P
N
S
E
A
E
S
V
P
E
N
V
P
K
Site 22
S176
L
P
P
K
R
P
L
S
S
S
H
E
A
S
E
Site 23
S177
P
P
K
R
P
L
S
S
S
H
E
A
S
E
G
Site 24
S178
P
K
R
P
L
S
S
S
H
E
A
S
E
G
Q
Site 25
S182
L
S
S
S
H
E
A
S
E
G
Q
A
K
D
A
Site 26
T190
E
G
Q
A
K
D
A
T
S
S
G
G
T
A
R
Site 27
T195
D
A
T
S
S
G
G
T
A
R
F
I
I
S
T
Site 28
T226
K
T
V
N
L
S
V
T
P
S
P
A
P
R
T
Site 29
S228
V
N
L
S
V
T
P
S
P
A
P
R
T
L
P
Site 30
T233
T
P
S
P
A
P
R
T
L
P
A
A
P
A
S
Site 31
S240
T
L
P
A
A
P
A
S
T
N
T
T
A
T
P
Site 32
T244
A
P
A
S
T
N
T
T
A
T
P
S
L
T
H
Site 33
T246
A
S
T
N
T
T
A
T
P
S
L
T
H
M
V
Site 34
S248
T
N
T
T
A
T
P
S
L
T
H
M
V
P
A
Site 35
S270
P
K
P
A
H
R
N
S
N
P
V
I
A
E
L
Site 36
T285
S
Q
A
I
N
S
G
T
L
L
S
K
P
S
P
Site 37
S288
I
N
S
G
T
L
L
S
K
P
S
P
P
L
P
Site 38
S291
G
T
L
L
S
K
P
S
P
P
L
P
P
K
R
Site 39
S302
P
P
K
R
G
I
P
S
T
S
V
P
T
L
E
Site 40
T303
P
K
R
G
I
P
S
T
S
V
P
T
L
E
S
Site 41
S304
K
R
G
I
P
S
T
S
V
P
T
L
E
S
A
Site 42
T316
E
S
A
A
A
I
T
T
K
T
P
S
D
E
R
Site 43
T318
A
A
A
I
T
T
K
T
P
S
D
E
R
E
K
Site 44
S320
A
I
T
T
K
T
P
S
D
E
R
E
K
S
T
Site 45
S326
P
S
D
E
R
E
K
S
T
C
S
M
G
S
E
Site 46
S329
E
R
E
K
S
T
C
S
M
G
S
E
L
L
P
Site 47
S339
S
E
L
L
P
M
I
S
P
R
S
P
S
P
P
Site 48
S342
L
P
M
I
S
P
R
S
P
S
P
P
L
P
T
Site 49
S344
M
I
S
P
R
S
P
S
P
P
L
P
T
H
I
Site 50
T349
S
P
S
P
P
L
P
T
H
I
P
P
E
P
P
Site 51
T358
I
P
P
E
P
P
R
T
P
P
F
P
A
K
T
Site 52
S377
P
E
I
E
F
P
P
S
L
D
L
H
Q
E
I
Site 53
S410
F
G
E
P
H
I
P
S
R
L
P
P
L
P
L
Site 54
S427
R
I
Q
Q
A
L
T
S
P
L
P
M
T
P
I
Site 55
T432
L
T
S
P
L
P
M
T
P
I
L
E
G
S
H
Site 56
S438
M
T
P
I
L
E
G
S
H
R
A
H
S
L
L
Site 57
S443
E
G
S
H
R
A
H
S
L
L
F
E
N
S
D
Site 58
S449
H
S
L
L
F
E
N
S
D
S
F
S
E
D
S
Site 59
S451
L
L
F
E
N
S
D
S
F
S
E
D
S
S
T
Site 60
S453
F
E
N
S
D
S
F
S
E
D
S
S
T
L
G
Site 61
S456
S
D
S
F
S
E
D
S
S
T
L
G
R
T
R
Site 62
S457
D
S
F
S
E
D
S
S
T
L
G
R
T
R
S
Site 63
T458
S
F
S
E
D
S
S
T
L
G
R
T
R
S
L
Site 64
T462
D
S
S
T
L
G
R
T
R
S
L
P
I
T
I
Site 65
S464
S
T
L
G
R
T
R
S
L
P
I
T
I
E
M
Site 66
T468
R
T
R
S
L
P
I
T
I
E
M
L
K
V
P
Site 67
T484
D
E
E
E
E
E
Q
T
C
P
S
T
F
S
E
Site 68
S487
E
E
E
Q
T
C
P
S
T
F
S
E
E
M
T
Site 69
T488
E
E
Q
T
C
P
S
T
F
S
E
E
M
T
P
Site 70
S490
Q
T
C
P
S
T
F
S
E
E
M
T
P
T
S
Site 71
T494
S
T
F
S
E
E
M
T
P
T
S
V
I
P
K
Site 72
T496
F
S
E
E
M
T
P
T
S
V
I
P
K
L
P
Site 73
S497
S
E
E
M
T
P
T
S
V
I
P
K
L
P
Q
Site 74
S514
R
E
E
E
E
K
E
S
D
S
D
S
E
G
P
Site 75
S516
E
E
E
K
E
S
D
S
D
S
E
G
P
I
Q
Site 76
S518
E
K
E
S
D
S
D
S
E
G
P
I
Q
Y
R
Site 77
S533
D
E
E
D
E
D
E
S
Y
Q
S
A
L
A
N
Site 78
Y534
E
E
D
E
D
E
S
Y
Q
S
A
L
A
N
K
Site 79
S536
D
E
D
E
S
Y
Q
S
A
L
A
N
K
V
K
Site 80
T547
N
K
V
K
R
K
D
T
L
A
M
K
L
N
H
Site 81
S557
M
K
L
N
H
R
P
S
E
P
E
L
N
L
N
Site 82
S565
E
P
E
L
N
L
N
S
W
P
C
K
S
K
E
Site 83
T584
I
R
H
Q
I
G
N
T
L
I
R
R
L
S
Q
Site 84
S590
N
T
L
I
R
R
L
S
Q
R
P
T
P
E
E
Site 85
T594
R
R
L
S
Q
R
P
T
P
E
E
L
E
Q
R
Site 86
T624
R
E
I
K
R
R
L
T
R
K
L
S
Q
R
P
Site 87
S628
R
R
L
T
R
K
L
S
Q
R
P
T
V
A
E
Site 88
T632
R
K
L
S
Q
R
P
T
V
A
E
L
L
A
R
Site 89
Y647
K
I
L
R
F
N
E
Y
V
E
V
T
D
A
Q
Site 90
Y656
E
V
T
D
A
Q
D
Y
D
R
R
A
D
K
P
Site 91
T668
D
K
P
W
T
K
L
T
P
A
D
K
A
A
I
Site 92
S684
K
E
L
N
E
F
K
S
S
E
M
E
V
H
E
Site 93
S685
E
L
N
E
F
K
S
S
E
M
E
V
H
E
E
Site 94
Y699
E
S
K
H
F
T
R
Y
H
R
P
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation