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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SND1
Full Name:
Staphylococcal nuclease domain-containing protein 1
Alias:
P100 co-activator; TDRD11; Tudor domain-containing protein 11
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
101997
Number AA:
910
UniProt ID:
Q7KZF4
International Prot ID:
IPI00140420
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016442
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0004518
GO:0003676
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0016246
GO:0044419
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
S
A
Q
S
G
G
S
Site 2
S7
_
M
A
S
S
A
Q
S
G
G
S
S
G
G
P
Site 3
S11
S
A
Q
S
G
G
S
S
G
G
P
A
V
P
T
Site 4
S29
G
I
I
K
M
V
L
S
G
C
A
I
I
V
R
Site 5
S52
P
E
R
Q
I
N
L
S
N
I
R
A
G
N
L
Site 6
T66
L
A
R
R
A
A
A
T
Q
P
D
A
K
D
T
Site 7
T73
T
Q
P
D
A
K
D
T
P
D
E
P
W
A
F
Site 8
T98
I
G
K
E
V
C
F
T
I
E
N
K
T
P
Q
Site 9
T103
C
F
T
I
E
N
K
T
P
Q
G
R
E
Y
G
Site 10
Y109
K
T
P
Q
G
R
E
Y
G
M
I
Y
L
G
K
Site 11
Y113
G
R
E
Y
G
M
I
Y
L
G
K
D
T
N
G
Site 12
T134
L
V
A
E
G
L
A
T
R
R
E
G
M
R
A
Site 13
S150
N
P
E
Q
N
R
L
S
E
C
E
E
Q
A
K
Site 14
S165
A
A
K
K
G
M
W
S
E
G
N
G
S
H
T
Site 15
S170
M
W
S
E
G
N
G
S
H
T
I
R
D
L
K
Site 16
T172
S
E
G
N
G
S
H
T
I
R
D
L
K
Y
T
Site 17
Y178
H
T
I
R
D
L
K
Y
T
I
E
N
P
R
H
Site 18
T179
T
I
R
D
L
K
Y
T
I
E
N
P
R
H
F
Site 19
T230
L
S
G
I
K
C
P
T
F
R
R
E
A
D
G
Site 20
S238
F
R
R
E
A
D
G
S
E
T
P
E
P
F
A
Site 21
T240
R
E
A
D
G
S
E
T
P
E
P
F
A
A
E
Site 22
Y304
V
D
W
S
I
A
V
Y
T
R
G
A
E
K
L
Site 23
Y329
R
L
R
I
W
R
D
Y
V
A
P
T
A
N
L
Site 24
T333
W
R
D
Y
V
A
P
T
A
N
L
D
Q
K
D
Site 25
Y365
V
K
L
N
S
G
D
Y
K
T
I
H
L
S
S
Site 26
T367
L
N
S
G
D
Y
K
T
I
H
L
S
S
I
R
Site 27
S371
D
Y
K
T
I
H
L
S
S
I
R
P
P
R
L
Site 28
S372
Y
K
T
I
H
L
S
S
I
R
P
P
R
L
E
Site 29
T383
P
R
L
E
G
E
N
T
Q
D
K
N
K
K
L
Site 30
Y394
N
K
K
L
R
P
L
Y
D
I
P
Y
M
F
E
Site 31
Y398
R
P
L
Y
D
I
P
Y
M
F
E
A
R
E
F
Site 32
T418
I
G
K
K
V
N
V
T
V
D
Y
I
R
P
A
Site 33
Y421
K
V
N
V
T
V
D
Y
I
R
P
A
S
P
A
Site 34
S426
V
D
Y
I
R
P
A
S
P
A
T
E
T
V
P
Site 35
T429
I
R
P
A
S
P
A
T
E
T
V
P
A
F
S
Site 36
T431
P
A
S
P
A
T
E
T
V
P
A
F
S
E
R
Site 37
S436
T
E
T
V
P
A
F
S
E
R
T
C
A
T
V
Site 38
T461
L
V
S
K
G
L
A
T
V
I
R
Y
R
Q
D
Site 39
S474
Q
D
D
D
Q
R
S
S
H
Y
D
E
L
L
A
Site 40
Y476
D
D
Q
R
S
S
H
Y
D
E
L
L
A
A
E
Site 41
S495
K
N
G
K
G
L
H
S
K
K
E
V
P
I
H
Site 42
S508
I
H
R
V
A
D
I
S
G
D
T
Q
K
A
K
Site 43
S527
F
L
Q
R
A
G
R
S
E
A
V
V
E
Y
V
Site 44
Y533
R
S
E
A
V
V
E
Y
V
F
S
G
S
R
L
Site 45
S536
A
V
V
E
Y
V
F
S
G
S
R
L
K
L
Y
Site 46
S538
V
E
Y
V
F
S
G
S
R
L
K
L
Y
L
P
Site 47
Y543
S
G
S
R
L
K
L
Y
L
P
K
E
T
C
L
Site 48
S578
V
Q
E
G
E
P
F
S
E
E
A
T
L
F
T
Site 49
T582
E
P
F
S
E
E
A
T
L
F
T
K
E
L
V
Site 50
T633
A
L
S
K
V
H
F
T
A
E
R
S
S
Y
Y
Site 51
S638
H
F
T
A
E
R
S
S
Y
Y
K
S
L
L
S
Site 52
Y639
F
T
A
E
R
S
S
Y
Y
K
S
L
L
S
A
Site 53
S642
E
R
S
S
Y
Y
K
S
L
L
S
A
E
E
A
Site 54
S645
S
Y
Y
K
S
L
L
S
A
E
E
A
A
K
Q
Site 55
Y661
K
E
K
V
W
A
H
Y
E
E
Q
P
V
E
E
Site 56
S679
V
L
E
E
K
E
R
S
A
S
Y
K
P
V
F
Site 57
S681
E
E
K
E
R
S
A
S
Y
K
P
V
F
V
T
Site 58
Y697
I
T
D
D
L
H
F
Y
V
Q
D
V
E
T
G
Site 59
S720
N
M
R
N
D
I
A
S
H
P
P
V
E
G
S
Site 60
S727
S
H
P
P
V
E
G
S
Y
A
P
R
R
G
E
Site 61
Y728
H
P
P
V
E
G
S
Y
A
P
R
R
G
E
F
Site 62
S755
A
R
V
E
K
V
E
S
P
A
K
I
H
V
F
Site 63
Y763
P
A
K
I
H
V
F
Y
I
D
Y
G
N
R
E
Site 64
S774
G
N
R
E
V
L
P
S
T
R
L
G
T
L
S
Site 65
T775
N
R
E
V
L
P
S
T
R
L
G
T
L
S
P
Site 66
S781
S
T
R
L
G
T
L
S
P
A
F
S
T
R
V
Site 67
T811
P
Q
D
D
D
A
R
T
D
A
V
D
S
V
V
Site 68
S816
A
R
T
D
A
V
D
S
V
V
R
D
I
Q
N
Site 69
Y878
F
Q
K
V
I
T
E
Y
L
N
A
Q
E
S
A
Site 70
S887
N
A
Q
E
S
A
K
S
A
R
L
N
L
W
R
Site 71
Y895
A
R
L
N
L
W
R
Y
G
D
F
R
A
D
D
Site 72
Y908
D
D
A
D
E
F
G
Y
S
R
_
_
_
_
_
Site 73
S909
D
A
D
E
F
G
Y
S
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation