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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTDH
Full Name:
Protein LYRIC
Alias:
3D3; AEG-1; Astrocyte elevated gene-1 AEG1; LYRIC; LYRIC/3D3; Lysine-rich CEACAM1 co-isolated protein; Metadherin
Type:
Adhesion
Mass (Da):
63837
Number AA:
582
UniProt ID:
Q86UE4
International Prot ID:
IPI00328715
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0051092
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
A
Q
Q
A
E
E
G
S
A
R
L
R
E
M
L
Site 2
S84
G
A
R
K
K
R
R
S
P
P
R
K
R
E
E
Site 3
S111
A
L
L
K
N
L
R
S
E
E
Q
K
K
K
N
Site 4
S123
K
K
N
R
K
K
L
S
E
K
P
K
P
N
G
Site 5
T143
A
E
G
E
A
V
R
T
P
Q
S
V
T
A
K
Site 6
S146
E
A
V
R
T
P
Q
S
V
T
A
K
Q
P
P
Site 7
S162
I
D
K
K
N
E
K
S
K
K
N
K
K
K
S
Site 8
S169
S
K
K
N
K
K
K
S
K
S
D
A
K
A
V
Site 9
S171
K
N
K
K
K
S
K
S
D
A
K
A
V
Q
N
Site 10
S179
D
A
K
A
V
Q
N
S
S
R
H
D
G
K
E
Site 11
S197
G
A
W
E
T
K
I
S
H
R
E
K
R
Q
Q
Site 12
T212
R
K
R
D
K
V
L
T
D
S
G
S
L
D
S
Site 13
S214
R
D
K
V
L
T
D
S
G
S
L
D
S
T
I
Site 14
S216
K
V
L
T
D
S
G
S
L
D
S
T
I
P
G
Site 15
S219
T
D
S
G
S
L
D
S
T
I
P
G
I
E
N
Site 16
T220
D
S
G
S
L
D
S
T
I
P
G
I
E
N
T
Site 17
T229
P
G
I
E
N
T
I
T
V
T
T
E
Q
L
T
Site 18
S239
T
E
Q
L
T
T
A
S
F
P
V
G
S
K
K
Site 19
S251
S
K
K
N
K
G
D
S
H
L
N
V
Q
V
S
Site 20
S258
S
H
L
N
V
Q
V
S
N
F
K
S
G
K
G
Site 21
S262
V
Q
V
S
N
F
K
S
G
K
G
D
S
T
L
Site 22
S267
F
K
S
G
K
G
D
S
T
L
Q
V
S
S
G
Site 23
T268
K
S
G
K
G
D
S
T
L
Q
V
S
S
G
L
Site 24
T280
S
G
L
N
E
N
L
T
V
N
G
G
G
W
N
Site 25
S290
G
G
G
W
N
E
K
S
V
K
L
S
S
Q
I
Site 26
S294
N
E
K
S
V
K
L
S
S
Q
I
S
A
G
E
Site 27
S295
E
K
S
V
K
L
S
S
Q
I
S
A
G
E
E
Site 28
S298
V
K
L
S
S
Q
I
S
A
G
E
E
K
W
N
Site 29
S306
A
G
E
E
K
W
N
S
V
S
P
A
S
A
G
Site 30
S308
E
E
K
W
N
S
V
S
P
A
S
A
G
K
R
Site 31
S311
W
N
S
V
S
P
A
S
A
G
K
R
K
T
E
Site 32
T317
A
S
A
G
K
R
K
T
E
P
S
A
W
S
Q
Site 33
S320
G
K
R
K
T
E
P
S
A
W
S
Q
D
T
G
Site 34
S339
N
G
K
D
W
G
R
S
W
S
D
R
S
I
F
Site 35
S341
K
D
W
G
R
S
W
S
D
R
S
I
F
S
G
Site 36
S344
G
R
S
W
S
D
R
S
I
F
S
G
I
G
S
Site 37
S347
W
S
D
R
S
I
F
S
G
I
G
S
T
A
E
Site 38
S357
G
S
T
A
E
P
V
S
Q
S
T
T
S
D
Y
Site 39
T361
E
P
V
S
Q
S
T
T
S
D
Y
Q
W
D
V
Site 40
S362
P
V
S
Q
S
T
T
S
D
Y
Q
W
D
V
S
Site 41
Y364
S
Q
S
T
T
S
D
Y
Q
W
D
V
S
R
N
Site 42
S369
S
D
Y
Q
W
D
V
S
R
N
Q
P
Y
I
D
Site 43
Y374
D
V
S
R
N
Q
P
Y
I
D
D
E
W
S
G
Site 44
S380
P
Y
I
D
D
E
W
S
G
L
N
G
L
S
S
Site 45
S386
W
S
G
L
N
G
L
S
S
A
D
P
N
S
D
Site 46
S387
S
G
L
N
G
L
S
S
A
D
P
N
S
D
W
Site 47
S392
L
S
S
A
D
P
N
S
D
W
N
A
P
A
E
Site 48
S411
W
V
D
E
E
R
A
S
L
L
K
S
Q
E
P
Site 49
S415
E
R
A
S
L
L
K
S
Q
E
P
I
P
D
D
Site 50
S426
I
P
D
D
Q
K
V
S
D
D
D
K
E
K
G
Site 51
S442
G
A
L
P
T
G
K
S
K
K
K
K
K
K
K
Site 52
S457
K
K
Q
G
E
D
N
S
T
A
Q
D
T
E
E
Site 53
T458
K
Q
G
E
D
N
S
T
A
Q
D
T
E
E
L
Site 54
T477
R
E
D
L
P
V
N
T
S
K
T
R
P
K
Q
Site 55
S478
E
D
L
P
V
N
T
S
K
T
R
P
K
Q
E
Site 56
S489
P
K
Q
E
K
A
F
S
L
K
T
I
S
T
S
Site 57
T492
E
K
A
F
S
L
K
T
I
S
T
S
D
P
A
Site 58
S494
A
F
S
L
K
T
I
S
T
S
D
P
A
E
V
Site 59
S496
S
L
K
T
I
S
T
S
D
P
A
E
V
L
V
Site 60
S506
A
E
V
L
V
K
N
S
Q
P
I
K
T
L
P
Site 61
T511
K
N
S
Q
P
I
K
T
L
P
P
A
T
S
T
Site 62
S521
P
A
T
S
T
E
P
S
V
I
L
S
K
S
D
Site 63
S525
T
E
P
S
V
I
L
S
K
S
D
S
D
K
S
Site 64
S527
P
S
V
I
L
S
K
S
D
S
D
K
S
S
S
Site 65
S529
V
I
L
S
K
S
D
S
D
K
S
S
S
Q
V
Site 66
S532
S
K
S
D
S
D
K
S
S
S
Q
V
P
P
I
Site 67
S533
K
S
D
S
D
K
S
S
S
Q
V
P
P
I
L
Site 68
S534
S
D
S
D
K
S
S
S
Q
V
P
P
I
L
Q
Site 69
S546
I
L
Q
E
T
D
K
S
K
S
N
T
K
Q
N
Site 70
S548
Q
E
T
D
K
S
K
S
N
T
K
Q
N
S
V
Site 71
T550
T
D
K
S
K
S
N
T
K
Q
N
S
V
P
P
Site 72
S554
K
S
N
T
K
Q
N
S
V
P
P
S
Q
T
K
Site 73
S558
K
Q
N
S
V
P
P
S
Q
T
K
S
E
T
S
Site 74
T560
N
S
V
P
P
S
Q
T
K
S
E
T
S
W
E
Site 75
S562
V
P
P
S
Q
T
K
S
E
T
S
W
E
S
P
Site 76
T564
P
S
Q
T
K
S
E
T
S
W
E
S
P
K
Q
Site 77
S565
S
Q
T
K
S
E
T
S
W
E
S
P
K
Q
I
Site 78
S568
K
S
E
T
S
W
E
S
P
K
Q
I
K
K
K
Site 79
T582
K
K
K
A
R
R
E
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation