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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYT12
Full Name:
Synaptotagmin-12
Alias:
Synaptotagmin XII; SytXII
Type:
Vesicle protein
Mass (Da):
46537
Number AA:
421
UniProt ID:
Q8IV01
International Prot ID:
IPI00219472
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0031410
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Synaptotagmin-12 pan-specific antibody AB-NN345-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN345-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
V
A
E
Y
H
L
S
V
I
K
S
P
P
G
Site 2
S15
Y
H
L
S
V
I
K
S
P
P
G
W
E
V
G
Site 3
T44
V
S
L
W
K
L
W
T
S
G
S
F
P
S
P
Site 4
S45
S
L
W
K
L
W
T
S
G
S
F
P
S
P
S
Site 5
S47
W
K
L
W
T
S
G
S
F
P
S
P
S
P
F
Site 6
S50
W
T
S
G
S
F
P
S
P
S
P
F
P
N
Y
Site 7
S52
S
G
S
F
P
S
P
S
P
F
P
N
Y
D
Y
Site 8
Y57
S
P
S
P
F
P
N
Y
D
Y
R
Y
L
Q
Q
Site 9
Y59
S
P
F
P
N
Y
D
Y
R
Y
L
Q
Q
K
Y
Site 10
Y61
F
P
N
Y
D
Y
R
Y
L
Q
Q
K
Y
G
E
Site 11
S87
A
W
N
A
Q
R
A
S
T
R
G
P
P
S
R
Site 12
T88
W
N
A
Q
R
A
S
T
R
G
P
P
S
R
K
Site 13
S93
A
S
T
R
G
P
P
S
R
K
G
S
L
S
I
Site 14
S97
G
P
P
S
R
K
G
S
L
S
I
E
D
T
F
Site 15
S99
P
S
R
K
G
S
L
S
I
E
D
T
F
E
S
Site 16
T103
G
S
L
S
I
E
D
T
F
E
S
I
S
E
L
Site 17
S108
E
D
T
F
E
S
I
S
E
L
G
P
L
E
L
Site 18
Y125
R
E
L
D
L
A
P
Y
G
T
L
R
K
S
Q
Site 19
T127
L
D
L
A
P
Y
G
T
L
R
K
S
Q
S
A
Site 20
S131
P
Y
G
T
L
R
K
S
Q
S
A
D
S
L
N
Site 21
S133
G
T
L
R
K
S
Q
S
A
D
S
L
N
S
I
Site 22
S136
R
K
S
Q
S
A
D
S
L
N
S
I
S
S
V
Site 23
S139
Q
S
A
D
S
L
N
S
I
S
S
V
S
N
T
Site 24
S141
A
D
S
L
N
S
I
S
S
V
S
N
T
F
G
Site 25
S142
D
S
L
N
S
I
S
S
V
S
N
T
F
G
Q
Site 26
T146
S
I
S
S
V
S
N
T
F
G
Q
D
F
T
L
Site 27
T152
N
T
F
G
Q
D
F
T
L
G
Q
V
E
V
S
Site 28
T164
E
V
S
M
E
Y
D
T
A
S
H
T
L
N
V
Site 29
S166
S
M
E
Y
D
T
A
S
H
T
L
N
V
A
V
Site 30
T168
E
Y
D
T
A
S
H
T
L
N
V
A
V
M
Q
Site 31
S186
L
L
E
R
E
E
A
S
F
E
S
C
F
M
R
Site 32
S189
R
E
E
A
S
F
E
S
C
F
M
R
V
S
L
Site 33
S195
E
S
C
F
M
R
V
S
L
L
P
D
E
Q
I
Site 34
Y213
S
R
I
Q
R
N
A
Y
S
I
F
F
D
E
K
Site 35
T228
F
S
I
P
L
D
P
T
A
L
E
E
K
S
L
Site 36
S234
P
T
A
L
E
E
K
S
L
R
F
S
V
F
G
Site 37
S238
E
E
K
S
L
R
F
S
V
F
G
I
D
E
D
Site 38
S250
D
E
D
E
R
N
V
S
T
G
V
V
E
L
K
Site 39
S269
D
L
P
L
Q
P
F
S
G
W
L
Y
L
Q
D
Site 40
Y273
Q
P
F
S
G
W
L
Y
L
Q
D
Q
N
K
A
Site 41
T317
L
I
W
T
N
D
K
T
T
A
D
P
F
V
K
Site 42
T318
I
W
T
N
D
K
T
T
A
D
P
F
V
K
V
Site 43
Y326
A
D
P
F
V
K
V
Y
L
L
Q
D
G
R
K
Site 44
S335
L
Q
D
G
R
K
M
S
K
K
K
T
A
V
K
Site 45
T339
R
K
M
S
K
K
K
T
A
V
K
R
D
D
P
Site 46
T371
Q
D
L
S
L
R
V
T
V
A
E
S
S
S
D
Site 47
S375
L
R
V
T
V
A
E
S
S
S
D
G
R
G
D
Site 48
S377
V
T
V
A
E
S
S
S
D
G
R
G
D
N
V
Site 49
T407
H
W
N
Q
M
L
A
T
L
R
R
P
V
S
M
Site 50
S413
A
T
L
R
R
P
V
S
M
W
H
A
V
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation