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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDKL3
Full Name:
Cyclin-dependent kinase-like 3
Alias:
Serine/threonine-protein kinase NKIAMRE
Type:
Mass (Da):
67514
Number AA:
592
UniProt ID:
Q8IVW4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Cyclin-dependent kinase-like 3; Serine/threonine protein kinase NKIAMRE pan-specific antibody AB-NK262-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK262-1#Cyclin-dependent kinase-like 3 / Serine/threonine protein kinase NKIAMRE (A505-H523, human) peptide - Powder PE-01BCO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BCO99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
Site 2
T17
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
Site 3
Y93
V
L
D
E
L
Q
H
Y
C
H
G
L
E
S
K
Site 4
Y105
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
Site 5
S134
K
P
E
N
I
L
V
S
Q
S
G
I
T
K
L
Site 6
Y157
L
A
A
P
G
D
I
Y
T
D
Y
V
A
T
R
Site 7
T158
A
A
P
G
D
I
Y
T
D
Y
V
A
T
R
W
Site 8
Y160
P
G
D
I
Y
T
D
Y
V
A
T
R
W
Y
R
Site 9
Y166
D
Y
V
A
T
R
W
Y
R
A
P
E
L
V
L
Site 10
T176
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
Site 11
Y178
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
Site 12
Y200
E
M
A
T
G
N
P
Y
L
P
S
S
S
D
L
Site 13
S203
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
Site 14
S204
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
Site 15
S205
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
Site 16
S229
P
H
L
Q
N
I
F
S
K
S
P
I
F
A
G
Site 17
Y252
P
K
N
A
R
K
K
Y
P
K
L
N
G
L
L
Site 18
S276
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
Site 19
S277
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Site 20
S278
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
Site 21
Y285
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
Site 22
T331
L
R
K
D
E
R
K
T
V
Y
T
N
T
L
L
Site 23
Y333
K
D
E
R
K
T
V
Y
T
N
T
L
L
S
S
Site 24
T334
D
E
R
K
T
V
Y
T
N
T
L
L
S
S
S
Site 25
T336
R
K
T
V
Y
T
N
T
L
L
S
S
S
V
L
Site 26
S341
T
N
T
L
L
S
S
S
V
L
G
K
E
I
E
Site 27
S371
K
G
G
R
G
D
I
S
E
P
K
K
K
E
Y
Site 28
Y378
S
E
P
K
K
K
E
Y
E
G
G
L
G
Q
Q
Site 29
S395
N
E
N
V
H
P
M
S
P
D
T
K
L
V
T
Site 30
T398
V
H
P
M
S
P
D
T
K
L
V
T
I
E
P
Site 31
T402
S
P
D
T
K
L
V
T
I
E
P
P
N
P
I
Site 32
T413
P
N
P
I
N
P
S
T
N
C
N
G
L
K
E
Site 33
S446
N
L
M
A
A
N
L
S
S
N
L
F
H
P
S
Site 34
S453
S
S
N
L
F
H
P
S
V
R
L
T
E
R
A
Site 35
T457
F
H
P
S
V
R
L
T
E
R
A
K
K
R
R
Site 36
T465
E
R
A
K
K
R
R
T
S
S
Q
S
I
G
Q
Site 37
S466
R
A
K
K
R
R
T
S
S
Q
S
I
G
Q
V
Site 38
S467
A
K
K
R
R
T
S
S
Q
S
I
G
Q
V
M
Site 39
S469
K
R
R
T
S
S
Q
S
I
G
Q
V
M
P
N
Site 40
S477
I
G
Q
V
M
P
N
S
R
Q
E
D
P
G
P
Site 41
S487
E
D
P
G
P
I
Q
S
Q
M
E
K
G
I
F
Site 42
S515
N
K
R
K
L
N
F
S
R
S
D
R
K
E
F
Site 43
S517
R
K
L
N
F
S
R
S
D
R
K
E
F
H
F
Site 44
T530
H
F
P
E
L
P
V
T
I
Q
S
K
D
T
K
Site 45
S551
I
K
M
L
K
R
E
S
K
K
T
E
S
S
K
Site 46
T554
L
K
R
E
S
K
K
T
E
S
S
K
I
P
T
Site 47
S557
E
S
K
K
T
E
S
S
K
I
P
T
L
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation