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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARK2
Full Name:
Serine/threonine-protein kinase MARK2
Alias:
EC 2.7.11.1; ELKL motif kinase 1; EMK; EMK1; Kinase MARK2; MAP/microtubule affinity-regulating kinase 2; PAR-1; Par1b; PAR-1b; Protein-serine/threonine kinase; Ser/Thr protein kinase PAR-1B; Serine/threonine kinase
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CAMK
group; CAMKL family; MARK subfamily
Mass (Da):
87911
Number AA:
788
UniProt ID:
Q7KZI7
International Prot ID:
IPI00555838
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0045197
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
MAP/microtubule affinity-regulating protein-serine kinase 2 pan-specific antibody AB-NK275-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK275-1#MAP/microtubule affinity-regulating protein-serine kinase 2 pan-specific antibody AB-NK275-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK275-2#Cdc25C (205-225), KinSub - Cdc25C phosphatase (V205-R225, human) peptide; Chktide peptide - Powder PE-01ACN95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACN95#MAP/microtubule affinity-regulating protein-serine kinase 2 (P19-G37, human) peptide - Powder PE-01BDR80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDR80#MAP/microtubule affinity-regulating protein-serine kinase 2 (G676-P690, human) peptide - Powder PE-01BDS80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDS80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
S
A
R
T
P
L
P
T
L
N
E
Site 2
T10
S
A
R
T
P
L
P
T
L
N
E
R
D
T
E
Site 3
T16
P
T
L
N
E
R
D
T
E
Q
P
T
L
G
H
Site 4
T20
E
R
D
T
E
Q
P
T
L
G
H
L
D
S
K
Site 5
S26
P
T
L
G
H
L
D
S
K
P
S
S
K
S
N
Site 6
S29
G
H
L
D
S
K
P
S
S
K
S
N
M
I
R
Site 7
S30
H
L
D
S
K
P
S
S
K
S
N
M
I
R
G
Site 8
S32
D
S
K
P
S
S
K
S
N
M
I
R
G
R
N
Site 9
S40
N
M
I
R
G
R
N
S
A
T
S
A
D
E
Q
Site 10
T42
I
R
G
R
N
S
A
T
S
A
D
E
Q
P
H
Site 11
S43
R
G
R
N
S
A
T
S
A
D
E
Q
P
H
I
Site 12
T58
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
Site 13
T87
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Site 14
S92
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
Site 15
S93
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
Site 16
T124
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
Site 17
Y126
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
Site 18
Y140
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
Site 19
S197
K
I
A
D
F
G
F
S
N
E
F
T
F
G
N
Site 20
T201
F
G
F
S
N
E
F
T
F
G
N
K
L
D
T
Site 21
T208
T
F
G
N
K
L
D
T
F
C
G
S
P
P
Y
Site 22
S212
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
Site 23
Y215
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
Site 24
Y226
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Site 25
S247
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
Site 26
Y267
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
Site 27
Y272
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
Site 28
T275
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
Site 29
S290
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
Site 30
T294
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
Site 31
Y316
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
Site 32
Y323
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
Site 33
T329
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Site 34
S334
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
Site 35
Y337
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
Site 36
T338
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
Site 37
S345
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
Site 38
Y351
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
Site 39
T357
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
K
Site 40
Y358
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
K
S
Site 41
Y363
A
T
Y
L
L
L
G
Y
K
S
S
E
L
E
G
Site 42
S365
Y
L
L
L
G
Y
K
S
S
E
L
E
G
D
T
Site 43
S366
L
L
L
G
Y
K
S
S
E
L
E
G
D
T
I
Site 44
T372
S
S
E
L
E
G
D
T
I
T
L
K
P
R
P
Site 45
T374
E
L
E
G
D
T
I
T
L
K
P
R
P
S
A
Site 46
S380
I
T
L
K
P
R
P
S
A
D
L
T
N
S
S
Site 47
T384
P
R
P
S
A
D
L
T
N
S
S
A
P
S
P
Site 48
S386
P
S
A
D
L
T
N
S
S
A
P
S
P
S
H
Site 49
S387
S
A
D
L
T
N
S
S
A
P
S
P
S
H
K
Site 50
S390
L
T
N
S
S
A
P
S
P
S
H
K
V
Q
R
Site 51
S392
N
S
S
A
P
S
P
S
H
K
V
Q
R
S
V
Site 52
S398
P
S
H
K
V
Q
R
S
V
S
A
N
P
K
Q
Site 53
S400
H
K
V
Q
R
S
V
S
A
N
P
K
Q
R
R
Site 54
S409
N
P
K
Q
R
R
F
S
D
Q
A
A
G
P
A
Site 55
T419
A
A
G
P
A
I
P
T
S
N
S
Y
S
K
K
Site 56
S420
A
G
P
A
I
P
T
S
N
S
Y
S
K
K
T
Site 57
S422
P
A
I
P
T
S
N
S
Y
S
K
K
T
Q
S
Site 58
Y423
A
I
P
T
S
N
S
Y
S
K
K
T
Q
S
N
Site 59
S424
I
P
T
S
N
S
Y
S
K
K
T
Q
S
N
N
Site 60
S429
S
Y
S
K
K
T
Q
S
N
N
A
E
N
K
R
Site 61
S443
R
P
E
E
D
R
E
S
G
R
K
A
S
S
T
Site 62
S448
R
E
S
G
R
K
A
S
S
T
A
K
V
P
A
Site 63
S449
E
S
G
R
K
A
S
S
T
A
K
V
P
A
S
Site 64
T450
S
G
R
K
A
S
S
T
A
K
V
P
A
S
P
Site 65
S456
S
T
A
K
V
P
A
S
P
L
P
G
L
E
R
Site 66
T466
P
G
L
E
R
K
K
T
T
P
T
P
S
T
N
Site 67
T467
G
L
E
R
K
K
T
T
P
T
P
S
T
N
S
Site 68
T469
E
R
K
K
T
T
P
T
P
S
T
N
S
V
L
Site 69
S471
K
K
T
T
P
T
P
S
T
N
S
V
L
S
T
Site 70
T472
K
T
T
P
T
P
S
T
N
S
V
L
S
T
S
Site 71
S474
T
P
T
P
S
T
N
S
V
L
S
T
S
T
N
Site 72
S477
P
S
T
N
S
V
L
S
T
S
T
N
R
S
R
Site 73
T478
S
T
N
S
V
L
S
T
S
T
N
R
S
R
N
Site 74
S479
T
N
S
V
L
S
T
S
T
N
R
S
R
N
S
Site 75
T480
N
S
V
L
S
T
S
T
N
R
S
R
N
S
P
Site 76
S483
L
S
T
S
T
N
R
S
R
N
S
P
L
L
E
Site 77
S486
S
T
N
R
S
R
N
S
P
L
L
E
R
A
S
Site 78
S493
S
P
L
L
E
R
A
S
L
G
Q
A
S
I
Q
Site 79
S498
R
A
S
L
G
Q
A
S
I
Q
N
G
K
D
S
Site 80
S505
S
I
Q
N
G
K
D
S
L
T
M
P
G
S
R
Site 81
T507
Q
N
G
K
D
S
L
T
M
P
G
S
R
A
S
Site 82
S511
D
S
L
T
M
P
G
S
R
A
S
T
A
S
A
Site 83
S514
T
M
P
G
S
R
A
S
T
A
S
A
S
A
A
Site 84
S523
A
S
A
S
A
A
V
S
A
A
R
P
R
Q
H
Site 85
S533
R
P
R
Q
H
Q
K
S
M
S
A
S
V
H
P
Site 86
S535
R
Q
H
Q
K
S
M
S
A
S
V
H
P
N
K
Site 87
S537
H
Q
K
S
M
S
A
S
V
H
P
N
K
A
S
Site 88
S544
S
V
H
P
N
K
A
S
G
L
P
P
T
E
S
Site 89
T549
K
A
S
G
L
P
P
T
E
S
N
C
E
V
P
Site 90
S551
S
G
L
P
P
T
E
S
N
C
E
V
P
R
P
Site 91
S559
N
C
E
V
P
R
P
S
T
A
P
Q
R
V
P
Site 92
T560
C
E
V
P
R
P
S
T
A
P
Q
R
V
P
V
Site 93
S569
P
Q
R
V
P
V
A
S
P
S
A
H
N
I
S
Site 94
S571
R
V
P
V
A
S
P
S
A
H
N
I
S
S
S
Site 95
S576
S
P
S
A
H
N
I
S
S
S
G
G
A
P
D
Site 96
S577
P
S
A
H
N
I
S
S
S
G
G
A
P
D
R
Site 97
S578
S
A
H
N
I
S
S
S
G
G
A
P
D
R
T
Site 98
T585
S
G
G
A
P
D
R
T
N
F
P
R
G
V
S
Site 99
S592
T
N
F
P
R
G
V
S
S
R
S
T
F
H
A
Site 100
S593
N
F
P
R
G
V
S
S
R
S
T
F
H
A
G
Site 101
S595
P
R
G
V
S
S
R
S
T
F
H
A
G
Q
L
Site 102
T596
R
G
V
S
S
R
S
T
F
H
A
G
Q
L
R
Site 103
Y613
R
D
Q
Q
N
L
P
Y
G
V
T
P
A
S
P
Site 104
T616
Q
N
L
P
Y
G
V
T
P
A
S
P
S
G
H
Site 105
S619
P
Y
G
V
T
P
A
S
P
S
G
H
S
Q
G
Site 106
S621
G
V
T
P
A
S
P
S
G
H
S
Q
G
R
R
Site 107
S624
P
A
S
P
S
G
H
S
Q
G
R
R
G
A
S
Site 108
S631
S
Q
G
R
R
G
A
S
G
S
I
F
S
K
F
Site 109
S633
G
R
R
G
A
S
G
S
I
F
S
K
F
T
S
Site 110
T639
G
S
I
F
S
K
F
T
S
K
F
V
R
R
N
Site 111
S640
S
I
F
S
K
F
T
S
K
F
V
R
R
N
L
Site 112
S648
K
F
V
R
R
N
L
S
F
R
F
A
R
R
N
Site 113
S661
R
N
L
N
E
P
E
S
K
D
R
V
E
T
L
Site 114
T667
E
S
K
D
R
V
E
T
L
R
P
H
V
V
G
Site 115
S675
L
R
P
H
V
V
G
S
G
G
N
D
K
E
K
Site 116
S692
F
R
E
A
K
P
R
S
L
R
F
T
W
S
M
Site 117
T696
K
P
R
S
L
R
F
T
W
S
M
K
T
T
S
Site 118
S698
R
S
L
R
F
T
W
S
M
K
T
T
S
S
M
Site 119
T702
F
T
W
S
M
K
T
T
S
S
M
E
P
N
E
Site 120
S722
R
K
V
L
D
A
N
S
C
Q
S
E
L
H
E
Site 121
Y731
Q
S
E
L
H
E
K
Y
M
L
L
C
M
H
G
Site 122
S759
V
C
K
L
P
R
L
S
L
N
G
V
R
F
K
Site 123
S769
G
V
R
F
K
R
I
S
G
T
S
M
A
F
K
Site 124
S772
F
K
R
I
S
G
T
S
M
A
F
K
N
I
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation