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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BRSK2
Full Name:
BR serine/threonine-protein kinase 2
Alias:
BR serine/threonine kinase 2; C11orf7; EC 2.7.11.1; PEN11B; SAD1B; Serine,threonine-protein kinase 29; Serine/threonine kinase 29; Serine/threonine- protein kinase 29; STK29
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CAMK
group; CAMKL family; BRSK subfamily
Mass (Da):
81633
Number AA:
736
UniProt ID:
Q8IWQ3
International Prot ID:
IPI00744296
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0030010
GO:0030182
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
BrskSubtide - BRSK2 protein kinase substrate peptide - Powder PE-01BGL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BGL99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
G
G
A
Q
H
A
Q
Y
V
G
P
Y
R
L
E
Site 2
T24
G
P
Y
R
L
E
K
T
L
G
K
G
Q
T
G
Site 3
S58
N
R
E
K
L
S
E
S
V
L
M
K
V
E
R
Site 4
Y85
V
L
K
L
H
D
V
Y
E
N
K
K
Y
L
Y
Site 5
Y90
D
V
Y
E
N
K
K
Y
L
Y
L
V
L
E
H
Site 6
Y92
Y
E
N
K
K
Y
L
Y
L
V
L
E
H
V
S
Site 7
Y106
S
G
G
E
L
F
D
Y
L
V
K
K
G
R
L
Site 8
T114
L
V
K
K
G
R
L
T
P
K
E
A
R
K
F
Site 9
T174
V
G
D
S
L
L
E
T
S
C
G
S
P
H
Y
Site 10
S175
G
D
S
L
L
E
T
S
C
G
S
P
H
Y
A
Site 11
S178
L
L
E
T
S
C
G
S
P
H
Y
A
C
P
E
Site 12
Y181
T
S
C
G
S
P
H
Y
A
C
P
E
V
I
R
Site 13
Y192
E
V
I
R
G
E
K
Y
D
G
R
K
A
D
V
Site 14
T260
V
D
A
A
R
R
L
T
L
E
H
I
Q
K
H
Site 15
S291
P
R
K
V
Q
I
R
S
L
P
S
L
E
D
I
Site 16
S294
V
Q
I
R
S
L
P
S
L
E
D
I
D
P
D
Site 17
S308
D
V
L
D
S
M
H
S
L
G
C
F
R
D
R
Site 18
S324
K
L
L
Q
D
L
L
S
E
E
E
N
Q
E
K
Site 19
Y334
E
N
Q
E
K
M
I
Y
F
L
L
L
D
R
K
Site 20
Y344
L
L
D
R
K
E
R
Y
P
S
Q
E
D
E
D
Site 21
S346
D
R
K
E
R
Y
P
S
Q
E
D
E
D
L
P
Site 22
S367
P
P
R
K
R
V
D
S
P
M
L
N
R
H
G
Site 23
S382
K
R
R
P
E
R
K
S
M
E
V
L
S
V
T
Site 24
S387
R
K
S
M
E
V
L
S
V
T
D
G
G
S
P
Site 25
T389
S
M
E
V
L
S
V
T
D
G
G
S
P
V
P
Site 26
S393
L
S
V
T
D
G
G
S
P
V
P
A
R
R
A
Site 27
S410
M
A
Q
H
G
Q
R
S
R
S
I
S
G
A
S
Site 28
S412
Q
H
G
Q
R
S
R
S
I
S
G
A
S
S
G
Site 29
S414
G
Q
R
S
R
S
I
S
G
A
S
S
G
L
S
Site 30
S417
S
R
S
I
S
G
A
S
S
G
L
S
T
S
P
Site 31
S418
R
S
I
S
G
A
S
S
G
L
S
T
S
P
L
Site 32
S421
S
G
A
S
S
G
L
S
T
S
P
L
S
S
P
Site 33
T422
G
A
S
S
G
L
S
T
S
P
L
S
S
P
R
Site 34
S423
A
S
S
G
L
S
T
S
P
L
S
S
P
R
V
Site 35
S426
G
L
S
T
S
P
L
S
S
P
R
V
T
P
H
Site 36
S427
L
S
T
S
P
L
S
S
P
R
V
T
P
H
P
Site 37
T431
P
L
S
S
P
R
V
T
P
H
P
S
P
R
G
Site 38
S435
P
R
V
T
P
H
P
S
P
R
G
S
P
L
P
Site 39
S439
P
H
P
S
P
R
G
S
P
L
P
T
P
K
G
Site 40
T443
P
R
G
S
P
L
P
T
P
K
G
T
P
V
H
Site 41
T447
P
L
P
T
P
K
G
T
P
V
H
T
P
K
E
Site 42
T451
P
K
G
T
P
V
H
T
P
K
E
S
P
A
G
Site 43
S455
P
V
H
T
P
K
E
S
P
A
G
T
P
N
P
Site 44
T459
P
K
E
S
P
A
G
T
P
N
P
T
P
P
S
Site 45
T463
P
A
G
T
P
N
P
T
P
P
S
S
P
S
V
Site 46
S466
T
P
N
P
T
P
P
S
S
P
S
V
G
G
V
Site 47
S467
P
N
P
T
P
P
S
S
P
S
V
G
G
V
P
Site 48
S469
P
T
P
P
S
S
P
S
V
G
G
V
P
W
R
Site 49
S481
P
W
R
A
R
L
N
S
I
K
N
S
F
L
G
Site 50
S485
R
L
N
S
I
K
N
S
F
L
G
S
P
R
F
Site 51
S489
I
K
N
S
F
L
G
S
P
R
F
H
R
R
K
Site 52
T501
R
R
K
L
Q
V
P
T
P
E
E
M
S
N
L
Site 53
S506
V
P
T
P
E
E
M
S
N
L
T
P
E
S
S
Site 54
T509
P
E
E
M
S
N
L
T
P
E
S
S
P
E
L
Site 55
S512
M
S
N
L
T
P
E
S
S
P
E
L
A
K
K
Site 56
S513
M
S
N
L
T
P
E
S
S
P
E
L
A
K
K
Site 57
S520
S
P
E
L
A
K
K
S
W
F
G
N
F
I
S
Site 58
S527
S
W
F
G
N
F
I
S
L
E
K
E
E
Q
I
Site 59
S566
S
L
S
H
S
V
I
S
Q
T
S
F
R
A
E
Site 60
S569
H
S
V
I
S
Q
T
S
F
R
A
E
Y
K
A
Site 61
Y574
Q
T
S
F
R
A
E
Y
K
A
T
G
G
P
A
Site 62
T577
F
R
A
E
Y
K
A
T
G
G
P
A
V
F
Q
Site 63
T594
V
K
F
Q
V
D
I
T
Y
T
E
G
G
E
A
Site 64
Y595
K
F
Q
V
D
I
T
Y
T
E
G
G
E
A
Q
Site 65
S609
Q
K
E
N
G
I
Y
S
V
T
F
T
L
L
S
Site 66
S616
S
V
T
F
T
L
L
S
G
P
S
R
R
F
K
Site 67
S619
F
T
L
L
S
G
P
S
R
R
F
K
R
V
V
Site 68
S635
T
I
Q
A
Q
L
L
S
T
H
D
P
P
A
A
Site 69
S646
P
P
A
A
Q
H
L
S
D
T
T
N
C
M
E
Site 70
S660
E
M
M
T
G
R
L
S
K
C
G
S
P
L
S
Site 71
S664
G
R
L
S
K
C
G
S
P
L
S
N
F
F
D
Site 72
S667
S
K
C
G
S
P
L
S
N
F
F
D
V
I
K
Site 73
S678
D
V
I
K
Q
L
F
S
D
E
K
N
G
Q
A
Site 74
S690
G
Q
A
A
Q
A
P
S
T
P
A
K
R
S
A
Site 75
T691
Q
A
A
Q
A
P
S
T
P
A
K
R
S
A
H
Site 76
S696
P
S
T
P
A
K
R
S
A
H
G
P
L
G
D
Site 77
S704
A
H
G
P
L
G
D
S
A
A
A
G
P
G
P
Site 78
Y717
G
P
G
G
D
A
E
Y
P
T
G
K
D
T
A
Site 79
T723
E
Y
P
T
G
K
D
T
A
K
M
G
P
P
T
Site 80
T730
T
A
K
M
G
P
P
T
A
R
R
E
Q
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation