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Updated November 2019
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Protein Info
Short Name:
HIPK1
Full Name:
Homeodomain-interacting protein kinase 1
Alias:
HIK1; homeodomain interacting protein kinase 1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2
Type:
EC 2.7.1.; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
CMGC
group; DYRK family; HIPK subfamily
Mass (Da):
130843
Number AA:
1210
UniProt ID:
Q86Z02
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Homeodomain-interacting protein-serine kinase 1 Y352 phosphosite-specific antibody AB-PK654#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK654#DYRKtide KinSub - DYR peptide substrate - Powder PE-01ACQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACQ95#Homeodomain-interacting protein-serine kinase 1 (C349-S355, human) pY352 phosphopeptide - Powder PE-04AKK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKK95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
S
Q
L
Q
V
F
S
P
P
S
V
S
S
S
Site 2
S15
F
S
P
P
S
V
S
S
S
A
F
C
S
A
K
Site 3
S16
S
P
P
S
V
S
S
S
A
F
C
S
A
K
K
Site 4
S20
V
S
S
S
A
F
C
S
A
K
K
L
K
I
E
Site 5
S29
K
K
L
K
I
E
P
S
G
W
D
V
S
G
Q
Site 6
S34
E
P
S
G
W
D
V
S
G
Q
S
S
N
D
K
Site 7
Y42
G
Q
S
S
N
D
K
Y
Y
T
H
S
K
T
L
Site 8
Y43
Q
S
S
N
D
K
Y
Y
T
H
S
K
T
L
P
Site 9
T44
S
S
N
D
K
Y
Y
T
H
S
K
T
L
P
A
Site 10
T48
K
Y
Y
T
H
S
K
T
L
P
A
T
Q
G
Q
Site 11
S98
S
S
G
S
A
A
T
S
T
F
Q
S
S
Q
T
Site 12
T99
S
G
S
A
A
T
S
T
F
Q
S
S
Q
T
L
Site 13
S102
A
A
T
S
T
F
Q
S
S
Q
T
L
T
H
R
Site 14
S103
A
T
S
T
F
Q
S
S
Q
T
L
T
H
R
S
Site 15
T105
S
T
F
Q
S
S
Q
T
L
T
H
R
S
N
V
Site 16
T107
F
Q
S
S
Q
T
L
T
H
R
S
N
V
S
L
Site 17
S110
S
Q
T
L
T
H
R
S
N
V
S
L
L
E
P
Site 18
Y118
N
V
S
L
L
E
P
Y
Q
K
C
G
L
K
R
Site 19
S127
K
C
G
L
K
R
K
S
E
E
V
D
S
N
G
Site 20
S132
R
K
S
E
E
V
D
S
N
G
S
V
Q
I
I
Site 21
S135
E
E
V
D
S
N
G
S
V
Q
I
I
E
E
H
Site 22
T161
G
A
A
A
T
T
T
T
V
T
T
K
S
S
S
Site 23
T163
A
A
T
T
T
T
V
T
T
K
S
S
S
S
S
Site 24
T164
A
T
T
T
T
V
T
T
K
S
S
S
S
S
G
Site 25
S166
T
T
T
V
T
T
K
S
S
S
S
S
G
E
G
Site 26
S168
T
V
T
T
K
S
S
S
S
S
G
E
G
D
Y
Site 27
S170
T
T
K
S
S
S
S
S
G
E
G
D
Y
Q
L
Site 28
Y175
S
S
S
G
E
G
D
Y
Q
L
V
Q
H
E
I
Site 29
T212
A
K
C
W
K
R
S
T
K
E
I
V
A
I
K
Site 30
S226
K
I
L
K
N
H
P
S
Y
A
R
Q
G
Q
I
Site 31
Y227
I
L
K
N
H
P
S
Y
A
R
Q
G
Q
I
E
Site 32
S236
R
Q
G
Q
I
E
V
S
I
L
S
R
L
S
S
Site 33
S239
Q
I
E
V
S
I
L
S
R
L
S
S
E
N
A
Site 34
S242
V
S
I
L
S
R
L
S
S
E
N
A
D
E
Y
Site 35
S243
S
I
L
S
R
L
S
S
E
N
A
D
E
Y
N
Site 36
Y249
S
S
E
N
A
D
E
Y
N
F
V
R
S
Y
E
Site 37
Y255
E
Y
N
F
V
R
S
Y
E
C
F
Q
H
K
N
Site 38
Y276
E
M
L
E
Q
N
L
Y
D
F
L
K
Q
N
K
Site 39
S285
F
L
K
Q
N
K
F
S
P
L
P
L
K
Y
I
Site 40
Y291
F
S
P
L
P
L
K
Y
I
R
P
I
L
Q
Q
Site 41
Y331
V
D
P
V
R
Q
P
Y
R
V
K
V
I
D
F
Site 42
S350
H
V
S
K
A
V
C
S
T
Y
L
Q
S
R
Y
Site 43
T351
V
S
K
A
V
C
S
T
Y
L
Q
S
R
Y
Y
Site 44
Y352
S
K
A
V
C
S
T
Y
L
Q
S
R
Y
Y
R
Homeodomain-interacting protein-serine kinase 1 Y352 phosphosite-specific antibody AB-PK654#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK654#Homeodomain-interacting protein-serine kinase 1 (C349-S355, human) pY352 phosphopeptide - Powder PE-04AKK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKK95
Site 45
S355
V
C
S
T
Y
L
Q
S
R
Y
Y
R
A
P
E
Site 46
Y357
S
T
Y
L
Q
S
R
Y
Y
R
A
P
E
I
I
Site 47
Y358
T
Y
L
Q
S
R
Y
Y
R
A
P
E
I
I
L
Site 48
Y392
L
F
L
G
W
P
L
Y
P
G
A
S
E
Y
D
Site 49
Y398
L
Y
P
G
A
S
E
Y
D
Q
I
R
Y
I
S
Site 50
Y403
S
E
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
Site 51
S405
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
Site 52
T407
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
E
Y
Site 53
Y414
T
Q
G
L
P
A
E
Y
L
L
S
A
G
T
K
Site 54
S417
L
P
A
E
Y
L
L
S
A
G
T
K
T
T
R
Site 55
T422
L
L
S
A
G
T
K
T
T
R
F
F
N
R
D
Site 56
Y434
N
R
D
P
N
L
G
Y
P
L
W
R
L
K
T
Site 57
T441
Y
P
L
W
R
L
K
T
P
E
E
H
E
L
E
Site 58
Y459
K
S
K
E
A
R
K
Y
I
F
N
C
L
D
D
Site 59
Y491
E
K
A
D
R
R
E
Y
I
D
L
L
K
K
M
Site 60
T508
I
D
A
D
K
R
I
T
P
L
K
T
L
N
H
Site 61
T512
K
R
I
T
P
L
K
T
L
N
H
Q
F
V
T
Site 62
Y549
C
K
R
R
V
H
M
Y
D
T
V
S
Q
I
K
Site 63
T551
R
R
V
H
M
Y
D
T
V
S
Q
I
K
S
P
Site 64
S553
V
H
M
Y
D
T
V
S
Q
I
K
S
P
F
T
Site 65
S557
D
T
V
S
Q
I
K
S
P
F
T
T
H
V
A
Site 66
T560
S
Q
I
K
S
P
F
T
T
H
V
A
P
N
T
Site 67
T561
Q
I
K
S
P
F
T
T
H
V
A
P
N
T
S
Site 68
S568
T
H
V
A
P
N
T
S
T
N
L
T
M
S
F
Site 69
T572
P
N
T
S
T
N
L
T
M
S
F
S
N
Q
L
Site 70
S574
T
S
T
N
L
T
M
S
F
S
N
Q
L
N
T
Site 71
S576
T
N
L
T
M
S
F
S
N
Q
L
N
T
V
H
Site 72
T581
S
F
S
N
Q
L
N
T
V
H
N
Q
A
S
V
Site 73
S587
N
T
V
H
N
Q
A
S
V
L
A
S
S
S
T
Site 74
S608
S
L
A
N
S
D
V
S
L
L
N
Y
Q
S
A
Site 75
Y612
S
D
V
S
L
L
N
Y
Q
S
A
L
Y
P
S
Site 76
Y617
L
N
Y
Q
S
A
L
Y
P
S
S
A
A
P
V
Site 77
T651
Q
T
D
P
F
Q
Q
T
F
I
V
C
P
P
A
Site 78
S696
A
Q
P
L
Q
I
Q
S
G
V
L
T
Q
G
S
Site 79
T761
Q
Q
I
L
L
P
S
T
W
Q
Q
L
P
G
V
Site 80
S786
M
I
P
E
A
M
G
S
G
Q
Q
L
A
D
W
Site 81
T805
S
H
G
N
Q
Y
S
T
I
M
Q
Q
P
S
L
Site 82
S838
H
V
V
R
Q
Q
Q
S
S
S
L
P
S
K
K
Site 83
S839
V
V
R
Q
Q
Q
S
S
S
L
P
S
K
K
N
Site 84
S840
V
R
Q
Q
Q
S
S
S
L
P
S
K
K
N
K
Site 85
S843
Q
Q
S
S
S
L
P
S
K
K
N
K
Q
S
A
Site 86
S849
P
S
K
K
N
K
Q
S
A
P
V
S
S
K
S
Site 87
S853
N
K
Q
S
A
P
V
S
S
K
S
S
L
D
V
Site 88
S854
K
Q
S
A
P
V
S
S
K
S
S
L
D
V
L
Site 89
S856
S
A
P
V
S
S
K
S
S
L
D
V
L
P
S
Site 90
S857
A
P
V
S
S
K
S
S
L
D
V
L
P
S
Q
Site 91
S871
Q
V
Y
S
L
V
G
S
S
P
L
R
T
T
S
Site 92
S872
V
Y
S
L
V
G
S
S
P
L
R
T
T
S
S
Site 93
T876
V
G
S
S
P
L
R
T
T
S
S
Y
N
S
L
Site 94
T877
G
S
S
P
L
R
T
T
S
S
Y
N
S
L
V
Site 95
S878
S
S
P
L
R
T
T
S
S
Y
N
S
L
V
P
Site 96
S879
S
P
L
R
T
T
S
S
Y
N
S
L
V
P
V
Site 97
Y880
P
L
R
T
T
S
S
Y
N
S
L
V
P
V
Q
Site 98
S882
R
T
T
S
S
Y
N
S
L
V
P
V
Q
D
Q
Site 99
S904
D
T
P
S
P
P
V
S
V
I
T
I
R
S
D
Site 100
S910
V
S
V
I
T
I
R
S
D
T
D
E
E
E
D
Site 101
T912
V
I
T
I
R
S
D
T
D
E
E
E
D
N
K
Site 102
Y920
D
E
E
E
D
N
K
Y
K
P
S
S
S
G
L
Site 103
S923
E
D
N
K
Y
K
P
S
S
S
G
L
K
P
R
Site 104
S924
D
N
K
Y
K
P
S
S
S
G
L
K
P
R
S
Site 105
S925
N
K
Y
K
P
S
S
S
G
L
K
P
R
S
N
Site 106
S931
S
S
G
L
K
P
R
S
N
V
I
S
Y
V
T
Site 107
S935
K
P
R
S
N
V
I
S
Y
V
T
V
N
D
S
Site 108
Y936
P
R
S
N
V
I
S
Y
V
T
V
N
D
S
P
Site 109
T938
S
N
V
I
S
Y
V
T
V
N
D
S
P
D
S
Site 110
S942
S
Y
V
T
V
N
D
S
P
D
S
D
S
S
L
Site 111
S945
T
V
N
D
S
P
D
S
D
S
S
L
S
S
P
Site 112
S947
N
D
S
P
D
S
D
S
S
L
S
S
P
Y
S
Site 113
S948
D
S
P
D
S
D
S
S
L
S
S
P
Y
S
T
Site 114
S950
P
D
S
D
S
S
L
S
S
P
Y
S
T
D
T
Site 115
S951
D
S
D
S
S
L
S
S
P
Y
S
T
D
T
L
Site 116
S954
S
S
L
S
S
P
Y
S
T
D
T
L
S
A
L
Site 117
T955
S
L
S
S
P
Y
S
T
D
T
L
S
A
L
R
Site 118
T957
S
S
P
Y
S
T
D
T
L
S
A
L
R
G
N
Site 119
S959
P
Y
S
T
D
T
L
S
A
L
R
G
N
S
G
Site 120
S965
L
S
A
L
R
G
N
S
G
S
V
L
E
G
P
Site 121
S967
A
L
R
G
N
S
G
S
V
L
E
G
P
G
R
Site 122
T984
A
D
G
T
G
T
R
T
I
I
V
P
P
L
K
Site 123
T998
K
T
Q
L
G
D
C
T
V
A
T
Q
A
S
G
Site 124
T1001
L
G
D
C
T
V
A
T
Q
A
S
G
L
L
S
Site 125
S1008
T
Q
A
S
G
L
L
S
N
K
T
K
P
V
A
Site 126
T1011
S
G
L
L
S
N
K
T
K
P
V
A
S
V
S
Site 127
S1016
N
K
T
K
P
V
A
S
V
S
G
Q
S
S
G
Site 128
S1018
T
K
P
V
A
S
V
S
G
Q
S
S
G
C
C
Site 129
T1027
Q
S
S
G
C
C
I
T
P
T
G
Y
R
A
Q
Site 130
T1029
S
G
C
C
I
T
P
T
G
Y
R
A
Q
R
G
Site 131
Y1031
C
C
I
T
P
T
G
Y
R
A
Q
R
G
G
T
Site 132
T1038
Y
R
A
Q
R
G
G
T
S
A
A
Q
P
L
N
Site 133
S1047
A
A
Q
P
L
N
L
S
Q
N
Q
Q
S
S
A
Site 134
S1053
L
S
Q
N
Q
Q
S
S
A
A
P
T
S
Q
E
Site 135
T1057
Q
Q
S
S
A
A
P
T
S
Q
E
R
S
S
N
Site 136
S1058
Q
S
S
A
A
P
T
S
Q
E
R
S
S
N
P
Site 137
S1062
A
P
T
S
Q
E
R
S
S
N
P
A
P
R
R
Site 138
S1063
P
T
S
Q
E
R
S
S
N
P
A
P
R
R
Q
Site 139
Y1082
A
P
L
S
Q
A
P
Y
T
F
Q
H
G
S
P
Site 140
T1083
P
L
S
Q
A
P
Y
T
F
Q
H
G
S
P
L
Site 141
S1088
P
Y
T
F
Q
H
G
S
P
L
H
S
T
G
H
Site 142
S1092
Q
H
G
S
P
L
H
S
T
G
H
P
H
L
A
Site 143
T1093
H
G
S
P
L
H
S
T
G
H
P
H
L
A
P
Site 144
S1107
P
A
P
A
H
L
P
S
Q
A
H
L
Y
T
Y
Site 145
Y1112
L
P
S
Q
A
H
L
Y
T
Y
A
A
P
T
S
Site 146
Y1114
S
Q
A
H
L
Y
T
Y
A
A
P
T
S
A
A
Site 147
S1134
S
S
I
A
H
L
F
S
P
Q
G
S
S
R
H
Site 148
S1138
H
L
F
S
P
Q
G
S
S
R
H
A
A
A
Y
Site 149
Y1145
S
S
R
H
A
A
A
Y
T
T
H
P
S
T
L
Site 150
T1146
S
R
H
A
A
A
Y
T
T
H
P
S
T
L
V
Site 151
T1151
A
Y
T
T
H
P
S
T
L
V
H
Q
V
P
V
Site 152
S1169
P
S
L
L
T
S
A
S
V
A
P
A
Q
Y
Q
Site 153
T1181
Q
Y
Q
H
Q
F
A
T
Q
S
Y
I
G
S
S
Site 154
S1183
Q
H
Q
F
A
T
Q
S
Y
I
G
S
S
R
G
Site 155
S1187
A
T
Q
S
Y
I
G
S
S
R
G
S
T
I
Y
Site 156
S1191
Y
I
G
S
S
R
G
S
T
I
Y
T
G
Y
P
Site 157
T1192
I
G
S
S
R
G
S
T
I
Y
T
G
Y
P
L
Site 158
Y1194
S
S
R
G
S
T
I
Y
T
G
Y
P
L
S
P
Site 159
T1195
S
R
G
S
T
I
Y
T
G
Y
P
L
S
P
T
Site 160
Y1197
G
S
T
I
Y
T
G
Y
P
L
S
P
T
K
I
Site 161
S1200
I
Y
T
G
Y
P
L
S
P
T
K
I
S
Q
Y
Site 162
T1202
T
G
Y
P
L
S
P
T
K
I
S
Q
Y
S
Y
Site 163
S1205
P
L
S
P
T
K
I
S
Q
Y
S
Y
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation