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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KSR
Full Name:
Kinase suppressor of Ras 1
Alias:
CAP kinase; Ceramide-activated protein kinase; HB; HB protein; Kinase KSR1; Kinase suppressor of ras 1; Kinase suppressor of RAS-1; KSR1; RSU2
Type:
Protein kinase, Ser/Thr (non-receptor);
TKL
group; RAF family
Mass (Da):
102032
Number AA:
921
UniProt ID:
Q8IVT5
International Prot ID:
IPI00651657
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-serine kinase suppressor of Ras 1 pan-specific antibody AB-NK090#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK090#Protein-serine kinase suppressor of Ras 1 S406 phosphosite-specific antibody AB-PK675#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK675#Protein-serine kinase suppressor of Ras 1 (R401-S407, human) pS406 phosphopeptide - Powder PE-04ANE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANE99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T58
G
S
L
R
G
L
R
T
K
C
A
V
S
N
D
Site 2
T67
C
A
V
S
N
D
L
T
Q
Q
E
I
R
T
L
Site 3
Y81
L
E
A
K
L
V
R
Y
I
C
K
Q
R
Q
C
Site 4
S91
K
Q
R
Q
C
K
L
S
V
A
P
G
E
R
T
Site 5
T98
S
V
A
P
G
E
R
T
P
E
L
N
S
Y
P
Site 6
S103
E
R
T
P
E
L
N
S
Y
P
R
F
S
D
W
Site 7
Y104
R
T
P
E
L
N
S
Y
P
R
F
S
D
W
L
Site 8
Y112
P
R
F
S
D
W
L
Y
T
F
N
V
R
P
E
Site 9
T113
R
F
S
D
W
L
Y
T
F
N
V
R
P
E
V
Site 10
T129
Q
E
I
P
R
D
L
T
L
D
A
L
L
E
M
Site 11
T144
N
E
A
K
V
K
E
T
L
R
R
C
G
A
S
Site 12
S151
T
L
R
R
C
G
A
S
G
D
E
C
G
R
L
Site 13
Y160
D
E
C
G
R
L
Q
Y
A
L
T
C
L
R
K
Site 14
T163
G
R
L
Q
Y
A
L
T
C
L
R
K
V
T
G
Site 15
T169
L
T
C
L
R
K
V
T
G
L
G
G
E
H
K
Site 16
S179
G
G
E
H
K
E
D
S
S
W
S
S
L
D
A
Site 17
S180
G
E
H
K
E
D
S
S
W
S
S
L
D
A
R
Site 18
S182
H
K
E
D
S
S
W
S
S
L
D
A
R
R
E
Site 19
S183
K
E
D
S
S
W
S
S
L
D
A
R
R
E
S
Site 20
S190
S
L
D
A
R
R
E
S
G
S
G
P
S
T
D
Site 21
S192
D
A
R
R
E
S
G
S
G
P
S
T
D
T
L
Site 22
T196
E
S
G
S
G
P
S
T
D
T
L
S
A
A
S
Site 23
T198
G
S
G
P
S
T
D
T
L
S
A
A
S
L
P
Site 24
S200
G
P
S
T
D
T
L
S
A
A
S
L
P
W
P
Site 25
S203
T
D
T
L
S
A
A
S
L
P
W
P
P
G
S
Site 26
S210
S
L
P
W
P
P
G
S
S
Q
L
G
R
A
G
Site 27
S211
L
P
W
P
P
G
S
S
Q
L
G
R
A
G
N
Site 28
S225
N
S
A
Q
G
P
R
S
I
S
V
S
A
L
P
Site 29
S227
A
Q
G
P
R
S
I
S
V
S
A
L
P
A
S
Site 30
S229
G
P
R
S
I
S
V
S
A
L
P
A
S
D
S
Site 31
S234
S
V
S
A
L
P
A
S
D
S
P
T
P
S
F
Site 32
S236
S
A
L
P
A
S
D
S
P
T
P
S
F
S
E
Site 33
T238
L
P
A
S
D
S
P
T
P
S
F
S
E
G
L
Site 34
S240
A
S
D
S
P
T
P
S
F
S
E
G
L
S
D
Site 35
S242
D
S
P
T
P
S
F
S
E
G
L
S
D
T
C
Site 36
S246
P
S
F
S
E
G
L
S
D
T
C
I
P
L
H
Site 37
S255
T
C
I
P
L
H
A
S
G
R
L
T
P
R
A
Site 38
T259
L
H
A
S
G
R
L
T
P
R
A
L
H
S
F
Site 39
S265
L
T
P
R
A
L
H
S
F
I
T
P
P
T
T
Site 40
T268
R
A
L
H
S
F
I
T
P
P
T
T
P
Q
L
Site 41
T271
H
S
F
I
T
P
P
T
T
P
Q
L
R
R
H
Site 42
T272
S
F
I
T
P
P
T
T
P
Q
L
R
R
H
T
Site 43
T279
T
P
Q
L
R
R
H
T
K
L
K
P
P
R
T
Site 44
T286
T
K
L
K
P
P
R
T
P
P
P
P
S
R
K
Site 45
S291
P
R
T
P
P
P
P
S
R
K
V
F
Q
L
L
Site 46
T303
Q
L
L
P
S
F
P
T
L
T
R
S
K
S
H
Site 47
T305
L
P
S
F
P
T
L
T
R
S
K
S
H
E
S
Site 48
S307
S
F
P
T
L
T
R
S
K
S
H
E
S
Q
L
Site 49
S309
P
T
L
T
R
S
K
S
H
E
S
Q
L
G
N
Site 50
S312
T
R
S
K
S
H
E
S
Q
L
G
N
R
I
D
Site 51
S322
G
N
R
I
D
D
V
S
S
M
R
F
D
L
S
Site 52
S323
N
R
I
D
D
V
S
S
M
R
F
D
L
S
H
Site 53
S329
S
S
M
R
F
D
L
S
H
G
S
P
Q
M
V
Site 54
S332
R
F
D
L
S
H
G
S
P
Q
M
V
R
R
D
Site 55
S343
V
R
R
D
I
G
L
S
V
T
H
R
F
S
T
Site 56
T345
R
D
I
G
L
S
V
T
H
R
F
S
T
K
S
Site 57
S349
L
S
V
T
H
R
F
S
T
K
S
W
L
S
Q
Site 58
T350
S
V
T
H
R
F
S
T
K
S
W
L
S
Q
V
Site 59
T397
R
I
S
F
L
P
L
T
R
L
R
R
T
E
S
Site 60
T402
P
L
T
R
L
R
R
T
E
S
V
P
S
D
I
Site 61
S404
T
R
L
R
R
T
E
S
V
P
S
D
I
N
N
Site 62
S407
R
R
T
E
S
V
P
S
D
I
N
N
P
V
D
Site 63
T423
A
A
E
P
H
F
G
T
L
P
K
A
L
T
K
Site 64
T429
G
T
L
P
K
A
L
T
K
K
E
H
P
P
A
Site 65
S442
P
A
M
N
H
L
D
S
S
S
N
P
S
S
T
Site 66
S443
A
M
N
H
L
D
S
S
S
N
P
S
S
T
T
Site 67
S444
M
N
H
L
D
S
S
S
N
P
S
S
T
T
S
Site 68
S447
L
D
S
S
S
N
P
S
S
T
T
S
S
T
P
Site 69
S448
D
S
S
S
N
P
S
S
T
T
S
S
T
P
S
Site 70
T449
S
S
S
N
P
S
S
T
T
S
S
T
P
S
S
Site 71
T450
S
S
N
P
S
S
T
T
S
S
T
P
S
S
P
Site 72
S451
S
N
P
S
S
T
T
S
S
T
P
S
S
P
A
Site 73
S452
N
P
S
S
T
T
S
S
T
P
S
S
P
A
P
Site 74
T453
P
S
S
T
T
S
S
T
P
S
S
P
A
P
F
Site 75
S455
S
T
T
S
S
T
P
S
S
P
A
P
F
P
T
Site 76
S456
T
T
S
S
T
P
S
S
P
A
P
F
P
T
S
Site 77
T462
S
S
P
A
P
F
P
T
S
S
N
P
S
S
A
Site 78
S463
S
P
A
P
F
P
T
S
S
N
P
S
S
A
T
Site 79
S464
P
A
P
F
P
T
S
S
N
P
S
S
A
T
T
Site 80
S467
F
P
T
S
S
N
P
S
S
A
T
T
P
P
N
Site 81
S468
P
T
S
S
N
P
S
S
A
T
T
P
P
N
P
Site 82
T470
S
S
N
P
S
S
A
T
T
P
P
N
P
S
P
Site 83
T471
S
N
P
S
S
A
T
T
P
P
N
P
S
P
G
Site 84
S476
A
T
T
P
P
N
P
S
P
G
Q
R
D
S
R
Site 85
S482
P
S
P
G
Q
R
D
S
R
F
N
F
P
A
A
Site 86
Y490
R
F
N
F
P
A
A
Y
F
I
H
H
R
Q
Q
Site 87
S567
E
E
P
E
A
G
K
S
E
A
E
D
D
E
D
Site 88
S581
D
E
V
D
D
L
P
S
S
R
R
P
W
R
G
Site 89
S582
E
V
D
D
L
P
S
S
R
R
P
W
R
G
P
Site 90
S591
R
P
W
R
G
P
I
S
R
K
A
S
Q
T
S
Site 91
S595
G
P
I
S
R
K
A
S
Q
T
S
V
Y
L
Q
Site 92
T597
I
S
R
K
A
S
Q
T
S
V
Y
L
Q
E
W
Site 93
Y659
F
K
K
E
V
M
N
Y
R
Q
T
R
H
E
N
Site 94
S694
C
K
G
R
T
L
H
S
F
V
R
D
P
K
T
Site 95
T701
S
F
V
R
D
P
K
T
S
L
D
I
N
K
T
Site 96
S702
F
V
R
D
P
K
T
S
L
D
I
N
K
T
R
Site 97
Y721
E
I
I
K
G
M
G
Y
L
H
A
K
G
I
V
Site 98
T786
P
E
I
V
R
E
M
T
P
G
K
D
E
D
Q
Site 99
S797
D
E
D
Q
L
P
F
S
K
A
A
D
V
Y
A
Site 100
S827
K
N
Q
A
A
E
A
S
I
W
Q
I
G
S
G
Site 101
T842
E
G
M
K
R
V
L
T
S
V
S
L
G
K
E
Site 102
S845
K
R
V
L
T
S
V
S
L
G
K
E
V
S
E
Site 103
S867
F
D
L
Q
E
R
P
S
F
S
L
L
M
D
M
Site 104
S886
P
K
L
N
R
R
L
S
H
P
G
H
F
W
K
Site 105
S894
H
P
G
H
F
W
K
S
A
E
I
N
S
S
K
Site 106
S900
K
S
A
E
I
N
S
S
K
V
V
P
R
F
E
Site 107
S916
F
G
L
G
V
L
E
S
S
N
P
K
M
_
_
Site 108
S917
G
L
G
V
L
E
S
S
N
P
K
M
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation